Pharmacokinetics, tolerability, and preliminary efficacy of human anti- Pseudomonas aeruginosa monoclonal antibodies in pneumonia and burn infection patients

Hybridoma

Volumn 16, Issue 5, 1997, Pages 413-420

  Harrison, Francisco J J ^a   Rohm, Detlef ^b   Kohzuki, Tsuneo ^c   Noguchi, Hiroshi ^c  

^a Harrison Clinical Research GmbH   (Germany)

^b BIOTEST AG   (Germany)

^c DAINIPPON SUMITOMO PHARMA CO LTD   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

HI 223; IMMUNOGLOBULIN M; IN 2A8; MH 4H7; MONOCLONAL ANTIBODY; SM 17220; UNCLASSIFIED DRUG;

ADULT; AGED; ANTIBODY TITER; ANTIGENICITY; ARTICLE; BURN INFECTION; CLINICAL ARTICLE; DRUG EFFICACY; DRUG HALF LIFE; DRUG MIXTURE; DRUG SAFETY; DRUG TOLERABILITY; FEMALE; HUMAN; INTRAVENOUS DRUG ADMINISTRATION; MALE; PNEUMONIA; PRIORITY JOURNAL; PSEUDOMONAS AERUGINOSA;

EID: 0030692764     PISSN: 0272457X     EISSN: None     Source Type: Journal    
DOI: 10.1089/hyb.1997.16.413     Document Type: Article

References (19)

1. Pennington JE: Pseudomonas aeruginosa. Vaccines and immunotherapy. Infect Dis Clin North Am 1990;4:259-270.
2. Nakhla LS, and Sanders R: Microbiological aspects of burns at Mount Vernon Hospital, UK. Burns 1991;17:309-312.
3. Pollack M, and Young LS: Protective activity of antibodies to exotoxin A and lipopolysaccharide at the onset of Pseudomonas aeruginosa septicemia in man. J Clin Invest 1979;63:276-286.
4. Cross AS, Sadoff JC, Iglewski BH, and Sokol PA: Evidence for the role of toxin A in the pathogenesis of infection with Pseudomonas aeruginosa in humans. J Infect Dis 1980; 142: 538-546.
5. Pennington JE, Pier GB, and Small GJ: Efficacy of intravenous immune globulin for treatment of experimental Pseudomonas aeruginosa pneumonia. J Crit Care 1986;1:4-10.
6. Van-Wye JE, Collins MS, Baylor M, Pennington JE, Hsu YP, Sampanvejsopa V, and Moss RB: Pseudomonas hyperimmune globulin passive immunotherapy for pulmonary exacerbations in cystic fibrosis. Pediatr Pulmonol 1990;9:7-18.
7. Saravolatz LD, Markowitz N, Collins MS, Bogdanoff D, and Pennington JE: Safety, pharmacokinetics, and functional activity of human anti-Pseudomonas aeruginosa monoclonal antibodies in septic and nonseptic patients. J Infect Dis 1991;164:803-806.
8. Daifuku R, Haenftling K, Young J, Groves ES, Turrell C, and Meyers FJ: Phase I study of antiliposaccharide human monoclonal antibody MAB-T88. Antimicrob Agents Chemother 1992;36:2349-2351.
9. Fisher CJ, Zimmerman J, Khazaeli MB, Albertson TE, Dellinger RP, Panacek EA, Foulke GE, Dating C, Smith CR, and LoBuglio AF: Initial evaluation of human monoclonal anti-lipid A antibody (HA-1A) in patients with sepsis syndrome. Crit Care Med 1990;18:1311-1315.
10. Yokota S, Ochi H, Ohtsuka H, Kato M, and Noguchi H: Heterogeneity of the L-rhamnose residue in the outer core of Pseudomonas aeruginosa lipopolysaccharide, characterized by using human monoclonal antibodies. Infect Immun 1988;57:1691-1696.
11. Terashima M, Uezumi I, Tomio T, Kato M, Irie K, Okuda T, Yokota S, and Noguchi H: Protective human monoclonal antibody directed to the outer core region of Pseudomonas aeruginosa lipopolysaccharide. Infect Immun 1991;59:1-6.
12. Ochi H, Ohtsuka H, Yokota S, Uezumi I, Terashima M, Irie K, and Noguchi H: Inhibitory activity on bacterial antibodies against flagella of Pseudomonas aeruginosa. Infect Immun 1991;59:550-554.
13. Uezumi I, Terashima M, Kohzuki T, Kato M, Irie K, Ochi H, and Noguchi H: Effects of a human antiflagellar monoclonal antibody in combination with antibiotics on P. aeruginosa infection. Antimicrob Agents Chemother 1992;36:1290-1295.
14. Noguchi H, Yokota S, Ohtsuka H, Kohzuki T, Terashima M, and Irie K: Broad-spectra human monoclonal antibodies that protect mice infected with P. aeruginosa. In: P. aeruginosa in human diseases. Antibiot Chemother. Vol. 4. Homma JY, Tanimoto H, Holder IA, Høiby N, and Döring G (Eds). Karger, Basel, Switzerland, 1991, pp. 172-184.
15. Yamaoka K, Tanigawara Y, and Nakagawa T: A pharmacokinetic analysis program (MULTI) for microcomputer. J Pharm Dyn 1981;4:879-885.
16. Homma JY: A new antigenic schema and live-cell slide-agglutination procedure for the infrasubspecific serologic classification of Pseudomonas aeruginosa. Jpn J Exp Med 1976;46:329-336.
17. Knirel YA, Vinogradov EV, Kocharova NA, Paramonov NA, Kochetkov NK, Dmitriev BA, Stanislavsky ES, and Lanyi B: The structure of O-specific polysaccharides and serological classification of Pseudomonas aeruginosa. Acta Microbiol Hung 1988;35:3-24.
18. Koshland ME: The coming of age of the immunoglobulin J chain. Annu Rev Immunol 1985;3:425-453.
19. Winkelhake JL: Immunoglobulin structure and effector functions. Immunochem (Mol Immunol) 1978;15:695-714.