The homeodomain of PAX6 is essential for PAX6-dependent activation of the rat glucagon gene promoter: Evidence for a PH0-like binding that induces an active conformation

Biochimica et Biophysica Acta - Gene Regulatory Mechanisms

Volumn 1789, Issue 5, 2009, Pages 403-412

  Grapp, Marcel ^a   Teichler, Sabine ^a   Kitz, Julia ^a   Dibaj, Payam ^a   Dickel, Corinna ^a   Knepel, Willhart ^a   Krätzner, Ralph ^a  

^a UNIVERSITY OF GÖTTINGEN   (Germany)

Author keywords

Binding conformation; DNA binding; PAX6 homeodomain; Regulation of glucagon gene transcription; Transcription factor

Indexed keywords

GLUCAGON; LUCIFERASE; MUTANT PROTEIN; TRANSCRIPTION FACTOR PAX6;

ANIMAL CELL; ARTICLE; BINDING AFFINITY; BINDING SITE; CONTROLLED STUDY; DELETION MUTANT; DNA SEQUENCE; GENE ACTIVATION; GENE CONSTRUCT; GENE MUTATION; GENETIC TRANSFECTION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN DEGRADATION; PROTEIN FUNCTION; PROTEIN MOTIF; REPORTER GENE; TRANSCRIPTION INITIATION;

ANIMALS; BASE SEQUENCE; CELL LINE; DATA INTERPRETATION, STATISTICAL; EYE PROTEINS; GLUCAGON; GLUCAGON-SECRETING CELLS; HOMEODOMAIN PROTEINS; MOLECULAR SEQUENCE DATA; MUTATION; PAIRED BOX TRANSCRIPTION FACTORS; PEPTIDE FRAGMENTS; PROMOTER REGIONS, GENETIC; PROTEIN BINDING; PROTEIN CONFORMATION; RATS; REPRESSOR PROTEINS; RESPONSE ELEMENTS; SEQUENCE ALIGNMENT; TRANSCRIPTIONAL ACTIVATION; TRYPSIN;

RATTUS;

EID: 67349105072     PISSN: 18749399     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bbagrm.2009.02.001     Document Type: Article

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