NMDA receptors in layer 4 spiny stellate cells of the mouse barrel cortex contain the NR2C subunit

Journal of Neuroscience

Volumn 26, Issue 2, 2006, Pages 708-715

  Binshtok, Alexander M ^a   Fleidervish, Ilya A ^a   Sprengel, Rolf ^b   Gutnick, Michael J ^a  

^a HEBREW UNIVERSITY OF JERUSALEM   (Israel)

^b MAX PLANCK INSTITUTE FOR MEDICAL RESEARCH   (Germany)

Author keywords

Excitatory postsynaptic current; NMDA channels; Patch clamp; Somatosensory cortex; Spiny stellate neuron; Tangential slice

Indexed keywords

BETA GALACTOSIDASE; MAGNESIUM ION; N METHYL DEXTRO ASPARTIC ACID; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; N METHYL DEXTRO ASPARTIC ACID RECEPTOR 2C; RECEPTOR SUBUNIT; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BRAIN ELECTROPHYSIOLOGY; BRAIN TISSUE; CONTROLLED STUDY; EXCITATORY POSTSYNAPTIC POTENTIAL; GENE EXPRESSION; HYPERPOLARIZATION; MARKER GENE; MEMBRANE CHANNEL; MOUSE; NEOCORTEX; NERVE CELL MEMBRANE CONDUCTANCE; NERVE CELL MEMBRANE POTENTIAL; NERVE CELL MEMBRANE STEADY POTENTIAL; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN ASSEMBLY; RECEPTOR BLOCKING; RECEPTOR INTRINSIC ACTIVITY; SOMATOSENSORY CORTEX; STELLATE CELL; TISSUE SECTION; TRANSGENIC MOUSE;

2-AMINO-5-PHOSPHONOVALERATE; ANIMALS; BICUCULLINE; EXCITATORY AMINO ACID AGONISTS; EXCITATORY AMINO ACID ANTAGONISTS; EXCITATORY POSTSYNAPTIC POTENTIALS; GENES, REPORTER; GLUTAMIC ACID; LAC OPERON; LIDOCAINE; MAGNESIUM; MEMBRANE POTENTIALS; MICE; MICE, TRANSGENIC; NERVE TISSUE PROTEINS; NEURONS; PATCH-CLAMP TECHNIQUES; PROMOTER REGIONS (GENETICS); PROTEIN SUBUNITS; QUINOXALINES; RECEPTORS, N-METHYL-D-ASPARTATE; SODIUM CHANNEL BLOCKERS; SOMATOSENSORY CORTEX; SYNAPSES; SYNAPTIC TRANSMISSION; TETRODOTOXIN;

EID: 32544439181     PISSN: 02706474     EISSN: None     Source Type: Journal    
DOI: 10.1523/JNEUROSCI.4409-05.2006     Document Type: Article

References (44)

1. Beattie EC, Carroll RC, Yu X, Morishita W, Yasuda H, von Zastrow M, Malenka RC (2000) Regulation of AMPA receptor endocytosis by a signaling mechanism shared with LTD. Nat Neurosci 3:1291-1300.
2. Bliss TV, Collingridge GL (1993) A synaptic model of memory: long-term potentiation in the hippocampus. Nature 361:31-39.
3. Brusa R, Zimmermann F, Koh DS, Feldmeyer D, Gass P, Seeburg PH, Sprengel R (1995) Early-onset epilepsy and postnatal lethality associated with an editing-deficient GluR-B allele in mice. Science 270:1677-1680.
4. Carson F (1990) Histotechnology: a self-instructional text, Ed 1. Chicago: ASCP.
5. Clark BA, Farrant M, Cull-Candy SG (1997) A direct comparison of the single-channel properties of synaptic and extrasynaptic NMDA receptors. J Neurosci 17:107-116.
6. Constantine-Paton M, Cline HT, Debski E (1990) Patterned activity, synaptic convergence, and the NMDA receptor in developing visual pathways. Annu Rev Neurosci 13:129-154.
7. Crair MC, Malenka RC (1995) A critical period for long-term potentiation at thalamocortical synapses. Nature 375:325-328.
8. Cull-Candy SG, Leszkiewicz DN (2004) Role of distinct NMDA receptor subtypes at central synapses. Sci STKE 2004:re16.
9. Das S, Sasaki YF, Rothe T, Premkumar LS, Takasu M, Crandall JE, Dikkes P, Conner DA, Rayudu PV, Cheung W, Chen HS, Lipton SA, Nakanishi N (1998) Increased NMDA current and spine density in mice lacking the NMDA receptor subunit NR3A. Nature 393:377-381.
10. DeFelipe J, Alonso-Nanclares L, Arellano JI (2002) Microstructure of the neocortex: comparative aspects. J Neurocytol 31:299-316.
11. Egger V, Feldmeyer D, Sakmann B (1999) Coincidence detection and changes of synaptic efficacy in spiny stellate neurons in rat barrel cortex. Nat Neurosci 2:1098-1105.
12. Farrant M, Feldmeyer D, Takahashi T, Cull-Candy SG (1994) NMDA-receptor channel diversity in the developing cerebellum. Nature 368:335-339.
13. Feldman DE, Nicoll RA, Malenka RC, Isaac JT (1998) Long-term depression at thalamocortical synapses in developing rat somatosensory cortex. Neuron 21:347-357.
14. Feldmeyer D, Egger V, Lubke J, Sakmann B (1999) Reliable synaptic connections between pairs of excitatory layer 4 neurones within a single "barrel" of developing rat somatosensory cortex. J Physiol (Lond) 521:169-190.
15. + current and slow cumulative spike adaptation in mouse and guinea-pig neocortical neurones in slices. J Physiol (Lond) 493:83-97.
16. Fleidervish IA, Binshtok AM, Gutnick MJ (1998) Functionally distinct NMDA receptors mediate horizontal connectivity within layer 4 of mouse barrel cortex. Neuron 21:1055-1065.
17. Gil Z, Amitai Y (1996) Adult thalamocortical transmission involves both NMDA and non-NMDA receptors. J Neurophysiol 76:2547-2554.
18. Green GM, Gibb AJ (2001) Characterization of the single-channel properties of NMDA receptors in laminae I and II of the dorsal horn of neonatal rat spinal cord. Eur J Neurosci 14:1590-1602.
19. Hoffmann H, Gremme T, Hatt H, Gottmann K (2000) Synaptic activity-dependent developmental regulation of NMDA receptor subunit expression in cultured neocortical neurons. J Neurochem 75:1590-1599.
20. Huettner JE, Bean BP (1988) Block of N-methyl-D-aspartate-activated current by the anticonvulsant MK-801: selective binding to open channels. Proc Natl Acad Sci USA 85:1307-1311.
21. + channels. Neuron 31:1027-1034.
22. Kimura S, Mullins JJ, Bunnemann B, Metzger R, Hilgenfeldt U, Zimmermann F, Jacob H, Fuxe K, Ganten D, Kaling M (1992) High blood pressure in transgenic mice carrying the rat angiotensinogen gene. EMBO J 11:821-827.
23. Kumar SS, Huguenard JR (2003) Pathway-specific differences in subunit composition of synaptic NMDA receptors on pyramidal neurons in neocortex. J Neurosci 23:10074-10083.
24. Lin JW, Ju W, Foster K, Lee SH, Ahmadian G, Wyszynski M, Wang YT, Sheng M (2000) Distinct molecular mechanisms and divergent endocytotic pathways of AMPA receptor internalization. Nat Neurosci 3:1282-1290.
25. McBain CJ, Mayer ML (1994) N-methyl-D-aspartic acid receptor structure and function. Physiol Rev 74:723-760.
26. Mercer EH, Hoyle GW, Kapur RP, Brinster RL, Palmiter RD (1991) The dopamine beta-hydroxylase gene promoter directs expression of E. coli lacZ to sympathetic and other neurons in adult transgenic mice. Neuron 7:703-716.
27. Misra C, Brickley SG, Wyllie DJ, Cull-Candy SG (2000) Slow deactivation kinetics of NMDA receptors containing NR1 and NR2D subunits in rat cerebellar Purkinje cells. J Physiol (Lond) 525:299-305.
28. 2+ in rat central neurones. J Physiol (Lond) 494:479-492.
29. Monyer H, Sprengel R, Schoepfer R, Herb A, Higuchi M, Lomeli H, Burnashev N, Sakmann B, Seeburg PH (1992) Heteromeric NMDA receptors: molecular and functional distinction of subtypes. Science 256:1217-1221.
30. Monyer H, Burnashev N, Laurie DJ, Sakmann B, Seeburg PH (1994) Developmental and regional expression in the rat brain and functional properties of four NMDA receptors. Neuron 12:529-540.
31. Munoz A, Woods TM, Jones EG (1999) Laminar and cellular distribution of AMPA, kainate, and NMDA receptor subunits in monkey sensory-motor cortex. J Comp Neurol 407:472-490.
32. Nakanishi S (1992) Molecular diversity of glutamate receptors and implications for brain function. Science 258:597-603.
33. 2+ signals evoked by coincident EPSPs and backpropagating action potentials in spiny stellate cells of layer 4 in the juvenile rat somatosensory barrel cortex. J Neurosci 24:1689-1699.
34. A receptors to synaptic and extrasynaptic membranes of cerebellar granule cells. J Neurosci 18:1693-1703.
35. Sah P, Hestrin S, Nicoll RA (1989) Tonic activation of NMDA receptors by ambient glutamate enhances excitability of neurons. Science 246:815-818.
36. Sanchez-Vives MV, McCormick DA (2000) Cellular and network mechanisms of rhythmic recurrent activity in neocortex. Nat Neurosci 3:1027-1034.
37. Sasaki YF, Rothe T, Premkumar LS, Das S, Cui J, Talantova MV, Wong HK, Gong X, Chan SF, Zhang D, Nakanishi N, Sucher NJ, Lipton SA (2002) Characterization and comparison of the NR3A subunit of the NMDA receptor in recombinant systems and primary cortical neurons. J Neurophysiol 87:2052-2063.
38. Schubert D, Kotter R, Zilles K, Luhmann HJ, Staiger JF (2003) Cell type-specific circuits of cortical layer IV spiny neurons. J Neurosci 23:2961-2970.
39. Suchanek B, Seeburg PH, Sprengel R (1997) Tissue specific control regions of the N-methyl-D-aspartate receptor subunit NR2C promoter. Biol Chem 378:929-934.
40. Sun L, Shipley MT, Lidow MS (2000) Expression of NR1, NR2A-D, and NR3 subunits of the NMDA receptor in the cerebral cortex and olfactory bulb of adult rat. Synapse 35:212-221.
41. Watanabe M, Inoue Y, Sakimura K, Mishina M (1992) Developmental changes in distribution of NMDA receptor channel subunit mRNAs. NeuroReport 3:1138-1140.
42. White EL, Rock MP (1980) Three-dimensional aspects and synaptic relationships of a Golgi-impregnated spiny stellate cell reconstructed from serial thin sections. J Neurocytol 9:615-636.
43. Wyllie DJ, Behe P, Nassar M, Schoepfer R, Colquhoun D (1996) Single-channel currents from recombinant NMDA NR1a/NR2D receptors expressed in Xenopus oocytes. Proc R Soc Lond B Biol Sci 263:1079-1086.
44. Zhu JJ, Connors BW (1999) Intrinsic firing patterns and whisker-evoked synaptic responses of neurons in the rat barrel cortex. J Neurophysiol 81:1171-1183.