Structural insights into the loss of penicillinase and the gain of ceftazidimase activities by OXA-145 β-lactamase in Pseudomonas aeruginosa

Journal of Antimicrobial Chemotherapy

Volumn 71, Issue 2, 2016, Pages 395-402

  Meziane Cherif, D ^a   Bonnet, R ^b   Haouz, A ^a   Courvalin, P ^a  

^a INSTITUT PASTEUR   (France)

^b UNIVERSITY HOSPITAL OF CLERMONT FERRAND   (France)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIAL ENZYME; BETA LACTAMASE; BICARBONATE; CEFTAZIDIME; CEPHALOSPORINASE; OXA 145 ENZYME; PENICILLIN DERIVATIVE; PENICILLIN G; PENICILLINASE; UNCLASSIFIED DRUG; MUTANT PROTEIN;

ARTICLE; CRYSTAL STRUCTURE; DRUG HYDROLYSIS; ENZYME ACTIVITY; ENZYME STRUCTURE; NONHUMAN; PSEUDOMONAS AERUGINOSA; SITE DIRECTED MUTAGENESIS; CHEMISTRY; ENZYME SPECIFICITY; ENZYMOLOGY; GENE DELETION; KINETICS; METABOLISM; MOLECULAR DYNAMICS; PROTEIN CONFORMATION; X RAY CRYSTALLOGRAPHY;

BETA-LACTAMASES; CRYSTALLOGRAPHY, X-RAY; KINETICS; MOLECULAR DYNAMICS SIMULATION; MUTAGENESIS, SITE-DIRECTED; MUTANT PROTEINS; PROTEIN CONFORMATION; PSEUDOMONAS AERUGINOSA; SEQUENCE DELETION; SUBSTRATE SPECIFICITY;

EID: 84959919108     PISSN: 03057453     EISSN: 14602091     Source Type: Journal    
DOI: 10.1093/jac/dkv375     Document Type: Article

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