Glucagon regulates its own synthesis by autocrine signaling

Proceedings of the National Academy of Sciences of the United States of America

Volumn 109, Issue 51, 2012, Pages 20925-20930

  Leibiger, Barbara ^a   Moede, Tilo ^a   Muhandiramlage, Thusitha P ^a   Kaiser, Daniel ^a   Sanchez, Pilar Vaca ^a   Leibiger, Ingo B ^a   Berggren, Per Olof ^a,b  

^a KAROLINSKA INSTITUTE   (Sweden)

^b Pohang University of Science and Technology (POSTECH)   (South Korea)

Author keywords

Gene expression; Signal transduction

Indexed keywords

GLUCAGON;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; GENE EXPRESSION; GLUCOSE BLOOD LEVEL; HORMONE RELEASE; HUMAN; HUMAN CELL; MOUSE; NONHUMAN; PANCREAS ISLET ALPHA CELL; PRIORITY JOURNAL; PROTEIN SYNTHESIS; SIGNAL TRANSDUCTION; UPREGULATION;

ANIMALS; AUTOCRINE COMMUNICATION; BLOOD GLUCOSE; CYCLIC AMP-DEPENDENT PROTEIN KINASES; GENE EXPRESSION REGULATION; GLUCAGON; HORMONES; HUMANS; INSULIN; MICE; PEPTIDES; PROTEIN BINDING; PROTEIN KINASE C; RECEPTORS, GLUCAGON; RNA, MESSENGER; SIGNAL TRANSDUCTION;

EID: 84871366458     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1212870110     Document Type: Article

References (46)

1. Leibiger IB, Leibiger B, Moede T, Berggren PO (1998) Exocytosis of insulin promotes insulin gene transcription via the insulin receptor/PI-3 kinase/p70 s6 kinase and CaM kinase pathways. Mol Cell 1(6):933-938.
2. Xu GG, Rothenberg PL (1998) Insulin receptor signaling in the β-cell influences insulin gene expression and insulin content: Evidence for autocrine β-cell regulation. Diabetes 47(8):1243-1252.
3. Wu H, et al. (1999) Insulin stimulates pancreatic-duodenal homoeobox factor-1 (PDX1) DNA-binding activity and insulin promoter activity in pancreatic β cells. Biochem J 344(Pt 3):813- 818.
4. Leibiger B, Wåhlander K, Berggren PO, Leibiger IB (2000) Glucose-stimulated insulin biosynthesis depends on insulin-stimulated insulin gene transcription. J Biol Chem 275(39):30153-30156.
5. da Silva Xavier G, Varadi A, Ainscow EK, Rutter GA (2000) Regulation of gene expression by glucose in pancreatic β cells (MIN6) via insulin secretion and activation of phosphatidylinositol 3′-kinase. J Biol Chem 275(46):36269-36277.
6. Andreozzi F, et al. (2004) Activation of the hexosamine pathway leads to phosphorylation of insulin receptor substrate-1 on Ser307 and Ser612 and impairs the phosphatidylinositol 3-kinase/Akt/mammalian target of rapamycin insulin biosynthetic pathway in RIN pancreatic β-cells. Endocrinology 145(6):2845-2857.
7. Luciani DS, Johnson JD (2005) Acute effects of insulin on beta-cells from transplantable human islets. Mol Cell Endocrinol 241(1-2):88-98.
8. Muller D, Huang GC, Amiel S, Jones PM, Persaud SJ (2006) Identification of insulin signaling elements in human beta-cells: Autocrine regulation of insulin gene expression. Diabetes 55(10):2835-2842.
9. Solinas G, Naugler W, Galimi F, Lee MS, Karin M (2006) Saturated fatty acids inhibit induction of insulin gene transcription by JNK-mediated phosphorylation of insulin-receptor substrates. Proc Natl Acad Sci USA 103(44):16454-16459.
10. Leibiger IB, Leibiger B, Berggren PO (2008) Insulin signaling in the pancreatic β-cell. Annu Rev Nutr 28:233-251.
11. Leibiger B, et al. (2001) Selective insulin signaling through A and B insulin receptors regulates transcription of insulin and glucokinase genes in pancreatic β cells. Mol Cell 7(3):559-570.
12. Uhles S, Moede T, Leibiger B, Berggren PO, Leibiger IB (2007) Selective gene activation by spatial segregation of insulin receptor B signaling. FASEB J 21(7):1609-1621.
13. Moede T, Leibiger B, Berggren PO, Leibiger IB (2001) Online monitoring of stimulus-induced gene expression in pancreatic β-cells. Diabetes 50(Suppl 1):S15-S19.
14. Hamaguchi K, Leiter EH (1990) Comparison of cytokine effects on mouse pancreatic alpha-cell and beta-cell lines: Viability, secretory function, and MHC antigen expression. Diabetes 39(4):415-425.
15. Ma X, et al. (2005) Glucagon stimulates exocytosis in mouse and rat pancreatic α-cells by binding to glucagon receptors. Mol Endocrinol 19(1):198-212.
16. Tian G, Sandler S, Gylfe E, Tengholm A (2011) Glucose- and hormone-induced cAMP oscillations in α- and β-cells within intact pancreatic islets. Diabetes 60(5):1535-1543.
17. Liu Z, et al. (2011) Insulin and glucagon regulate pancreatic α-cell proliferation. PLoS ONE 6(1):e16096.
18. Christophe J (1996) Glucagon and its receptor in various tissues. Ann N Y Acad Sci 805:31-42.
19. Unson CG (2002) Molecular determinants of gluca/gon receptor signaling. Biopolymers 66(4):218-235.
20. Jin T (2008) Mechanisms underlying proglucagon gene expression. J Endocrinol 198(1):17-28.
21. Miller CP, Lin JC, Habener JF (1993) Transcription of the rat glucagon gene by the cyclic AMP response element-binding protein CREB is modulated by adjacent CREB-associated proteins. Mol Cell Biol 13(11):7080-7090.
22. Gonzalez GA, Montminy MR (1989) Cyclic AMP stimulates somatostatin gene transcription by phosphorylation of CREB at serine 133. Cell 59(4):675-680.
23. Yamamoto KK, Gonzalez GA, Biggs WH, 3rd, Montminy MR (1988) Phosphorylation-induced binding and transcriptional efficacy of nuclear factor CREB. Nature 334(6182):494-498.
24. Herzig S, et al. (2001) CREB regulates hepatic gluconeogenesis through the coactivator PGC-1. Nature 413(6852):179-183.
25. Dalle S, et al. (2004) Glucagon promotes cAMP-response element-binding protein phosphorylation via activation of ERK1/2 in MIN6 cell line and isolated islets of Langerhans. J Biol Chem 279(19):20345-20355.
26. Kovac S, Xiao L, Shulkes A, Patel O, Baldwin GS (2010) Gastrin increases its own synthesis in gastrointestinal cancer cells via the CCK2 receptor. FEBS Lett 584(21):4413-4418.
27. Zoja C, Bettoni S, Morigi M, Remuzzi G, Rambaldi A (1992) Interleukin-1 regulates cytokine gene expression in human mesangial cells through the interleukin-1 receptor type 1. J Am Soc Nephrol 2(12):1709-1715.
28. Caprioli F, et al. (2008) Autocrine regulation of IL-21 production in human T lymphocytes. J Immunol 180(3):1800-1807.
29. Kim I, Kim CH, Yim YS, Ahn YS (2008) Autocrine function of erythropoietin in IGF-1-induced erythropoietin biosynthesis. Neuroreport 19(17):1699-1703.
30. Parrott JA, Mosher R, Kim G, Skinner MK (2000) Autocrine interactions of keratinocyte growth factor, hepatocyte growth factor, and kit-ligand in the regulation of normal ovarian surface epithelial cells. Endocrinology 141(7):2532-2539.
31. Saijonmaa O, Nyman T, Fyhrquist F (1992) Endothelin-1 stimulates its own synthesis in human endothelial cells. Biochem Biophys Res Commun 188(1):286-291.
32. Saito S, Hirata Y, Imai T, Marumo F (1995) Autocrine regulation of the endothelin-1 gene in rat endothelial cells. J Cardiovasc Pharmacol 26(Suppl 3):S84-S87.
33. Philippe J (1989) Glucagon gene transcription is negatively regulated by insulin in a hamster islet cell line. J Clin Invest 84(2):672-677.
34. Philippe J, et al. (1988) Alpha cell-speci fic expression of the glucagon gene is conferred to the glucagon promoter element by the interactions of DNA-binding proteins. Mol Cell Biol 8(11):4877-4888.
35. Knepel W, Chafitz J, Habener JF (1990) Transcriptional activation of the rat glucagon gene by the cyclic AMP-responsive element in pancreatic islet cells. Mol Cell Biol 10(12):6799-6804.
36. Drucker DJ, Campos R, Reynolds R, Stobie K, Brubaker PL (1991) The rat glucagon gene is regulated by a protein kinase A-dependent pathway in pancreatic islet cells. Endocrinology 128(1):394-400.
37. Philippe J, Drucker DJ, Habener JF (1987) Glucagon gene transcription in an islet cell line is regulated via a protein kinase C-activated pathway. J Biol Chem 262(4):1823-1828.
38. Fürstenau U, Schwaninger M, Blume R, Kennerknecht I, Knepel W (1997) Characterization of a novel protein kinase C response element in the glucagon gene. Mol Cell Biol 17(4):1805-1816.
39. Gelling RW, et al. (2003) Lower blood glucose, hyperglucagonemia, and pancreatic alpha cell hyperplasia in glucagon receptor knockout mice. Proc Natl Acad Sci USA 100(3):1438-1443.
40. Vuguin PM, et al. (2006) Ablation of the glucagon receptor gene increases fetal lethality and produces alterations in islet development and maturation. Endocrinology 147(9):3995-4006.
41. Weigle DS (1987) Pulsatile secretion of fuel-regulatory hormones. Diabetes 36(6):764-775.
42. Hellman B, Salehi A, Gylfe E, Dansk H, Grapengiesser E (2009) Glucose generates coincident insulin and somatostatin pulses and antisynchronous glucagon pulses from human pancreatic islets. Endocrinology 150(12):5334-5340.
43. Liu Y, Mziaut H, Ivanova A, Solimena M (2009) Beta cells at the crossroads: Choosing between insulin granule production and proliferation. Diabetes Obes Metab 11(Suppl 4):54-64.
44. Leibiger B, et al. (1998) Short-term regulation of insulin gene transcription by glucose. Proc Natl Acad Sci USA 95(16):9307-9312.
45. -Delta Delta C(T) method. Methods 25(4):402-408.
46. Dyer RB, Herzog NK (1995) Isolation of intact nuclei for nuclear extract preparation from a fragile B-lymphocyte cell line. Biotechniques 19(2):192-195.