Protective role of zinc in ameliorating arsenic-induced oxidative stress and histological changes in rat liver

Journal of Environmental Pathology, Toxicology and Oncology

Volumn 29, Issue 2, 2010, Pages 91-100

  Kumar, Ashok ^a   Malhotra, Anshoo ^a   Nair, Praveen ^a   Garg, M L ^a   Dhawan, Devinder K ^a  

^a PANJAB UNIVERSITY   (India)

Author keywords

Antioxidants; Arsenic; Liver

Indexed keywords

ARSENIC; ARSENITE SODIUM; CATALASE; DRINKING WATER; GLUTATHIONE; GLUTATHIONE PEROXIDASE; GLUTATHIONE REDUCTASE; LIPID PEROXIDASE; SUPEROXIDE DISMUTASE; ZINC SULFATE; ZINC;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL DEGENERATION; CONTROLLED STUDY; DIET SUPPLEMENTATION; DRUG EFFECT; ENZYME ACTIVITY; HEPATITIS; HISTOPATHOLOGY; LIPID PEROXIDATION; LIVER CELL; LIVER HISTOLOGY; LIVER INJURY; LIVER NECROSIS; LIVER PROTECTION; LIVER TOXICITY; MALE; NONHUMAN; OXIDATIVE STRESS; PERIPORTAL NECROSIS; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; RAT; SPRAGUE DAWLEY RAT; TREATMENT DURATION; WISTAR RAT; ANIMAL; BODY WEIGHT; DRUG EFFECTS; LIVER; METABOLISM; ORGAN SIZE; PATHOLOGY; TOXICITY;

RATTUS; RATTUS NORVEGICUS;

ANIMALS; ARSENIC; BODY WEIGHT; LIPID PEROXIDATION; LIVER; MALE; ORGAN SIZE; OXIDATIVE STRESS; RATS; RATS, SPRAGUE-DAWLEY; ZINC;

EID: 77953345283     PISSN: 07318898     EISSN: None     Source Type: Journal    
DOI: 10.1615/JEnvironPatholToxicolOncol.v29.i2.30     Document Type: Article

References (37)

1. Tibbetts J. Water world 2000. Environ Health Perspect. 2000 Feb;108(2):A69-73.
2. Chiou JM, Wang SL, Chen CJ, Deng CR, Lin W, Tai TY. Arsenic ingestion and increased microvascular disease risk: observations from the south-western arseniasisendemic area in Taiwan. Int J Epidemiol. 2005 Aug;34(4):936-43.
3. Smith AH, Marshall G, Yuan Y, Ferreccio C, Liaw J, von Ehrenstein O, Steinmaus C, Bates MN, Selvin S. Increased mortality from lung cancer and bronchiectasis in young adults after exposure to arsenic in utero and in early childhood. Environ Health Perspect. 2006;114(8):1293-6.
4. Abernathy CO, Liu YP, Longfellow D, Aposhian HV, Beck B, Fowler B, Goyer R, Menzer R, Rossman T, Thompson C. Arsenic: Health effects, mechanisms of actions, and research issues. Environ Health Perspect. 1999;107:593-7.
5. Hei T.K, Liu SX, Walderen C. Mutagenicity of arsenic in mammalian cells: role of reactive oxygen species Proc Natl Acad Sci U S A. 1998;95(14):8103-7.
6. Nordenson I, Beckman L. Is the genotoxicity effect of arsenic mediated by oxygen free radicals? Hum Hered. 1991;41(1):71-3.
7. Shen ZY, Shen J, Chen MH, Wu XY, Wu MH, Zang Y. The inhibition of growth and angiogenesis in heterotransplanted esophegal carcinoma via intratumoral injection of arsenic trioxide. Oncol Rep. 2003 Nov-Dec;10(6):1869-74.
8. Franzblau A, Lilis R. Acute arsenic intoxication from environmental arsenic exposure. Arch Environ Health. 1989 Nov-Dec;44(6):385-90.
9. Piontek M, Hengels KJ, Borchard F, Strohmeyer G. Noncirrhotic liver fi brosis after chronic arsenic poisoning [in German]. Dtsch Med Wochenschr. 1989 Oct 27;114(43):1653-7.
10. Salgueiro MJ, Zubillaga M, Lysionek A, Cremaschi G, Goldman CG, Caro R, De poli T, Hager A, Weill R, Boccio J. Zinc status and immune system relationship: a review. Biol Trace Elem Res. 2000 Sep;76(3):193-205.
11. Ha KN, Chen Y, Cai J, Stenburg P. Increased glutathione synthesis through an ARE-Nrf2 dependent pathway by zinc in the RPE: implication of protection against oxidative stress. Invest Ophthalmol Vis Sci. 2006;47:2709-15.
12. Klaassen CD, Liu , Choudhuri S. Metallothionein: an intracellular protein to protect against cadmium toxicity. Annu Rev Pharmacol Toxicol. 1999;39: 267-94.
13. Sidhu P, Garg ML, Dhawan DK. Time dependent study to evaluate the effi cacy of zinc on hepatic marker enzymes and elemental profi le in serum and liver of protein defi cient rats. BioMetals 2005;18: 97-106
14. Sidhu P, Garg ML and Dhawan DK. Zinc protects rat liver histo-architecture from detrimental effects of nickel. Biometals. 2006;19:301-13.
15. Kreppel H, Liu J, Liu Y, Reichl FX, Klaassen CD. Zinc-induced arsenite tolerance in mice. Fundam Appl Toxicol. 1994 Jul;23(1):32-7.
16. Malhotra A, Dhawan DK. Zinc improves antioxidaive enzymes in red blood cells and hematology in lithium treated rats. Nutr Res. 2008 Jan;28(1): 43-50.
17. Wills ED. Mechanism of lipid peroxide formation in animal tissues. Biochem J. 1966;99:667-76.
18. Ellman GL. Tissue sulphydryl groups. Arch Biochem Biophys. 1959 May;82(1):70-7.
19. Luck H. Catalase. In: Bergmeyer HU, editor. Methods of enzymatic analysis. New York: Academic Press; 1971. p. 885-93.
20. Kono Y. Generation of superoxide radical during autooxidation of hydroxylamine and an assay for superoxide dismutase. Arch Biochem Biophys. 1978 Feb;186(1):189-95.
21. Carlberg I, Mannervik B. Glutathione reductase. Methods Enzymol. 1985;113:484-90.
22. Lowry OH, Rorebrough NJ, Farr AL, Randall, J. Protein measurement with the Folin phenol reagent. J Biol Chem. 1951 Nov;193(1):265-75.
23. Bashir S, Sharma Y, Irshad M, Nag TC, Tiwari M, Kabra M, Dogra TD. Arsenic induced apoptosis in rat liver following repeated 60 days exposure. Toxicology. 2006 Jan 5;217(1):63-70.
24. Nandi D, Patra RC, Swarup D. Effect of cysteine, methionine, ascorbic acid and thiamine on arsenicinduced oxidative stress and biochemical alterations in rats. Toxicology. 2005 Jul 1;211(1-2):26-35.
25. Santra A, Maiti A, Das S, Lahiri S, Charkaborty SK, Mazumdar DNG. Hepatic damage caused by chronic arsenic toxicity in experimental animals. Clin Toxicol. 2000;38:395-405.
26. Hughes MF, Kenyon EM, Edwards BC, Mitchel CT, Del Razo LM, Thomas DJ. Accumulation and metabolism of arsenic in mice after repeated oral administration of arsenate. Toxicol Appl Pharmacol. 2003;191:202-10.
27. Camps J, Bargallo T, Gimenez A, Alie S, Caballeria J, Pares A, Joven J, Masana L, Rodes J. Relationship between hepatic lipid peroxidation and fi brogenesis in carbon tetrachloride treated rats: effect of zinc administration. Clin Sci (Lond). 1992 Dec;83(6): 695-700.
28. Yu BP. Cellular defenses against damage from reactive oxygen species. Physiol Rev. 1994 Jan;74(1): 139-62.
29. Cathcart RF 3rd. Vitamin C: the nontoxic, nonratelimited antioxidant free free radical scavenger. Med Hypotheses. 1985 Sep;18(1):61-77.
30. Vahter M. Mechanisms of arsenic biotransformation. Toxicology. 2002 Dec 27;181-182:21-7.
31. Kyle ME, Miccadei S, Nakae D, Farber JL. Superoxide dismutase and catalase protect cultured hepatocytes from the cytotoxicity of acetaminophen. Biochem Biophys Res Commun. 1987 Dec 31;149(3):889-96.
32. Matés JM, Sánchez-Jiménez F. Antioxidants and their implications on pathophysiologic processes. Front Biosci. 1999 Mar 15;4:D339-45.
33. Modi M, Kaul RK, Kannan GM, Flora SJ. Co-ad-ministration of zinc and n-acetylcysteine prevents arsenic-induced tissue oxidative stress in male rats. J Trace Elem Med Biol. 2006;20(3):197-04.
34. Flora R, Flora SJ. Protective value of Aloe vera against some toxic effects of arsenic in rats. Phytother Res. 2005;19:23-8.
35. Lenartowicz E. A complex effect of arsenite on the formation of alpha ketoglutarate in rat liver. Arch Biochem Biophys. 1990 Dec;283(2):388-96.
36. Cunningham ML, Zvelebil MJ, Fairlamb AH. Mechanism of inhibition of trypanothione reductase and glutathione reductase by trivalent organic arsenicals. Eur J Biochem. 1994 Apr 1;221(1):285-95.
37. Wang TS, Kuo CF, Jan KY, Huang H. Arsenite induces apoptosis in Chinese hamster ovary cells by generation of reactive oxygen species. J Cell Physiol. 1996 Nov;169(2):256-68.