Adjunctive Systemic Corticosteroids for Hospitalized Community-Acquired Pneumonia: Systematic Review and Meta-Analysis 2015 Update

Scientific Reports

Volumn 5, Issue , 2015, Pages

  Horita, Nobuyuki ^a   Otsuka, Tatsuya ^b   Haranaga, Shusaku ^c   Namkoong, Ho ^d   Miki, Makoto ^e   Miyashita, Naoyuki ^f   Higa, Futoshi ^g   Takahashi, Hiroshi ^h   Yoshida, Masahiro ⁱ   Kohno, Shigeru ^j   Kaneko, Takeshi ^a  

^a YOKOHAMA CITY UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^b TOHOKU ROSAI HOSPITAL   (Japan)

^c UNIVERSITY OF THE RYUKYUS   (Japan)

^d KEIO UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^e Sendai Red Cross Hospital   (Japan)

^f KAWASAKI MEDICAL SCHOOL   (Japan)

^g National Hospital Organization Okinawa National Hospital   (Japan)

^h Saka General Hospital   (Japan)

ⁱ INTERNATIONAL UNIVERSITY OF HEALTH AND WELFARE   (Japan)

^j NAGASAKI UNIVERSITY GRADUATE SCHOOL OF BIOMEDICAL SCIENCES   (Japan)

more..

Author keywords

[No Author keywords available]

Indexed keywords

ANTIINFECTIVE AGENT; ANTIINFLAMMATORY AGENT; CORTICOSTEROID;

COMBINATION DRUG THERAPY; COMMUNITY-ACQUIRED INFECTIONS; HOSPITALIZATION; HUMAN; INTENSIVE CARE UNIT; LENGTH OF STAY; META ANALYSIS; MORTALITY; ODDS RATIO; PNEUMONIA; TREATMENT OUTCOME;

ADRENAL CORTEX HORMONES; ANTI-BACTERIAL AGENTS; ANTI-INFLAMMATORY AGENTS; COMMUNITY-ACQUIRED INFECTIONS; DRUG THERAPY, COMBINATION; HOSPITALIZATION; HUMANS; INTENSIVE CARE UNITS; LENGTH OF STAY; ODDS RATIO; PNEUMONIA; TREATMENT OUTCOME;

EID: 84941795682     PISSN: None     EISSN: 20452322     Source Type: Journal    
DOI: 10.1038/srep14061     Document Type: Review

References (31)

1. Garnacho-Montero, J. et al. Determinants of outcome in patients with bacteraemic pneumococcal pneumonia: importance of early adequate treatment. Scand. J. Infect. Dis. 42, 185-92 (2010).
2. Musher, D. M. & Thorner, A. R. Community-acquired pneumonia. N. Engl. J. Med. 371, 1619-28 (2014).
3. Wunderink, R. G. & Waterer, G.W. Clinical practice. Community-acquired pneumonia. N. Engl. J. Med. 370, 543-51 (2014).
4. Brouwer, M. C. et al. Corticosteroids for acute bacterial meningitis. Cochrane. Database. Syst. Rev. 6, CD004405 (2013).
5. Moran, J. L., Graham, P. L., Rockliff, S. & Bersten, A. D. Updating the evidence for the role of corticosteroids in severe sepsis and septic shock: a Bayesian meta-analytic perspective. Crit. Care. 14, R134 (2010).
6. Rhen, T. & Cidlowski, J. A. Antiinflammatory action of glucocorticoids - new mechanisms for old drugs. N. Engl. J. Med. 353, 1711-23 (2005).
7. McHardy, V. U. & Schonell, M. E. Ampicillin dosage and use of prednisolone in treatment of pneumonia: co-operative controlled trial. Br. Med. J. 4, 569-73 (1972).
8. Marik, P., Kraus, P., Sribante, J., Havlik, I. & Lipman, J. W. Hydrocortisone and tumor necrosis factor in severe community-acquired pneumonia. a randomized controlled study. Chest. 104, 389-392 (1993).
9. Confalonieri, M. et al. Hydrocortisone infusion for severe community-acquired pneumonia: a preliminary randomized study. Am. J. Respir. Crit. Care Med. 171, 242-8 (2005).
10. Mikami, K. et al. Efficacy of corticosteroids in the treatment of community-acquired pneumonia requiring hospitalization. Lung. 185, 249-55 (2007).
11. Snijders, D., Daniels, J. M., de Graaff, C. S., van der Werf, T. S. & Boersma, W. G. Efficacy of corticosteroids in community-acquired pneumonia: a randomized double-blinded clinical trial. Am. J. Respir. Crit. Care Med. 181, 975-82 (2010).
12. Fernández-Serrano, S. et al. Effect of corticosteroids on the clinical course of community-acquired pneumonia: a randomized controlled trial. Crit. Care. 15, R96 (2011).
13. Meijvis, S. C. et al. Dexamethasone and length of hospital stay in patients with community-acquired pneumonia: a randomised, double-blind, placebo-controlled trial. Lancet. 377, 2023-30 (2011).
14. Sabry, N. A. & Omar, E. E. D. Corticosteroids and ICU Course of Community Acquired Pneumonia in Egyptian Settings. Pharmacology & Pharmacy. 2, 73-81 (2011).
15. Blum, C. A. et al. Adjunct prednisone therapy for patients with community-acquired pneumonia: a multicentre, double-blind, randomised, placebo-controlled trial. Lancet. pii:S0140-6736(14)62447-8 (2015).
16. Torres, A. et al. Effect of corticosteroids on treatment failure among hospitalized patients with severe community-acquired pneumonia and high inflammatory response: a randomized clinical trial. JAMA. 313, 677-86 (2015).
17. Salluh, J. I. et al. Cortisol levels and adrenal response in severe community-acquired pneumonia: a systematic review of the literature. J. Crit. Care. 25, 541.e1-8 (2010).
18. Siempos, I. I., Vardakas, K. Z., Kopterides, P. & Falagas, M. E. Adjunctive therapies for community-acquired pneumonia: a systematic review. J. Antimicrob. Chemother. 62, 661-8 (2008).
19. Chen, Y., Li, K., Pu, H. & Wu, T. Corticosteroids for pneumonia. Cochrane Database Syst. Rev. 3, CD007720 (2011).
20. Nie, W., Zhang, Y., Cheng, J. & Xiu, Q. Corticosteroids in the treatment of community-acquired pneumonia in adults: a meta-analysis. PLoS One. 7, e47926 (2012).
21. Cheng, M., Pan, Z. Y., Yang, J. & Gao, Y. D. Corticosteroid therapy for severe community-acquired pneumonia: a meta-analysis. Respir. Care. 59, 557-63 (2014).
22. Shafiq, M., Mansoor, M. S., Khan, A. A., Sohail, M. R. & Murad, M. H. Adjuvant steroid therapy in community-acquired pneumonia: a systematic review and meta-analysis. J. Hosp. Med. 8, 68-75 (2013).
23. Higgins, P. J. & Green, S. Cochrane Handbook for Systematic Reviews of Interventions (Version 5.1.0). 2011. Available from: http://handbook.cochrane.org/ Accessed on March 25th (2015).
24. Hozo, S. P., Djulbegovic, B. & Hozo, I. Estimating the mean and variance from the median, range, and the size of a sample. BMC. Med. Res. Methodol. 5, 13 (2005).
25. Higgins, J. P., Thompson, S. G., Deeks, J. J. & Altman, D. G. Measuring inconsistency in meta-analyses. BMJ. 327, 557-560 (2003).
26. Mandell L. A. et al. Infectious Diseases Society of America/American Thoracic Society consensus guidelines on the management of community-acquired pneumonia in adults. Clin Infect Dis. 44, S27-72 (2007).
27. Leuppi, J. D. et al. Short-term vs conventional glucocorticoid therapy in acute exacerbations of chronic obstructive pulmonary disease: the REDUCE randomized clinical trial. JAMA. 309, 2223-31 (2013).
28. Tang, B. M., Craig, J. C., Eslick, G. D., Seppelt, I. & McLean, A. S. Use of corticosteroids in acute lung injury and acute respiratory distress syndrome: a systematic review and meta-analysis. Crit. Care Med. 37, 1594-603 (2009).
29. Dellinger, R. P. et al. Surviving Sepsis Campaign: international guidelines for management of severe sepsis and septic shock: 2008. Crit. Care Med. 36, 296-327 (2008).
30. Garcia-Vidal, C. et al. Effects of systemic steroids in patients with severe community-acquired pneumonia. Eur. Respir. J. 30, 951-6 (2007).
31. Bela, N. et al. Efficacy of methylprednisolone in children with severe community acquired pneumonia. Pediatric. Pulmonology. 48, 168-175 (2013).