Potential Transfer of Polyglutamine and CAG-Repeat RNA in Extracellular Vesicles in Huntington’s Disease: Background and Evaluation in Cell Culture

Cellular and Molecular Neurobiology

Volumn 36, Issue 3, 2016, Pages 459-470

  Zhang, Xuan ^a,b   Abels, Erik R ^a,b   Redzic, Jasmina S ^c   Margulis, Julia ^d   Finkbeiner, Steve ^d   Breakefield, Xandra O ^a,b  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

^c UNIVERSITY OF COLORADO   (United States)

^d UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Exosomes; Huntington s disease; Neurodegeneration; Trinucleotide repeat

Indexed keywords

AMYLOID BETA PROTEIN; GREEN FLUORESCENT PROTEIN; HUNTINGTIN; MESSENGER RNA; POLYGLUTAMINE; PRION PROTEIN; PROTEIN AGGREGATE; RNA; PEPTIDE;

CAG REPEAT; CELL CULTURE; CELL VIABILITY ASSAY; COMPARATIVE STUDY; CONTROLLED STUDY; EXON; EXOSOME; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; HUNTINGTON CHOREA; NERVE DEGENERATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; REVIEW; SUCROSE DENSITY GRADIENT CENTRIFUGATION; TRINUCLEOTIDE REPEAT; WESTERN BLOTTING; ANIMAL; GENETICS; METABOLISM; MOUSE; NEOSTRIATUM; PATHOLOGY; REAL TIME POLYMERASE CHAIN REACTION;

ANIMALS; CELLS, CULTURED; EXTRACELLULAR VESICLES; GREEN FLUORESCENT PROTEINS; HUMANS; HUNTINGTIN PROTEIN; HUNTINGTON DISEASE; MICE; NEOSTRIATUM; PEPTIDES; REAL-TIME POLYMERASE CHAIN REACTION; RNA; TRINUCLEOTIDE REPEAT EXPANSION;

EID: 84960087164     PISSN: 02724340     EISSN: 15736830     Source Type: Journal    
DOI: 10.1007/s10571-016-0350-7     Document Type: Review

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