Severe nasal clefting and abnormal embryonic apoptosis in Alx3/Alx4 double mutant mice

Development

Volumn 128, Issue 20, 2001, Pages 3975-3986

  Beverdam, A ^a   Brouwer, A ^a   Reijnen, M ^a   Korving, J ^a   Meijlink, F ^a  

^a HUBRECHT INSTITUTE   (Netherlands)

Author keywords

Apoptosis; Aristaless related genes; Cephalic neural crest; Cleft face; Craniofacial development; Homeobox gene; Limb development; Mouse; Strong's luxoid

Indexed keywords

ALX3 PROTEIN; ALX4 PROTEIN; HOMEODOMAIN PROTEIN; UNCLASSIFIED DRUG;

ALLELE; APOPTOSIS; ARTICLE; CONTROLLED STUDY; CRANIOFACIAL DEVELOPMENT; CRANIOFACIAL MALFORMATION; DISEASE SEVERITY; EMBRYO; FACIAL BONE; GENE DELETION; GENE FUNCTION; GENE INSERTION; GENE SEQUENCE; HOMOZYGOSITY; MOUSE; MOUSE MUTANT; NEURAL CREST; NEWBORN; NONHUMAN; NOSE MALFORMATION; PHENOTYPE; PRIORITY JOURNAL; PROTEIN DOMAIN;

ANIMALS; APOPTOSIS; CRANIOFACIAL ABNORMALITIES; DNA-BINDING PROTEINS; GENE EXPRESSION REGULATION, DEVELOPMENTAL; GESTATIONAL AGE; HOMEODOMAIN PROTEINS; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MICE, MUTANT STRAINS; NASAL BONE; PHENOTYPE; PROTEINS; TRANSCRIPTION FACTORS;

MAMMALIA;

EID: 0034754798     PISSN: 09501991     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (37)

1. Expression patterns of group-I aristaless-related genes during craniofacial and limb development
2. Emx homeogenes and mouse brain development
3. Polydactylous limbs in Strong's Luxoid mice result from ectopic polarixing activity
4. Ectopic expression of Hoxb-8 causes duplication of the ZPA in the forelimb and homeotic transformation of axial structures
5. The triple origin of skull in higher vertebrates: A study in quail-chick chimeras
6. Temporospatial cell interactions regulating mandibular and maxillary arch patterning
7. The embryological development of the effects of Strong's Luxoid gene in the mouse
8. Responses to selection for plus and minus modifiers of some effects of Strong's luxoid gene on the mouse skeleton
9. The role of sonic hedgehog in normal and abnormal craniofacial morphogenesis
10. Developmental patterning and evolution of the mammalian viscerocranium: Genetic insights into comparative morphology
11. Patterning of neural crest derivatives in the avian embryo: In vivo and in vitro studies
12. Expression patterns of the paired-related homeobox genes MHox/Prx1 and S8/Prx2 suggest roles in development of the heart and the forebrain
13. Prx-1 functions cooperatively with another paired-related homeobox gene, prx-2, to maintain cell fates within the craniofacial mesenchyme
14. Paired-related homeobox genes cooperate in handplate and hindlimb zeugopod morphogenesis
15. Haploinsufficiency of the human homeobox gene ALX4 causes skull ossification defects
16. Fate map of the developing chick face: Analysis of expansion of facial primordia and establishment of the primary palate
17. A population of caudally migrating cranial neural crest cells; functional and evolutionary implications
18. Vertebrate aristaless-related genes
19. Polydactyly and ectopic ZPA formation in Alx-4 mutant mice
20. Mutations in mouse aristaless-like4 cause Strong's Luxoid polydactyly
21. Physical and genetic interactions between Alx4 and Cart1
22. Epithelial-mesenchymal interactions in the outgrowth of limb buds and facial primordia in chick embryos
23. Genetic analysis of craniofacial development in the vertebrate embryo
24. The role of Alx-4 in the establishment of anteroposterior polarity during vertebrate limb development
25. Mouse Alx3: An aristaless-like homeobox gene expressed during embryogenesis in ectomesenchyme and lateral plate mesoderm
26. Prx1 and Prx2 in skeletogenesis: Roles in the craniofacial region, inner ear and limbs
27. Prx1 and Prx2 are upstream regulators of sonic hedgehog, and control cell proliferation during mandibular arch morphogenesis
28. The head and face
29. Morphogenesis of the Vertebrates
30. Site-specific heterodimerization by paired class homeodomain proteins mediates selective transcriptional responses
31. Specification of the anterior hindbrain and establishment of a normal mid/hindbrain organizer is dependent on Gbx2 gene function
32. Epithelial-mesenchymal interactions in the development of chick facial primordia and the target of retinoid action
33. Haploinsufficiency of ALX4 as a potential cause of parietal foramina in the 11p11.2 contiguous gene-deletion syndrome
34. The ALX4 homeobox gene is mutated in patients with ossification defects of the skull
35. The gene for the homeodomain-containing protein Cart-1 is expressed in cells that have a chondrogenic potential during embryonic development
36. Prenatal folic acid treatment suppresses acrania and meroanencephaly in mice mutant for the Cart1 homeobox gene