Environmentally relevant concentrations of arsenite induce dose-dependent differential genotoxicity through poly(ADP-ribose) polymerase inhibition and oxidative stress in mouse thymus cells

Toxicological Sciences

Volumn 149, Issue 1, 2016, Pages 31-41

  Xu, Huan ^a   Zhou, Xixi ^a   Wen, Xia ^b   Lauer, Fredine T ^a   Liu, Ke Jian ^a   Hudson, Laurie G ^a   Aleksunes, Lauren M ^b   Burchiel, Scott W ^a  

^a UNIVERSITY OF NEW MEXICO   (United States)

^b RUTGERS UNIVERSITY   (United States)

Author keywords

arsenic exporters; arsenite induced genotoxicity; mouse thymus cells; oxidative stress; poly(ADP ribose) polymerase (PARP) inhibition; zinc

Indexed keywords

3,4 DIHYDRO 5[4 (1 PIPERINDINYL)BUTOXYL] 1(2H)ISOQUINOLINE; ANTIOXIDANT; ARSENIC TRIOXIDE; MULTIDRUG RESISTANCE ASSOCIATED PROTEIN 1; MULTIDRUG RESISTANCE PROTEIN 1; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE INHIBITOR; TEMPOL; UNCLASSIFIED DRUG; ZINC; ARSENOUS ACID DERIVATIVE;

ANIMAL CELL; ARTICLE; CELL VIABILITY; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; DNA DAMAGE; DNA REPAIR; DOUBLE STRANDED DNA BREAK; ENZYME INHIBITION; GENOTOXICITY; MALE; MOUSE; NONHUMAN; OXIDATIVE STRESS; THYMOCYTE; ANIMAL; APOPTOSIS; C57BL MOUSE; CELL LINE; DOSE RESPONSE; DRUG EFFECTS; METABOLISM; MUTAGEN TESTING; THYMUS;

ANIMALS; APOPTOSIS; ARSENITES; CELL LINE; DNA DAMAGE; DOSE-RESPONSE RELATIONSHIP, DRUG; MICE; MICE, INBRED C57BL; MUTAGENICITY TESTS; OXIDATIVE STRESS; POLY(ADP-RIBOSE) POLYMERASE INHIBITORS; THYMUS GLAND; ZINC;

EID: 84960108703     PISSN: 10966080     EISSN: 10960929     Source Type: Journal    
DOI: 10.1093/toxsci/kfv211     Document Type: Article

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