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Volumn 20, Issue , 2015, Pages 109-115

The NMDA receptor 'glycine modulatory site' in schizophrenia: D-serine, glycine, and beyond

Author keywords

[No Author keywords available]

Indexed keywords

BENZOIC ACID; BITOPERIN; CYCLOSERINE; DEXTRO ALANINE; DEXTRO AMINO ACID OXIDASE; DEXTRO SERINE; GLYCINE; GLYCINE RECEPTOR ANTAGONIST; GLYCINE TRANSPORTER; GLYCINE TRANSPORTER 1; GLYCINE TRANSPORTER 1 ANTAGONIST; GLYCINE TRANSPORTER 2; KYNURENIC ACID; KYNURENINE AMINOTRANSFERASE; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; NEUROLEPTIC AGENT; PHOSPHOGLYCERATE DEHYDROGENASE; PLACEBO; RACEMASE; SARCOSINE; UNCLASSIFIED DRUG; DOPAMINE; SERINE;

EID: 84919608198     PISSN: 14714892     EISSN: 14714973     Source Type: Journal    
DOI: 10.1016/j.coph.2014.12.004     Document Type: Review
Times cited : (164)

References (63)
  • 3
    • 84904804929 scopus 로고    scopus 로고
    • Biological insights from 108 schizophrenia-associated genetic loci
    • Schizophrenia Working Group of the Psychiatric Genomics C: Biological insights from 108 schizophrenia-associated genetic loci. Nature 2014, 511:421-427.
    • (2014) Nature , vol.511 , pp. 421-427
  • 4
    • 0032441894 scopus 로고    scopus 로고
    • Modulation of N-methyl-D-aspartate receptor function by glycine transport
    • Bergeron R, Meyer TM, Coyle JT, Greene RW: Modulation of N-methyl-D-aspartate receptor function by glycine transport. Proc Natl Acad Sci U S A 1998, 95:15730-15734.
    • (1998) Proc Natl Acad Sci U S A , vol.95 , pp. 15730-15734
    • Bergeron, R.1    Meyer, T.M.2    Coyle, J.T.3    Greene, R.W.4
  • 5
    • 0033539510 scopus 로고    scopus 로고
    • Serine racemase: A glial enzyme synthesizing D-serine to regulate glutamate-N-methyl-D-aspartate neurotransmission
    • Wolosker H, Blackshaw S, Snyder SH: Serine racemase: a glial enzyme synthesizing D-serine to regulate glutamate-N-methyl-D-aspartate neurotransmission. Proc Natl Acad Sci U S A 1999, 96:13409-13414.
    • (1999) Proc Natl Acad Sci U S A , vol.96 , pp. 13409-13414
    • Wolosker, H.1    Blackshaw, S.2    Snyder, S.H.3
  • 6
    • 0028988978 scopus 로고
    • D-Serine, an endogenous synaptic modulator: Localization to astrocytes and glutamate-stimulated release
    • Schell MJ, Molliver ME, Snyder SH: D-Serine, an endogenous synaptic modulator: localization to astrocytes and glutamate-stimulated release. Proc Natl Acad Sci U S A 1995, 92:3948-3952.
    • (1995) Proc Natl Acad Sci U S A , vol.92 , pp. 3948-3952
    • Schell, M.J.1    Molliver, M.E.2    Snyder, S.H.3
  • 7
    • 0027473657 scopus 로고
    • Endogenous D-serine in rat brain: N-methyl-D-aspartate receptor-related distribution and aging
    • Hashimoto A, Nishikawa T, Oka T, Takahashi K: Endogenous D-serine in rat brain: N-methyl-D-aspartate receptor-related distribution and aging. J Neurochem 1993, 60:783-786.
    • (1993) J Neurochem , vol.60 , pp. 783-786
    • Hashimoto, A.1    Nishikawa, T.2    Oka, T.3    Takahashi, K.4
  • 12
    • 78650664020 scopus 로고    scopus 로고
    • Brain-specific Phgdh deletion reveals a pivotal role for L-serine biosynthesis in controlling the level of D-serine, an N-methyl-Daspartate receptor co-agonist, in adult brain
    • Yang JH, Wada A, Yoshida K, Miyoshi Y, Sayano T, Esaki K, Kinoshita MO, Tomonaga S, Azuma N, Watanabe M et al.: Brain-specific Phgdh deletion reveals a pivotal role for L-serine biosynthesis in controlling the level of D-serine, an N-methyl-Daspartate receptor co-agonist, in adult brain. J Biol Chem 2010, 285:41380-41390.
    • (2010) J Biol Chem , vol.285 , pp. 41380-41390
    • Yang, J.H.1    Wada, A.2    Yoshida, K.3    Miyoshi, Y.4    Sayano, T.5    Esaki, K.6    Kinoshita, M.O.7    Tomonaga, S.8    Azuma, N.9    Watanabe, M.10
  • 13
    • 17244382523 scopus 로고    scopus 로고
    • Glutamate receptor activation triggers a calcium-dependent and SNARE protein-dependent release of the gliotransmitter D-serine
    • Mothet JP, Pollegioni L, Ouanounou G, Martineau M, Fossier P, Baux G: Glutamate receptor activation triggers a calcium-dependent and SNARE protein-dependent release of the gliotransmitter D-serine. Proc Natl Acad Sci U S A 2005, 102:5606-5611.
    • (2005) Proc Natl Acad Sci U S A , vol.102 , pp. 5606-5611
    • Mothet, J.P.1    Pollegioni, L.2    Ouanounou, G.3    Martineau, M.4    Fossier, P.5    Baux, G.6
  • 15
    • 84864720463 scopus 로고    scopus 로고
    • Cell selective conditional null mutations of serine racemase demonstrate a predominate localization in cortical glutamatergic neurons
    • Benneyworth MA, Li Y, Basu AC, Bolshakov VY, Coyle JT: Cell selective conditional null mutations of serine racemase demonstrate a predominate localization in cortical glutamatergic neurons. Cell Mol Neurobiol 2012, 32:613-624.
    • (2012) Cell Mol Neurobiol , vol.32 , pp. 613-624
    • Benneyworth, M.A.1    Li, Y.2    Basu, A.C.3    Bolshakov, V.Y.4    Coyle, J.T.5
  • 16
    • 84896491914 scopus 로고    scopus 로고
    • D-Serine and serine racemase are localized to neurons in the adult mouse and human forebrain
    • Balu DT, Takagi S, Puhl MD, Benneyworth MA, Coyle JT: D-Serine and serine racemase are localized to neurons in the adult mouse and human forebrain. Cell Mol Neurobiol 2014, 34:419-435.
    • (2014) Cell Mol Neurobiol , vol.34 , pp. 419-435
    • Balu, D.T.1    Takagi, S.2    Puhl, M.D.3    Benneyworth, M.A.4    Coyle, J.T.5
  • 20
    • 0029014595 scopus 로고
    • Regional distribution and developmental variation of the glycine transporters GLYT1 and GLYT2 in the rat CNS
    • Zafra F, Gomeza J, Olivares L, Aragon C, Gimenez C: Regional distribution and developmental variation of the glycine transporters GLYT1 and GLYT2 in the rat CNS. Eur J Neurosci 1995, 7:1342-1352.
    • (1995) Eur J Neurosci , vol.7 , pp. 1342-1352
    • Zafra, F.1    Gomeza, J.2    Olivares, L.3    Aragon, C.4    Gimenez, C.5
  • 21
    • 15244347525 scopus 로고    scopus 로고
    • Localization of the GLYT1 glycine transporter at glutamatergic synapses in the rat brain
    • Cubelos B, Gimenez C, Zafra F: Localization of the GLYT1 glycine transporter at glutamatergic synapses in the rat brain. Cereb Cortex 2005, 15:448-459.
    • (2005) Cereb Cortex , vol.15 , pp. 448-459
    • Cubelos, B.1    Gimenez, C.2    Zafra, F.3
  • 22
    • 0024564076 scopus 로고
    • A glycine site associated with N-methyl-D-aspartic acid receptors: Characterization and identification of a new class of antagonists
    • Kessler M, Terramani T, Lynch G, Baudry M: A glycine site associated with N-methyl-D-aspartic acid receptors: characterization and identification of a new class of antagonists. J Neurochem 1989, 52:1319-1328.
    • (1989) J Neurochem , vol.52 , pp. 1319-1328
    • Kessler, M.1    Terramani, T.2    Lynch, G.3    Baudry, M.4
  • 23
    • 0035478066 scopus 로고    scopus 로고
    • The brain metabolite kynurenic acid inhibits alpha7 nicotinic receptor activity and increases non-alpha7 nicotinic receptor expression: Physiopathological implications
    • Hilmas C, Pereira EF, Alkondon M, Rassoulpour A, Schwarcz R, Albuquerque EX: The brain metabolite kynurenic acid inhibits alpha7 nicotinic receptor activity and increases non-alpha7 nicotinic receptor expression: physiopathological implications. J Neurosci 2001, 21:7463-7473.
    • (2001) J Neurosci , vol.21 , pp. 7463-7473
    • Hilmas, C.1    Pereira, E.F.2    Alkondon, M.3    Rassoulpour, A.4    Schwarcz, R.5    Albuquerque, E.X.6
  • 29
    • 84874876185 scopus 로고    scopus 로고
    • Increased prevalence of diverse N-methyl-D-aspartate glutamate receptor antibodies in patients with an initial diagnosis of schizophrenia: Specific relevance of IgG NR1a antibodies for distinction from N-methyl-D-aspartate glutamate receptor encephalitis
    • Steiner J, Walter M, Glanz W, Sarnyai Z, Bernstein HG, Vielhaber S, Kastner A, Skalej M, Jordan W, Schiltz K et al.: Increased prevalence of diverse N-methyl-D-aspartate glutamate receptor antibodies in patients with an initial diagnosis of schizophrenia: specific relevance of IgG NR1a antibodies for distinction from N-methyl-D-aspartate glutamate receptor encephalitis. JAMA Psychiatry 2013, 70:271-278.
    • (2013) JAMA Psychiatry , vol.70 , pp. 271-278
    • Steiner, J.1    Walter, M.2    Glanz, W.3    Sarnyai, Z.4    Bernstein, H.G.5    Vielhaber, S.6    Kastner, A.7    Skalej, M.8    Jordan, W.9    Schiltz, K.10
  • 37
    • 75749095178 scopus 로고    scopus 로고
    • Genetic loss of D-amino acid oxidase activity reverses schizophrenia-like phenotypes in mice
    • Labrie V, Wang W, Barger SW, Baker GB, Roder JC: Genetic loss of D-amino acid oxidase activity reverses schizophrenia-like phenotypes in mice. Genes Brain Behav 2009, 9:11-25.
    • (2009) Genes Brain Behav , vol.9 , pp. 11-25
    • Labrie, V.1    Wang, W.2    Barger, S.W.3    Baker, G.B.4    Roder, J.C.5
  • 40
    • 0035798252 scopus 로고    scopus 로고
    • Kynurenic acid levels are elevated in the cerebrospinal fluid of patients with schizophrenia
    • Erhardt S, Blennow K, Nordin C, Skogh E, Lindstrom LH, Engberg G: Kynurenic acid levels are elevated in the cerebrospinal fluid of patients with schizophrenia. Neurosci Lett 2001, 313:96-98.
    • (2001) Neurosci Lett , vol.313 , pp. 96-98
    • Erhardt, S.1    Blennow, K.2    Nordin, C.3    Skogh, E.4    Lindstrom, L.H.5    Engberg, G.6
  • 47
    • 0029116094 scopus 로고
    • Dose-finding trial of D-cycloserine added to neuroleptics for negative symptoms in schizophrenia
    • Goff DC, Tsai G, Manoach DS, Coyle JT: Dose-finding trial of D-cycloserine added to neuroleptics for negative symptoms in schizophrenia. Am J Psychiatry 1995, 152:1213-1215.
    • (1995) Am J Psychiatry , vol.152 , pp. 1213-1215
    • Goff, D.C.1    Tsai, G.2    Manoach, D.S.3    Coyle, J.T.4
  • 48
    • 0028246912 scopus 로고
    • Acute but not chronic activation of the NMDA-coupled glycine receptor with D-cycloserine facilitates learning and retention
    • Quartermain D, Mower J, Rafferty MF, Herting RL, Lanthorn TH: Acute but not chronic activation of the NMDA-coupled glycine receptor with D-cycloserine facilitates learning and retention. Eur J Pharmacol 1994, 257:7-12.
    • (1994) Eur J Pharmacol , vol.257 , pp. 7-12
    • Quartermain, D.1    Mower, J.2    Rafferty, M.F.3    Herting, R.L.4    Lanthorn, T.H.5
  • 49
    • 77949447469 scopus 로고    scopus 로고
    • Strategies to enhance N-methyl-D-aspartate receptor-mediated neurotransmission in schizophrenia, a critical review and meta-analysis
    • Tsai GE, Lin PY: Strategies to enhance N-methyl-D-aspartate receptor-mediated neurotransmission in schizophrenia, a critical review and meta-analysis. Curr Pharm Des 2010, 16:522-537.
    • (2010) Curr Pharm des , vol.16 , pp. 522-537
    • Tsai, G.E.1    Lin, P.Y.2
  • 50
    • 35748969317 scopus 로고    scopus 로고
    • The Cognitive Negative Symptoms in Schizophrenia Trial (CONSIST): The efficacy of glutamatergic agents for negative symptoms and cognitive impairments
    • Buchanan RW, Javitt DC, Marder SR, Schooler NR, Gold JM, McMahon RP, Heresco-Levy U, Carpenter WT: The Cognitive Negative Symptoms in Schizophrenia Trial (CONSIST): the efficacy of glutamatergic agents for negative symptoms and cognitive impairments. Am J Psychiatry 2007, 164:1593-1602.
    • (2007) Am J Psychiatry , vol.164 , pp. 1593-1602
    • Buchanan, R.W.1    Javitt, D.C.2    Marder, S.R.3    Schooler, N.R.4    Gold, J.M.5    McMahon, R.P.6    Heresco-Levy, U.7    Carpenter, W.T.8
  • 51
    • 3142737856 scopus 로고    scopus 로고
    • The NMDA receptor glycine modulatory site: A therapeutic target for improving cognition and reducing negative symptoms in schizophrenia
    • Coyle JT, Tsai G: The NMDA receptor glycine modulatory site: a therapeutic target for improving cognition and reducing negative symptoms in schizophrenia. Psychopharmacology (Berl) 2004, 174:32-38.
    • (2004) Psychopharmacology (Berl) , vol.174 , pp. 32-38
    • Coyle, J.T.1    Tsai, G.2
  • 52
    • 84877751491 scopus 로고    scopus 로고
    • Identity of endogenous NMDAR glycine site agonist in amygdala is determined by synaptic activity level
    • Li Y, Sacchi S, Pollegioni L, Basu AC, Coyle JT, Bolshakov VY: Identity of endogenous NMDAR glycine site agonist in amygdala is determined by synaptic activity level. Nat Commun 2013, 4:1760.
    • (2013) Nat Commun , vol.4 , pp. 1760
    • Li, Y.1    Sacchi, S.2    Pollegioni, L.3    Basu, A.C.4    Coyle, J.T.5    Bolshakov, V.Y.6
  • 53
    • 75549091955 scopus 로고    scopus 로고
    • The neurobiology of D-amino acid oxidase and its involvement in schizophrenia
    • Verrall L, Burnet PW, Betts JF, Harrison PJ: The neurobiology of D-amino acid oxidase and its involvement in schizophrenia. Mol Psychiatry 2010, 15:122-137.
    • (2010) Mol Psychiatry , vol.15 , pp. 122-137
    • Verrall, L.1    Burnet, P.W.2    Betts, J.F.3    Harrison, P.J.4
  • 54
    • 84890018607 scopus 로고    scopus 로고
    • Add-on treatment of benzoate for schizophrenia: A randomized, double-blind, placebo-controlled trial of D-amino acid oxidase inhibitor
    • Lane HY, Lin CH, Green MF, Hellemann G, Huang CC, Chen PW, Tun R, Chang YC, Tsai GE: Add-on treatment of benzoate for schizophrenia: a randomized, double-blind, placebo-controlled trial of D-amino acid oxidase inhibitor. JAMA Psychiatry 2013, 70:1267-1275.
    • (2013) JAMA Psychiatry , vol.70 , pp. 1267-1275
    • Lane, H.Y.1    Lin, C.H.2    Green, M.F.3    Hellemann, G.4    Huang, C.C.5    Chen, P.W.6    Tun, R.7    Chang, Y.C.8    Tsai, G.E.9
  • 56
    • 84862603083 scopus 로고    scopus 로고
    • Kynurenines in the mammalian brain: When physiology meets pathology
    • Schwarcz R, Bruno JP, Muchowski PJ, Wu HQ: Kynurenines in the mammalian brain: when physiology meets pathology. Nat Rev Neurosci 2012, 13:465-477.
    • (2012) Nat Rev Neurosci , vol.13 , pp. 465-477
    • Schwarcz, R.1    Bruno, J.P.2    Muchowski, P.J.3    Wu, H.Q.4
  • 57
    • 84868322747 scopus 로고    scopus 로고
    • Metabotropic glutamate receptors for new treatments in schizophrenia
    • Herman EJ, Bubser M, Conn PJ, Jones CK: Metabotropic glutamate receptors for new treatments in schizophrenia. Handb Exp Pharmacol 2012, 29:7-365.
    • (2012) Handb Exp Pharmacol , vol.29 , pp. 7-365
    • Herman, E.J.1    Bubser, M.2    Conn, P.J.3    Jones, C.K.4
  • 58
    • 84875226029 scopus 로고    scopus 로고
    • Kynurenic acid as an antagonist of alpha7 nicotinic acetylcholine receptors in the brain: Facts and challenges
    • Albuquerque EX, Schwarcz R: Kynurenic acid as an antagonist of alpha7 nicotinic acetylcholine receptors in the brain: facts and challenges. Biochem Pharmacol 2013, 85:1027-1032.
    • (2013) Biochem Pharmacol , vol.85 , pp. 1027-1032
    • Albuquerque, E.X.1    Schwarcz, R.2
  • 60
    • 84856079359 scopus 로고    scopus 로고
    • Muscarinic nicotinic acetylcholine receptor agonists and allosteric modulators for the treatment of schizophrenia
    • Jones CK, Byun N, Bubser M: Muscarinic nicotinic acetylcholine receptor agonists and allosteric modulators for the treatment of schizophrenia. Neuropsychopharmacology 2012, 37:16-42.
    • (2012) Neuropsychopharmacology , vol.37 , pp. 16-42
    • Jones, C.K.1    Byun, N.2    Bubser, M.3
  • 61
    • 84880429114 scopus 로고    scopus 로고
    • CASK regulates SAP97 conformation and its interactions with AMPA and NMDA receptors
    • Lin EI, Jeyifous O, Green WN: CASK regulates SAP97 conformation and its interactions with AMPA and NMDA receptors. J Neurosci 2013, 33:12067-12076.
    • (2013) J Neurosci , vol.33 , pp. 12067-12076
    • Lin, E.I.1    Jeyifous, O.2    Green, W.N.3
  • 63
    • 84901461172 scopus 로고    scopus 로고
    • Involvement of ClC-3 chloride/proton exchangers in controlling glutamatergic synaptic strength in cultured hippocampal neurons
    • Guzman RE, Alekov AK, Filippov M, Hegermann J, Fahlke C: Involvement of ClC-3 chloride/proton exchangers in controlling glutamatergic synaptic strength in cultured hippocampal neurons. Front Cell Neurosci 2014, 8:143.
    • (2014) Front Cell Neurosci , vol.8 , pp. 143
    • Guzman, R.E.1    Alekov, A.K.2    Filippov, M.3    Hegermann, J.4    Fahlke, C.5


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