Als mutations in FUS cause neuronal dysfunction and death in caenorhabditis elegans by a dominant gain-of-function mechanism

Human Molecular Genetics

Volumn 21, Issue 1, 2012, Pages 1-9

  Murakami, Tetsuro ^a,b   Yang, Seung Pil ^a,b   Xie, Lin ^b,c   Kawano, Taizo ^b,c   Fu, Donald ^a,b   Mukai, Asuka ^a,b   Bohm, Christopher ^a,b   Chen, Fusheng ^a,b   Robertson, Janice ^a,b   Suzuki, Hiroshi ^a,b   Tartaglia, Gian Gaetano ^d   Vendruscolo, Michele ^d   Schierle, Gabriele S Kaminski ^d   Chan, Fiona T S ^d   Moloney, Aileen ^d   Crowther, Damian ^d   Kaminski, Clemens F ^d   Zhen, Mei ^b,c   St George Hyslop, Peter ^a,b,d  

^a UNIVERSITY OF TORONTO   (Canada)

^b UNIVERSITY OF TORONTO   (Canada)

^c MOUNT SINAI HOSPITAL   (Canada)

^d UNIVERSITY OF CAMBRIDGE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOPLASM PROTEIN; PROTEIN FUS; UNCLASSIFIED DRUG;

AMYOTROPHIC LATERAL SCLEROSIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CAENORHABDITIS ELEGANS; CONTROLLED STUDY; GAIN OF FUNCTION MUTATION; GENE MUTATION; GENE OVEREXPRESSION; LIFESPAN; LOSS OF FUNCTION MUTATION; MOTOR DYSFUNCTION; NEUROTOXICITY; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION;

AMYOTROPHIC LATERAL SCLEROSIS; ANIMALS; ANIMALS, GENETICALLY MODIFIED; CAENORHABDITIS ELEGANS; CELL DEATH; DISEASE MODELS, ANIMAL; FEMALE; HUMANS; MALE; MOTOR NEURONS; MUTATION; RNA-BINDING PROTEIN FUS;

EID: 83455213568     PISSN: 09646906     EISSN: 14602083     Source Type: Journal    
DOI: 10.1093/hmg/ddr417     Document Type: Article

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