메뉴 건너뛰기




Volumn 72, Issue 9, 2013, Pages 1575-1580

Inactivation of tankyrases reduces experimental fibrosis by inhibiting canonical Wnt signalling

Author keywords

[No Author keywords available]

Indexed keywords

ANTIFIBROTIC AGENT; BETA CATENIN; BLEOMYCIN; COLLAGEN; MESSENGER RNA; SMALL INTERFERING RNA; TANKYRASE; TRANSFORMING GROWTH FACTOR BETA RECEPTOR 1; UNCLASSIFIED DRUG; WNT PROTEIN; XAV 939;

EID: 84881480768     PISSN: 00034967     EISSN: 14682060     Source Type: Journal    
DOI: 10.1136/annrheumdis-2012-202275     Document Type: Article
Times cited : (74)

References (20)
  • 1
    • 8444251784 scopus 로고    scopus 로고
    • The Wnt signaling pathway in development and disease
    • DOI 10.1146/annurev.cellbio.20.010403.113126
    • Logan CY, Nusse R. The Wnt signaling pathway in development and disease. Annu Rev Cell Dev Biol 2004;20:781-810. (Pubitemid 39488658)
    • (2004) Annual Review of Cell and Developmental Biology , vol.20 , pp. 781-810
    • Logan, C.Y.1    Nusse, R.2
  • 2
    • 70349932747 scopus 로고    scopus 로고
    • Towards an integrated view of Wnt signaling in development
    • van Amerongen R, Nusse R. Towards an integrated view of Wnt signaling in development. Development 2009;136:3205-14.
    • (2009) Development , vol.136 , pp. 3205-3214
    • Van Amerongen, R.1    Nusse, R.2
  • 3
    • 67650230896 scopus 로고    scopus 로고
    • Wnt/beta-catenin signaling: Components, mechanisms, and diseases
    • MacDonald BT, Tamai K, He X. Wnt/beta-catenin signaling: components, mechanisms, and diseases. Dev Cell 2009;17:9-26.
    • (2009) Dev Cell , vol.17 , pp. 9-26
    • MacDonald, B.T.1    Tamai, K.2    He, X.3
  • 4
    • 60249086335 scopus 로고    scopus 로고
    • The role of Dickkopf-1 in bone development, homeostasis, and disease
    • Pinzone JJ, Hall BM, Thudi NK, et al. The role of Dickkopf-1 in bone development, homeostasis, and disease. Blood 2009;113:517-25.
    • (2009) Blood , vol.113 , pp. 517-525
    • Pinzone, J.J.1    Hall, B.M.2    Thudi, N.K.3
  • 5
    • 82755197822 scopus 로고    scopus 로고
    • Inhibition of glycogen synthase kinase 3beta induces dermal fibrosis by activation of the canonical Wnt pathway
    • Bergmann C, Akhmetshina A, Dees C, et al. Inhibition of glycogen synthase kinase 3beta induces dermal fibrosis by activation of the canonical Wnt pathway. Ann Rheum Dis 2011;70:2191-8.
    • (2011) Ann Rheum Dis , vol.70 , pp. 2191-2198
    • Bergmann, C.1    Akhmetshina, A.2    Dees, C.3
  • 6
    • 84859500585 scopus 로고    scopus 로고
    • Beta-catenin is a central mediator of pro-fibrotic Wnt signaling in systemic sclerosis
    • Beyer C, Schramm A, Akhmetshina A, et al. beta-catenin is a central mediator of pro-fibrotic Wnt signaling in systemic sclerosis. Ann Rheum Dis 2012;71:761-7.
    • (2012) Ann Rheum Dis , vol.71 , pp. 761-767
    • Beyer, C.1    Schramm, A.2    Akhmetshina, A.3
  • 7
    • 79958077377 scopus 로고    scopus 로고
    • Nuclear beta-catenin is increased in systemic sclerosis pulmonary fibrosis and promotes lung fibroblast migration and proliferation
    • Lam AP, Flozak AS, Russell S, et al. Nuclear beta-catenin is increased in systemic sclerosis pulmonary fibrosis and promotes lung fibroblast migration and proliferation. Am J Respir Cell Mol Biol 2011;45:915-22.
    • (2011) Am J Respir Cell Mol Biol , vol.45 , pp. 915-922
    • Lam, A.P.1    Flozak, A.S.2    Russell, S.3
  • 8
    • 84863923526 scopus 로고    scopus 로고
    • Wnt/beta-catenin signaling is hyperactivated in systemic sclerosis and induces Smad-dependent fibrotic responses in mesenchymal cells
    • Wei J, Fang F, Lam AP, et al. Wnt/beta-catenin signaling is hyperactivated in systemic sclerosis and induces Smad-dependent fibrotic responses in mesenchymal cells. Arthritis Rheum 2012;64:2734-45.
    • (2012) Arthritis Rheum , vol.64 , pp. 2734-2745
    • Wei, J.1    Fang, F.2    Lam, A.P.3
  • 9
    • 79958036406 scopus 로고    scopus 로고
    • Canonical Wnt signaling induces skin fibrosis and subcutaneous lipoatrophy: A novel mouse model for scleroderma?
    • Wei J, Melichian D, Komura K, et al. Canonical Wnt signaling induces skin fibrosis and subcutaneous lipoatrophy: a novel mouse model for scleroderma? Arthritis Rheum 2011;63:1707-17.
    • (2011) Arthritis Rheum , vol.63 , pp. 1707-1717
    • Wei, J.1    Melichian, D.2    Komura, K.3
  • 10
    • 84859179083 scopus 로고    scopus 로고
    • Activation of canonical Wnt signalling is required for TGF-beta-mediated fibrosis
    • Akhmetshina A, Palumbo K, Dees C, et al. Activation of canonical Wnt signalling is required for TGF-beta-mediated fibrosis. Nat Commun 2012;3:735.
    • (2012) Nat Commun , vol.3 , pp. 735
    • Akhmetshina, A.1    Palumbo, K.2    Dees, C.3
  • 11
    • 33751530490 scopus 로고    scopus 로고
    • Mining the Wnt pathway for cancer therapeutics
    • DOI 10.1038/nrd2154, PII NRD2154
    • Barker N, Clevers H. Mining the Wnt pathway for cancer therapeutics. Nat Rev Drug Discov 2006;5:997-1014. (Pubitemid 44835127)
    • (2006) Nature Reviews Drug Discovery , vol.5 , Issue.12 , pp. 997-1014
    • Barker, N.1    Clevers, H.2
  • 12
    • 70349695861 scopus 로고    scopus 로고
    • Tankyrase inhibition stabilizes axin and antagonizes Wnt signalling
    • Huang SM, Mishina YM, Liu S, et al. Tankyrase inhibition stabilizes axin and antagonizes Wnt signalling. Nature 2009;461:614-20.
    • (2009) Nature , vol.461 , pp. 614-620
    • Huang, S.M.1    Mishina, Y.M.2    Liu, S.3
  • 13
    • 79956122627 scopus 로고    scopus 로고
    • Platelet-derived serotonin links vascular disease and tissue fibrosis
    • Dees C, Akhmetshina A, Zerr P, et al. Platelet-derived serotonin links vascular disease and tissue fibrosis. J Exp Med 2011;208:961-72.
    • (2011) J Exp Med , vol.208 , pp. 961-972
    • Dees, C.1    Akhmetshina, A.2    Zerr, P.3
  • 14
    • 79955567838 scopus 로고    scopus 로고
    • Inhibition of Notch signaling prevents experimental fibrosis and induces regression of established fibrosis
    • Dees C, Zerr P, Tomcik M, et al. Inhibition of Notch signaling prevents experimental fibrosis and induces regression of established fibrosis. Arthritis Rheum 2011;63:1396-404.
    • (2011) Arthritis Rheum , vol.63 , pp. 1396-1404
    • Dees, C.1    Zerr, P.2    Tomcik, M.3
  • 15
    • 84860464142 scopus 로고    scopus 로고
    • Inhibition of activator protein 1 signaling abrogates transforming growth factor beta-mediated activation of fibroblasts and prevents experimental fibrosis
    • Avouac J, Palumbo K, Tomcik M, et al. Inhibition of activator protein 1 signaling abrogates transforming growth factor beta-mediated activation of fibroblasts and prevents experimental fibrosis. Arthritis Rheum 2012;64:1642-52.
    • (2012) Arthritis Rheum , vol.64 , pp. 1642-1652
    • Avouac, J.1    Palumbo, K.2    Tomcik, M.3
  • 16
    • 3242733298 scopus 로고    scopus 로고
    • Atelocollagen-mediated synthetic small interfering RNA delivery for effective gene silencing in vitro and in vivo
    • Minakuchi Y, Takeshita F, Kosaka N, et al. Atelocollagen-mediated synthetic small interfering RNA delivery for effective gene silencing in vitro and in vivo. Nucleic Acids Res 2004;32:e109.
    • (2004) Nucleic Acids Res , vol.32
    • Minakuchi, Y.1    Takeshita, F.2    Kosaka, N.3
  • 17
    • 84859503196 scopus 로고    scopus 로고
    • Inhibition of hedgehog signalling prevents experimental fibrosis and induces regression of established fibrosis
    • Horn A, Kireva T, Palumbo-Zerr K, et al. Inhibition of hedgehog signalling prevents experimental fibrosis and induces regression of established fibrosis. Ann Rheum Dis 2012;71:785-9.
    • (2012) Ann Rheum Dis , vol.71 , pp. 785-789
    • Horn, A.1    Kireva, T.2    Palumbo-Zerr, K.3
  • 18
    • 84860917655 scopus 로고    scopus 로고
    • Stimulation of soluble guanylate cyclase reduces experimental dermal fibrosis
    • Beyer C, Reich N, Schindler SC, et al. Stimulation of soluble guanylate cyclase reduces experimental dermal fibrosis. Ann Rheum Dis 2012;71:1019-26.
    • (2012) Ann Rheum Dis , vol.71 , pp. 1019-1026
    • Beyer, C.1    Reich, N.2    Schindler, S.C.3
  • 19
    • 84867254044 scopus 로고    scopus 로고
    • Inhibition of hedgehog signaling for the treatment of murine sclerodermatous chronic graft-versus-host disease
    • Zerr P, Palumbo-Zerr K, Distler A, et al. Inhibition of hedgehog signaling for the treatment of murine sclerodermatous chronic graft-versus-host disease. Blood 2012;120:2909-17.
    • (2012) Blood , vol.120 , pp. 2909-2917
    • Zerr, P.1    Palumbo-Zerr, K.2    Distler, A.3
  • 20
    • 79958280454 scopus 로고    scopus 로고
    • Targeting the Wnt/beta-catenin signaling pathway in human cancers
    • Yao H, Ashihara E, Maekawa T. Targeting the Wnt/beta-catenin signaling pathway in human cancers. Expert Opin Ther Targets 2011;15:873-87.
    • (2011) Expert Opin Ther Targets , vol.15 , pp. 873-887
    • Yao, H.1    Ashihara, E.2    Maekawa, T.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.