메뉴 건너뛰기




Volumn 32, Issue SUPPL. 1, 2008, Pages

Immunomodulatory therapies for sepsis: unexpected effects with macrolides

Author keywords

Clarithromycin; Immunomodulation; Sepsis

Indexed keywords

ANTIINFECTIVE AGENT; AZITHROMYCIN; BETA LACTAM; CLARITHROMYCIN; DROTRECOGIN; ENDOTOXIN ANTIBODY; ERYTHROMYCIN; ETANERCEPT; HYDROCORTISONE; IMMUNOMODULATING AGENT; INSULIN; LENERCEPT; MACROLIDE; PLACEBO; TUMOR NECROSIS FACTOR ANTIBODY;

EID: 53849142125     PISSN: 09248579     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ijantimicag.2008.06.004     Document Type: Article
Times cited : (37)

References (32)
  • 1
    • 34247128362 scopus 로고    scopus 로고
    • Deaths: leading causes for 2004
    • Heron M. Deaths: leading causes for 2004. Natl Vital Stat Rep 56 (2007) 1-95
    • (2007) Natl Vital Stat Rep , vol.56 , pp. 1-95
    • Heron, M.1
  • 3
    • 37549020378 scopus 로고    scopus 로고
    • Surviving Sepsis Campaign: international guidelines for management of severe sepsis and septic shock: 2008
    • Dellinger R.P., Levy M.M., Carlet J.M., Bion J., Parker M.M., Jaeschke R., et al. Surviving Sepsis Campaign: international guidelines for management of severe sepsis and septic shock: 2008. Crit Care Med 36 (2008) 296-327
    • (2008) Crit Care Med , vol.36 , pp. 296-327
    • Dellinger, R.P.1    Levy, M.M.2    Carlet, J.M.3    Bion, J.4    Parker, M.M.5    Jaeschke, R.6
  • 4
    • 0037426726 scopus 로고    scopus 로고
    • The pathophysiology and treatment of sepsis
    • Hotchkiss R.S., and Karl I.E. The pathophysiology and treatment of sepsis. N Engl J Med 348 (2003) 138-150
    • (2003) N Engl J Med , vol.348 , pp. 138-150
    • Hotchkiss, R.S.1    Karl, I.E.2
  • 5
    • 0037090339 scopus 로고    scopus 로고
    • Clinical trials of immunomodulatory therapies in severe sepsis and septic shock
    • Vincent J.L., Sun Q., and Dubois M.J. Clinical trials of immunomodulatory therapies in severe sepsis and septic shock. Clin Infect Dis 34 (2003) 1084-1093
    • (2003) Clin Infect Dis , vol.34 , pp. 1084-1093
    • Vincent, J.L.1    Sun, Q.2    Dubois, M.J.3
  • 6
    • 0029043636 scopus 로고
    • A second large controlled clinical study of E5, a monoclonal antibody to endotoxin: results of a prospective, multicenter, randomized, controlled trial. The E5 Sepsis Study Group
    • Bone R.C., Balk R.A., Fein A.M., Perl T.M., Wenzel R.P., Reines H.D., et al. A second large controlled clinical study of E5, a monoclonal antibody to endotoxin: results of a prospective, multicenter, randomized, controlled trial. The E5 Sepsis Study Group. Crit Care Med 23 (1995) 994-1006
    • (1995) Crit Care Med , vol.23 , pp. 994-1006
    • Bone, R.C.1    Balk, R.A.2    Fein, A.M.3    Perl, T.M.4    Wenzel, R.P.5    Reines, H.D.6
  • 7
    • 33747502519 scopus 로고    scopus 로고
    • Safety and efficacy of affinity-purified, anti-tumor necrosis factor-alpha, ovine Fab for injection (CytoFab) in severe sepsis
    • Rice T.W., Wheeler A.P., Morris P.E., Paz H.L., Russell J.A., Edens T.R., et al. Safety and efficacy of affinity-purified, anti-tumor necrosis factor-alpha, ovine Fab for injection (CytoFab) in severe sepsis. Crit Care Med 34 (2006) 2271-2281
    • (2006) Crit Care Med , vol.34 , pp. 2271-2281
    • Rice, T.W.1    Wheeler, A.P.2    Morris, P.E.3    Paz, H.L.4    Russell, J.A.5    Edens, T.R.6
  • 8
    • 9344246862 scopus 로고    scopus 로고
    • Assessment of the safety and efficacy of the monoclonal anti-tumor necrosis factor antibody-fragment, MAK 195F, in patients with sepsis and septic shock: a multicenter, randomized, placebo-controlled, dose-ranging study
    • Reinhart K., Wiegand-Löhnert C., Grimminger F., Kaul M., Withington S., Treacher D., et al. Assessment of the safety and efficacy of the monoclonal anti-tumor necrosis factor antibody-fragment, MAK 195F, in patients with sepsis and septic shock: a multicenter, randomized, placebo-controlled, dose-ranging study. Crit Care Med 24 (1996) 733-742
    • (1996) Crit Care Med , vol.24 , pp. 733-742
    • Reinhart, K.1    Wiegand-Löhnert, C.2    Grimminger, F.3    Kaul, M.4    Withington, S.5    Treacher, D.6
  • 9
    • 0029835023 scopus 로고    scopus 로고
    • INTERSEPT: an international, multicenter, placebo-controlled trial of monoclonal antibody to human tumor necrosis factor-alpha in patients with sepsis. International Sepsis Trial Study Group
    • Cohen J., and Carlet J. INTERSEPT: an international, multicenter, placebo-controlled trial of monoclonal antibody to human tumor necrosis factor-alpha in patients with sepsis. International Sepsis Trial Study Group. Crit Care Med 24 (1996) 1431-1440
    • (1996) Crit Care Med , vol.24 , pp. 1431-1440
    • Cohen, J.1    Carlet, J.2
  • 10
    • 0035100346 scopus 로고    scopus 로고
    • Lenercept (p55 tumor necrosis factor receptor fusion protein) in severe sepsis and early septic shock: a randomized, double-blind, placebo-controlled, multicenter phase III trial with 1,342 patients
    • Abraham E., Laterre P.F., Garbino J., Pingleton S., Butler T., Dugernier T., et al. Lenercept (p55 tumor necrosis factor receptor fusion protein) in severe sepsis and early septic shock: a randomized, double-blind, placebo-controlled, multicenter phase III trial with 1,342 patients. Crit Care Med 29 (2001) 503-510
    • (2001) Crit Care Med , vol.29 , pp. 503-510
    • Abraham, E.1    Laterre, P.F.2    Garbino, J.3    Pingleton, S.4    Butler, T.5    Dugernier, T.6
  • 11
    • 8244235133 scopus 로고    scopus 로고
    • p55 tumor necrosis factor receptor fusion protein in the treatment of patients with severe sepsis and septic shock. A randomized controlled multicenter trial. Ro 45-2081 Study Group
    • Abraham E., Glauser M.P., Butler T., Garbino J., Gelmont D., Laterre P.F., et al. p55 tumor necrosis factor receptor fusion protein in the treatment of patients with severe sepsis and septic shock. A randomized controlled multicenter trial. Ro 45-2081 Study Group. JAMA 277 (1997) 1531-1538
    • (1997) JAMA , vol.277 , pp. 1531-1538
    • Abraham, E.1    Glauser, M.P.2    Butler, T.3    Garbino, J.4    Gelmont, D.5    Laterre, P.F.6
  • 13
    • 25444492831 scopus 로고    scopus 로고
    • Drotrecogin alfa (activated) for adults with severe sepsis and a low risk of death
    • Abraham E., Laterre P.F., Garg R., Levy H., Talwar D., Trzaskoma B.L., et al. Drotrecogin alfa (activated) for adults with severe sepsis and a low risk of death. N Engl J Med 353 (2005) 1332-1341
    • (2005) N Engl J Med , vol.353 , pp. 1332-1341
    • Abraham, E.1    Laterre, P.F.2    Garg, R.3    Levy, H.4    Talwar, D.5    Trzaskoma, B.L.6
  • 15
    • 0037151571 scopus 로고    scopus 로고
    • Effect of treatment with low doses of hydrocortisone and fludrocortisone on mortality in patients with septic shock
    • Annane D., Sébille V., Charpentier C., Bollaert P.E., François B., Korach J.M., et al. Effect of treatment with low doses of hydrocortisone and fludrocortisone on mortality in patients with septic shock. JAMA 288 (2002) 862-871
    • (2002) JAMA , vol.288 , pp. 862-871
    • Annane, D.1    Sébille, V.2    Charpentier, C.3    Bollaert, P.E.4    François, B.5    Korach, J.M.6
  • 17
    • 0038143318 scopus 로고    scopus 로고
    • Long-term efficacy and safety of clarithromycin treatment in patients with diffuse panbronchiolitis
    • Kadota J., Mukae H., Ishii H., Nagata T., Kaida H., Tomono K., et al. Long-term efficacy and safety of clarithromycin treatment in patients with diffuse panbronchiolitis. Respir Med 97 (2003) 844-850
    • (2003) Respir Med , vol.97 , pp. 844-850
    • Kadota, J.1    Mukae, H.2    Ishii, H.3    Nagata, T.4    Kaida, H.5    Tomono, K.6
  • 18
    • 3543117815 scopus 로고    scopus 로고
    • Macrolide activities beyond their antimicrobial effects: macrolides in diffuse panbronchiolitis and cystic fibrosis
    • Schultz M.J. Macrolide activities beyond their antimicrobial effects: macrolides in diffuse panbronchiolitis and cystic fibrosis. J Antimicrob Chemother 54 (2005) 21-28
    • (2005) J Antimicrob Chemother , vol.54 , pp. 21-28
    • Schultz, M.J.1
  • 19
    • 36849073243 scopus 로고    scopus 로고
    • Macrolides beyond the conventional antimicrobials: a class of potent immunomodulators
    • Giamarellos-Bourboulis E.J. Macrolides beyond the conventional antimicrobials: a class of potent immunomodulators. Int J Antimicrob Agents 31 (2008) 12-20
    • (2008) Int J Antimicrob Agents , vol.31 , pp. 12-20
    • Giamarellos-Bourboulis, E.J.1
  • 20
    • 0036001168 scopus 로고    scopus 로고
    • Clarithromycin suppresses lipopolysaccharide-induced interleukin-8 production by human monocytes through AP-1 and NF-κB transcription factors
    • Kikuchi T., Hagiwara K., Honda Y., Gomi K., Kobayashi T., Takahashi H., et al. Clarithromycin suppresses lipopolysaccharide-induced interleukin-8 production by human monocytes through AP-1 and NF-κB transcription factors. J Antimicrob Chemother 49 (2002) 745-755
    • (2002) J Antimicrob Chemother , vol.49 , pp. 745-755
    • Kikuchi, T.1    Hagiwara, K.2    Honda, Y.3    Gomi, K.4    Kobayashi, T.5    Takahashi, H.6
  • 21
    • 17744376776 scopus 로고    scopus 로고
    • Lower mortality among patients with community-acquired pneumonia treated with a macrolide plus a beta-lactam agent versus a beta-lactam agent alone
    • García Vázquez E., Mensa J., Martínez J.A., Marcos M.A., Puig J., Ortega M., et al. Lower mortality among patients with community-acquired pneumonia treated with a macrolide plus a beta-lactam agent versus a beta-lactam agent alone. Eur J Clin Microbiol Infect Dis 24 (2005) 190-195
    • (2005) Eur J Clin Microbiol Infect Dis , vol.24 , pp. 190-195
    • García Vázquez, E.1    Mensa, J.2    Martínez, J.A.3    Marcos, M.A.4    Puig, J.5    Ortega, M.6
  • 22
    • 0037442372 scopus 로고    scopus 로고
    • Addition of a macrolide to a beta-lactam-based empirical antibiotic regimen is associated with lower in-hospital mortality for patients with bacteremic pneumococcal pneumonia
    • Martínez J.A., Horcajada J.P., Almela M., Marco F., Soriano A., García E., et al. Addition of a macrolide to a beta-lactam-based empirical antibiotic regimen is associated with lower in-hospital mortality for patients with bacteremic pneumococcal pneumonia. Clin Infect Dis 36 (2003) 389-395
    • (2003) Clin Infect Dis , vol.36 , pp. 389-395
    • Martínez, J.A.1    Horcajada, J.P.2    Almela, M.3    Marco, F.4    Soriano, A.5    García, E.6
  • 23
    • 33847173420 scopus 로고    scopus 로고
    • Antibiotics for bacteremic pneumonia: improved outcomes with macrolides but not fluoroquinolones
    • Metersky M.L., Ma A., Houck P.M., and Bratzler D.W. Antibiotics for bacteremic pneumonia: improved outcomes with macrolides but not fluoroquinolones. Chest 131 (2007) 466-473
    • (2007) Chest , vol.131 , pp. 466-473
    • Metersky, M.L.1    Ma, A.2    Houck, P.M.3    Bratzler, D.W.4
  • 24
    • 0347361713 scopus 로고    scopus 로고
    • Immunomodulatory clarithromycin treatment of experimental sepsis and acute pyelonephritis caused by multidrug-resistant Pseudomonas aeruginosa
    • Giamarellos-Bourboulis E.J., Adamis T., Laoutaris G., Sabracos L., Koussoulas V., Mouktaroudi M., et al. Immunomodulatory clarithromycin treatment of experimental sepsis and acute pyelonephritis caused by multidrug-resistant Pseudomonas aeruginosa. Antimicrob Agents Chemother 48 (2004) 93-99
    • (2004) Antimicrob Agents Chemother , vol.48 , pp. 93-99
    • Giamarellos-Bourboulis, E.J.1    Adamis, T.2    Laoutaris, G.3    Sabracos, L.4    Koussoulas, V.5    Mouktaroudi, M.6
  • 25
    • 33644929201 scopus 로고    scopus 로고
    • Clarithromycin is an effective immunomodulator when administered late in experimental pyelonephritis by multidrug-resistant Pseudomonas aeruginosa
    • Giamarellos-Bourboulis E.J., Antonopoulou A., Raftogiannis M., Koutoukas P., Tsaganos T., Tziortzioti V., et al. Clarithromycin is an effective immunomodulator when administered late in experimental pyelonephritis by multidrug-resistant Pseudomonas aeruginosa. BMC Infect Dis 6 (2006) 31
    • (2006) BMC Infect Dis , vol.6 , pp. 31
    • Giamarellos-Bourboulis, E.J.1    Antonopoulou, A.2    Raftogiannis, M.3    Koutoukas, P.4    Tsaganos, T.5    Tziortzioti, V.6
  • 29
    • 41149115725 scopus 로고    scopus 로고
    • Immunomodulatory effect of three-day continuous administration of clarithromycin for experimental sepsis due to multidrug-resistant Pseudomonas aeruginosa
    • Baziaka F., Giamarellos-Bourboulis E.J., Raftogiannis M., Adamis T., Tziortzioti V., Sabracos L., et al. Immunomodulatory effect of three-day continuous administration of clarithromycin for experimental sepsis due to multidrug-resistant Pseudomonas aeruginosa. J Chemother 20 (2008) 63-68
    • (2008) J Chemother , vol.20 , pp. 63-68
    • Baziaka, F.1    Giamarellos-Bourboulis, E.J.2    Raftogiannis, M.3    Adamis, T.4    Tziortzioti, V.5    Sabracos, L.6
  • 30
    • 53849098128 scopus 로고    scopus 로고
    • Abbott Laboratories. Clarithromycin for intravenous injection. Clinical expert report. Data on file; December 1998.
    • Abbott Laboratories. Clarithromycin for intravenous injection. Clinical expert report. Data on file; December 1998.
  • 31
    • 0037389094 scopus 로고    scopus 로고
    • 2001 SCCM/ESICM/ACCP/ATS/SIS international sepsis definitions conference
    • Levy M., Fink M.P., Marshall J.C., Abraham E., Angus D., Cook D., et al. 2001 SCCM/ESICM/ACCP/ATS/SIS international sepsis definitions conference. Crit Care Med 31 (2003) 1250-1256
    • (2003) Crit Care Med , vol.31 , pp. 1250-1256
    • Levy, M.1    Fink, M.P.2    Marshall, J.C.3    Abraham, E.4    Angus, D.5    Cook, D.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.