Differential requirements for AP-2 in clathrin-mediated endocytosis

Journal of Cell Biology

Volumn 162, Issue 5, 2003, Pages 773-779

  Conner, Sean D ^a   Schmid, Sandra L ^a  

^a SCRIPPS RESEARCH INSTITUTE   (United States)

Author keywords

AAK1; AP 2; Clathrin; Endocytosis; Kinase

Indexed keywords

ADAPTOR ASSOCIATED KINASE; CLATHRIN; PHOSPHOTRANSFERASE; TRANSCRIPTION FACTOR AP 2; TRANSFERRIN RECEPTOR; UNCLASSIFIED DRUG;

ADENOVIRUS; ARTICLE; ENDOCYTOSIS; ENZYME INHIBITION; GENE OVEREXPRESSION; HELA CELL; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; STOICHIOMETRY;

ADAPTOR PROTEIN COMPLEX 2; CLATHRIN; COATED PITS, CELL-MEMBRANE; ENDOCYTOSIS; HELA CELLS; HUMANS; PHOSPHORYLATION; RECOMBINANT FUSION PROTEINS; TRANSFERRIN;

ADENOVIRIDAE;

EID: 0042733637     PISSN: 00219525     EISSN: None     Source Type: Journal    
DOI: 10.1083/jcb.200304069     Document Type: Article

References (30)

1. Altschuler, Y., S.M. Barbas, L.J. Terlecky, K. Tang, S. Hardy, K.E. Mostov, and S.L. Schmid. 1998. Redundant and distinct functions for dynamin-1 and dynamin-2 isoforms. J. Cell Biol. 143:1871-1881.
2. Brodsky, F.M., C.Y. Chen, C. Knuehl, M.C. Towler, and D.E. Wakeham. 2001. Biological basket weaving: formation and function of clathrin-coated vesicles. Annu. Rev. Cell Dev. Biol. 17:517-568.
3. Carter, L.L., T.E. Redelmeier, L.A. Woollenweber, and S.L. Schmid. 1993. Multiple GTP-binding proteins participate in clathrin-coated vesicle- mediated endocytosis. J. Cell Biol. 120:37-45.
4. Collins, B.M., A.J. McCoy, H.M. Kent, P.R. Evans, and D.J. Owen. 2002. Molecular architecture and functional model of the endocytic AP-2 complex. Cell. 109:523-535.
5. Conner, S.D., and S.L. Schmid. 2002. Identification of an adaptor-associated kinase, AAK1, as a regulator of clathrin-mediated endocytosis. J. Cell Biol. 156:921-929.
6. Cope, M.J., S. Yang, C. Shang, and D.G. Drubin. 1999. Novel protein kinases Ark1p and Prk1p associate with and regulate the cortical actin cytoskeleton in budding yeast. J. Cell Biol. 144:1203-1218.
7. Damke, H., T. Baba, D.E. Warnock, and S.L. Schmid. 1994. Induction of mutant dynamin specifically blocks endocytic coated vesicle formation. J. Cell Biol. 127:915-934.
8. Fingerhut, A., K. von Figura, and S. Honing. 2001. Binding of AP-2 to sorting signals is modulated by AP-2 phosphorylation. J. Biol. Chem. 276:5476-5482.
9. Ford, M.G., I.G. Mills, B.J. Peter, Y. Vallis, G.J. Praefcke, P.R. Evans, and H.T. McMahon. 2002. Curvature of clathrin-coated pits driven by epsin. Nature. 419:361-366.
10. Goodman, O.B., Jr., J.G. Krupnick, F. Santini, V.V. Gurevich, R.B. Penn, A.W. Gagnon, J.H. Keen, and J.L. Benovic. 1996. Beta-arrestin acts as a clathrin adaptor in endocytosis of the beta2-adrenergic receptor. Nature. 383:447-450.
11. Huang, K.M., K. D'Hondt, H. Riezman, and S.K. Lemmon. 1999. Clathrin functions in the absence of heterotetrameric adaptors and AP180-related proteins in yeast. EMBO J. 18:3897-3908.
12. Jiang, X., and A. Sorkin. 2003. Epidermal growth factor internalization through clathrin-coated pits requires Cbl RING finger and proline-rich domains but not receptor polyubiquitylation. Traffic. In press.
13. Kirchhausen, T. 1999. Adaptors for clathrin-mediated traffic. Annu. Rev. Cell Dev. Biol. 15:705-732.
14. Korolchuk, V.I., and G. Banting. 2002. CK2 and GAK/auxilin2 are major protein kinases in clathrin-coated vesicles. Traffic. 3:428-439.
15. Lamaze, C., T. Baba, T.E. Redelmeier, and S.L. Schmid. 1993. Recruitment of epidermal growth factor and transferrin receptors into coated pits in vitro: differing biochemical requirements. Mol. Biol. Cell. 4:715-727.
16. Lin, F.T., K.M. Krueger, H.E. Kendall, Y. Daaka, Z.L. Fredericks, J.A. Pitcher, and R.J. Lefkowitz. 1997. Clathrin-mediated endocytosis of the beta-adrenergic receptor is regulated by phosphorylation/dephosphorylation of beta-arrestin1. J. Biol. Chem. 272:31051-31057.
17. Metzler, M., V. Legendre-Guillemin, L. Gan, V. Chopra, A. Kwok, P.S. McPherson, and M.R. Hayden. 2001. HIP1 functions in clathrin-mediated endocytosis through binding to clathrin and adaptor protein 2. J. Biol. Chem. 276:39271-39276.
18. Mishra, S.K., N.R. Agostinelli, T.J. Brett, I. Mizukami, T.S. Ross, and L.M. Traub. 2001. Clathrin- and AP-2-binding sites in H1P1 uncover a general assembly role for endocytic accessory proteins. J. Biol. Chem. 276:46230-46236.
19. Mishra, S.K., P.A. Keyel, M.J. Hawryluk, N.R. Agostinelli, S.C. Watkins, and L.M. Traub. 2002. Disabled-2 exhibits the properties of a cargo-selective endocytic clathrin adaptor. EMBO J. 21:4915-4926.
20. Morgan, J.R., X. Zhao, M. Womack, K. Prasad, G.J. Augustine, and E.M. Lafer. 1999. A role for the clathrin assembly domain of AP180 in synaptic vesicle endocytosis. J. Neurosci. 19:10201-10212.
21. Motley, A., N. Bright, M. Seaman, and M. Robinson. 2003. Clathrin-mediated endocytosis in AP-2-depleted cells. J. Cell Biol. 162:909-918.
22. Olusanya, O., P.D. Andrews, J.R. Swedlow, and E. Smythe. 2001. Phosphorylation of threonine 156 of the μ2 subunit of the AP-2 complex is essential for endocytosis in vitro and in vivo. Curr Biol. 11:896-900.
23. Ricotta, D., S.D. Conner, S.L. Schmid, K. von Figura, and S. Honing. 2002. Phosphorylation of the AP-2 μ subunit by AAK1 mediates high affinity binding to membrane protein sorting signals. J. Cell Biol. 156:791-795.
24. Robinson, M.S. 1993. Assembly and targeting of adaptin chimeras in transfected cells. J. Cell Biol. 123:67-77.
25. Slepnev, V.I., and P. De Camilli. 2000. Accessory factors in clathrin-dependent synaptic vesicle endocytosis. Nat. Rev. Neurosci. 1:161-172.
26. Smythe, E., L.L. Carter, and S.L. Schmid. 1992. Cytosol- and clathrin-dependent stimulation of endocytosis in vitro by purified adaptors. J. Cell Biol. 119:1163-1171.
27. Tebar, F., S.K. Bohlander, and A. Sorkin. 1999. Clathrin assembly lymphoid myeloid leukemia (CALM) protein: localization in endocytic-coated pits, interactions with clathrin, and the impact of overexpression on clathrin-mediated traffic. Mol. Biol. Cell. 10:2687-2702.
28. Traub, L.M., M.A. Downs, J.L. Westrich, and D.H. Fremont. 1999. Crystal structure of the alpha appendage of AP-2 reveals a recruitment platform for clathrin-coat assembly. Proc. Natl. Acad. Sci. USA. 96:8907-8912.
29. Umeda, A., A. Meyerholz, and E. Ungewickell. 2000. Identification of the universal cofactor (auxilin 2) in clathrin coat dissociation. Eur. J. Cell Biol. 79:336-342.
30. Wilde, A., and F.M. Brodsky. 1996. In vivo phosphorylation of adaptors regulates their interaction with clathrin. J. Cell Biol. 135:635-645.