PCSK9 regulates neuronal apoptosis by adjusting ApoER2 levels and signaling

Cellular and Molecular Life Sciences

Volumn 69, Issue 11, 2012, Pages 1903-1916

  Kysenius, Kai ^a   Muggalla, Pranuthi ^a   Mätlik, Kert ^b   Arumäe, Urmas ^b   Huttunen, Henri J ^a  

^a UNIVERSITY OF HELSINKI   (Finland)

^b UNIVERSITY OF HELSINKI   (Finland)

Author keywords

ApoER2; Apoptosis; JNK; Neuron; PCSK9; VLDLR

Indexed keywords

APOLIPOPROTEIN; APOLIPOPROTEIN RECEPTOR 2; CASPASE 3; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; NEUROPROTECTIVE AGENT; PROPROTEIN CONVERTASE SUBTILISIN KEXIN TYPE 9; PROTEIN C JUN; UNCLASSIFIED DRUG; VERY LOW DENSITY LIPOPROTEIN RECEPTOR;

APOPTOSIS; ARTICLE; BRAIN REGION; CELL PROLIFERATION; CELL SURVIVAL; CELL VIABILITY; CEREBELLUM; CONCENTRATION RESPONSE; CONTROLLED STUDY; DNA SYNTHESIS; DRUG EFFICACY; DRUG MECHANISM; ENZYME ACTIVITY; HUMAN; HUMAN CELL; NERVE CELL; NEUROPROTECTION; PROTEIN CLEAVAGE; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION;

ANIMALS; APOPTOSIS; CASPASE 3; HEK293 CELLS; HUMAN UMBILICAL VEIN ENDOTHELIAL CELLS; HUMANS; LDL-RECEPTOR RELATED PROTEINS; MICE; NEURONS; PHOSPHORYLATION; POTASSIUM; PROPROTEIN CONVERTASES; PROTO-ONCOGENE PROTEINS C-JUN; RNA INTERFERENCE; SERINE ENDOPEPTIDASES; SIGNAL TRANSDUCTION;

EID: 84862902876     PISSN: 1420682X     EISSN: 14209071     Source Type: Journal    
DOI: 10.1007/s00018-012-0977-6     Document Type: Article

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