Tribbles homologue 3 stimulates canonical TGF-β signalling to regulate fibroblast activation and tissue fibrosis

Annals of the Rheumatic Diseases

Volumn 75, Issue 3, 2016, Pages 609-616

  Tomcik, Michal ^a,b   Palumbo Zerr, Katrin ^a   Zerr, Pawel ^a   Sumova, Barbora ^a,b   Avouac, Jerome ^c   Dees, Clara ^a   Distler, Alfiya ^a   Becvar, Radim ^b   Distler, Oliver ^d   Schett, Georg ^a   Senolt, Ladislav ^b   Distler, Jörg H W ^a  

^a UNIVERSITY OF ERLANGEN NUREMBERG   (Germany)

^b CHARLES UNIVERSITY   (Czech Republic)

^c UNIVERSITÉ PARIS DESCARTES   (France)

^d UNIVERSITY HOSPITAL ZURICH   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

BLEOMYCIN; COLLAGEN; CONNECTIVE TISSUE GROWTH FACTOR; HYDROXYPROLINE; MEMBRANE PROTEIN; PLASMINOGEN ACTIVATOR INHIBITOR 1; SMAD PROTEIN; SMALL INTERFERING RNA; TRANSFORMING GROWTH FACTOR BETA; TRIBBLES HOMOLOGUE 3; UNCLASSIFIED DRUG; ANTINEOPLASTIC ANTIBIOTIC; CELL CYCLE PROTEIN; PROTEIN SERINE THREONINE KINASE; REPRESSOR PROTEIN; SMAD3 PROTEIN; TGF-BETA TYPE I RECEPTOR; TRANSFORMING GROWTH FACTOR BETA RECEPTOR; TRB3 PROTEIN, MOUSE; TRIB3 PROTEIN, HUMAN;

ADULT; AGED; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL DIFFERENTIATION; CLINICAL ARTICLE; CONTROLLED STUDY; ENDOTHELIUM CELL; FEMALE; FIBROBLAST; GENE AMPLIFICATION; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOFLUORESCENCE TEST; IMMUNOHISTOCHEMISTRY; MALE; MYOFIBROBLAST; NONHUMAN; PHENOTYPE; POLYMERASE CHAIN REACTION; POSITIVE FEEDBACK; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN CONTENT; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN SYNTHESIS; QUANTITATIVE ANALYSIS; SIGNAL TRANSDUCTION; SITE DIRECTED MUTAGENESIS; SKIN FIBROSIS; SYSTEMIC SCLEROSIS; WESTERN BLOTTING; ANIMAL; ANTAGONISTS AND INHIBITORS; CASE CONTROL STUDY; CELL CULTURE; CHEMICALLY INDUCED; CYTOLOGY; DERMIS; DISEASE MODEL; FIBROSIS; GENE SILENCING; GENE TARGETING; GENETICS; METABOLISM; MIDDLE AGED; MOUSE; REAL TIME POLYMERASE CHAIN REACTION; SKIN DISEASE; YOUNG ADULT;

ADULT; AGED; ANIMALS; ANTIBIOTICS, ANTINEOPLASTIC; BLEOMYCIN; CASE-CONTROL STUDIES; CELL CYCLE PROTEINS; CELLS, CULTURED; COLLAGEN; DERMIS; DISEASE MODELS, ANIMAL; FEMALE; FIBROBLASTS; FIBROSIS; GENE KNOCK-IN TECHNIQUES; GENE KNOCKDOWN TECHNIQUES; HUMANS; IMMUNOHISTOCHEMISTRY; MALE; MICE; MIDDLE AGED; PROTEIN-SERINE-THREONINE KINASES; REAL-TIME POLYMERASE CHAIN REACTION; RECEPTORS, TRANSFORMING GROWTH FACTOR BETA; REPRESSOR PROTEINS; SCLERODERMA, SYSTEMIC; SIGNAL TRANSDUCTION; SKIN DISEASES; SMAD3 PROTEIN; TRANSFORMING GROWTH FACTOR BETA; YOUNG ADULT;

EID: 84960115459     PISSN: 00034967     EISSN: 14682060     Source Type: Journal    
DOI: 10.1136/annrheumdis-2014-206234     Document Type: Article

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