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Volumn 456, Issue , 2016, Pages 107-114

Imbalanced cholesterol metabolism in Alzheimer's disease

Author keywords

Alzheimer's disease; ApoE; A ; Cholesterol; LRP1; PCSK9

Indexed keywords

AMYLOID BETA PROTEIN; AMYLOID PRECURSOR PROTEIN; APOLIPOPROTEIN E; CHOLESTEROL; KEXIN; LOW DENSITY LIPOPROTEIN RECEPTOR RELATED PROTEIN; OXYSTEROL; PROPROTEIN CONVERTASE SUBTILISIN KEXIN TYPE 9; UNCLASSIFIED DRUG;

EID: 84960444400     PISSN: 00098981     EISSN: 18733492     Source Type: Journal    
DOI: 10.1016/j.cca.2016.02.024     Document Type: Review
Times cited : (107)

References (59)
  • 1
    • 84870625593 scopus 로고    scopus 로고
    • A bioinorganic view of Alzheimer's disease: when misplaced metal ions (re)direct the electrons to the wrong target
    • Faller P., Hureau C. A bioinorganic view of Alzheimer's disease: when misplaced metal ions (re)direct the electrons to the wrong target. Chem. Weinheim Bergstr. Ger. 2012, 18:15910-15920.
    • (2012) Chem. Weinheim Bergstr. Ger. , vol.18 , pp. 15910-15920
    • Faller, P.1    Hureau, C.2
  • 2
    • 84869869399 scopus 로고    scopus 로고
    • Association studies of several cholesterol-related genes (ABCA1, CETP and LIPC) with serum lipids and risk of Alzheimer's disease
    • Xiao Z., Wang J., Chen W., Wang P., Zeng H., Chen W. Association studies of several cholesterol-related genes (ABCA1, CETP and LIPC) with serum lipids and risk of Alzheimer's disease. Lipids Health Dis. 2012, 11:163.
    • (2012) Lipids Health Dis. , vol.11 , pp. 163
    • Xiao, Z.1    Wang, J.2    Chen, W.3    Wang, P.4    Zeng, H.5    Chen, W.6
  • 3
    • 79955051063 scopus 로고    scopus 로고
    • Linking lipids to Alzheimer's disease: cholesterol and beyond
    • Di Paolo G., Kim T.W. Linking lipids to Alzheimer's disease: cholesterol and beyond. Nat. Rev. Neurosci. 2011, 12:284-296.
    • (2011) Nat. Rev. Neurosci. , vol.12 , pp. 284-296
    • Di Paolo, G.1    Kim, T.W.2
  • 4
    • 84939954649 scopus 로고    scopus 로고
    • Cholesterol metabolism and homeostasis in the brain
    • Zhang J., Liu Q. Cholesterol metabolism and homeostasis in the brain. Protein Cell 2015, 6:254-264.
    • (2015) Protein Cell , vol.6 , pp. 254-264
    • Zhang, J.1    Liu, Q.2
  • 5
    • 84884339335 scopus 로고    scopus 로고
    • Cerebral and extracerebral cholesterol metabolism and CSF markers of Alzheimer's disease
    • Popp J., Meichsner S., Kolsch H., et al. Cerebral and extracerebral cholesterol metabolism and CSF markers of Alzheimer's disease. Biochem. Pharmacol. 2013, 86:37-42.
    • (2013) Biochem. Pharmacol. , vol.86 , pp. 37-42
    • Popp, J.1    Meichsner, S.2    Kolsch, H.3
  • 6
    • 84864812652 scopus 로고    scopus 로고
    • Effect of western and high fat diets on memory and cholinergic measures in the rat
    • Kosari S., Badoer E., Nguyen J.C., Killcross A.S., Jenkins T.A. Effect of western and high fat diets on memory and cholinergic measures in the rat. Behav. Brain Res. 2012, 235:98-103.
    • (2012) Behav. Brain Res. , vol.235 , pp. 98-103
    • Kosari, S.1    Badoer, E.2    Nguyen, J.C.3    Killcross, A.S.4    Jenkins, T.A.5
  • 7
    • 0037031125 scopus 로고    scopus 로고
    • Apolipoprotein E epsilon4 allele, elevated midlife total cholesterol level, and high midlife systolic blood pressure are independent risk factors for late-life Alzheimer disease
    • Kivipelto M., Helkala E.L., Laakso M.P., et al. Apolipoprotein E epsilon4 allele, elevated midlife total cholesterol level, and high midlife systolic blood pressure are independent risk factors for late-life Alzheimer disease. Ann. Intern. Med. 2002, 137:149-155.
    • (2002) Ann. Intern. Med. , vol.137 , pp. 149-155
    • Kivipelto, M.1    Helkala, E.L.2    Laakso, M.P.3
  • 8
    • 33947500485 scopus 로고    scopus 로고
    • Serum cholesterol changes after midlife and late-life cognition: twenty-one-year follow-up study
    • Solomon A., Kareholt I., Ngandu T., et al. Serum cholesterol changes after midlife and late-life cognition: twenty-one-year follow-up study. Neurology 2007, 68:751-756.
    • (2007) Neurology , vol.68 , pp. 751-756
    • Solomon, A.1    Kareholt, I.2    Ngandu, T.3
  • 9
    • 62449242294 scopus 로고    scopus 로고
    • Contribution of vascular risk factors to the progression in Alzheimer disease
    • Helzner E.P., Luchsinger J.A., Scarmeas N., et al. Contribution of vascular risk factors to the progression in Alzheimer disease. Arch. Neurol. 2009, 66:343-348.
    • (2009) Arch. Neurol. , vol.66 , pp. 343-348
    • Helzner, E.P.1    Luchsinger, J.A.2    Scarmeas, N.3
  • 10
    • 47849109721 scopus 로고    scopus 로고
    • Involvement of cholesterol in the pathogenesis of Alzheimer's disease: role of statins
    • Pregelj P. Involvement of cholesterol in the pathogenesis of Alzheimer's disease: role of statins. Psychiatr. Danub. 2008, 20:162-167.
    • (2008) Psychiatr. Danub. , vol.20 , pp. 162-167
    • Pregelj, P.1
  • 11
    • 80053928598 scopus 로고    scopus 로고
    • Cholesterol level and statin use in Alzheimer disease: I. Review of epidemiological and preclinical studies
    • Shepardson N.E., Shankar G.M., Selkoe D.J. Cholesterol level and statin use in Alzheimer disease: I. Review of epidemiological and preclinical studies. Arch. Neurol. 2011, 68:1239-1244.
    • (2011) Arch. Neurol. , vol.68 , pp. 1239-1244
    • Shepardson, N.E.1    Shankar, G.M.2    Selkoe, D.J.3
  • 12
    • 79959348158 scopus 로고    scopus 로고
    • Simvastatin and other HMG-CoA reductase inhibitors on brain cholesterol levels in Alzheimer's disease
    • Longenberger J., Shah Z.A. Simvastatin and other HMG-CoA reductase inhibitors on brain cholesterol levels in Alzheimer's disease. Curr. Alzheimer Res. 2011, 8:434-442.
    • (2011) Curr. Alzheimer Res. , vol.8 , pp. 434-442
    • Longenberger, J.1    Shah, Z.A.2
  • 13
    • 84983514598 scopus 로고    scopus 로고
    • Early statin use and the progression of Alzheimer disease: a total population-based case-control study
    • Lin F.C., Chuang Y.S., Hsieh H.M., et al. Early statin use and the progression of Alzheimer disease: a total population-based case-control study. Medicine 2015, 94.
    • (2015) Medicine , vol.94
    • Lin, F.C.1    Chuang, Y.S.2    Hsieh, H.M.3
  • 14
    • 84856072382 scopus 로고    scopus 로고
    • Comparative lipidomic analysis of mouse and human brain with Alzheimer disease
    • Chan R.B., Oliveira T.G., Cortes E.P., et al. Comparative lipidomic analysis of mouse and human brain with Alzheimer disease. J. Biol. Chem. 2012, 287:2678-2688.
    • (2012) J. Biol. Chem. , vol.287 , pp. 2678-2688
    • Chan, R.B.1    Oliveira, T.G.2    Cortes, E.P.3
  • 15
    • 57449119576 scopus 로고    scopus 로고
    • Activity-regulated cytoskeleton-associated protein in rodent brain is down-regulated by high fat diet in vivo and by 27-hydroxycholesterol in vitro
    • Mateos L., Akterin S., Gil-Bea F.J., et al. Activity-regulated cytoskeleton-associated protein in rodent brain is down-regulated by high fat diet in vivo and by 27-hydroxycholesterol in vitro. Brain Pathol. 2009, 19:69-80.
    • (2009) Brain Pathol. , vol.19 , pp. 69-80
    • Mateos, L.1    Akterin, S.2    Gil-Bea, F.J.3
  • 16
    • 0033933738 scopus 로고    scopus 로고
    • Expression profile of transcripts in Alzheimer's disease tangle-bearing CA1 neurons
    • Ginsberg S.D., Hemby S.E., Lee V.M., Eberwine J.H., Trojanowski J.Q. Expression profile of transcripts in Alzheimer's disease tangle-bearing CA1 neurons. Ann. Neurol. 2000, 48:77-87.
    • (2000) Ann. Neurol. , vol.48 , pp. 77-87
    • Ginsberg, S.D.1    Hemby, S.E.2    Lee, V.M.3    Eberwine, J.H.4    Trojanowski, J.Q.5
  • 17
    • 82855172098 scopus 로고    scopus 로고
    • Positive correlation between elevated plasma cholesterol levels and cognitive impairments in LDL receptor knockout mice: relevance of cortico-cerebral mitochondrial dysfunction and oxidative stress
    • de Oliveira J., Hort M.A., Moreira E.L., et al. Positive correlation between elevated plasma cholesterol levels and cognitive impairments in LDL receptor knockout mice: relevance of cortico-cerebral mitochondrial dysfunction and oxidative stress. Neuroscience 2011, 197:99-106.
    • (2011) Neuroscience , vol.197 , pp. 99-106
    • de Oliveira, J.1    Hort, M.A.2    Moreira, E.L.3
  • 18
    • 79960795564 scopus 로고    scopus 로고
    • ApoB100/LDLR-/- hypercholesterolaemic mice as a model for mild cognitive impairment and neuronal damage
    • Ramirez C., Sierra S., Tercero I., et al. ApoB100/LDLR-/- hypercholesterolaemic mice as a model for mild cognitive impairment and neuronal damage. PLoS One 2011, 6.
    • (2011) PLoS One , vol.6
    • Ramirez, C.1    Sierra, S.2    Tercero, I.3
  • 19
    • 84866687889 scopus 로고    scopus 로고
    • Hypercholesterolemia accelerates intraneuronal accumulation of Abeta oligomers resulting in memory impairment in Alzheimer's disease model mice
    • Umeda T., Tomiyama T., Kitajima E., et al. Hypercholesterolemia accelerates intraneuronal accumulation of Abeta oligomers resulting in memory impairment in Alzheimer's disease model mice. Life Sci. 2012, 91:1169-1176.
    • (2012) Life Sci. , vol.91 , pp. 1169-1176
    • Umeda, T.1    Tomiyama, T.2    Kitajima, E.3
  • 20
    • 84863238360 scopus 로고    scopus 로고
    • Simvastatin blocks blood-brain barrier disruptions induced by elevated cholesterol both in vivo and in vitro
    • Jiang X., Guo M., Su J., et al. Simvastatin blocks blood-brain barrier disruptions induced by elevated cholesterol both in vivo and in vitro. Int. J. Alzheimers Dis. 2012, 2012:109324.
    • (2012) Int. J. Alzheimers Dis. , vol.2012 , pp. 109324
    • Jiang, X.1    Guo, M.2    Su, J.3
  • 21
    • 42649109113 scopus 로고    scopus 로고
    • Caffeine blocks disruption of blood brain barrier in a rabbit model of Alzheimer's disease
    • Chen X., Gawryluk J.W., Wagener J.F., Ghribi O., Geiger J.D. Caffeine blocks disruption of blood brain barrier in a rabbit model of Alzheimer's disease. J. Neuroinflammation 2008, 5:12.
    • (2008) J. Neuroinflammation , vol.5 , pp. 12
    • Chen, X.1    Gawryluk, J.W.2    Wagener, J.F.3    Ghribi, O.4    Geiger, J.D.5
  • 22
    • 0030755944 scopus 로고    scopus 로고
    • A new function for the LDL receptor: transcytosis of LDL across the blood-brain barrier
    • Dehouck B., Fenart L., Dehouck M.P., Pierce A., Torpier G., Cecchelli R. A new function for the LDL receptor: transcytosis of LDL across the blood-brain barrier. J. Cell Biol. 1997, 138:877-889.
    • (1997) J. Cell Biol. , vol.138 , pp. 877-889
    • Dehouck, B.1    Fenart, L.2    Dehouck, M.P.3    Pierce, A.4    Torpier, G.5    Cecchelli, R.6
  • 23
    • 84926312823 scopus 로고    scopus 로고
    • Amyloid beta oligomers in Alzheimer's disease pathogenesis, treatment, and diagnosis
    • Viola K.L., Klein W.L. Amyloid beta oligomers in Alzheimer's disease pathogenesis, treatment, and diagnosis. Acta Neuropathol. 2015, 129:183-206.
    • (2015) Acta Neuropathol. , vol.129 , pp. 183-206
    • Viola, K.L.1    Klein, W.L.2
  • 24
    • 77953282057 scopus 로고
    • Direct binding of cholesterol to the amyloid precursor protein: an important interaction in lipid-Alzheimer's disease relationships?
    • Beel A.J., Sakakura M., Barrett P.J., Sanders C.R. Direct binding of cholesterol to the amyloid precursor protein: an important interaction in lipid-Alzheimer's disease relationships?. Biochim. Biophys. Acta 1801, 2010:975-982.
    • (1801) Biochim. Biophys. Acta , vol.2010 , pp. 975-982
    • Beel, A.J.1    Sakakura, M.2    Barrett, P.J.3    Sanders, C.R.4
  • 25
    • 45549093275 scopus 로고    scopus 로고
    • Independent inhibition of Alzheimer disease beta- and gamma-secretase cleavage by lowered cholesterol levels
    • Grimm M.O., Grimm H.S., Tomic I., Beyreuther K., Hartmann T., Bergmann C. Independent inhibition of Alzheimer disease beta- and gamma-secretase cleavage by lowered cholesterol levels. J. Biol. Chem. 2008, 283:11302-11311.
    • (2008) J. Biol. Chem. , vol.283 , pp. 11302-11311
    • Grimm, M.O.1    Grimm, H.S.2    Tomic, I.3    Beyreuther, K.4    Hartmann, T.5    Bergmann, C.6
  • 26
    • 77955469334 scopus 로고    scopus 로고
    • The acyl-coenzyme A: cholesterol acyltransferase inhibitor CI-1011 reverses diffuse brain amyloid pathology in aged amyloid precursor protein transgenic mice
    • Huttunen H.J., Havas D., Peach C., et al. The acyl-coenzyme A: cholesterol acyltransferase inhibitor CI-1011 reverses diffuse brain amyloid pathology in aged amyloid precursor protein transgenic mice. J. Neuropathol. Exp. Neurol. 2010, 69:777-788.
    • (2010) J. Neuropathol. Exp. Neurol. , vol.69 , pp. 777-788
    • Huttunen, H.J.1    Havas, D.2    Peach, C.3
  • 27
    • 62149140601 scopus 로고    scopus 로고
    • Differential effects of 24-hydroxycholesterol and 27-hydroxycholesterol on beta-amyloid precursor protein levels and processing in human neuroblastoma SH-SY5Y cells
    • Prasanthi J.R., Huls A., Thomasson S., Thompson A., Schommer E., Ghribi O. Differential effects of 24-hydroxycholesterol and 27-hydroxycholesterol on beta-amyloid precursor protein levels and processing in human neuroblastoma SH-SY5Y cells. Mol. Neurodegener. 2009, 4:1.
    • (2009) Mol. Neurodegener. , vol.4 , pp. 1
    • Prasanthi, J.R.1    Huls, A.2    Thomasson, S.3    Thompson, A.4    Schommer, E.5    Ghribi, O.6
  • 28
    • 74149083432 scopus 로고    scopus 로고
    • Adeno-associated virus gene therapy with cholesterol 24-hydroxylase reduces the amyloid pathology before or after the onset of amyloid plaques in mouse models of Alzheimer's disease
    • Hudry E., Van Dam D., Kulik W., et al. Adeno-associated virus gene therapy with cholesterol 24-hydroxylase reduces the amyloid pathology before or after the onset of amyloid plaques in mouse models of Alzheimer's disease. Mol. Ther. 2010, 18:44-53.
    • (2010) Mol. Ther. , vol.18 , pp. 44-53
    • Hudry, E.1    Van Dam, D.2    Kulik, W.3
  • 29
    • 0842303768 scopus 로고    scopus 로고
    • Changes in the levels of cerebral and extracerebral sterols in the brain of patients with Alzheimer's disease
    • Heverin M., Bogdanovic N., Lutjohann D., et al. Changes in the levels of cerebral and extracerebral sterols in the brain of patients with Alzheimer's disease. J. Lipid Res. 2004, 45:186-193.
    • (2004) J. Lipid Res. , vol.45 , pp. 186-193
    • Heverin, M.1    Bogdanovic, N.2    Lutjohann, D.3
  • 30
    • 84899097056 scopus 로고    scopus 로고
    • Atherosclerosis and Alzheimer-diseases with a common cause? Inflammation, oxysterols, vasculature
    • Lathe R., Sapronova A., Kotelevtsev Y. Atherosclerosis and Alzheimer-diseases with a common cause? Inflammation, oxysterols, vasculature. BMC Geriatr. 2014, 14:36.
    • (2014) BMC Geriatr. , vol.14 , pp. 36
    • Lathe, R.1    Sapronova, A.2    Kotelevtsev, Y.3
  • 31
    • 84874107996 scopus 로고    scopus 로고
    • 24S-hydroxycholesterol in plasma: a marker of cholesterol turnover in neurodegenerative diseases
    • Leoni V., Caccia C. 24S-hydroxycholesterol in plasma: a marker of cholesterol turnover in neurodegenerative diseases. Biochimie 2013, 95:595-612.
    • (2013) Biochimie , vol.95 , pp. 595-612
    • Leoni, V.1    Caccia, C.2
  • 32
    • 84899490048 scopus 로고    scopus 로고
    • Cholesterol as a causative factor in Alzheimer's disease: a debatable hypothesis
    • Wood W.G., Li L., Muller W.E., Eckert G.P. Cholesterol as a causative factor in Alzheimer's disease: a debatable hypothesis. J. Neurochem. 2014, 129:559-572.
    • (2014) J. Neurochem. , vol.129 , pp. 559-572
    • Wood, W.G.1    Li, L.2    Muller, W.E.3    Eckert, G.P.4
  • 33
    • 84861903643 scopus 로고    scopus 로고
    • Structural differences between apoE3 and apoE4 may be useful in developing therapeutic agents for Alzheimer's disease
    • Frieden C., Garai K. Structural differences between apoE3 and apoE4 may be useful in developing therapeutic agents for Alzheimer's disease. Proc. Natl. Acad. Sci. U. S. A. 2012, 109:8913-8918.
    • (2012) Proc. Natl. Acad. Sci. U. S. A. , vol.109 , pp. 8913-8918
    • Frieden, C.1    Garai, K.2
  • 34
    • 79954748692 scopus 로고    scopus 로고
    • Cerebral amyloid-beta PET with florbetaben (18F) in patients with Alzheimer's disease and healthy controls: a multicentre phase 2 diagnostic study
    • Barthel H., Gertz H.J., Dresel S., et al. Cerebral amyloid-beta PET with florbetaben (18F) in patients with Alzheimer's disease and healthy controls: a multicentre phase 2 diagnostic study. Lancet Neurol. 2011, 10:424-435.
    • (2011) Lancet Neurol. , vol.10 , pp. 424-435
    • Barthel, H.1    Gertz, H.J.2    Dresel, S.3
  • 35
    • 84942912595 scopus 로고    scopus 로고
    • Phospholipid dysregulation contributes to ApoE4-associated cognitive deficits in Alzheimer's disease pathogenesis
    • Zhu L., Zhong M., Elder G.A., et al. Phospholipid dysregulation contributes to ApoE4-associated cognitive deficits in Alzheimer's disease pathogenesis. Proc. Natl. Acad. Sci. U. S. A. 2015, 112:11965-11970.
    • (2015) Proc. Natl. Acad. Sci. U. S. A. , vol.112 , pp. 11965-11970
    • Zhu, L.1    Zhong, M.2    Elder, G.A.3
  • 36
    • 29444460533 scopus 로고    scopus 로고
    • Apolipoprotein (apo) E4 enhances amyloid beta peptide production in cultured neuronal cells: apoE structure as a potential therapeutic target
    • Ye S., Huang Y., Mullendorff K., et al. Apolipoprotein (apo) E4 enhances amyloid beta peptide production in cultured neuronal cells: apoE structure as a potential therapeutic target. Proc. Natl. Acad. Sci. U. S. A. 2005, 102:18700-18705.
    • (2005) Proc. Natl. Acad. Sci. U. S. A. , vol.102 , pp. 18700-18705
    • Ye, S.1    Huang, Y.2    Mullendorff, K.3
  • 37
    • 33645732146 scopus 로고    scopus 로고
    • No genetic association between PCSK9 polymorphisms and Alzheimer's disease and plasma cholesterol level in Japanese patients
    • Shibata N., Ohnuma T., Higashi S., et al. No genetic association between PCSK9 polymorphisms and Alzheimer's disease and plasma cholesterol level in Japanese patients. Psychiatr. Genet. 2005, 15:239.
    • (2005) Psychiatr. Genet. , vol.15 , pp. 239
    • Shibata, N.1    Ohnuma, T.2    Higashi, S.3
  • 38
    • 77952514025 scopus 로고    scopus 로고
    • Analysis of lipid pathway genes indicates association of sequence variation near SREBF1/TOM1L2/ATPAF2 with dementia risk
    • Reynolds C.A., Hong M.G., Eriksson U.K., et al. Analysis of lipid pathway genes indicates association of sequence variation near SREBF1/TOM1L2/ATPAF2 with dementia risk. Hum. Mol. Genet. 2010, 19:2068-2078.
    • (2010) Hum. Mol. Genet. , vol.19 , pp. 2068-2078
    • Reynolds, C.A.1    Hong, M.G.2    Eriksson, U.K.3
  • 40
    • 84888641561 scopus 로고    scopus 로고
    • Dyslipidaemia: RNAi targeting PCSK9 decreases lipid levels in a human trial
    • Cully M. Dyslipidaemia: RNAi targeting PCSK9 decreases lipid levels in a human trial. Nat. Rev. Cardiol. 2013, 10:682.
    • (2013) Nat. Rev. Cardiol. , vol.10 , pp. 682
    • Cully, M.1
  • 41
    • 83555173282 scopus 로고    scopus 로고
    • PCSK9 siRNA inhibits HUVEC apoptosis induced by ox-LDL via Bcl/Bax-caspase9-caspase3 pathway
    • Wu C.Y., Tang Z.H., Jiang L., Li X.F., Jiang Z.S., Liu L.S. PCSK9 siRNA inhibits HUVEC apoptosis induced by ox-LDL via Bcl/Bax-caspase9-caspase3 pathway. Mol. Cell. Biochem. 2012, 359:347-358.
    • (2012) Mol. Cell. Biochem. , vol.359 , pp. 347-358
    • Wu, C.Y.1    Tang, Z.H.2    Jiang, L.3    Li, X.F.4    Jiang, Z.S.5    Liu, L.S.6
  • 42
    • 84866499818 scopus 로고    scopus 로고
    • PCSK9 siRNA suppresses the inflammatory response induced by oxLDL through inhibition of NF-kappaB activation in THP-1-derived macrophages
    • Tang Z., Jiang L., Peng J., et al. PCSK9 siRNA suppresses the inflammatory response induced by oxLDL through inhibition of NF-kappaB activation in THP-1-derived macrophages. Int. J. Mol. Med. 2012, 30:931-938.
    • (2012) Int. J. Mol. Med. , vol.30 , pp. 931-938
    • Tang, Z.1    Jiang, L.2    Peng, J.3
  • 43
    • 51049099776 scopus 로고    scopus 로고
    • PCSK9 is required for the disposal of non-acetylated intermediates of the nascent membrane protein BACE1
    • Jonas M.C., Costantini C., Puglielli L. PCSK9 is required for the disposal of non-acetylated intermediates of the nascent membrane protein BACE1. EMBO Rep. 2008, 9:916-922.
    • (2008) EMBO Rep. , vol.9 , pp. 916-922
    • Jonas, M.C.1    Costantini, C.2    Puglielli, L.3
  • 44
    • 59049092157 scopus 로고    scopus 로고
    • Two endoplasmic reticulum (ER)/ER Golgi intermediate compartment-based lysine acetyltransferases post-translationally regulate BACE1 levels
    • Ko M.H., Puglielli L. Two endoplasmic reticulum (ER)/ER Golgi intermediate compartment-based lysine acetyltransferases post-translationally regulate BACE1 levels. J. Biol. Chem. 2009, 284:2482-2492.
    • (2009) J. Biol. Chem. , vol.284 , pp. 2482-2492
    • Ko, M.H.1    Puglielli, L.2
  • 45
    • 77956844399 scopus 로고    scopus 로고
    • PCSK9 is not involved in the degradation of LDL receptors and BACE1 in the adult mouse brain
    • Liu M., Wu G., Baysarowich J., et al. PCSK9 is not involved in the degradation of LDL receptors and BACE1 in the adult mouse brain. J. Lipid Res. 2010, 51:2611-2618.
    • (2010) J. Lipid Res. , vol.51 , pp. 2611-2618
    • Liu, M.1    Wu, G.2    Baysarowich, J.3
  • 46
    • 70349560700 scopus 로고    scopus 로고
    • Aggregated LDL in contact with macrophages induces local increases in free cholesterol levels that regulate local actin polymerization
    • Grosheva I., Haka A.S., Qin C., Pierini L.M., Maxfield F.R. Aggregated LDL in contact with macrophages induces local increases in free cholesterol levels that regulate local actin polymerization. Arterioscler. Thromb. Vasc. Biol. 2009, 29:1615-1621.
    • (2009) Arterioscler. Thromb. Vasc. Biol. , vol.29 , pp. 1615-1621
    • Grosheva, I.1    Haka, A.S.2    Qin, C.3    Pierini, L.M.4    Maxfield, F.R.5
  • 47
    • 58649104220 scopus 로고    scopus 로고
    • LRP1 controls intracellular cholesterol storage and fatty acid synthesis through modulation of Wnt signaling
    • Terrand J., Bruban V., Zhou L., et al. LRP1 controls intracellular cholesterol storage and fatty acid synthesis through modulation of Wnt signaling. J. Biol. Chem. 2009, 284:381-388.
    • (2009) J. Biol. Chem. , vol.284 , pp. 381-388
    • Terrand, J.1    Bruban, V.2    Zhou, L.3
  • 48
    • 78650347671 scopus 로고    scopus 로고
    • Neuronal LRP1 knockout in adult mice leads to impaired brain lipid metabolism and progressive, age-dependent synapse loss and neurodegeneration
    • Liu Q., Trotter J., Zhang J., et al. Neuronal LRP1 knockout in adult mice leads to impaired brain lipid metabolism and progressive, age-dependent synapse loss and neurodegeneration. J. Neurosci. 2010, 30:17068-17078.
    • (2010) J. Neurosci. , vol.30 , pp. 17068-17078
    • Liu, Q.1    Trotter, J.2    Zhang, J.3
  • 49
    • 84977908568 scopus 로고    scopus 로고
    • Genetic polymorphisms of lipid metabolism gene SAR1 homolog B and the risk of Alzheimer's disease and vascular dementia
    • Chen J.H., Hsieh C.J., Huang Y.L., et al. Genetic polymorphisms of lipid metabolism gene SAR1 homolog B and the risk of Alzheimer's disease and vascular dementia. J. Formos. Med. Assoc. 2015.
    • (2015) J. Formos. Med. Assoc.
    • Chen, J.H.1    Hsieh, C.J.2    Huang, Y.L.3
  • 50
    • 34748897213 scopus 로고    scopus 로고
    • Amyloid precursor protein regulates brain apolipoprotein E and cholesterol metabolism through lipoprotein receptor LRP1
    • Liu Q., Zerbinatti C.V., Zhang J., et al. Amyloid precursor protein regulates brain apolipoprotein E and cholesterol metabolism through lipoprotein receptor LRP1. Neuron 2007, 56:66-78.
    • (2007) Neuron , vol.56 , pp. 66-78
    • Liu, Q.1    Zerbinatti, C.V.2    Zhang, J.3
  • 51
    • 75149159119 scopus 로고    scopus 로고
    • Association of the LRP1 gene and cognitive performance with amnestic mild cognitive impairment in elderly Chinese
    • Shi Y.M., Zhou H., Zhang Z.J., et al. Association of the LRP1 gene and cognitive performance with amnestic mild cognitive impairment in elderly Chinese. Int. Psychogeriatr. 2009, 21:1072-1080.
    • (2009) Int. Psychogeriatr. , vol.21 , pp. 1072-1080
    • Shi, Y.M.1    Zhou, H.2    Zhang, Z.J.3
  • 52
    • 68549085398 scopus 로고    scopus 로고
    • Genetic interaction between tau and the apolipoprotein E receptor LRP1 increases Alzheimer's disease risk
    • Vazquez-Higuera J.L., Mateo I., Sanchez-Juan P., et al. Genetic interaction between tau and the apolipoprotein E receptor LRP1 increases Alzheimer's disease risk. Dement. Geriatr. Cogn. Disord. 2009, 28:116-120.
    • (2009) Dement. Geriatr. Cogn. Disord. , vol.28 , pp. 116-120
    • Vazquez-Higuera, J.L.1    Mateo, I.2    Sanchez-Juan, P.3
  • 53
    • 77955604553 scopus 로고    scopus 로고
    • Low-density lipoprotein receptor-related protein 1 (LRP1) mediates neuronal Abeta42 uptake and lysosomal trafficking
    • Fuentealba R.A., Liu Q., Zhang J., et al. Low-density lipoprotein receptor-related protein 1 (LRP1) mediates neuronal Abeta42 uptake and lysosomal trafficking. PLoS One 2010, 5.
    • (2010) PLoS One , vol.5
    • Fuentealba, R.A.1    Liu, Q.2    Zhang, J.3
  • 54
    • 81555200043 scopus 로고    scopus 로고
    • Neurovascular pathways to neurodegeneration in Alzheimer's disease and other disorders
    • Zlokovic B.V. Neurovascular pathways to neurodegeneration in Alzheimer's disease and other disorders. Nat. Rev. Neurosci. 2011, 12:723-738.
    • (2011) Nat. Rev. Neurosci. , vol.12 , pp. 723-738
    • Zlokovic, B.V.1
  • 55
    • 0034521392 scopus 로고    scopus 로고
    • Clearance of Alzheimer's amyloid-ss(1-40) peptide from brain by LDL receptor-related protein-1 at the blood-brain barrier
    • Shibata M., Yamada S., Kumar S.R., et al. Clearance of Alzheimer's amyloid-ss(1-40) peptide from brain by LDL receptor-related protein-1 at the blood-brain barrier. J. Clin. Invest. 2000, 106:1489-1499.
    • (2000) J. Clin. Invest. , vol.106 , pp. 1489-1499
    • Shibata, M.1    Yamada, S.2    Kumar, S.R.3
  • 56
    • 80053652475 scopus 로고    scopus 로고
    • LRP1 mediates bidirectional transcytosis of amyloid-beta across the blood-brain barrier
    • 2323.e2321-2311
    • Pflanzner T., Janko M.C., Andre-Dohmen B., et al. LRP1 mediates bidirectional transcytosis of amyloid-beta across the blood-brain barrier. Neurobiol. Aging 2011, 32. 2323.e2321-2311.
    • (2011) Neurobiol. Aging , vol.32
    • Pflanzner, T.1    Janko, M.C.2    Andre-Dohmen, B.3
  • 57
    • 34948888151 scopus 로고    scopus 로고
    • Clearance of amyloid-beta by circulating lipoprotein receptors
    • Sagare A., Deane R., Bell R.D., et al. Clearance of amyloid-beta by circulating lipoprotein receptors. Nat. Med. 2007, 13:1029-1031.
    • (2007) Nat. Med. , vol.13 , pp. 1029-1031
    • Sagare, A.1    Deane, R.2    Bell, R.D.3
  • 58
    • 33745588826 scopus 로고    scopus 로고
    • Major involvement of low-density lipoprotein receptor-related protein 1 in the clearance of plasma free amyloid beta-peptide by the liver
    • Tamaki C., Ohtsuki S., Iwatsubo T., et al. Major involvement of low-density lipoprotein receptor-related protein 1 in the clearance of plasma free amyloid beta-peptide by the liver. Pharm. Res. 2006, 23:1407-1416.
    • (2006) Pharm. Res. , vol.23 , pp. 1407-1416
    • Tamaki, C.1    Ohtsuki, S.2    Iwatsubo, T.3
  • 59
    • 0036627214 scopus 로고    scopus 로고
    • Circulating amyloid-beta peptide crosses the blood-brain barrier in aged monkeys and contributes to Alzheimer's disease lesions
    • Mackic J.B., Bading J., Ghiso J., et al. Circulating amyloid-beta peptide crosses the blood-brain barrier in aged monkeys and contributes to Alzheimer's disease lesions. Vasc. Pharmacol. 2002, 38:303-313.
    • (2002) Vasc. Pharmacol. , vol.38 , pp. 303-313
    • Mackic, J.B.1    Bading, J.2    Ghiso, J.3


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