Family-wide Structural Analysis of Human Numb-Associated Protein Kinases

Structure

Volumn 24, Issue 3, 2016, Pages 401-411

  Sorrell, Fiona J ^a   Szklarz, Marta ^a   Abdul Azeez, Kamal R ^a   Elkins, Jon M ^a   Knapp, Stefan ^a,b  

^a UNIVERSITY OF OXFORD   (United Kingdom)

^b GOETHE UNIVERSITY   (Germany)

Author keywords

AAK1; activation segment; BIKE; inhibitor selectivity; Numb associated kinase (NAK)

Indexed keywords

5 (3 FLUOROPHENYL) N (3 PIPERIDINYL) 3 UREIDO 2 THIOPHENECARBOXAMIDE; ADAPTOR ASSOCIATED KINASE 1; BARICITINIB; BMP 2 INDUCIBLE KINASE; LESTAURTINIB; PROTEIN KINASE; UNCLASSIFIED DRUG; AAK1 PROTEIN, HUMAN; BMP2K PROTEIN, HUMAN; CYSTEINE; GAK PROTEIN, HUMAN; PROTEIN BINDING; PROTEIN KINASE INHIBITOR; PROTEIN SERINE THREONINE KINASE; SIGNAL PEPTIDE; STK16 PROTEIN, HUMAN; TRANSCRIPTION FACTOR;

ARTICLE; CONTROLLED STUDY; CRYSTAL STRUCTURE; ENZYME PHOSPHORYLATION; HUMAN; HYDROGEN BOND; ISOTHERMAL TITRATION CALORIMETRY; PHYLOGENY; PRIORITY JOURNAL; REGULATORY MECHANISM; SEDIMENTATION RATE; AMINO ACID SEQUENCE; BINDING SITE; CHEMISTRY; CONSERVED SEQUENCE; METABOLISM; MOLECULAR MODEL;

AMINO ACID SEQUENCE; BINDING SITES; CONSERVED SEQUENCE; CYSTEINE; HUMANS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; MODELS, MOLECULAR; PROTEIN BINDING; PROTEIN KINASE INHIBITORS; PROTEIN-SERINE-THREONINE KINASES; TRANSCRIPTION FACTORS;

EID: 84959475438     PISSN: 09692126     EISSN: 18784186     Source Type: Journal    
DOI: 10.1016/j.str.2015.12.015     Document Type: Article

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