Glucose-dependent downregulation of glucagon gene expression mediated by selective interactions between ALX3 and PAX6 in mouse alpha cells

Diabetologia

Volumn 59, Issue 4, 2016, Pages 766-775

  Mirasierra, Mercedes ^a,b   Vallejo, Mario ^a,b  

^a INSTITUTO DE SALUD CARLOS III   (Spain)

^b INSTITUTO DE INVESTIGACIONES BIOMÉDICAS ALBERTO SOLS   (Spain)

Author keywords

Alpha cells; Glucagon; Glucose dependent gene expression; Homeodomain; Paired domain; Transcription

Indexed keywords

GLUCOSE; HETERODIMER; SMALL INTERFERING RNA; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR ARISTALESS LIKE HOMEOBOX 3; TRANSCRIPTION FACTOR PAX6; UNCLASSIFIED DRUG; ALX3 PROTEIN, MOUSE; GLUCAGON; HOMEODOMAIN PROTEIN; PAX6 PROTEIN, MOUSE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BINDING SITE; CHROMATIN IMMUNOPRECIPITATION; CONTROLLED STUDY; DNA BINDING; DOWN REGULATION; GEL MOBILITY SHIFT ASSAY; GENE; GENE EXPRESSION; GENETIC TRANSFECTION; GLUCAGON GENE; IMMUNOPRECIPITATION; MALE; MOUSE; NONHUMAN; PANCREAS ISLET ALPHA CELL; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN INTERACTION; PROTEIN PROTEIN INTERACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; WILD TYPE; ANIMAL; CELL LINE; IN VITRO STUDY; METABOLISM;

ANIMALS; CELL LINE; ELECTROPHORETIC MOBILITY SHIFT ASSAY; GLUCAGON; GLUCAGON-SECRETING CELLS; GLUCOSE; HOMEODOMAIN PROTEINS; IMMUNOPRECIPITATION; IN VITRO TECHNIQUES; MALE; MICE; PAX6 TRANSCRIPTION FACTOR; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION;

EID: 84959509785     PISSN: 0012186X     EISSN: 14320428     Source Type: Journal    
DOI: 10.1007/s00125-015-3849-4     Document Type: Article

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