Arsenic induces DNA damage via reactive oxygen species in human cells

Environmental Health and Preventive Medicine

Volumn 6, Issue 1, 2001, Pages 27-32

  Li, Dasheng ^a,b   Morimoto, Kanehisa ^a   Takeshita, Tatsuya ^a   Lu, Yuquan ^a  

^a OSAKA UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^b Guizhou Prov Antiepidemic Station   (China)

Author keywords

Arsenic; DNA damage; Human cells; Reactive oxygen species; Single cell gel electrophoresis (SCGE) assay

Indexed keywords

ARSENIC; CATALASE; DIMETHYL SULFOXIDE; HYDROGEN PEROXIDE; HYDROXYL RADICAL; REACTIVE OXYGEN METABOLITE; SCAVENGER;

ARTICLE; CELL PROTECTION; CELL STRAIN HL 60; COMET ASSAY; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; DNA DAMAGE; DOSE RESPONSE; GENOTOXICITY; HUMAN; HUMAN CELL; MONONUCLEAR CELL; OXIDATIVE STRESS;

EID: 0035052298     PISSN: 1342078X     EISSN: None     Source Type: Journal    
DOI: 10.1265/ehpm.2001.27     Document Type: Article

References (32)

1. Arsenic: Health effects, mechanisms of actions, and research issues
2. Arsenite enhances DNA double-strand breaks and cell-killing of methyl methane-sulfonate-treated cells by inhibiting the excision of alkali-labile sites
3. Arsenite retards DNA break rejoining by inhibiting DNA ligation
4. Inhibition of poly (ADP-ribose) polymerase by arsenite
5. Mutagenicity of arsenic in mammalian cells: Role of reactive oxygen species
6. Glutathione peroxidase and catalase modulate the genotoxicity of arsenite
7. The role of oxidative DNA damage in human arsenic carcinogenesis: Detection of 8-hydroxy-2′-deoxyguanosine in arsenic-related Bowen's disease
8. Arsenic-induced DNA-strand breaks associated with DNA-protein crosslinks in human fetal lung fibroblasts
9. A simple technique for quantitation of low levels of DNA damage in individual cells
10. Single-cell gel electrophoresis (SCG)-A review and discussion
11. Classification and evaluation of comets in single cell gel electrophoresis assay
12. Environmental variation of arsenic levels in human blood determines by neutron activation analysis
13. Regulation of hydrogen peroxide generation in cultured endothelial cells
14. Oxidative metabolism in the alveolar macrophage: Analysis by flow cytometry
15. Intracellular hydrogen peroxide and superoxide anion detection in endothelial cells
16. Oxygen radical-induced single-strand DNA breaks and repair of the damage in a cell-free system
17. Modulation of cellular antioxidant defense activities by sodium arsenite in human fibroblasts
18. Arsenite induces apoptosis in Chinese hamster ovary cells by generation of reactive oxygen species
19. Stimulation of reactive oxygen, but not reactive nitrogen species, in vascular endothelial cells exposed to low levels of arsenite
20. Yield of DNA strand breaks after base oxidation of plasmid DNA
21. Formation, prevention and repair of DNA damage by ion/hydrogen peroxide
22. Reactive oxygen species and oxidative DNA damage
23. Superoxide accelerates DNA damage by elevating free-ion levels
24. Arsenic trioxide selectively induces acute promyelocytic leukemia cell apoptosis via a hydrogen peroxide-dependent pathway
25. NADH oxidase activation is involved in arsenite-induced oxidative DNA damage in human vascular smooth muscle cells
26. Involvement of reactive oxygen species and caspase 3 activation in arsenite-induced apoptosis
27. The kinetics of repair of oxidative DNA damage (strand breaks and oxidised pyrimidines) in human cells
28. Comet assay to detect nitric oxide-dependent DNA damage in mammalian cells
29. Teardrop assay: A detection method for individual apoptotic cells with DNA fragmentation
30. Arsenic trioxide and melarsoprol induce programmed cell death in myeloid leukemia cell lines and function in a PML and PML-RARalpha independent manner
31. Apoptosis in HL-60 cells induced by 3-chloro-4-(dichloromethyl)-5-hydroxy-2(5H)-furanone (MX)
32. Optimization of single-cell gel electrophoresis (SCGE) for quantitative analysis of neuronal DNA damage