메뉴 건너뛰기




Volumn 8, Issue 4, 2011, Pages 434-442

Simvastatin and other HMG-CoA reductase inhibitors on brain cholesterol levels in alzheimer's disease

Author keywords

Alzheimer's disease; Amyloid beta; Cholesterol; Dementia; HMG CoA reductase inhibitors

Indexed keywords

AMYLOID BETA PROTEIN; ANTILIPEMIC AGENT; ATORVASTATIN; BETA SECRETASE 1; CHOLESTEROL; FLUINDOSTATIN; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; METHYL BETA CYCLODEXTRIN; MEVINOLIN; PLACEBO; PRAVASTATIN; SIMVASTATIN;

EID: 79959348158     PISSN: 15672050     EISSN: 18755828     Source Type: Journal    
DOI: 10.2174/156720511795745393     Document Type: Review
Times cited : (19)

References (47)
  • 1
    • 34249825804 scopus 로고    scopus 로고
    • Effect of HMG-CoA reductase inhibitors on beta-amyloid peptide levels: Implications for Alzheimer's disease
    • Hoglund K, Blennow K. Effect of HMG-CoA reductase inhibitors on beta-amyloid peptide levels: implications for Alzheimer's disease. CNS Drugs 21(6): 449-62 (2007).
    • (2007) CNS Drugs , vol.21 , Issue.6 , pp. 449-462
    • Hoglund, K.1    Blennow, K.2
  • 3
    • 33846048569 scopus 로고    scopus 로고
    • Simvastatin enhances learning and memory independent of amyloid load in mice
    • Li L, Cao D, Kim H, Lester R, Fukuchi K. Simvastatin enhances learning and memory independent of amyloid load in mice. Ann Neurol 60(6): 729-39 (2006).
    • (2006) Ann Neurol , vol.60 , Issue.6 , pp. 729-739
    • Li, L.1    Cao, D.2    Kim, H.3    Lester, R.4    Fukuchi, K.5
  • 4
    • 60349113111 scopus 로고    scopus 로고
    • Gamma-secretase catalyzes sequential cleavages of the AbetaPP transmembrane domain
    • Xu X. Gamma-secretase catalyzes sequential cleavages of the AbetaPP transmembrane domain. J Alzheimers Dis 16(2): 211-24 (2009).
    • (2009) J Alzheimers Dis , vol.16 , Issue.2 , pp. 211-224
    • Xu, X.1
  • 5
    • 0037319288 scopus 로고    scopus 로고
    • Converging pathogenic mechanisms in vascular and neurodegenerative dementia
    • Iadecola C, Gorelick PB. Converging pathogenic mechanisms in vascular and neurodegenerative dementia. Stroke 34(2): 335-7 (2003).
    • (2003) Stroke , vol.34 , Issue.2 , pp. 335-337
    • Iadecola, C.1    Gorelick, P.B.2
  • 6
    • 67349131967 scopus 로고    scopus 로고
    • Human and rodent amyloid-beta peptides differentially bind heme: Relevance to the human susceptibility to Alzheimer's disease
    • Atamna H, Frey WH, Ko N. Human and rodent amyloid-beta peptides differentially bind heme: relevance to the human susceptibility to Alzheimer's disease. Arch Biochem Biophys 487(1): 59-65 (2009).
    • (2009) Arch Biochem Biophys , vol.487 , Issue.1 , pp. 59-65
    • Atamna, H.1    Frey, W.H.2    Ko, N.3
  • 7
    • 0344667494 scopus 로고    scopus 로고
    • Membrane dynamics, cholesterol homeostasis, and Alzheimer's disease
    • Chauhan NB. Membrane dynamics, cholesterol homeostasis, and Alzheimer's disease. J Lipid Res 44(11): 2019-29 (2003).
    • (2003) J Lipid Res , vol.44 , Issue.11 , pp. 2019-2029
    • Chauhan, N.B.1
  • 8
    • 0029942903 scopus 로고    scopus 로고
    • Origin of cholesterol in myelin
    • Morell P, Jurevics H. Origin of cholesterol in myelin. Neurochem Res Apr 21(4): 463-70 (1996).
    • (1996) Neurochem Res Apr , vol.21 , Issue.4 , pp. 463-470
    • Morell, P.1    Jurevics, H.2
  • 9
    • 0029926299 scopus 로고    scopus 로고
    • Glutamate excitotoxicity in transient global cerebral ischemia
    • Paschen W. Glutamate excitotoxicity in transient global cerebral ischemia. Acta Neurobiol Exp (Wars) 56(1): 313-22 (1996).
    • (1996) Acta Neurobiol Exp (Wars) , vol.56 , Issue.1 , pp. 313-322
    • Paschen, W.1
  • 10
    • 71049180369 scopus 로고    scopus 로고
    • Inflammatory mechanisms in ischemic stroke: Therapeutic approaches
    • Lakhan SE, Kirchgessner A, Hofer M. Inflammatory mechanisms in ischemic stroke: therapeutic approaches. J Transl Med 7: 97 (2009).
    • (2009) J Transl Med , vol.7 , pp. 97
    • Lakhan, S.E.1    Kirchgessner, A.2    Hofer, M.3
  • 11
    • 33749556982 scopus 로고    scopus 로고
    • Modulation of microglial pro-inflammatory and neurotoxic activity for the treatment of Parkinson's disease
    • Liu B. Modulation of microglial pro-inflammatory and neurotoxic activity for the treatment of Parkinson's disease. AAPS J 8(3): E606-21 (2006).
    • (2006) AAPS J , vol.8 , Issue.3 , pp. 606-621
    • Liu, B.1
  • 12
    • 50949117770 scopus 로고    scopus 로고
    • Dopaminergic neuron-specific oxidative stress caused by dopamine itself
    • Miyazaki I, Asanuma M. Dopaminergic neuron-specific oxidative stress caused by dopamine itself. Acta Med Okayama 62(3): 141-50 (2008).
    • (2008) Acta Med Okayama , vol.62 , Issue.3 , pp. 141-150
    • Miyazaki, I.1    Asanuma, M.2
  • 13
    • 0034199085 scopus 로고    scopus 로고
    • Factors affecting levodopa effects in Parkinson's disease
    • Ogawa N. Factors affecting levodopa effects in Parkinson's disease. Acta Med Okayama 54(3): 95-101 (2000).
    • (2000) Acta Med Okayama , vol.54 , Issue.3 , pp. 95-101
    • Ogawa, N.1
  • 14
    • 62249096975 scopus 로고    scopus 로고
    • Glutathione dysregulation and the etiology and progression of human diseases
    • Ballatori N, Krance SM, Notenboom S, Shi S, Tieu K, Hammond CL. Glutathione dysregulation and the etiology and progression of human diseases. Biol Chem 390(3): 191-214 (2009).
    • (2009) Biol Chem , vol.390 , Issue.3 , pp. 191-214
    • Ballatori, N.1    Krance, S.M.2    Notenboom, S.3    Shi, S.4    Tieu, K.5    Hammond, C.L.6
  • 15
    • 33646826619 scopus 로고    scopus 로고
    • Oxidative damage of DJ-1 is linked to sporadic Parkinson and Alzheimer diseases
    • Choi J, Sullards MC, Olzmann JA, Rees HD, Weintraub ST, Bostwick DE, et al. Oxidative damage of DJ-1 is linked to sporadic Parkinson and Alzheimer diseases. J Biol Chem 281(16): 10816-10824 (2006).
    • (2006) J Biol Chem , vol.281 , Issue.16 , pp. 10816-10824
    • Choi, J.1    Sullards, M.C.2    Olzmann, J.A.3    Rees, H.D.4    Weintraub, S.T.5    Bostwick, D.E.6
  • 16
    • 67349253085 scopus 로고    scopus 로고
    • Oxidatively modified proteins in Alzheimer's disease (AD), mild cognitive impairment and animal models of AD: Role of Abeta in pathogenesis
    • Sultana R, Perluigi M, Butterfield DA. Oxidatively modified proteins in Alzheimer's disease (AD), mild cognitive impairment and animal models of AD: role of Abeta in pathogenesis. Acta Neuropathol 118(1): 131-150 (2009).
    • (2009) Acta Neuropathol , vol.118 , Issue.1 , pp. 131-150
    • Sultana, R.1    Perluigi, M.2    Butterfield, D.A.3
  • 17
    • 77955485786 scopus 로고    scopus 로고
    • Potential in vivo amelioration by N-acetyl-L-cysteine of oxidative stress in brain in human double mutant APP/PS-1 knock-in mice: Toward therapeutic modulation of mild cognitive impairment
    • Huang Q, Aluise CD, Joshi G, Sultana R, St Clair DK, Markesbery WR, et al. Potential in vivo amelioration by N-acetyl-L-cysteine of oxidative stress in brain in human double mutant APP/PS-1 knock-in mice: toward therapeutic modulation of mild cognitive impairment. J Neurosci Res 88 (12): 2618-2629 (2010).
    • (2010) J Neurosci Res , vol.88 , Issue.12 , pp. 2618-2629
    • Huang, Q.1    Aluise, C.D.2    Joshi, G.3    Sultana, R.4    Clair, D.K.5    Markesbery, W.R.6
  • 18
    • 0043172479 scopus 로고    scopus 로고
    • The glutamatergic system and Alzheimer's disease: Therapeutic implications
    • Butterfield DA, Pocernich CB. The glutamatergic system and Alzheimer's disease: therapeutic implications. CNS Drugs 17(9): 641-652 (2003).
    • (2003) CNS Drugs , vol.17 , Issue.9 , pp. 641-652
    • Butterfield, D.A.1    Pocernich, C.B.2
  • 19
    • 0029906146 scopus 로고    scopus 로고
    • Neuropsychological and psychiatric differences between Alzheimer's disease and Parkinson's disease with dementia
    • Starkstein SE, Sabe L, Petracca G, Chemerinski E, Kuzis G, Merello M, et al. Neuropsychological and psychiatric differences between Alzheimer's disease and Parkinson's disease with dementia. J Neurol Neurosurg Psychiatry 61(4): 381-387 (1996).
    • (1996) J Neurol Neurosurg Psychiatry , vol.61 , Issue.4 , pp. 381-387
    • Starkstein, S.E.1    Sabe, L.2    Petracca, G.3    Chemerinski, E.4    Kuzis, G.5    Merello, M.6
  • 20
    • 0035114397 scopus 로고    scopus 로고
    • Neuropsychiatric differences between Parkinson's disease with dementia and Alzheimer's disease
    • Aarsland D, Cummings JL, Larsen JP. Neuropsychiatric differences between Parkinson's disease with dementia and Alzheimer's disease. Int J Geriatr Psychiatry 16(2): 184-91 (2001).
    • (2001) Int J Geriatr Psychiatry , vol.16 , Issue.2 , pp. 184-191
    • Aarsland, D.1    Cummings, J.L.2    Larsen, J.P.3
  • 22
  • 23
    • 0035897938 scopus 로고    scopus 로고
    • Midlife vascular risk factors and Alzheimer's disease in later life: Longitudinal, population based study
    • Kivipelto M, Helkala EL, Laakso MP, Hanninen T, Hallikainen M, Alhainen K, et al. Midlife vascular risk factors and Alzheimer's disease in later life: longitudinal, population based study. BMJ 322(7300): 1447-1451 (2001).
    • (2001) BMJ , vol.322 , Issue.7300 , pp. 1447-1451
    • Kivipelto, M.1    Helkala, E.L.2    Laakso, M.P.3    Hanninen, T.4    Hallikainen, M.5    Alhainen, K.6
  • 24
    • 33947500485 scopus 로고    scopus 로고
    • Serum cholesterol changes after midlife and late-life cognition: Twenty-one-year follow-up study
    • Solomon A, Kareholt I, Ngandu T, Winblad B, Nissinen A, Tuomilehto J, et al. Serum cholesterol changes after midlife and late-life cognition: twenty-one-year follow-up study. Neurology 68(10): 751-756 (2007).
    • (2007) Neurology , vol.68 , Issue.10 , pp. 751-756
    • Solomon, A.1    Kareholt, I.2    Ngandu, T.3    Winblad, B.4    Nissinen, A.5    Tuomilehto, J.6
  • 25
    • 67749114631 scopus 로고    scopus 로고
    • Midlife serum cholesterol and increased risk of Alzheimer's and vascular dementia three decades later
    • Solomon A, Kivipelto M, Wolozin B, Zhou J, Whitmer RA. Midlife serum cholesterol and increased risk of Alzheimer's and vascular dementia three decades later. Dement Geriatr Cogn Disord 28(1): 75-80 (2009).
    • (2009) Dement Geriatr Cogn Disord , vol.28 , Issue.1 , pp. 75-80
    • Solomon, A.1    Kivipelto, M.2    Wolozin, B.3    Zhou, J.4    Whitmer, R.A.5
  • 26
    • 0037164314 scopus 로고    scopus 로고
    • Pravastatin in elderly individuals at risk of vascular disease (PROSPER): A randomised controlled trial
    • Shepherd J, Blauw GJ, Murphy MB, Bollen EL, Buckley BM, Cobbe SM, et al. Pravastatin in elderly individuals at risk of vascular disease (PROSPER): a randomised controlled trial. Lancet 360(9346):1623-1630 (2002).
    • (2002) Lancet , vol.360 , Issue.9346 , pp. 1623-1630
    • Shepherd, J.1    Blauw, G.J.2    Murphy, M.B.3    Bollen, E.L.4    Buckley, B.M.5    Cobbe, S.M.6
  • 27
    • 0026740298 scopus 로고
    • Comparative effects of pravastatin and lovastatin on nighttime sleep and daytime performance
    • Roth T, Richardson GR, Sullivan JP, Lee RM, Merlotti L, Roehrs T. Comparative effects of pravastatin and lovastatin on nighttime sleep and daytime performance. Clin Cardiol 15(6): 426-32 (1992).
    • (1992) Clin Cardiol , vol.15 , Issue.6 , pp. 426-432
    • Roth, T.1    Richardson, G.R.2    Sullivan, J.P.3    Lee, R.M.4    Merlotti, L.5    Roehrs, T.6
  • 28
    • 67650751079 scopus 로고    scopus 로고
    • Cholesterol 24-hydroxylase: An enzyme of cholesterol turnover in the brain
    • Russell DW, Halford RW, Ramirez DM, Shah R, Kotti T. Cholesterol 24-hydroxylase: an enzyme of cholesterol turnover in the brain. Annu Rev Biochem 78: 1017-40 (2009).
    • (2009) Annu Rev Biochem , vol.78 , pp. 1017-1040
    • Russell, D.W.1    Halford, R.W.2    Ramirez, D.M.3    Shah, R.4    Kotti, T.5
  • 29
    • 33745109326 scopus 로고    scopus 로고
    • High-dose statin treatment does not alter plasma marker for brain cholesterol metabolism in patients with moderately elevated plasma cholesterol levels
    • Thelen KM, Laaksonen R, Paiva H, Lehtimaki T, Lutjohann D. High-dose statin treatment does not alter plasma marker for brain cholesterol metabolism in patients with moderately elevated plasma cholesterol levels. J Clin Pharmacol 46(7): 812-816 (2006).
    • (2006) J Clin Pharmacol , vol.46 , Issue.7 , pp. 812-816
    • Thelen, K.M.1    Laaksonen, R.2    Paiva, H.3    Lehtimaki, T.4    Lutjohann, D.5
  • 30
    • 67650473070 scopus 로고    scopus 로고
    • Drug development for Alzheimer's disease: Where are we now and where are we headed?
    • Sabbagh MN. Drug development for Alzheimer's disease: where are we now and where are we headed? Am J Geriatr Pharmacother 7(3): 167-85 (2009).
    • (2009) Am J Geriatr Pharmacother , vol.7 , Issue.3 , pp. 167-185
    • Sabbagh, M.N.1
  • 31
    • 0001504829 scopus 로고    scopus 로고
    • Simvastatin strongly reduces levels of Alzheimer's disease beta -amyloid peptides Abeta 42 and Abeta 40 in vitro and in vivo
    • Fassbender K, Simons M, Bergmann C, Stroick M, Lutjohann D, Keller P, et al. Simvastatin strongly reduces levels of Alzheimer's disease beta -amyloid peptides Abeta 42 and Abeta 40 in vitro and in vivo. Proc Natl Acad Sci USA 98(10): 5856-5861 (2001).
    • (2001) Proc Natl Acad Sci USA , vol.98 , Issue.10 , pp. 5856-5861
    • Fassbender, K.1    Simons, M.2    Bergmann, C.3    Stroick, M.4    Lutjohann, D.5    Keller, P.6
  • 32
    • 78650636473 scopus 로고    scopus 로고
    • Changes in Cognition and Amyloid-beta Processing with Long Term Cholesterol Reduction using Atorvastatin in Aged Dogs
    • Murphy MP, Morales J, Beckett TL, Astarita G, Piomelli D, Weidner A, et al. Changes in Cognition and Amyloid-beta Processing with Long Term Cholesterol Reduction using Atorvastatin in Aged Dogs. J Alzheimers Dis Aug 30: (2010).
    • (2010) J Alzheimers Dis Aug , pp. 30
    • Murphy, M.P.1    Morales, J.2    Beckett, T.L.3    Astarita, G.4    Piomelli, D.5    Weidner, A.6
  • 33
    • 0041382978 scopus 로고    scopus 로고
    • Lovastatin enhances Abeta production and senile plaque deposition in female Tg2576 mice
    • Park IH, Hwang EM, Hong HS, Boo JH, Oh SS, Lee J, et al. Lovastatin enhances Abeta production and senile plaque deposition in female Tg2576 mice. Neurobiol Aging 24(5): 637-643 (2003).
    • (2003) Neurobiol Aging , vol.24 , Issue.5 , pp. 637-643
    • Park, I.H.1    Hwang, E.M.2    Hong, H.S.3    Boo, J.H.4    Oh, S.S.5    Lee, J.6
  • 34
    • 70350061584 scopus 로고    scopus 로고
    • Simvastatin therapy prevents brain trauma-induced increases in beta-amyloid peptide levels
    • Abrahamson EE, Ikonomovic MD, Dixon CE, DeKosky ST. Simvastatin therapy prevents brain trauma-induced increases in beta-amyloid peptide levels. Ann Neurol 66(3): 407-414 (2009).
    • (2009) Ann Neurol , vol.66 , Issue.3 , pp. 407-414
    • Abrahamson, E.E.1    Ikonomovic, M.D.2    Dixon, C.E.3    Dekosky, S.T.4
  • 35
    • 68149148938 scopus 로고    scopus 로고
    • Simvastatin improves cerebrovascular function and counters soluble amyloid-beta, inflammation and oxidative stress in aged APP mice
    • Tong XK, Nicolakakis N, Fernandes P, Ongali B, Brouillette J, Quirion R, et al. Simvastatin improves cerebrovascular function and counters soluble amyloid-beta, inflammation and oxidative stress in aged APP mice. Neurobiol Dis 35(3): 406-14 (2009).
    • (2009) Neurobiol Dis , vol.35 , Issue.3 , pp. 406-414
    • Tong, X.K.1    Nicolakakis, N.2    Fernandes, P.3    Ongali, B.4    Brouillette, J.5    Quirion, R.6
  • 36
    • 0033772113 scopus 로고    scopus 로고
    • Decreased prevalence of Alzheimer disease associated with 3-hydroxy-3-methyglutaryl coenzyme A reductase inhibitors
    • Wolozin B, Kellman W, Ruosseau P, Celesia GG, Siegel G. Decreased prevalence of Alzheimer disease associated with 3-hydroxy-3-methyglutaryl coenzyme A reductase inhibitors. Arch Neurol 57(10): 1439-1443 (2000).
    • (2000) Arch Neurol , vol.57 , Issue.10 , pp. 1439-1443
    • Wolozin, B.1    Kellman, W.2    Ruosseau, P.3    Celesia, G.G.4    Siegel, G.5
  • 37
    • 0942278990 scopus 로고    scopus 로고
    • Association between statin use and Alzheimer's disease
    • Zamrini E, McGwin G, Roseman JM. Association between statin use and Alzheimer's disease. Neuroepidemiology 23(1-2): 94-8 (2004).
    • (2004) Neuroepidemiology , vol.23 , Issue.1-2 , pp. 94-98
    • Zamrini, E.1    McGwin, G.2    Roseman, J.M.3
  • 38
    • 12144290725 scopus 로고    scopus 로고
    • Plasma levels of beta-amyloid(1-40), beta-amyloid(1-42), and total beta-amyloid remain unaffected in adult patients with hypercholesterolemia after treatment with statins
    • Hoglund K, Wiklund O, Vanderstichele H, Eikenberg O, Vanmechelen E, Blennow K. Plasma levels of beta-amyloid(1-40), beta-amyloid(1-42), and total beta-amyloid remain unaffected in adult patients with hypercholesterolemia after treatment with statins. Arch Neurol 61(3): 333-3337 (2004).
    • (2004) Arch Neurol , vol.61 , Issue.3 , pp. 333-3337
    • Hoglund, K.1    Wiklund, O.2    Vanderstichele, H.3    Eikenberg, O.4    Vanmechelen, E.5    Blennow, K.6
  • 40
    • 20844440894 scopus 로고    scopus 로고
    • Atorvastatin for the treatment of mild to moderate Alzheimer disease: Preliminary results
    • Sparks DL, Sabbagh MN, Connor DJ, Lopez J, Launer LJ, Browne P, et al. Atorvastatin for the treatment of mild to moderate Alzheimer disease: preliminary results. Arch Neurol 62(5): 753-757 (2005).
    • (2005) Arch Neurol , vol.62 , Issue.5 , pp. 753-757
    • Sparks, D.L.1    Sabbagh, M.N.2    Connor, D.J.3    Lopez, J.4    Launer, L.J.5    Browne, P.6
  • 41
    • 44849101912 scopus 로고    scopus 로고
    • Effects of simvastatin on cerebrospinal fluid biomarkers and cognition in middle-aged adults at risk for Alzheimer's disease
    • Carlsson CM, Gleason CE, Hess TM, Moreland KA, Blazel HM, Koscik RL, et al. Effects of simvastatin on cerebrospinal fluid biomarkers and cognition in middle-aged adults at risk for Alzheimer's disease. J Alzheimers Dis 13(2): 187-197 (2008).
    • (2008) J Alzheimers Dis , vol.13 , Issue.2 , pp. 187-197
    • Carlsson, C.M.1    Gleason, C.E.2    Hess, T.M.3    Moreland, K.A.4    Blazel, H.M.5    Koscik, R.L.6
  • 42
    • 77957333479 scopus 로고    scopus 로고
    • Long-Term Statin Therapy is Associated with Better Episodic Memory in Aged Familial Hypercholesterolemia Patients in Comparison with Population Controls
    • Hyttinen L, Tuulio-Henriksson A, Vuorio AF, Kuosmanen N, Harkanen T, Koskinen S, et al. Long-Term Statin Therapy is Associated with Better Episodic Memory in Aged Familial Hypercholesterolemia Patients in Comparison with Population Controls. J Alzheimers Dis Jun 21: (2010).
    • (2010) J Alzheimers Dis Jun , pp. 21
    • Hyttinen, L.1    Tuulio-Henriksson, A.2    Vuorio, A.F.3    Kuosmanen, N.4    Harkanen, T.5    Koskinen, S.6
  • 46
    • 77954989381 scopus 로고    scopus 로고
    • Statins and cognitive functioning in the elderly: A population-based study
    • Benito-Leon J, Louis ED, Vega S, Bermejo-Pareja F. Statins and cognitive functioning in the elderly: a population-based study. J Alzheimers Dis 21(1): 95-102 (2010).
    • (2010) J Alzheimers Dis , vol.21 , Issue.1 , pp. 95-102
    • Benito-Leon, J.1    Louis, E.D.2    Vega, S.3    Bermejo-Pareja, F.4
  • 47
    • 57649136760 scopus 로고    scopus 로고
    • Developing drugs that can cross the blood-brain barrier: Applications to Alzheimer's disease
    • Banks WA. Developing drugs that can cross the blood-brain barrier: applications to Alzheimer's disease. BMC Neurosci 9 Suppl 3:S2 (2008).
    • (2008) BMC Neurosci 9 Suppl , vol.3
    • Banks, W.A.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.