Functional analysis of a novel genome-wide association study signal in SMAD3 that confers protection from coronary artery disease

Arteriosclerosis, Thrombosis, and Vascular Biology

Volumn 36, Issue 5, 2016, Pages 972-983

  Turner, Adam W ^a   Martinuk, Amy ^a   Silva, Anada ^a   Lau, Paulina ^a   Nikpay, Majid ^a   Eriksson, Per ^b   Folkersen, Lasse ^b,c   Perisic, Ljubica ^b   Hedin, Ulf ^b   Soubeyrand, Sebastien ^a   McPherson, Ruth ^a  

^a UNIVERSITY OF OTTAWA HEART INSTITUTE   (Canada)

^b KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

^c TECHNICAL UNIVERSITY OF DENMARK   (Denmark)

Author keywords

binding sites; coronary artery disease; genome wide association study; genomics; SMAD3 protein

Indexed keywords

SMAD3 PROTEIN; SMALL INTERFERING RNA; TRANSCRIPTION FACTOR AP 1; SMAD3 PROTEIN, HUMAN;

ALLELE; ARTERY MUSCLE; ARTICLE; ATHEROSCLEROTIC PLAQUE; CELL VIABILITY; CHROMATIN IMMUNOPRECIPITATION; CONTROLLED STUDY; CORONARY ARTERY DISEASE; ENHANCER REGION; EPIGENETICS; FEMALE; GENE LOCUS; GENE MAPPING; GENOME-WIDE ASSOCIATION STUDY; HUMAN; HUMAN CELL; HUMAN TISSUE; INTRON; PRIORITY JOURNAL; PROTEIN EXPRESSION; QUANTITATIVE TRAIT LOCUS; RISK; SINGLE NUCLEOTIDE POLYMORPHISM; SMOOTH MUSCLE CELL; BINDING SITE; CELL CULTURE; CELL PROLIFERATION; CELL SURVIVAL; CORONARY BLOOD VESSEL; GENETIC PREDISPOSITION; GENETIC TRANSFECTION; GENETICS; HAPLOTYPE; METABOLISM; PATHOLOGY; PHENOTYPE; PROMOTER REGION; PROTECTION; RISK FACTOR; RNA INTERFERENCE; VASCULAR SMOOTH MUSCLE;

BINDING SITES; CELL PROLIFERATION; CELL SURVIVAL; CELLS, CULTURED; CORONARY ARTERY DISEASE; CORONARY VESSELS; ENHANCER ELEMENTS, GENETIC; GENETIC PREDISPOSITION TO DISEASE; GENOME-WIDE ASSOCIATION STUDY; HAPLOTYPES; HUMANS; INTRONS; MUSCLE, SMOOTH, VASCULAR; MYOCYTES, SMOOTH MUSCLE; PHENOTYPE; PLAQUE, ATHEROSCLEROTIC; POLYMORPHISM, SINGLE NUCLEOTIDE; PROMOTER REGIONS, GENETIC; PROTECTIVE FACTORS; QUANTITATIVE TRAIT LOCI; RISK FACTORS; RNA INTERFERENCE; SMAD3 PROTEIN; TRANSCRIPTION FACTOR AP-1; TRANSFECTION;

EID: 84960347855     PISSN: 10795642     EISSN: 15244636     Source Type: Journal    
DOI: 10.1161/ATVBAHA.116.307294     Document Type: Article

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