Psychiatric Risk Gene Transcription Factor 4 Regulates Intrinsic Excitability of Prefrontal Neurons via Repression of SCN10a and KCNQ1

Neuron

Volumn 90, Issue 1, 2016, Pages 43-55

  Rannals, Matthew D ^a   Hamersky, Gregory R ^a   Page, Stephanie Cerceo ^a   Campbell, Morganne N ^a   Briley, Aaron ^a   Gallo, Ryan A ^a   Phan, BaDoi N ^a   Hyde, Thomas M ^a,b   Kleinman, Joel E ^a,b   Shin, Joo Heon ^a   Jaffe, Andrew E ^a,c   Weinberger, Daniel R ^a,b   Maher, Brady J ^a,b  

^a JOHNS HOPKINS UNIVERSITY   (United States)

^b JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c JOHNS HOPKINS BLOOMBERG SCHOOL OF PUBLIC HEALTH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BASIC HELIX LOOP HELIX TRANSCRIPTION FACTOR; POTASSIUM CHANNEL KCNQ1; SODIUM CHANNEL NAV1.8; TRANSCRIPTION FACTOR 4; UNCLASSIFIED DRUG; BASIC HELIX LOOP HELIX LEUCINE ZIPPER TRANSCRIPTION FACTOR; DNA BINDING PROTEIN; MESSENGER RNA; SMALL INTERFERING RNA; TCF4 PROTEIN, MOUSE; TCF4 PROTEIN, RAT; TRANSCRIPTION FACTOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BRAIN CELL; CONTROLLED STUDY; ELECTROPORATION; FEMALE; GENETIC DISORDER; GENETIC RISK; MENTAL DISEASE; MOUSE MODEL; NERVE CELL EXCITABILITY; NEUROLOGIC DISEASE; NONHUMAN; PATHOPHYSIOLOGY; PITT HOPKINS SYNDROME; PLEIOTROPY; PREFRONTAL CORTEX; PRIORITY JOURNAL; RAT; RNA TRANSLATION; SPIKE; ANIMAL; CRISPR CAS SYSTEM; DISEASE MODEL; EMBRYOLOGY; FACIES; GENE EXPRESSION REGULATION; GENETIC PREDISPOSITION; GENETICS; HAPLOINSUFFICIENCY; HYPERVENTILATION; INTELLECTUAL IMPAIRMENT; METABOLISM; MOUSE; PATCH CLAMP TECHNIQUE; PREGNANCY; SCHIZOPHRENIA; WISTAR RAT;

ANIMALS; BASIC HELIX-LOOP-HELIX LEUCINE ZIPPER TRANSCRIPTION FACTORS; CRISPR-CAS SYSTEMS; DISEASE MODELS, ANIMAL; DNA-BINDING PROTEINS; ELECTROPORATION; FACIES; FEMALE; GENE EXPRESSION REGULATION, DEVELOPMENTAL; GENETIC PREDISPOSITION TO DISEASE; HAPLOINSUFFICIENCY; HYPERVENTILATION; INTELLECTUAL DISABILITY; KCNQ1 POTASSIUM CHANNEL; MICE; NAV1.8 VOLTAGE-GATED SODIUM CHANNEL; PATCH-CLAMP TECHNIQUES; PREFRONTAL CORTEX; PREGNANCY; RATS; RATS, WISTAR; RNA, MESSENGER; RNA, SMALL INTERFERING; SCHIZOPHRENIA; TRANSCRIPTION FACTORS;

EID: 84959887346     PISSN: 08966273     EISSN: 10974199     Source Type: Journal    
DOI: 10.1016/j.neuron.2016.02.021     Document Type: Article

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