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Volumn 76, Issue , 2016, Pages 39-66

The Therapeutic Role of d-Cycloserine in Schizophrenia

Author keywords

D Cycloserine; Glutamate; Glycine; Pharmacology; Plasticity; Schizophrenia

Indexed keywords

CYCLOSERINE; DEXTRO SERINE; GLUTAMIC ACID; GLYCINE; GLYCINE RECEPTOR; GLYCINE RECEPTOR ANTAGONIST; LAMOTRIGINE; N METHYL DEXTRO ASPARTIC ACID RECEPTOR;

EID: 84960194412     PISSN: 10543589     EISSN: 15578925     Source Type: Book Series    
DOI: 10.1016/bs.apha.2016.02.001     Document Type: Chapter
Times cited : (8)

References (145)
  • 1
    • 84896732939 scopus 로고    scopus 로고
    • Methylome-wide association study of schizophrenia: Identifying blood biomarker signatures of environmental insults
    • Aberg K.A., McClay J.L., Nerella S., Clark S., Kumar G., Chen W., van den Oord E.J. Methylome-wide association study of schizophrenia: Identifying blood biomarker signatures of environmental insults. JAMA Psychiatry 2014, 71(3):255-264. 10.1001/jamapsychiatry.2013.3730.
    • (2014) JAMA Psychiatry , vol.71 , Issue.3 , pp. 255-264
    • Aberg, K.A.1    McClay, J.L.2    Nerella, S.3    Clark, S.4    Kumar, G.5    Chen, W.6    van den Oord, E.J.7
  • 3
    • 84932604863 scopus 로고    scopus 로고
    • D-Cycloserine vs placebo as adjunct to cognitive behavioral therapy for obsessive-compulsive disorder and interaction with antidepressants: A randomized clinical trial
    • Andersson E., Hedman E., Enander J., Radu Djurfeldt D., Ljotsson B., Cervenka S., Ruck C. d-Cycloserine vs placebo as adjunct to cognitive behavioral therapy for obsessive-compulsive disorder and interaction with antidepressants: A randomized clinical trial. JAMA Psychiatry 2015, 72(7):659-667. 10.1001/jamapsychiatry.2015.0546.
    • (2015) JAMA Psychiatry , vol.72 , Issue.7 , pp. 659-667
    • Andersson, E.1    Hedman, E.2    Enander, J.3    Radu Djurfeldt, D.4    Ljotsson, B.5    Cervenka, S.6    Ruck, C.7
  • 4
    • 78649906486 scopus 로고    scopus 로고
    • Neuroplasticity signaling pathways linked to the pathophysiology of schizophrenia
    • S0149-7634(10)00169-7 [pii]
    • Balu D.T., Coyle J.T. Neuroplasticity signaling pathways linked to the pathophysiology of schizophrenia. Neuroscience and Biobehavioral Reviews 2012, 35(3):848-870. S0149-7634(10)00169-7 [pii].
    • (2012) Neuroscience and Biobehavioral Reviews , vol.35 , Issue.3 , pp. 848-870
    • Balu, D.T.1    Coyle, J.T.2
  • 5
    • 84919608198 scopus 로고    scopus 로고
    • The NMDA receptor 'glycine modulatory site' in schizophrenia: D-serine, glycine, and beyond
    • Balu D.T., Coyle J.T. The NMDA receptor 'glycine modulatory site' in schizophrenia: D-serine, glycine, and beyond. Current Opinion in Pharmacology 2015, 20:109-115. 10.1016/j.coph.2014.12.004.
    • (2015) Current Opinion in Pharmacology , vol.20 , pp. 109-115
    • Balu, D.T.1    Coyle, J.T.2
  • 6
    • 47249164327 scopus 로고    scopus 로고
    • Lamina-specific abnormalities of NMDA receptor-associated postsynaptic protein transcripts in the prefrontal cortex in schizophrenia and bipolar disorder
    • 1301604 [pii]
    • Beneyto M., Meador-Woodruff J.H. Lamina-specific abnormalities of NMDA receptor-associated postsynaptic protein transcripts in the prefrontal cortex in schizophrenia and bipolar disorder. Neuropsychopharmacology 2008, 33(9):2175-2186. 1301604 [pii]. 10.1038/sj.npp.1301604.
    • (2008) Neuropsychopharmacology , vol.33 , Issue.9 , pp. 2175-2186
    • Beneyto, M.1    Meador-Woodruff, J.H.2
  • 7
    • 32544439181 scopus 로고    scopus 로고
    • NMDA receptors in layer 4 spiny stellate cells of the mouse barrel cortex contain the NR2C subunit
    • 26/2/708 [pii]
    • Binshtok A.M., Fleidervish I.A., Sprengel R., Gutnick M.J. NMDA receptors in layer 4 spiny stellate cells of the mouse barrel cortex contain the NR2C subunit. Journal of Neuroscience 2006, 26(2):708-715. 26/2/708 [pii]. 10.1523/JNEUROSCI.4409-05.2006.
    • (2006) Journal of Neuroscience , vol.26 , Issue.2 , pp. 708-715
    • Binshtok, A.M.1    Fleidervish, I.A.2    Sprengel, R.3    Gutnick, M.J.4
  • 8
    • 0022187757 scopus 로고
    • Plasma amino acids in relation to cerebrospinal fluid monoamine metabolites in schizophrenic patients and healthy controls
    • Bjerkenstedt L., Edman G., Hagenfeldt L., Sedvall G., Wiesel F.A. Plasma amino acids in relation to cerebrospinal fluid monoamine metabolites in schizophrenic patients and healthy controls. British Journal of Psychiatry 1985, 147:276-282.
    • (1985) British Journal of Psychiatry , vol.147 , pp. 276-282
    • Bjerkenstedt, L.1    Edman, G.2    Hagenfeldt, L.3    Sedvall, G.4    Wiesel, F.A.5
  • 9
    • 0036627616 scopus 로고    scopus 로고
    • Integrative role for serotonergic and glutamatergic receptor mechanisms in the action of NMDA antagonists: Potential relationships to antipsychotic drug actions on NMDA antagonist responsiveness
    • Breese G.R., Knapp D.J., Moy S.S. Integrative role for serotonergic and glutamatergic receptor mechanisms in the action of NMDA antagonists: Potential relationships to antipsychotic drug actions on NMDA antagonist responsiveness. Neuroscience & Biobehavioral Reviews 2002, 26(4):441-455.
    • (2002) Neuroscience & Biobehavioral Reviews , vol.26 , Issue.4 , pp. 441-455
    • Breese, G.R.1    Knapp, D.J.2    Moy, S.S.3
  • 10
    • 0031947285 scopus 로고    scopus 로고
    • Effects of NMDA antagonism on striatal dopamine release in healthy subjects: Application of a novel PET approach
    • Breier A., Adler C.M., Weisenfeld N., Su T.P., Elman I., Picken L., Pickar D. Effects of NMDA antagonism on striatal dopamine release in healthy subjects: Application of a novel PET approach. Synapse 1998, 29:142-147.
    • (1998) Synapse , vol.29 , pp. 142-147
    • Breier, A.1    Adler, C.M.2    Weisenfeld, N.3    Su, T.P.4    Elman, I.5    Picken, L.6    Pickar, D.7
  • 11
    • 35748969317 scopus 로고    scopus 로고
    • The cognitive and negative symptoms in schizophrenia trial (CONSIST): The efficacy of glutamatergic agents for negative symptoms and cognitive impairments
    • Buchanan R.W., Javitt D.C., Marder S.R., Schooler N.R., Gold J.M., McMahon R.P., Carpenter W.T. The cognitive and negative symptoms in schizophrenia trial (CONSIST): The efficacy of glutamatergic agents for negative symptoms and cognitive impairments. The American Journal of Psychiatry 2007, 164(10):1593-1602.
    • (2007) The American Journal of Psychiatry , vol.164 , Issue.10 , pp. 1593-1602
    • Buchanan, R.W.1    Javitt, D.C.2    Marder, S.R.3    Schooler, N.R.4    Gold, J.M.5    McMahon, R.P.6    Carpenter, W.T.7
  • 12
    • 84942740187 scopus 로고    scopus 로고
    • The long-lasting antidepressant effects of rapastinel (GLYX-13) are associated with a metaplasticity process in the medial prefrontal cortex and hippocampus
    • Burgdorf J., Zhang X.L., Weiss C., Gross A., Boikess S.R., Kroes R.A., Moskal J.R. The long-lasting antidepressant effects of rapastinel (GLYX-13) are associated with a metaplasticity process in the medial prefrontal cortex and hippocampus. Neuroscience 2015, 308:202-211. 10.1016/j.neuroscience.2015.09.004.
    • (2015) Neuroscience , vol.308 , pp. 202-211
    • Burgdorf, J.1    Zhang, X.L.2    Weiss, C.3    Gross, A.4    Boikess, S.R.5    Kroes, R.A.6    Moskal, J.R.7
  • 15
    • 84919387336 scopus 로고    scopus 로고
    • Complex associative memory processing and sleep: A systematic review and meta-analysis of behavioural evidence and underlying EEG mechanisms
    • Chatburn A., Lushington K., Kohler M.J. Complex associative memory processing and sleep: A systematic review and meta-analysis of behavioural evidence and underlying EEG mechanisms. Neuroscience & Biobehavioral Reviews 2014, 47:646-655. 10.1016/j.neubiorev.2014.10.018.
    • (2014) Neuroscience & Biobehavioral Reviews , vol.47 , pp. 646-655
    • Chatburn, A.1    Lushington, K.2    Kohler, M.J.3
  • 16
    • 65649084122 scopus 로고    scopus 로고
    • Growth factor-dependent trafficking of cerebellar NMDA receptors via protein kinase B/Akt phosphorylation of NR2C
    • S0896-6273(09)00296-7 [pii]
    • Chen B.S., Roche K.W. Growth factor-dependent trafficking of cerebellar NMDA receptors via protein kinase B/Akt phosphorylation of NR2C. Neuron 2009, 62(4):471-478. S0896-6273(09)00296-7 [pii]. 10.1016/j.neuron.2009.04.015.
    • (2009) Neuron , vol.62 , Issue.4 , pp. 471-478
    • Chen, B.S.1    Roche, K.W.2
  • 17
    • 84942200058 scopus 로고    scopus 로고
    • The impact of NMDA receptor hypofunction on GABAergic neurons in the pathophysiology of schizophrenia
    • Cohen S.M., Tsien R.W., Goff D.C., Halassa M.M. The impact of NMDA receptor hypofunction on GABAergic neurons in the pathophysiology of schizophrenia. Schizophrenia Research 2015, 167(1-3):98-107. 10.1016/j.schres.2014.12.026.
    • (2015) Schizophrenia Research , vol.167 , Issue.1-3 , pp. 98-107
    • Cohen, S.M.1    Tsien, R.W.2    Goff, D.C.3    Halassa, M.M.4
  • 18
    • 84892620489 scopus 로고    scopus 로고
    • Genome-wide association studies: Findings at the major histocompatibility complex locus in psychosis
    • Corvin A., Morris D.W. Genome-wide association studies: Findings at the major histocompatibility complex locus in psychosis. Biological Psychiatry 2014, 75(4):276-283. 10.1016/j.biopsych.2013.09.018.
    • (2014) Biological Psychiatry , vol.75 , Issue.4 , pp. 276-283
    • Corvin, A.1    Morris, D.W.2
  • 19
    • 0025249952 scopus 로고
    • An open trial of glycine as an adjunct to neuroleptics in chronic treatment-refractory schizophrenics
    • Costa J., Khaled E., Sramek J., Bunney W., Potkin S.G. An open trial of glycine as an adjunct to neuroleptics in chronic treatment-refractory schizophrenics. Journal of Clinical Psychopharmacology 1990, 10:71-72.
    • (1990) Journal of Clinical Psychopharmacology , vol.10 , pp. 71-72
    • Costa, J.1    Khaled, E.2    Sramek, J.3    Bunney, W.4    Potkin, S.G.5
  • 20
    • 33747083749 scopus 로고    scopus 로고
    • Effects of D-cycloserine on extinction: Translation from preclinical to clinical work
    • Davis M., Ressler K., Rothbaum B.O., Richardson R. Effects of D-cycloserine on extinction: Translation from preclinical to clinical work. Biological Psychiatry 2006, 60(4):369-375.
    • (2006) Biological Psychiatry , vol.60 , Issue.4 , pp. 369-375
    • Davis, M.1    Ressler, K.2    Rothbaum, B.O.3    Richardson, R.4
  • 21
    • 84866640784 scopus 로고    scopus 로고
    • Phencyclidine/schizophrenia: One view toward the past, the other to the future
    • Domino E.F., Luby E.D. Phencyclidine/schizophrenia: One view toward the past, the other to the future. Schizophrenia Bulletin 2012, 38(5):914-919. 10.1093/schbul/sbs011.
    • (2012) Schizophrenia Bulletin , vol.38 , Issue.5 , pp. 914-919
    • Domino, E.F.1    Luby, E.D.2
  • 22
    • 84901218352 scopus 로고    scopus 로고
    • D-cycloserine enhances both intrinsic excitability of CA1 hippocampal neurons and expression of activity-regulated cytoskeletal (Arc) protein
    • Donzis E.J., Thompson L.T. D-cycloserine enhances both intrinsic excitability of CA1 hippocampal neurons and expression of activity-regulated cytoskeletal (Arc) protein. Neuroscience Letters 2014, 571:50-54. 10.1016/j.neulet.2014.04.035.
    • (2014) Neuroscience Letters , vol.571 , pp. 50-54
    • Donzis, E.J.1    Thompson, L.T.2
  • 23
    • 77249087107 scopus 로고    scopus 로고
    • Structural determinants of D-cycloserine efficacy at the NR1/NR2C NMDA receptors
    • 30/7/2741 [pii]
    • Dravid S.M., Burger P.B., Prakash A., Geballe M.T., Yadav R., Le P., Traynelis S.F. Structural determinants of D-cycloserine efficacy at the NR1/NR2C NMDA receptors. Journal of Neuroscience 2010, 30(7):2741-2754. 30/7/2741 [pii]. 10.1523/JNEUROSCI.5390-09.2010.
    • (2010) Journal of Neuroscience , vol.30 , Issue.7 , pp. 2741-2754
    • Dravid, S.M.1    Burger, P.B.2    Prakash, A.3    Geballe, M.T.4    Yadav, R.5    Le, P.6    Traynelis, S.F.7
  • 26
    • 0036641749 scopus 로고    scopus 로고
    • D-cycloserine augmentation of risperidone in the deficit syndrome of schizophrenia
    • Evins A., Amico E., Posever T., Toker R., Goff D. D-cycloserine augmentation of risperidone in the deficit syndrome of schizophrenia. Schizophrenia Research 2002, 56:19-23.
    • (2002) Schizophrenia Research , vol.56 , pp. 19-23
    • Evins, A.1    Amico, E.2    Posever, T.3    Toker, R.4    Goff, D.5
  • 28
    • 84887996404 scopus 로고    scopus 로고
    • Sleep-dependent declarative memory consolidation-Unaffected after blocking NMDA or AMPA receptors but enhanced by NMDA coagonist D-cycloserine
    • Feld G.B., Lange T., Gais S., Born J. Sleep-dependent declarative memory consolidation-Unaffected after blocking NMDA or AMPA receptors but enhanced by NMDA coagonist D-cycloserine. Neuropsychopharmacology 2013, 38(13):2688-2697. 10.1038/npp.2013.179.
    • (2013) Neuropsychopharmacology , vol.38 , Issue.13 , pp. 2688-2697
    • Feld, G.B.1    Lange, T.2    Gais, S.3    Born, J.4
  • 30
    • 0026778929 scopus 로고
    • Effect on memory processing by D-cycloserine, an agonist of the NMDA/glycine receptor
    • Flood J., Morley J., Lanthorn T. Effect on memory processing by D-cycloserine, an agonist of the NMDA/glycine receptor. European Journal of Pharmacology 1992, 221:249-254.
    • (1992) European Journal of Pharmacology , vol.221 , pp. 249-254
    • Flood, J.1    Morley, J.2    Lanthorn, T.3
  • 32
    • 84902180976 scopus 로고    scopus 로고
    • Bitopertin: The good news and bad news
    • Goff D.C. Bitopertin: The good news and bad news. JAMA Psychiatry 2014, 71(6):621-622. 10.1001/jamapsychiatry.2014.257.
    • (2014) JAMA Psychiatry , vol.71 , Issue.6 , pp. 621-622
    • Goff, D.C.1
  • 33
    • 56049099989 scopus 로고    scopus 로고
    • Once-weekly d-cycloserine effects on negative symptoms and cognition in schizophrenia: An exploratory study
    • S0920-9964(08)00375-7 [pii]
    • Goff D.C., Cather C., Gottlieb J.D., Evins A.E., Walsh J., Raeke L., Green M.F. Once-weekly d-cycloserine effects on negative symptoms and cognition in schizophrenia: An exploratory study. Schizophrenia Research 2008, 106(2-3):320-327. S0920-9964(08)00375-7 [pii]. 10.1016/j.schres.2008.08.012.
    • (2008) Schizophrenia Research , vol.106 , Issue.2-3 , pp. 320-327
    • Goff, D.C.1    Cather, C.2    Gottlieb, J.D.3    Evins, A.E.4    Walsh, J.5    Raeke, L.6    Green, M.F.7
  • 34
    • 0034843738 scopus 로고    scopus 로고
    • The emerging role of glutamate in the pathophysiology and treatment of schizophrenia
    • Goff D.C., Coyle J.T. The emerging role of glutamate in the pathophysiology and treatment of schizophrenia. The American Journal of Psychiatry 2001, 158:1367-1377.
    • (2001) The American Journal of Psychiatry , vol.158 , pp. 1367-1377
    • Goff, D.C.1    Coyle, J.T.2
  • 35
    • 0033557737 scopus 로고    scopus 로고
    • A placebo-controlled crossover trial of D-cycloserine added to clozapine in patients with schizophrenia
    • Goff D., Henderson D., Evins A., Amico E. A placebo-controlled crossover trial of D-cycloserine added to clozapine in patients with schizophrenia. Biological Psychiatry 1999, 45:512-514.
    • (1999) Biological Psychiatry , vol.45 , pp. 512-514
    • Goff, D.1    Henderson, D.2    Evins, A.3    Amico, E.4
  • 36
    • 0037087350 scopus 로고    scopus 로고
    • Modulation of brain and serum glutamatergic concentrations following a switch from conventional neuroleptics to olanzapine
    • Goff D.C., Hennen J., Tsai G., Evins A.E., Yurgelun-Todd D., Renshaw P. Modulation of brain and serum glutamatergic concentrations following a switch from conventional neuroleptics to olanzapine. Biological Psychiatry 2002, 51:493-497.
    • (2002) Biological Psychiatry , vol.51 , pp. 493-497
    • Goff, D.C.1    Hennen, J.2    Tsai, G.3    Evins, A.E.4    Yurgelun-Todd, D.5    Renshaw, P.6
  • 37
    • 20944441298 scopus 로고    scopus 로고
    • A six-month, placebo-controlled trial of D-cycloserine co-administered with conventional antipsychotics in schizophrenia patients
    • Goff D.C., Herz L., Posever T., Shih V., Tsai G., Henderson D.C., Schoenfeld D. A six-month, placebo-controlled trial of D-cycloserine co-administered with conventional antipsychotics in schizophrenia patients. Psychopharmacology 2005, 179(1):144-150.
    • (2005) Psychopharmacology , vol.179 , Issue.1 , pp. 144-150
    • Goff, D.C.1    Herz, L.2    Posever, T.3    Shih, V.4    Tsai, G.5    Henderson, D.C.6    Schoenfeld, D.7
  • 38
    • 39649116488 scopus 로고    scopus 로고
    • Lamotrigine as add-on therapy in schizophrenia: Results of 2 placebo-controlled trials
    • 00004714-200712000-00005 [pii]
    • Goff D.C., Keefe R., Citrome L., Davy K., Krystal J.H., Large C., Webster E.L. Lamotrigine as add-on therapy in schizophrenia: Results of 2 placebo-controlled trials. Journal of Clinical Psychopharmacology 2007, 27(6):582-589. 00004714-200712000-00005 [pii]. 10.1097/jcp.0b013e31815abf34.
    • (2007) Journal of Clinical Psychopharmacology , vol.27 , Issue.6 , pp. 582-589
    • Goff, D.C.1    Keefe, R.2    Citrome, L.3    Davy, K.4    Krystal, J.H.5    Large, C.6    Webster, E.L.7
  • 40
    • 0029116094 scopus 로고
    • Dose-finding trial of D-cycloserine added to neuroleptics for negative symptoms in schizophrenia
    • Goff D.C., Tsai G., Manoach D.S., Coyle J.T. Dose-finding trial of D-cycloserine added to neuroleptics for negative symptoms in schizophrenia. The American Journal of Psychiatry 1995, 152:1213-1215.
    • (1995) The American Journal of Psychiatry , vol.152 , pp. 1213-1215
    • Goff, D.C.1    Tsai, G.2    Manoach, D.S.3    Coyle, J.T.4
  • 43
    • 84878517979 scopus 로고    scopus 로고
    • Effect of D-cycloserine in conjunction with fear extinction training on extracellular signal-regulated kinase activation in the medial prefrontal cortex and amygdala in rat
    • Gupta S.C., Hillman B.G., Prakash A., Ugale R.R., Stairs D.J., Dravid S.M. Effect of D-cycloserine in conjunction with fear extinction training on extracellular signal-regulated kinase activation in the medial prefrontal cortex and amygdala in rat. European Journal of Neuroscience 2013, 37(11):1811-1822. 10.1111/ejn.12197.
    • (2013) European Journal of Neuroscience , vol.37 , Issue.11 , pp. 1811-1822
    • Gupta, S.C.1    Hillman, B.G.2    Prakash, A.3    Ugale, R.R.4    Stairs, D.J.5    Dravid, S.M.6
  • 44
    • 84920646061 scopus 로고    scopus 로고
    • Genetic risk for schizophrenia: Convergence on synaptic pathways involved in plasticity
    • Hall J., Trent S., Thomas K.L., O'Donovan M.C., Owen M.J. Genetic risk for schizophrenia: Convergence on synaptic pathways involved in plasticity. Biological Psychiatry 2015, 77(1):52-58. 10.1016/j.biopsych.2014.07.011.
    • (2015) Biological Psychiatry , vol.77 , Issue.1 , pp. 52-58
    • Hall, J.1    Trent, S.2    Thomas, K.L.3    O'Donovan, M.C.4    Owen, M.J.5
  • 45
    • 70450182118 scopus 로고    scopus 로고
    • Coupling of the NMDA receptor to neuroprotective and neurodestructive events
    • Hardingham G.E. Coupling of the NMDA receptor to neuroprotective and neurodestructive events. Biochemical Society Transactions 2009, 37(Pt 6):1147-1160. 10.1042/bst0371147.
    • (2009) Biochemical Society Transactions , vol.37 , pp. 1147-1160
    • Hardingham, G.E.1
  • 46
    • 39049133870 scopus 로고    scopus 로고
    • Neonatal inflammation produces selective behavioural deficits and alters N-methyl-D-aspartate receptor subunit mRNA in the adult rat brain
    • Harre E.M., Galic M.A., Mouihate A., Noorbakhsh F., Pittman Q.J. Neonatal inflammation produces selective behavioural deficits and alters N-methyl-D-aspartate receptor subunit mRNA in the adult rat brain. European Journal of Neuroscience 2008, 27(3):644-653. 10.1111/j.1460-9568.2008.06031.x.
    • (2008) European Journal of Neuroscience , vol.27 , Issue.3 , pp. 644-653
    • Harre, E.M.1    Galic, M.A.2    Mouihate, A.3    Noorbakhsh, F.4    Pittman, Q.J.5
  • 47
    • 0036184549 scopus 로고    scopus 로고
    • Placebo-controlled trial of D-cycloserine added to conventional neuroleptics, olanzapine, or risperidone in schizophrenia
    • Heresco-Levy U., Ermilov M., Shimoni J., Shapira B., Silipo G., Javitt D.C. Placebo-controlled trial of D-cycloserine added to conventional neuroleptics, olanzapine, or risperidone in schizophrenia. The American Journal of Psychiatry 2002, 159:480-482.
    • (2002) The American Journal of Psychiatry , vol.159 , pp. 480-482
    • Heresco-Levy, U.1    Ermilov, M.2    Shimoni, J.3    Shapira, B.4    Silipo, G.5    Javitt, D.C.6
  • 48
    • 15444377601 scopus 로고    scopus 로고
    • D-serine efficacy as add-on pharmacotherapy to risperidone and olanzapine for treatment-refractory schizophrenia
    • Heresco-Levy U., Javitt D.C., Ebstein R., Vass A., Lichtenberg P., Bar G., Ermilov M. D-serine efficacy as add-on pharmacotherapy to risperidone and olanzapine for treatment-refractory schizophrenia. Biological Psychiatry 2005, 57(6):577-585.
    • (2005) Biological Psychiatry , vol.57 , Issue.6 , pp. 577-585
    • Heresco-Levy, U.1    Javitt, D.C.2    Ebstein, R.3    Vass, A.4    Lichtenberg, P.5    Bar, G.6    Ermilov, M.7
  • 49
    • 0029658545 scopus 로고    scopus 로고
    • Double-blind, placebo-controlled, crossover trial of glycine adjuvant therapy for treatment-resistant schizophrenia
    • Heresco-Levy U., Javitt D., Ermilov M., Mordel C., Horowitz A., Kelly D. Double-blind, placebo-controlled, crossover trial of glycine adjuvant therapy for treatment-resistant schizophrenia. British Journal of Psychiatry 1996, 169:610-617.
    • (1996) British Journal of Psychiatry , vol.169 , pp. 610-617
    • Heresco-Levy, U.1    Javitt, D.2    Ermilov, M.3    Mordel, C.4    Horowitz, A.5    Kelly, D.6
  • 52
    • 79955474438 scopus 로고    scopus 로고
    • Behavioral analysis of NR2C knockout mouse reveals deficit in acquisition of conditioned fear and working memory
    • S1074-7427(11)00009-8 [pii]
    • Hillman B.G., Gupta S.C., Stairs D.J., Buonanno A., Dravid S.M. Behavioral analysis of NR2C knockout mouse reveals deficit in acquisition of conditioned fear and working memory. Neurobiology of Learning and Memory 2011, 95:404-414. S1074-7427(11)00009-8 [pii]. 10.1016/j.nlm.2011.01.008.
    • (2011) Neurobiology of Learning and Memory , vol.95 , pp. 404-414
    • Hillman, B.G.1    Gupta, S.C.2    Stairs, D.J.3    Buonanno, A.4    Dravid, S.M.5
  • 55
    • 84938988888 scopus 로고    scopus 로고
    • Neuronal serine racemase regulates extracellular D-serine levels in the adult mouse hippocampus
    • Ishiwata S., Umino A., Balu D.T., Coyle J.T., Nishikawa T. Neuronal serine racemase regulates extracellular D-serine levels in the adult mouse hippocampus. Journal of Neural Transmission (Vienna) 2015, 122(8):1099-1103. 10.1007/s00702-015-1388-2.
    • (2015) Journal of Neural Transmission (Vienna) , vol.122 , Issue.8 , pp. 1099-1103
    • Ishiwata, S.1    Umino, A.2    Balu, D.T.3    Coyle, J.T.4    Nishikawa, T.5
  • 57
    • 15944428993 scopus 로고    scopus 로고
    • Inhibition of system A-mediated glycine transport in cortical synaptosomes by therapeutic concentrations of clozapine: Implications for mechanisms of action
    • Javitt D.C., Duncan L., Balla A., Sershen H. Inhibition of system A-mediated glycine transport in cortical synaptosomes by therapeutic concentrations of clozapine: Implications for mechanisms of action. Molecular Psychiatry 2005, 10:275-287.
    • (2005) Molecular Psychiatry , vol.10 , pp. 275-287
    • Javitt, D.C.1    Duncan, L.2    Balla, A.3    Sershen, H.4
  • 59
    • 0025952455 scopus 로고
    • Recent advances in the phencyclidine model of schizophrenia
    • Javitt D., Zukin S. Recent advances in the phencyclidine model of schizophrenia. The American Journal of Psychiatry 1991, 148:1301-1308.
    • (1991) The American Journal of Psychiatry , vol.148 , pp. 1301-1308
    • Javitt, D.1    Zukin, S.2
  • 62
    • 33847373855 scopus 로고    scopus 로고
    • Novel regional and developmental NMDA receptor expression patterns uncovered in NR2C subunit-beta-galactosidase knock-in mice
    • S1044-7431(06)00277-6 [pii]
    • Karavanova I., Vasudevan K., Cheng J., Buonanno A. Novel regional and developmental NMDA receptor expression patterns uncovered in NR2C subunit-beta-galactosidase knock-in mice. Molecular and Cellular Neuroscience 2007, 34(3):468-480. S1044-7431(06)00277-6 [pii]. 10.1016/j.mcn.2006.12.001.
    • (2007) Molecular and Cellular Neuroscience , vol.34 , Issue.3 , pp. 468-480
    • Karavanova, I.1    Vasudevan, K.2    Cheng, J.3    Buonanno, A.4
  • 63
    • 0019293020 scopus 로고
    • Low cerebrospinal glutamate in schizophrenic patients and a new hypothesis on schizophrenia
    • Kim J.S., Kornhuber H.H., Schmid-Burgk W., Holzmuller B. Low cerebrospinal glutamate in schizophrenic patients and a new hypothesis on schizophrenia. Neuroscience Letters 1980, 20:379-382.
    • (1980) Neuroscience Letters , vol.20 , pp. 379-382
    • Kim, J.S.1    Kornhuber, H.H.2    Schmid-Burgk, W.3    Holzmuller, B.4
  • 64
    • 84942109073 scopus 로고    scopus 로고
    • Exploratory analysis for a targeted patient population responsive to the metabotropic glutamate 2/3 receptor agonist pomaglumetad methionyl in schizophrenia
    • Kinon B.J., Millen B.A., Zhang L., McKinzie D.L. Exploratory analysis for a targeted patient population responsive to the metabotropic glutamate 2/3 receptor agonist pomaglumetad methionyl in schizophrenia. Biological Psychiatry 2015, 78(11):754-762. 10.1016/j.biopsych.2015.03.016.
    • (2015) Biological Psychiatry , vol.78 , Issue.11 , pp. 754-762
    • Kinon, B.J.1    Millen, B.A.2    Zhang, L.3    McKinzie, D.L.4
  • 66
    • 20944439080 scopus 로고    scopus 로고
    • Preliminary evidence of attenuation of the disruptive effects of the NMDA glutamate receptor antagonist, ketamine, on working memory by pretreatment with the group II metabotropic glutamate receptor agonist, LY354740, in healthy human subjects
    • Krystal J.H., Abi-Saab W., Perry E., D'Souza D.C., Liu N., Gueorguieva R., Breier A. Preliminary evidence of attenuation of the disruptive effects of the NMDA glutamate receptor antagonist, ketamine, on working memory by pretreatment with the group II metabotropic glutamate receptor agonist, LY354740, in healthy human subjects. Psychopharmacology 2005, 179(1):303-309.
    • (2005) Psychopharmacology , vol.179 , Issue.1 , pp. 303-309
    • Krystal, J.H.1    Abi-Saab, W.2    Perry, E.3    D'Souza, D.C.4    Liu, N.5    Gueorguieva, R.6    Breier, A.7
  • 67
    • 0028323167 scopus 로고
    • Subanesthetic effects of the noncompetitive NMDA antagonist, ketamine, in humans: Psychotomimetic, perceptual, cognitive, and neuroendocrine responses
    • Krystal J.H., Karper L.P., Seibyl J.P., Freeman G.K., Delaney R., Bremner J.D., Charney D.S. Subanesthetic effects of the noncompetitive NMDA antagonist, ketamine, in humans: Psychotomimetic, perceptual, cognitive, and neuroendocrine responses. Archives of General Psychiatry 1994, 51:199-214.
    • (1994) Archives of General Psychiatry , vol.51 , pp. 199-214
    • Krystal, J.H.1    Karper, L.P.2    Seibyl, J.P.3    Freeman, G.K.4    Delaney, R.5    Bremner, J.D.6    Charney, D.S.7
  • 69
    • 84890018607 scopus 로고    scopus 로고
    • Add-on treatment of benzoate for schizophrenia: A randomized, double-blind, placebo-controlled trial of D-amino acid oxidase inhibitor
    • Lane H.Y., Lin C.H., Green M.F., Hellemann G., Huang C.C., Chen P.W., Tsai G.E. Add-on treatment of benzoate for schizophrenia: A randomized, double-blind, placebo-controlled trial of D-amino acid oxidase inhibitor. JAMA Psychiatry 2013, 70(12):1267-1275. 10.1001/jamapsychiatry.2013.2159.
    • (2013) JAMA Psychiatry , vol.70 , Issue.12 , pp. 1267-1275
    • Lane, H.Y.1    Lin, C.H.2    Green, M.F.3    Hellemann, G.4    Huang, C.C.5    Chen, P.W.6    Tsai, G.E.7
  • 70
    • 57349128912 scopus 로고    scopus 로고
    • D-cycloserine facilitates extinction the first time but not the second time: An examination of the role of NMDA across the course of repeated extinction sessions
    • npp200832 [pii]
    • Langton J.M., Richardson R. D-cycloserine facilitates extinction the first time but not the second time: An examination of the role of NMDA across the course of repeated extinction sessions. Neuropsychopharmacology 2008, 33(13):3096-3102. npp200832 [pii]. 10.1038/npp.2008.32.
    • (2008) Neuropsychopharmacology , vol.33 , Issue.13 , pp. 3096-3102
    • Langton, J.M.1    Richardson, R.2
  • 71
    • 0026576890 scopus 로고
    • Does modulation of glutamatergic function represent a viable therapeutic strategy in Alzheimer's disease?
    • Lawlor B.A., Davis K.L. Does modulation of glutamatergic function represent a viable therapeutic strategy in Alzheimer's disease?. Biological Psychiatry 1992, 31:337-350.
    • (1992) Biological Psychiatry , vol.31 , pp. 337-350
    • Lawlor, B.A.1    Davis, K.L.2
  • 72
    • 16844375149 scopus 로고    scopus 로고
    • D-cycloserine facilitates extinction of learned fear: Effects on reacquisition and generalized extinction
    • Ledgerwood L., Richardson R., Cranney J. D-cycloserine facilitates extinction of learned fear: Effects on reacquisition and generalized extinction. Biological Psychiatry 2005, 57(8):841-847.
    • (2005) Biological Psychiatry , vol.57 , Issue.8 , pp. 841-847
    • Ledgerwood, L.1    Richardson, R.2    Cranney, J.3
  • 73
    • 70350136988 scopus 로고    scopus 로고
    • Neuroplasticity of excitatory and inhibitory cortical circuits in schizophrenia
    • Lewis D.A. Neuroplasticity of excitatory and inhibitory cortical circuits in schizophrenia. Dialogues in Clinical Neuroscience 2009, 11(3):269-280.
    • (2009) Dialogues in Clinical Neuroscience , vol.11 , Issue.3 , pp. 269-280
    • Lewis, D.A.1
  • 74
    • 84896934536 scopus 로고    scopus 로고
    • Effects of prenatal chronic mild stress exposure on hippocampal cell proliferation, expression of GSK-3alpha, beta and NR2B in adult offspring during fear extinction in rats
    • Li M., Li X., Zhang X., Ren J., Jiang H., Wang Y., Cheng W. Effects of prenatal chronic mild stress exposure on hippocampal cell proliferation, expression of GSK-3alpha, beta and NR2B in adult offspring during fear extinction in rats. International Journal of Developmental Neuroscience 2014, 35:16-24. 10.1016/j.ijdevneu.2014.02.004.
    • (2014) International Journal of Developmental Neuroscience , vol.35 , pp. 16-24
    • Li, M.1    Li, X.2    Zhang, X.3    Ren, J.4    Jiang, H.5    Wang, Y.6    Cheng, W.7
  • 76
    • 42749095376 scopus 로고    scopus 로고
    • Circuit-based framework for understanding neurotransmitter and risk gene interactions in schizophrenia
    • S0166-2236(08)00089-1 [pii]
    • Lisman J.E., Coyle J.T., Green R.W., Javitt D.C., Benes F.M., Heckers S., Grace A.A. Circuit-based framework for understanding neurotransmitter and risk gene interactions in schizophrenia. Trends in Neurosciences 2008, 31(5):234-242. S0166-2236(08)00089-1 [pii]. 10.1016/j.tins.2008.02.005.
    • (2008) Trends in Neurosciences , vol.31 , Issue.5 , pp. 234-242
    • Lisman, J.E.1    Coyle, J.T.2    Green, R.W.3    Javitt, D.C.4    Benes, F.M.5    Heckers, S.6    Grace, A.A.7
  • 77
    • 33947331063 scopus 로고    scopus 로고
    • NMDA receptor subunits have differential roles in mediating excitotoxic neuronal death both in vitro and in vivo
    • 27/11/2846 [pii]
    • Liu Y., Wong T.P., Aarts M., Rooyakkers A., Liu L., Lai T.W., Wang Y.T. NMDA receptor subunits have differential roles in mediating excitotoxic neuronal death both in vitro and in vivo. Journal of Neuroscience 2007, 27(11):2846-2857. 27/11/2846 [pii]. 10.1523/JNEUROSCI.0116-07.2007.
    • (2007) Journal of Neuroscience , vol.27 , Issue.11 , pp. 2846-2857
    • Liu, Y.1    Wong, T.P.2    Aarts, M.3    Rooyakkers, A.4    Liu, L.5    Lai, T.W.6    Wang, Y.T.7
  • 80
    • 0030861444 scopus 로고    scopus 로고
    • Clozapine blunts N-methyl-D-aspartate antagonist-induced psychosis: A study with ketamine
    • Malhotra A., Adler C., Kennison S., Elman I., Pickar D., Breier A. Clozapine blunts N-methyl-D-aspartate antagonist-induced psychosis: A study with ketamine. Biological Psychiatry 1997, 42:664-668.
    • (1997) Biological Psychiatry , vol.42 , pp. 664-668
    • Malhotra, A.1    Adler, C.2    Kennison, S.3    Elman, I.4    Pickar, D.5    Breier, A.6
  • 81
    • 0030749913 scopus 로고    scopus 로고
    • Ketamine-induced exacerbation of psychotic symptoms and cognitive impairment in neuroleptic-free schizophrenics
    • Malhotra A., Pinals D., Adler C., Elman I., Clifton A., Pickar D., Breier A. Ketamine-induced exacerbation of psychotic symptoms and cognitive impairment in neuroleptic-free schizophrenics. Neuropsychopharmacology 1997, 17:141-150.
    • (1997) Neuropsychopharmacology , vol.17 , pp. 141-150
    • Malhotra, A.1    Pinals, D.2    Adler, C.3    Elman, I.4    Clifton, A.5    Pickar, D.6    Breier, A.7
  • 82
    • 73749087024 scopus 로고    scopus 로고
    • Reduced overnight consolidation of procedural learning in chronic medicated schizophrenia is related to specific sleep stages
    • S0022-3956(09)00147-2 [pii]
    • Manoach D.S., Thakkar K.N., Stroynowski E., Ely A., McKinley S.K., Wamsley E., Stickgold R. Reduced overnight consolidation of procedural learning in chronic medicated schizophrenia is related to specific sleep stages. Journal of Psychiatric Research 2010, 44(2):112-120. S0022-3956(09)00147-2 [pii]. 10.1016/j.jpsychires.2009.06.011.
    • (2010) Journal of Psychiatric Research , vol.44 , Issue.2 , pp. 112-120
    • Manoach, D.S.1    Thakkar, K.N.2    Stroynowski, E.3    Ely, A.4    McKinley, S.K.5    Wamsley, E.6    Stickgold, R.7
  • 83
    • 33748285229 scopus 로고    scopus 로고
    • Extinction training in conjunction with a partial agonist of the glycine site on the NMDA receptor erases memory trace
    • Mao S.C., Hsiao Y.H., Gean P.W. Extinction training in conjunction with a partial agonist of the glycine site on the NMDA receptor erases memory trace. Journal of Neuroscience 2006, 26(35):8892-8899. 10.1523/JNEUROSCI.0365-06.2006.
    • (2006) Journal of Neuroscience , vol.26 , Issue.35 , pp. 8892-8899
    • Mao, S.C.1    Hsiao, Y.H.2    Gean, P.W.3
  • 84
    • 57349093472 scopus 로고    scopus 로고
    • Augmentation of fear extinction by D-cycloserine is blocked by proteasome inhibitors
    • Mao S.C., Lin H.C., Gean P.W. Augmentation of fear extinction by D-cycloserine is blocked by proteasome inhibitors. Neuropsychopharmacology 2008, 33(13):3085-3095. 10.1038/npp.2008.30.
    • (2008) Neuropsychopharmacology , vol.33 , Issue.13 , pp. 3085-3095
    • Mao, S.C.1    Lin, H.C.2    Gean, P.W.3
  • 85
    • 3042542923 scopus 로고    scopus 로고
    • Glycine transporter type 1 blockade changes NMDA receptor-mediated responses and LTP in hippocampal CA1 pyramidal cells by altering extracellular glycine levels
    • Martina M., Gorfinkel Y., Halman S., Lowe J.A., Periyalwar P., Schmidt C.J., Bergeron R. Glycine transporter type 1 blockade changes NMDA receptor-mediated responses and LTP in hippocampal CA1 pyramidal cells by altering extracellular glycine levels. Journal of Physiology 2004, 557(Pt 2):489-500. 10.1113/jphysiol.2004.063321.
    • (2004) Journal of Physiology , vol.557 , pp. 489-500
    • Martina, M.1    Gorfinkel, Y.2    Halman, S.3    Lowe, J.A.4    Periyalwar, P.5    Schmidt, C.J.6    Bergeron, R.7
  • 86
    • 84892577155 scopus 로고    scopus 로고
    • Major histocompatibility complex I in brain development and schizophrenia
    • McAllister A.K. Major histocompatibility complex I in brain development and schizophrenia. Biological Psychiatry 2014, 75(4):262-268. 10.1016/j.biopsych.2013.10.003.
    • (2014) Biological Psychiatry , vol.75 , Issue.4 , pp. 262-268
    • McAllister, A.K.1
  • 87
    • 77955716777 scopus 로고    scopus 로고
    • Impaired extinction retention in adolescent rats: Effects of D-cycloserine
    • npp201092 [pii]
    • McCallum J., Kim J.H., Richardson R. Impaired extinction retention in adolescent rats: Effects of D-cycloserine. Neuropsychopharmacology 2010, 35(10):2134-2142. npp201092 [pii]. 10.1038/npp.2010.92.
    • (2010) Neuropsychopharmacology , vol.35 , Issue.10 , pp. 2134-2142
    • McCallum, J.1    Kim, J.H.2    Richardson, R.3
  • 89
    • 0033588176 scopus 로고    scopus 로고
    • Mice with reduced NMDA receptor expression display behaviors related to schizophrenia
    • Mohn A., Gainetdinov P., Caron M., Koller B. Mice with reduced NMDA receptor expression display behaviors related to schizophrenia. Cell 1999, 98:427-436.
    • (1999) Cell , vol.98 , pp. 427-436
    • Mohn, A.1    Gainetdinov, P.2    Caron, M.3    Koller, B.4
  • 90
    • 0024801149 scopus 로고
    • D-cycloserine, a positive modulator of the N-methyl-D-aspartate receptor, enhances performance of learning tasks in rats
    • Monahan J., Handelmann G., Hood W., Cordi A. D-cycloserine, a positive modulator of the N-methyl-D-aspartate receptor, enhances performance of learning tasks in rats. Pharmacology, Biochemistry, and Behavior 1989, 34:649-653.
    • (1989) Pharmacology, Biochemistry, and Behavior , vol.34 , pp. 649-653
    • Monahan, J.1    Handelmann, G.2    Hood, W.3    Cordi, A.4
  • 91
    • 0028343648 scopus 로고
    • Developmental and regional expression in the rat brain and functional properties of four NMDA receptors
    • 0896-6273(94)90210-0 [pii]
    • Monyer H., Burnashev N., Laurie D.J., Sakmann B., Seeburg P.H. Developmental and regional expression in the rat brain and functional properties of four NMDA receptors. Neuron 1994, 12(3):529-540. 0896-6273(94)90210-0 [pii].
    • (1994) Neuron , vol.12 , Issue.3 , pp. 529-540
    • Monyer, H.1    Burnashev, N.2    Laurie, D.J.3    Sakmann, B.4    Seeburg, P.H.5
  • 92
    • 3242804412 scopus 로고    scopus 로고
    • Consolidation of human motor cortical neuroplasticity by D-cycloserine
    • 1300517 [pii]
    • Nitsche M.A., Jaussi W., Liebetanz D., Lang N., Tergau F., Paulus W. Consolidation of human motor cortical neuroplasticity by D-cycloserine. Neuropsychopharmacology 2004, 29(8):1573-1578. 1300517 [pii]. 10.1038/sj.npp.1300517.
    • (2004) Neuropsychopharmacology , vol.29 , Issue.8 , pp. 1573-1578
    • Nitsche, M.A.1    Jaussi, W.2    Liebetanz, D.3    Lang, N.4    Tergau, F.5    Paulus, W.6
  • 93
    • 44349151445 scopus 로고    scopus 로고
    • A meta-analysis of D-cycloserine and the facilitation of fear extinction and exposure therapy
    • S0006-3223(08)00106-6 [pii]
    • Norberg M.M., Krystal J.H., Tolin D.F. A meta-analysis of D-cycloserine and the facilitation of fear extinction and exposure therapy. Biological Psychiatry 2008, 63(12):1118-1126. S0006-3223(08)00106-6 [pii]. 10.1016/j.biopsych.2008.01.012.
    • (2008) Biological Psychiatry , vol.63 , Issue.12 , pp. 1118-1126
    • Norberg, M.M.1    Krystal, J.H.2    Tolin, D.F.3
  • 94
    • 77952849225 scopus 로고    scopus 로고
    • The N-methyl-D-aspartate receptor co-agonist D-cycloserine facilitates declarative learning and hippocampal activity in humans
    • S0006-3223(10)00064-8 [pii]
    • Onur O.A., Schlaepfer T.E., Kukolja J., Bauer A., Jeung H., Patin A., Hurlemann R. The N-methyl-D-aspartate receptor co-agonist D-cycloserine facilitates declarative learning and hippocampal activity in humans. Biological Psychiatry 2010, 67(12):1205-1211. S0006-3223(10)00064-8 [pii]. 10.1016/j.biopsych.2010.01.022.
    • (2010) Biological Psychiatry , vol.67 , Issue.12 , pp. 1205-1211
    • Onur, O.A.1    Schlaepfer, T.E.2    Kukolja, J.3    Bauer, A.4    Jeung, H.5    Patin, A.6    Hurlemann, R.7
  • 95
    • 84941901144 scopus 로고    scopus 로고
    • Augmentation of cognitive and behavioural therapies (CBT) with d-cycloserine for anxiety and related disorders
    • Ori R., Amos T., Bergman H., Soares-Weiser K., Ipser J.C., Stein D.J. Augmentation of cognitive and behavioural therapies (CBT) with d-cycloserine for anxiety and related disorders. Cochrane Database of Systemic Reviews 2015, 5:Cd007803. 10.1002/14651858.CD007803.pub2.
    • (2015) Cochrane Database of Systemic Reviews , vol.5
    • Ori, R.1    Amos, T.2    Bergman, H.3    Soares-Weiser, K.4    Ipser, J.C.5    Stein, D.J.6
  • 97
    • 84856208924 scopus 로고    scopus 로고
    • D-cycloserine enhances spatial memory in spontaneous place recognition in rats
    • Ozawa T., Kumeji M., Yamada K., Ichitani Y. D-cycloserine enhances spatial memory in spontaneous place recognition in rats. Neuroscience Letters 2012, 509(1):13-16. 10.1016/j.neulet.2011.12.031.
    • (2012) Neuroscience Letters , vol.509 , Issue.1 , pp. 13-16
    • Ozawa, T.1    Kumeji, M.2    Yamada, K.3    Ichitani, Y.4
  • 98
    • 16844387460 scopus 로고    scopus 로고
    • Effects of multiple exposures to D-cycloserine on extinction of conditioned fear in rats
    • Parnas A.S., Weber M., Richardson R. Effects of multiple exposures to D-cycloserine on extinction of conditioned fear in rats. Neurobiology of Learning and Memory 2005, 83(3):224-231.
    • (2005) Neurobiology of Learning and Memory , vol.83 , Issue.3 , pp. 224-231
    • Parnas, A.S.1    Weber, M.2    Richardson, R.3
  • 99
    • 34948858402 scopus 로고    scopus 로고
    • Activation of mGlu2/3 receptors as a new approach to treat schizophrenia: A randomized phase 2 clinical trial
    • nm1632 [pii]
    • Patil S.T., Zhang L., Martenyi F., Lowe S.L., Jackson K.A., Andreev B.V., Schoepp D.D. Activation of mGlu2/3 receptors as a new approach to treat schizophrenia: A randomized phase 2 clinical trial. Nature Medicine 2007, 13(9):1102-1107. nm1632 [pii]. 10.1038/nm1632.
    • (2007) Nature Medicine , vol.13 , Issue.9 , pp. 1102-1107
    • Patil, S.T.1    Zhang, L.2    Martenyi, F.3    Lowe, S.L.4    Jackson, K.A.5    Andreev, B.V.6    Schoepp, D.D.7
  • 101
    • 0020058343 scopus 로고
    • Normal cerebrospinal fluid and brain glutamate levels in schizophrenia do not support the hypothesis of glutamatergic neuronal dysfunction
    • Perry T.L. Normal cerebrospinal fluid and brain glutamate levels in schizophrenia do not support the hypothesis of glutamatergic neuronal dysfunction. Neuroscience Letters 1982, 28:81-85.
    • (1982) Neuroscience Letters , vol.28 , pp. 81-85
    • Perry, T.L.1
  • 102
    • 0028246912 scopus 로고
    • Acute but not chronic activation of the NMDA-coupled glycine receptor with d-cycloserine facilitates learning and retention
    • Quartermain D., Mower J., Rafferty M.F., Herting R.L., Lanthorn T.H. Acute but not chronic activation of the NMDA-coupled glycine receptor with d-cycloserine facilitates learning and retention. European Journal of Pharmacology 1994, 257:7-12.
    • (1994) European Journal of Pharmacology , vol.257 , pp. 7-12
    • Quartermain, D.1    Mower, J.2    Rafferty, M.F.3    Herting, R.L.4    Lanthorn, T.H.5
  • 104
    • 79953199424 scopus 로고    scopus 로고
    • Triheteromeric NR1/NR2A/NR2B receptors constitute the major N-methyl-D-aspartate receptor population in adult hippocampal synapses
    • Rauner C., Kohr G. Triheteromeric NR1/NR2A/NR2B receptors constitute the major N-methyl-D-aspartate receptor population in adult hippocampal synapses. Journal of Biological Chemistry 2011, 286(9):7558-7566. 10.1074/jbc.M110.182600.
    • (2011) Journal of Biological Chemistry , vol.286 , Issue.9 , pp. 7558-7566
    • Rauner, C.1    Kohr, G.2
  • 105
    • 84876344768 scopus 로고    scopus 로고
    • The effects of intra-hippocampal microinfusion of D-cycloserine on fear extinction, and the expression of NMDA receptor subunit NR2B and neurogenesis in the hippocampus in rats
    • Ren J., Li X., Zhang X., Li M., Wang Y., Ma Y. The effects of intra-hippocampal microinfusion of D-cycloserine on fear extinction, and the expression of NMDA receptor subunit NR2B and neurogenesis in the hippocampus in rats. Progress in Neuropsychopharmacology and Biological Psychiatry 2013, 44:257-264. 10.1016/j.pnpbp.2013.02.017.
    • (2013) Progress in Neuropsychopharmacology and Biological Psychiatry , vol.44 , pp. 257-264
    • Ren, J.1    Li, X.2    Zhang, X.3    Li, M.4    Wang, Y.5    Ma, Y.6
  • 106
    • 4644355629 scopus 로고    scopus 로고
    • Cognitive enhancers as adjuncts to psychotherapy: Use of D-cycloserine in phobic individuals to facilitate extinction of fear
    • Ressler K.J., Rothbaum B.O., Tannenbaum L., Anderson P., Graap K., Zimand E., Davis M. Cognitive enhancers as adjuncts to psychotherapy: Use of D-cycloserine in phobic individuals to facilitate extinction of fear. Archives of General Psychiatry 2004, 61(11):1136-1144.
    • (2004) Archives of General Psychiatry , vol.61 , Issue.11 , pp. 1136-1144
    • Ressler, K.J.1    Rothbaum, B.O.2    Tannenbaum, L.3    Anderson, P.4    Graap, K.5    Zimand, E.6    Davis, M.7
  • 107
    • 79951830076 scopus 로고    scopus 로고
    • D-cycloserine enhances memory consolidation in the plus-maze retest paradigm
    • 2011-02594-012 [pii]
    • Rodgers R.J., Harvest H., Hassall C., Kaddour L.A. D-cycloserine enhances memory consolidation in the plus-maze retest paradigm. Behavioral Neuroscience 2011, 125(1):106-116. 2011-02594-012 [pii]. 10.1037/a0022343.
    • (2011) Behavioral Neuroscience , vol.125 , Issue.1 , pp. 106-116
    • Rodgers, R.J.1    Harvest, H.2    Hassall, C.3    Kaddour, L.A.4
  • 110
    • 34047261852 scopus 로고    scopus 로고
    • Evidence from gene knockout studies implicates Asc-1 as the primary transporter mediating d-serine reuptake in the mouse CNS
    • Rutter A.R., Fradley R.L., Garrett E.M., Chapman K.L., Lawrence J.M., Rosahl T.W., Patel S. Evidence from gene knockout studies implicates Asc-1 as the primary transporter mediating d-serine reuptake in the mouse CNS. European Journal of Neuroscience 2007, 25(6):1757-1766. 10.1111/j.1460-9568.2007.05446.x.
    • (2007) European Journal of Neuroscience , vol.25 , Issue.6 , pp. 1757-1766
    • Rutter, A.R.1    Fradley, R.L.2    Garrett, E.M.3    Chapman, K.L.4    Lawrence, J.M.5    Rosahl, T.W.6    Patel, S.7
  • 111
    • 84904804929 scopus 로고    scopus 로고
    • Biological insights from 108 schizophrenia-associated genetic loci
    • Schizophrenia Working Group of the Psychiatric Genomics Consortium Biological insights from 108 schizophrenia-associated genetic loci. Nature 2014, 511(7510):421-427. 10.1038/nature13595.
    • (2014) Nature , vol.511 , Issue.7510 , pp. 421-427
  • 112
    • 84939166986 scopus 로고    scopus 로고
    • A role beyond learning for NMDA receptors in reward-based decision-making-a pharmacological study using d-cycloserine
    • Scholl J., Gunthner J., Kolling N., Favaron E., Rushworth M.F., Harmer C.J., Reinecke A. A role beyond learning for NMDA receptors in reward-based decision-making-a pharmacological study using d-cycloserine. Neuropsychopharmacology 2014, 39(12):2900-2909. 10.1038/npp.2014.144.
    • (2014) Neuropsychopharmacology , vol.39 , Issue.12 , pp. 2900-2909
    • Scholl, J.1    Gunthner, J.2    Kolling, N.3    Favaron, E.4    Rushworth, M.F.5    Harmer, C.J.6    Reinecke, A.7
  • 113
    • 82955167869 scopus 로고    scopus 로고
    • Effects of chronic oral treatment with aripiprazole on the expression of NMDA receptor subunits and binding sites in rat brain
    • Segnitz N., Ferbert T., Schmitt A., Gass P., Gebicke-Haerter P.J., Zink M. Effects of chronic oral treatment with aripiprazole on the expression of NMDA receptor subunits and binding sites in rat brain. Psychopharmacology 2011, 217(1):127-142. 10.1007/s00213-011-2262-z.
    • (2011) Psychopharmacology , vol.217 , Issue.1 , pp. 127-142
    • Segnitz, N.1    Ferbert, T.2    Schmitt, A.3    Gass, P.4    Gebicke-Haerter, P.J.5    Zink, M.6
  • 115
  • 116
    • 84877580950 scopus 로고    scopus 로고
    • D-cycloserine enhancement of fear extinction is specific to successful exposure sessions: Evidence from the treatment of height phobia
    • Smits J.A., Rosenfield D., Otto M.W., Powers M.B., Hofmann S.G., Telch M.J., Tart C.D. D-cycloserine enhancement of fear extinction is specific to successful exposure sessions: Evidence from the treatment of height phobia. Biological Psychiatry 2013, 73(11):1054-1058. 10.1016/j.biopsych.2012.12.009.
    • (2013) Biological Psychiatry , vol.73 , Issue.11 , pp. 1054-1058
    • Smits, J.A.1    Rosenfield, D.2    Otto, M.W.3    Powers, M.B.4    Hofmann, S.G.5    Telch, M.J.6    Tart, C.D.7
  • 117
    • 84886304673 scopus 로고    scopus 로고
    • Pomaglumetad methionyl: No significant difference as an adjunctive treatment for patients with prominent negative symptoms of schizophrenia compared to placebo
    • Stauffer V.L., Millen B.A., Andersen S., Kinon B.J., Lagrandeur L., Lindenmayer J.P., Gomez J.C. Pomaglumetad methionyl: No significant difference as an adjunctive treatment for patients with prominent negative symptoms of schizophrenia compared to placebo. Schizophrenia Research 2013, 150(2-3):434-441. 10.1016/j.schres.2013.08.020.
    • (2013) Schizophrenia Research , vol.150 , Issue.2-3 , pp. 434-441
    • Stauffer, V.L.1    Millen, B.A.2    Andersen, S.3    Kinon, B.J.4    Lagrandeur, L.5    Lindenmayer, J.P.6    Gomez, J.C.7
  • 118
    • 84892415121 scopus 로고    scopus 로고
    • GluN2C/GluN2D subunit-selective NMDA receptor potentiator CIQ reverses MK-801-induced impairment in prepulse inhibition and working memory in Y-maze test in mice
    • Suryavanshi P.S., Ugale R.R., Yilmazer-Hanke D., Stairs D.J., Dravid S.M. GluN2C/GluN2D subunit-selective NMDA receptor potentiator CIQ reverses MK-801-induced impairment in prepulse inhibition and working memory in Y-maze test in mice. British Journal of Pharmacology 2014, 171(3):799-809. 10.1111/bph.12518.
    • (2014) British Journal of Pharmacology , vol.171 , Issue.3 , pp. 799-809
    • Suryavanshi, P.S.1    Ugale, R.R.2    Yilmazer-Hanke, D.3    Stairs, D.J.4    Dravid, S.M.5
  • 119
    • 84857082115 scopus 로고    scopus 로고
    • Clozapine, but not haloperidol, enhances glial D-serine and L-glutamate release in rat frontal cortex and primary cultured astrocytes
    • Tanahashi S., Yamamura S., Nakagawa M., Motomura E., Okada M. Clozapine, but not haloperidol, enhances glial D-serine and L-glutamate release in rat frontal cortex and primary cultured astrocytes. British Journal of Pharmacology 2012, 165(5):1543-1555. 10.1111/j.1476-5381.2011.01638.x.
    • (2012) British Journal of Pharmacology , vol.165 , Issue.5 , pp. 1543-1555
    • Tanahashi, S.1    Yamamura, S.2    Nakagawa, M.3    Motomura, E.4    Okada, M.5
  • 121
    • 0026671647 scopus 로고
    • Hippocampus-dependent learning facilitated by a monoclonal antibody or D-cycloserine
    • Thompson L.T., Moskal J.R., Disterhoft J.F. Hippocampus-dependent learning facilitated by a monoclonal antibody or D-cycloserine. Nature 1992, 359:638-641.
    • (1992) Nature , vol.359 , pp. 638-641
    • Thompson, L.T.1    Moskal, J.R.2    Disterhoft, J.F.3
  • 122
    • 62649086513 scopus 로고    scopus 로고
    • The efficacy of lamotrigine in clozapine-resistant schizophrenia: A systematic review and meta-analysis
    • S0920-9964(09)00003-6 [pii]
    • Tiihonen J., Wahlbeck K., Kiviniemi V. The efficacy of lamotrigine in clozapine-resistant schizophrenia: A systematic review and meta-analysis. Schizophrenia Research 2009, 109(1-3):10-14. S0920-9964(09)00003-6 [pii]. 10.1016/j.schres.2009.01.002.
    • (2009) Schizophrenia Research , vol.109 , Issue.1-3 , pp. 10-14
    • Tiihonen, J.1    Wahlbeck, K.2    Kiviniemi, V.3
  • 124
    • 32144442536 scopus 로고    scopus 로고
    • D-alanine added to antipsychotics for the treatment of schizophrenia
    • Tsai G.E., Yang P., Chang Y.C., Chong M.Y. D-alanine added to antipsychotics for the treatment of schizophrenia. Biological Psychiatry 2006, 59(3):230-234. 10.1016/j.biopsych.2005.06.032.
    • (2006) Biological Psychiatry , vol.59 , Issue.3 , pp. 230-234
    • Tsai, G.E.1    Yang, P.2    Chang, Y.C.3    Chong, M.Y.4
  • 125
    • 0032403626 scopus 로고    scopus 로고
    • D-serine added to antipsychotics for the treatment of schizophrenia
    • Tsai G., Yang P., Chung L.-C., Lange N., Coyle J. D-serine added to antipsychotics for the treatment of schizophrenia. Biological Psychiatry 1998, 44:1081-1089.
    • (1998) Biological Psychiatry , vol.44 , pp. 1081-1089
    • Tsai, G.1    Yang, P.2    Chung, L.-C.3    Lange, N.4    Coyle, J.5
  • 127
    • 9244243064 scopus 로고    scopus 로고
    • Glutamatergic drugs for schizophrenia: A systematic review and meta-analysis
    • Tuominen H.J., Tiihonen J., Wahlbeck K. Glutamatergic drugs for schizophrenia: A systematic review and meta-analysis. Schizophrenia Research 2005, 72:225-234.
    • (2005) Schizophrenia Research , vol.72 , pp. 225-234
    • Tuominen, H.J.1    Tiihonen, J.2    Wahlbeck, K.3
  • 128
    • 84900411478 scopus 로고    scopus 로고
    • A randomized, double-blind, proof-of-concept study of the effect of bitopertin, a glycine reuptake 2 inhibitor, on negative symptoms of schizophrenia
    • Umbricht D., Alberati D., Martin-Facklam M., Borroni E., Youssef E.A., Ostland M., Santarelli L. A randomized, double-blind, proof-of-concept study of the effect of bitopertin, a glycine reuptake 2 inhibitor, on negative symptoms of schizophrenia. JAMA Psychiatry 2014, 71(6):637-646.
    • (2014) JAMA Psychiatry , vol.71 , Issue.6 , pp. 637-646
    • Umbricht, D.1    Alberati, D.2    Martin-Facklam, M.3    Borroni, E.4    Youssef, E.A.5    Ostland, M.6    Santarelli, L.7
  • 129
    • 0032974130 scopus 로고    scopus 로고
    • D-cycloserine increases positive symptoms in chronic schizophrenic patients when administered in addition to antipsychotics: A double-blind, parallel, placebo-controlled study
    • van Berckel B.N.M., Evenblij C.N., van Loon B.J.A.M., Maas M.F., van der Geld M.A.M., Wynne H.J., Kahn R.S. D-cycloserine increases positive symptoms in chronic schizophrenic patients when administered in addition to antipsychotics: A double-blind, parallel, placebo-controlled study. Neuropsychopharmacology 1999, 21:203-210.
    • (1999) Neuropsychopharmacology , vol.21 , pp. 203-210
    • van Berckel, B.N.M.1    Evenblij, C.N.2    van Loon, B.J.A.M.3    Maas, M.F.4    van der Geld, M.A.M.5    Wynne, H.J.6    Kahn, R.S.7
  • 132
    • 0024286543 scopus 로고
    • Glycine therapy of schizophrenia (letter)
    • Waziri R. Glycine therapy of schizophrenia (letter). Biological Psychiatry 1988, 23:209-214.
    • (1988) Biological Psychiatry , vol.23 , pp. 209-214
    • Waziri, R.1
  • 133
    • 1642472904 scopus 로고    scopus 로고
    • Psychological Corporation, San Antonio, TX
    • Wechsler D. Wechsler memory scale 1997, Psychological Corporation, San Antonio, TX. 3rd ed.
    • (1997) Wechsler memory scale
    • Wechsler, D.1
  • 134
  • 135
    • 35648956795 scopus 로고    scopus 로고
    • Effects of D-cycloserine on extinction: Consequences of prior exposure to imipramine
    • Werner-Seidler A., Richardson R. Effects of D-cycloserine on extinction: Consequences of prior exposure to imipramine. Biological Psychiatry 2007, 62(10):1195-1197. 10.1016/j.biopsych.2007.04.010.
    • (2007) Biological Psychiatry , vol.62 , Issue.10 , pp. 1195-1197
    • Werner-Seidler, A.1    Richardson, R.2
  • 136
    • 3042782805 scopus 로고    scopus 로고
    • Density of glutamic acid decarboxylase 67 messenger RNA-containing neurons that express the N-methyl-D-aspartate receptor subunit NR2A in the anterior cingulate cortex in schizophrenia and bipolar disorder
    • Woo T.U., Walsh J.P., Benes F.M. Density of glutamic acid decarboxylase 67 messenger RNA-containing neurons that express the N-methyl-D-aspartate receptor subunit NR2A in the anterior cingulate cortex in schizophrenia and bipolar disorder. Archives of General Psychiatry 2004, 61(7):649-657. 10.1001/archpsyc.61.7.649.
    • (2004) Archives of General Psychiatry , vol.61 , Issue.7 , pp. 649-657
    • Woo, T.U.1    Walsh, J.P.2    Benes, F.M.3
  • 137
    • 57749184338 scopus 로고    scopus 로고
    • NMDA receptor subunit expression in GABAergic interneurons in the prefrontal cortex: Application of laser microdissection technique
    • Xi D., Keeler B., Zhang W., Houle J.D., Gao W.J. NMDA receptor subunit expression in GABAergic interneurons in the prefrontal cortex: Application of laser microdissection technique. Journal of Neuroscience Methods 2009, 176(2):172-181. 10.1016/j.jneumeth.2008.09.013.
    • (2009) Journal of Neuroscience Methods , vol.176 , Issue.2 , pp. 172-181
    • Xi, D.1    Keeler, B.2    Zhang, W.3    Houle, J.D.4    Gao, W.J.5
  • 139
    • 84863279487 scopus 로고    scopus 로고
    • Deletion of glutamate delta-1 receptor in mouse leads to aberrant emotional and social behaviors
    • Yadav R., Gupta S.C., Hillman B.G., Bhatt J.M., Stairs D.J., Dravid S.M. Deletion of glutamate delta-1 receptor in mouse leads to aberrant emotional and social behaviors. PLoS One 2012, 7(3):e32969. 10.1371/journal.pone.0032969.
    • (2012) PLoS One , vol.7 , Issue.3
    • Yadav, R.1    Gupta, S.C.2    Hillman, B.G.3    Bhatt, J.M.4    Stairs, D.J.5    Dravid, S.M.6
  • 140
    • 34347374299 scopus 로고    scopus 로고
    • D-cycloserine improves functional recovery and reinstates long-term potentiation (LTP) in a mouse model of closed head injury
    • fj.06-7856com [pii]
    • Yaka R., Biegon A., Grigoriadis N., Simeonidou C., Grigoriadis S., Alexandrovich A.G., Shohami E. D-cycloserine improves functional recovery and reinstates long-term potentiation (LTP) in a mouse model of closed head injury. FASEB Journal 2007, 21(9):2033-2041. fj.06-7856com [pii]. 10.1096/fj.06-7856com.
    • (2007) FASEB Journal , vol.21 , Issue.9 , pp. 2033-2041
    • Yaka, R.1    Biegon, A.2    Grigoriadis, N.3    Simeonidou, C.4    Grigoriadis, S.5    Alexandrovich, A.G.6    Shohami, E.7
  • 141
    • 65249173062 scopus 로고    scopus 로고
    • Variant BDNF Val66Met polymorphism affects extinction of conditioned aversive memory
    • Yu H., Wang Y., Pattwell S., Jing D., Liu T., Zhang Y., Chen Z.Y. Variant BDNF Val66Met polymorphism affects extinction of conditioned aversive memory. Journal of Neuroscience 2009, 29(13):4056-4064. 10.1523/JNEUROSCI.5539-08.2009.
    • (2009) Journal of Neuroscience , vol.29 , Issue.13 , pp. 4056-4064
    • Yu, H.1    Wang, Y.2    Pattwell, S.3    Jing, D.4    Liu, T.5    Zhang, Y.6    Chen, Z.Y.7
  • 142
    • 13644265544 scopus 로고    scopus 로고
    • Functional magnetic resonance imaging studies of schizophrenic patients during word production: Effects of D-cycloserine
    • Yurgelun-Todd D.A., Coyle J.T., Gruber S.A., Renshaw P.F., Silveri M.M., Amico E., Goff D.C. Functional magnetic resonance imaging studies of schizophrenic patients during word production: Effects of D-cycloserine. Psychiatry Research 2005, 138(1):23-31.
    • (2005) Psychiatry Research , vol.138 , Issue.1 , pp. 23-31
    • Yurgelun-Todd, D.A.1    Coyle, J.T.2    Gruber, S.A.3    Renshaw, P.F.4    Silveri, M.M.5    Amico, E.6    Goff, D.C.7
  • 144
    • 84909952684 scopus 로고    scopus 로고
    • Glycine induces bidirectional modifications in N-methyl-D-aspartate receptor-mediated synaptic responses in hippocampal CA1 neurons
    • Zhang X.Y., Ji F., Wang N., Chen L.L., Tian T., Lu W. Glycine induces bidirectional modifications in N-methyl-D-aspartate receptor-mediated synaptic responses in hippocampal CA1 neurons. Journal of Biological Chemistry 2014, 289(45):31200-31211. 10.1074/jbc.M114.570630.
    • (2014) Journal of Biological Chemistry , vol.289 , Issue.45 , pp. 31200-31211
    • Zhang, X.Y.1    Ji, F.2    Wang, N.3    Chen, L.L.4    Tian, T.5    Lu, W.6
  • 145
    • 77953604398 scopus 로고    scopus 로고
    • Inhibition of NMDARs in the nucleus reticularis of the thalamus produces delta frequency bursting
    • Zhang Y., Llinas R.R., Lisman J.E. Inhibition of NMDARs in the nucleus reticularis of the thalamus produces delta frequency bursting. Frontiers in Neural Circuits 2009, 3:20. 10.3389/neuro.04.020.2009.
    • (2009) Frontiers in Neural Circuits , vol.3 , pp. 20
    • Zhang, Y.1    Llinas, R.R.2    Lisman, J.E.3


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