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Volumn 20, Issue 2, 2008, Pages 162-167

Involvement of cholesterol in the pathogenesis of Alzheimer's disease: Role of statins

Author keywords

Alzheimer's disease; Cholesterol, statins; Sigma receptors; Vascular dementias

Indexed keywords

AMYLOID BETA PROTEIN; CHOLESTEROL; CHOLINESTERASE INHIBITOR; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR;

EID: 47849109721     PISSN: 03535053     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article
Times cited : (20)

References (62)
  • 2
    • 0037407403 scopus 로고    scopus 로고
    • Third National Health and Nutrition Examination Survey; National Cholesterol Education Program. NCEP-defined metabolic syndrome, diabetes, and prevalence of coronary heart disease among NHANES III participants age 50 years and older
    • Alexander CM, Landsman PB, Teutsch SM & Haffner SM: Third National Health and Nutrition Examination Survey; National Cholesterol Education Program. NCEP-defined metabolic syndrome, diabetes, and prevalence of coronary heart disease among NHANES III participants age 50 years and older. Diabetes 2003; 52:1210-4.
    • (2003) Diabetes , vol.52 , pp. 1210-1214
    • Alexander, C.M.1    Landsman, P.B.2    Teutsch, S.M.3    Haffner, S.M.4
  • 3
  • 4
    • 38449108594 scopus 로고    scopus 로고
    • Vascular dementia: Pharmacological treatment approaches and perspectives
    • Baskys A & Hou AC: Vascular dementia: pharmacological treatment approaches and perspectives. Clin Interv Aging 2007; 2(3):327-35.
    • (2007) Clin Interv Aging , vol.2 , Issue.3 , pp. 327-335
    • Baskys, A.1    Hou, A.C.2
  • 6
    • 0028350718 scopus 로고
    • Pathological alterations of the cerebral microvasculature in Alzheimer's disease and related dementing disorders
    • Buée L, Hof PR, Bouras C, Delacourte A, Perl DP, Morrison JH & Fillit HM: Pathological alterations of the cerebral microvasculature in Alzheimer's disease and related dementing disorders. Acta Neuropathol 1994; 87:469-80.
    • (1994) Acta Neuropathol , vol.87 , pp. 469-480
    • Buée, L.1    Hof, P.R.2    Bouras, C.3    Delacourte, A.4    Perl, D.P.5    Morrison, J.H.6    Fillit, H.M.7
  • 7
    • 22244473990 scopus 로고    scopus 로고
    • Detergent-resistant membranes in human erythrocytes and their connection to the membrane-skeleton
    • Ciana A, Balduini C & Minetti G: Detergent-resistant membranes in human erythrocytes and their connection to the membrane-skeleton. J Biosci 2005; 30:317-28.
    • (2005) J Biosci , vol.30 , pp. 317-328
    • Ciana, A.1    Balduini, C.2    Minetti, G.3
  • 10
    • 35348866703 scopus 로고    scopus 로고
    • O-GlcNAc modification in diabetes and Alzheimer's disease
    • Dias WB & Hart GW: O-GlcNAc modification in diabetes and Alzheimer's disease. Mol Biosyst. 2007; 3:766-72.
    • (2007) Mol Biosyst , vol.3 , pp. 766-772
    • Dias, W.B.1    Hart, G.W.2
  • 12
    • 0032814109 scopus 로고    scopus 로고
    • Cerebrovascular dementia: A guide to diagnosis and treatment
    • Erkinjuntti T: Cerebrovascular dementia: a guide to diagnosis and treatment. CNS Drugs 1999; 12:35-48.
    • (1999) CNS Drugs , vol.12 , pp. 35-48
    • Erkinjuntti, T.1
  • 13
    • 37449019095 scopus 로고    scopus 로고
    • Cerebrovascular disease, vascular cognitive impairment and dementia
    • Erkinjunttia T: Cerebrovascular disease, vascular cognitive impairment and dementia. Psychiatry 2008; 7:15-9.
    • (2008) Psychiatry , vol.7 , pp. 15-19
    • Erkinjunttia, T.1
  • 14
    • 0033958076 scopus 로고    scopus 로고
    • Serum cholesterol, APOE genotype, and the risk of Alzheimer's disease: A population-based study of African Americans
    • Evans RM, Emsley CL, Gao S, Sahota A, Hall KS, Farlow MR & Hendrie H: Serum cholesterol, APOE genotype, and the risk of Alzheimer's disease: a population-based study of African Americans. Neurology 2000; 54:240-2.
    • (2000) Neurology , vol.54 , pp. 240-242
    • Evans, R.M.1    Emsley, C.L.2    Gao, S.3    Sahota, A.4    Hall, K.S.5    Farlow, M.R.6    Hendrie, H.7
  • 15
    • 2442684094 scopus 로고    scopus 로고
    • Cholesterol and APOE genotype interact to influence Alzheimer disease progression
    • Evans RM, Hui S, Perkins A, Lahiri DK, Poirier J & Farlow MR: Cholesterol and APOE genotype interact to influence Alzheimer disease progression. Neurology 2004; 62:1869-71.
    • (2004) Neurology , vol.62 , pp. 1869-1871
    • Evans, R.M.1    Hui, S.2    Perkins, A.3    Lahiri, D.K.4    Poirier, J.5    Farlow, M.R.6
  • 19
    • 1942485807 scopus 로고    scopus 로고
    • Sigma-1 receptor ligands: Potential in the treatment of neuropsychiatric disorders
    • Hayashi T & Su TP: Sigma-1 receptor ligands: potential in the treatment of neuropsychiatric disorders. CNS Drugs 2004; 18:269-84.
    • (2004) CNS Drugs , vol.18 , pp. 269-284
    • Hayashi, T.1    Su, T.P.2
  • 20
    • 0034125007 scopus 로고    scopus 로고
    • Incidence and course of dementia in people with Down's syndrome: Findings from a population-based study
    • Holland AJ, Hon J, Huppert FA & Stevens F: Incidence and course of dementia in people with Down's syndrome: findings from a population-based study. J Intellect. Disabil. Res 2000; 44:138-46.
    • (2000) J Intellect. Disabil. Res , vol.44 , pp. 138-146
    • Holland, A.J.1    Hon, J.2    Huppert, F.A.3    Stevens, F.4
  • 21
    • 0031593592 scopus 로고    scopus 로고
    • Neuropathology of Alzheimer's disease: A critical update
    • Jellinger KA & Bancher C: Neuropathology of Alzheimer's disease: a critical update. J Neural Transm Suppl 1998; 54:77-95.
    • (1998) J Neural Transm Suppl , vol.54 , pp. 77-95
    • Jellinger, K.A.1    Bancher, C.2
  • 22
    • 0036323445 scopus 로고    scopus 로고
    • Alzheimer disease and cerebrovascular pathology: An update
    • Jellinger KA: Alzheimer disease and cerebrovascular pathology: an update. J Neural Transm 2002; 109:813-36.
    • (2002) J Neural Transm , vol.109 , pp. 813-836
    • Jellinger, K.A.1
  • 23
    • 0033202045 scopus 로고    scopus 로고
    • Overlap between pathology of Alzheimer disease and vascular dementia
    • Kalaria RN & Ballard C: Overlap between pathology of Alzheimer disease and vascular dementia. Alzheimer Dis Assoc Disord 1999; 13:S115-23.
    • (1999) Alzheimer Dis Assoc Disord , vol.13
    • Kalaria, R.N.1    Ballard, C.2
  • 26
    • 34948895062 scopus 로고    scopus 로고
    • Inhibition of Barret's adenocarcinoma cell growth by simvastatin: Involvement of COX-2 and apoptosis-related proteins
    • Konturek PC, Burnat G & Hahn EG: Inhibition of Barret's adenocarcinoma cell growth by simvastatin: involvement of COX-2 and apoptosis-related proteins. J Physiol Pharmacol 2007; 58:141-8.
    • (2007) J Physiol Pharmacol , vol.58 , pp. 141-148
    • Konturek, P.C.1    Burnat, G.2    Hahn, E.G.3
  • 31
    • 36048966568 scopus 로고    scopus 로고
    • Statin therapy and stroke prevention: What was known, what is new and what is next?
    • Mazighi M, Lavallée PC, Labreuche J & Amarenco P: Statin therapy and stroke prevention: what was known, what is new and what is next? Curr Opin Lipidol 2007;18:622-5.
    • (2007) Curr Opin Lipidol , vol.18 , pp. 622-625
    • Mazighi, M.1    Lavallée, P.C.2    Labreuche, J.3    Amarenco, P.4
  • 32
    • 0020618569 scopus 로고
    • Apolipoprotein E polymorphism and coronary artery disease
    • Menzel HJ, Kladetzky RG & Assmann G: Apolipoprotein E polymorphism and coronary artery disease. Arteriosclerosis 1983; 3: 310-5.
    • (1983) Arteriosclerosis , vol.3 , pp. 310-315
    • Menzel, H.J.1    Kladetzky, R.G.2    Assmann, G.3
  • 35
    • 37649022746 scopus 로고    scopus 로고
    • Statin therapy in stroke prevention: A meta-analysis involving 121,000 patients
    • O'Regan C, Wu P, Arora P, Perri D & Mills EJ: Statin therapy in stroke prevention: a meta-analysis involving 121,000 patients. Am J Med 2008;121:24-33.
    • (2008) Am J Med , vol.121 , pp. 24-33
    • O'Regan, C.1    Wu, P.2    Arora, P.3    Perri, D.4    Mills, E.J.5
  • 36
    • 18744417222 scopus 로고    scopus 로고
    • Cerebrospinal fluid levels of biomarkers and activity of acetylcholinesterase (AChE) and butyrylcholinesterase in AD patients before and after treatment with different AChE inhibitors
    • Parnetti L, Amici S, Lanari A, Romani C, Antognelli C, Andreasen N, Minthon L, Davidsson P, Pottel H, Blennow K & Gallai V: Cerebrospinal fluid levels of biomarkers and activity of acetylcholinesterase (AChE) and butyrylcholinesterase in AD patients before and after treatment with different AChE inhibitors. Neurol Sci 2002; 23 Suppl 2:S95-6.
    • (2002) Neurol Sci , vol.23 , Issue.SUPPL. 2
    • Parnetti, L.1    Amici, S.2    Lanari, A.3    Romani, C.4    Antognelli, C.5    Andreasen, N.6    Minthon, L.7    Davidsson, P.8    Pottel, H.9    Blennow, K.10    Gallai, V.11
  • 38
    • 33846842234 scopus 로고    scopus 로고
    • The role of muscle activation pattern and calcineurin in acetylcholinesterase regulation in rat skeletal muscles
    • Pregelj P, Trinkaus M, Zupan D, Trontelj JJ & Sketelj J: The role of muscle activation pattern and calcineurin in acetylcholinesterase regulation in rat skeletal muscles. J Neurosci 2007; 27:1106-13.
    • (2007) J Neurosci , vol.27 , pp. 1106-1113
    • Pregelj, P.1    Trinkaus, M.2    Zupan, D.3    Trontelj, J.J.4    Sketelj, J.5
  • 39
    • 0345669752 scopus 로고    scopus 로고
    • Alzheimer's disease: The cholesterol connection
    • Puglielli L, Tanzi RE & Kovacs DM: Alzheimer's disease: the cholesterol connection. Nat Neurosci 2003; 6:345-51.
    • (2003) Nat Neurosci , vol.6 , pp. 345-351
    • Puglielli, L.1    Tanzi, R.E.2    Kovacs, D.M.3
  • 40
    • 33846057321 scopus 로고    scopus 로고
    • The metabolic syndrome and Alzheimer disease
    • Razay G, Vreugdenhil A & Wilcock G. The metabolic syndrome and Alzheimer disease. Arch Neurol 2007; 64:93-6.
    • (2007) Arch Neurol , vol.64 , pp. 93-96
    • Razay, G.1    Vreugdenhil, A.2    Wilcock, G.3
  • 41
    • 0034711699 scopus 로고    scopus 로고
    • Prevalence and outcomes of vascular cognitive impairment
    • Rockwood K, Wentzel C & Hachinski V: Prevalence and outcomes of vascular cognitive impairment. Neurology 2000; 54:447-51.
    • (2000) Neurology , vol.54 , pp. 447-451
    • Rockwood, K.1    Wentzel, C.2    Hachinski, V.3
  • 42
    • 8644279643 scopus 로고    scopus 로고
    • Vascular cognitive disorder: A new diagnostic category updating vascular cognitive impairment and vascular dementia
    • Roman GC, Sachdev P & Royall DR: Vascular cognitive disorder: a new diagnostic category updating vascular cognitive impairment and vascular dementia. J Neurol Sci 2004; 226:81-7.
    • (2004) J Neurol Sci , vol.226 , pp. 81-87
    • Roman, G.C.1    Sachdev, P.2    Royall, D.R.3
  • 43
    • 0033546660 scopus 로고    scopus 로고
    • APOE genotype, plasma lipids, lipoproteins, and AD in community elderly
    • Romas SN, Tang MX, Berglund L & Mayeux R: APOE genotype, plasma lipids, lipoproteins, and AD in community elderly. Neurology 1999; 53:517-21.
    • (1999) Neurology , vol.53 , pp. 517-521
    • Romas, S.N.1    Tang, M.X.2    Berglund, L.3    Mayeux, R.4
  • 47
    • 0031054674 scopus 로고    scopus 로고
    • Brain infarction and the clinical expression of Alzheimer disease. The Nun Study
    • Snowdon DA, Greiner LH & Mortimer JA: Brain infarction and the clinical expression of Alzheimer disease. The Nun Study. JAMA 1997; 2 77:813-17.
    • (1997) JAMA , vol.2 , Issue.77 , pp. 813-817
    • Snowdon, D.A.1    Greiner, L.H.2    Mortimer, J.A.3
  • 48
    • 23744468393 scopus 로고    scopus 로고
    • Implications of the metabolic syndrome: The new epidemic
    • Sorrentino MJ: Implications of the metabolic syndrome: the new epidemic. Am J Cardiol 2005; 96:3E-7E.
    • (2005) Am J Cardiol , vol.96
    • Sorrentino, M.J.1
  • 49
    • 33745739157 scopus 로고    scopus 로고
    • Circulating cholesterol levels, apolipoprotein E genotype and dementia severity influence the benefit of atorvastatin treatment in Alzheimer's disease: Results of the Alzheimer's Disease Cholesterol-Lowering Treatment (ADCLT) trial
    • Sparks DL, Connor DJ, Sabbagh MN, Petersen RB, Lopez J & Browne P: Circulating cholesterol levels, apolipoprotein E genotype and dementia severity influence the benefit of atorvastatin treatment in Alzheimer's disease: results of the Alzheimer's Disease Cholesterol-Lowering Treatment (ADCLT) trial. Acta Neurol Scand Suppl 2006; 185:3-7.
    • (2006) Acta Neurol Scand Suppl , vol.185 , pp. 3-7
    • Sparks, D.L.1    Connor, D.J.2    Sabbagh, M.N.3    Petersen, R.B.4    Lopez, J.5    Browne, P.6
  • 52
    • 0028832051 scopus 로고
    • Apolipoprotein E polymorphism predicts death from coronary heart disease in a longitudinal study of elderly Finnish men
    • Stengard JH, Zerba KE, Pekkanen J, Ehnholm C, Nissinen A & Sing CF: Apolipoprotein E polymorphism predicts death from coronary heart disease in a longitudinal study of elderly Finnish men. Circulation 1995; 91: 265-9.
    • (1995) Circulation , vol.91 , pp. 265-269
    • Stengard, J.H.1    Zerba, K.E.2    Pekkanen, J.3    Ehnholm, C.4    Nissinen, A.5    Sing, C.F.6
  • 54
    • 0034513218 scopus 로고    scopus 로고
    • Fatal attractions of proteins. A comprehensive hypothetical mechanism underlying Alzheimer's disease and other neurodegenerative disorders
    • Trojanowski JQ & Lee VM: "Fatal attractions" of proteins. A comprehensive hypothetical mechanism underlying Alzheimer's disease and other neurodegenerative disorders. Ann N Y Acad Sci 2000; 924:62-7.
    • (2000) Ann N Y Acad Sci , vol.924 , pp. 62-67
    • Trojanowski, J.Q.1    Lee, V.M.2
  • 56
    • 0020478765 scopus 로고
    • Abnormal lipoprotein receptor-binding activity of the human E apoprotein due to cysteine-arginine interchange at a single site
    • Weisgraber KH, Innerarity TL & Mahley RW: Abnormal lipoprotein receptor-binding activity of the human E apoprotein due to cysteine-arginine interchange at a single site. J Biol Chem 1982; 257: 2518-21.
    • (1982) J Biol Chem , vol.257 , pp. 2518-2521
    • Weisgraber, K.H.1    Innerarity, T.L.2    Mahley, R.W.3
  • 57
    • 0347318065 scopus 로고    scopus 로고
    • Cholesterol and the biology of Alzheimer's disease
    • Wolozin B: Cholesterol and the biology of Alzheimer's disease. Neuron 41:2004; 7-10.
    • (2004) Neuron , vol.41 , pp. 7-10
    • Wolozin, B.1
  • 58
    • 0036186663 scopus 로고    scopus 로고
    • Serum lipoprotein levels, statin use, and cognitive function in older women
    • Yaffe K, Barrett-Connor E, Lin F & Grady D: Serum lipoprotein levels, statin use, and cognitive function in older women. Arch. Neurol 2002; 59:378-84.
    • (2002) Arch. Neurol , vol.59 , pp. 378-384
    • Yaffe, K.1    Barrett-Connor, E.2    Lin, F.3    Grady, D.4
  • 59
    • 7744239901 scopus 로고    scopus 로고
    • The metabolic syndrome, inflammation, and risk of cognitive decline
    • Yaffe K, Kanaya A & Lindquist K, et al: The metabolic syndrome, inflammation, and risk of cognitive decline. JAMA 2004; 292:2237-42.
    • (2004) JAMA , vol.292 , pp. 2237-2242
    • Yaffe, K.1    Kanaya, A.2    Lindquist, K.3
  • 60
    • 37449020071 scopus 로고    scopus 로고
    • The molecular pathology of Alzheimer's disease
    • Yatesa D, & McLoughlina DM: The molecular pathology of Alzheimer's disease. Psychiatry 2008; 1:1-5.
    • (2008) Psychiatry , vol.1 , pp. 1-5
    • Yatesa, D.1    McLoughlina, D.M.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.