Human monocytes are severely impaired in base and DNA double-strand break repair that renders them vulnerable to oxidative stress

Proceedings of the National Academy of Sciences of the United States of America

Volumn 108, Issue 52, 2011, Pages 21105-21110

  Bauer, Martina ^a   Goldstein, Michael ^a   Christmann, Markus ^a   Becker, Huong ^a   Heylmann, Daniel ^a   Kaina, Bernd ^a  

^a UNIVERSITY MEDICAL CENTER MAINZ   (Germany)

Author keywords

Dendritic cells; DNA damage response; Macrophages; Monocytes

Indexed keywords

ATM PROTEIN; ATR PROTEIN; CASPASE 3; CASPASE 7; CASPASE 8; CHECKPOINT KINASE 1; CHECKPOINT KINASE 2; DNA; DNA DEPENDENT PROTEIN KINASE; DOUBLE STRANDED DNA; FAS ANTIGEN; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE 1; OXIDIZED LOW DENSITY LIPOPROTEIN; POLYDEOXYRIBONUCLEOTIDE SYNTHASE; PROTEIN P53; REACTIVE OXYGEN METABOLITE; XRCC1 PROTEIN;

ARTICLE; CELL CYCLE REGULATION; CELL ISOLATION; CELL MATURATION; CONTROLLED STUDY; DENDRITIC CELL; DNA DAMAGE; DNA REPAIR; ENZYME ACTIVATION; HUMAN; HUMAN CELL; IONIZING RADIATION; MACROPHAGE; MONOCYTE; NORMAL HUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN EXPRESSION;

APOPTOSIS; BLOTTING, WESTERN; CELL DIFFERENTIATION; CENTRIFUGATION; COMET ASSAY; DENDRITIC CELLS; DNA BREAKS, DOUBLE-STRANDED; DNA PRIMERS; FLOW CYTOMETRY; HUMANS; MACROPHAGES; MONOCYTES; OLIGONUCLEOTIDES; OXIDATIVE STRESS; REACTIVE OXYGEN SPECIES; REAL-TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION;

EID: 84855490596     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1111919109     Document Type: Article

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