Crystal structure of the narrow-spectrum OXA-46 class D β-lactamase: Relationship between active-site lysine carbamylation and inhibition by polycarboxylates

Antimicrobial Agents and Chemotherapy

Volumn 54, Issue 5, 2010, Pages 2167-2174

  Docquier, Jean Denis ^a   Benvenuti, Manuela ^a   Calderone, Vito ^a,b   Giuliani, Francesco ^a   Kapetis, Dimos ^a   De Luca, Filomena ^a   Rossolini, Gian Maria ^a   Mangani, Stefano ^a,b  

^a UNIVERSITY OF SIENA   (Italy)

^b UNIVERSITY OF FLORENCE   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIAL ENZYME; BETA LACTAMASE; LYSINE; OXA 46; SERINE; TARTARIC ACID; UNCLASSIFIED DRUG;

ARTICLE; BACTERIUM ISOLATE; CARBAMOYLATION; CELL HETEROGENEITY; CRYSTAL STRUCTURE; CRYSTALLIZATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN CONFORMATION; PSEUDOMONAS AERUGINOSA;

AMINO ACID SEQUENCE; ANIONS; BETA-LACTAM RESISTANCE; BETA-LACTAMASES; CARBOXYLIC ACIDS; CATALYTIC DOMAIN; CONSERVED SEQUENCE; CRYSTALLOGRAPHY, X-RAY; LYSINE; MOLECULAR SEQUENCE DATA; OXALATES; PROTEIN STRUCTURE, QUATERNARY; PROTEIN STRUCTURE, SECONDARY; PROTEIN STRUCTURE, TERTIARY; PSEUDOMONAS AERUGINOSA; STRUCTURE-ACTIVITY RELATIONSHIP; TARTRATES;

EID: 77951249585     PISSN: 00664804     EISSN: 10986596     Source Type: Journal    
DOI: 10.1128/AAC.01517-09     Document Type: Article

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