IL-12 induced the generation of IL-21-and IFN-γ-co-expressing poly-functional CD4+ T cells from human naive CD4+ T cells

Cell Cycle

Volumn 14, Issue 21, 2015, Pages 3362-3372

  Yu, Sifei ^a   Jia, Lei ^a   Zhang, Yannan ^a   Zhong, Junmin ^b   Yang, Binyan ^a   Wu, Changyou ^a  

^a SUN YAT SEN UNIVERSITY   (China)

^b Guangzhou Women and Children's Medical Center   (China)

Author keywords

Differentiation; Human; IL 12; IL 21; Poly functional CD4+ T cells

Indexed keywords

CD40 LIGAND; CHEMOKINE RECEPTOR CXCR3; CHEMOKINE RECEPTOR CXCR5; GAMMA INTERFERON; INTERLEUKIN 12; INTERLEUKIN 2; INTERLEUKIN 21; PROGRAMMED DEATH 1 RECEPTOR; PROTEIN BCL 6; STAT1 PROTEIN; STAT4 PROTEIN; TRANSCRIPTION FACTOR T BET; TUMOR NECROSIS FACTOR ALPHA; BCL6 PROTEIN, HUMAN; DNA BINDING PROTEIN; IFNG PROTEIN, HUMAN; INTERLEUKIN DERIVATIVE; STAT1 PROTEIN, HUMAN; STAT4 PROTEIN, HUMAN; T BOX TRANSCRIPTION FACTOR; T-BOX TRANSCRIPTION FACTOR TBX21;

ARTICLE; CD4+ T LYMPHOCYTE; CONTROLLED STUDY; CYTOKINE PRODUCTION; DOWN REGULATION; ENZYME INHIBITION; ENZYME REGULATION; GENE EXPRESSION REGULATION; HUMAN; HUMAN CELL; IN VITRO STUDY; LYMPHOCYTE ACTIVATION; LYMPHOCYTE DIFFERENTIATION; MEMORY T LYMPHOCYTE; NEWBORN; PHENOTYPE; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN INDUCTION; PROTEIN PHOSPHORYLATION; PROTEIN SECRETION; SIGNAL TRANSDUCTION; TH1 CELL; UPREGULATION; CELL CULTURE; CELL DIFFERENTIATION; CYTOLOGY; DRUG EFFECTS; FETUS BLOOD; IMMUNOLOGICAL MEMORY; IMMUNOLOGY; KINETICS; METABOLISM;

CD4-POSITIVE T-LYMPHOCYTES; CELL DIFFERENTIATION; CELLS, CULTURED; DNA-BINDING PROTEINS; FETAL BLOOD; HUMANS; IMMUNOLOGIC MEMORY; INFANT, NEWBORN; INTERFERON-GAMMA; INTERLEUKIN-12; INTERLEUKINS; KINETICS; PHENOTYPE; PROTO-ONCOGENE PROTEINS C-BCL-6; SIGNAL TRANSDUCTION; STAT1 TRANSCRIPTION FACTOR; STAT4 TRANSCRIPTION FACTOR; T-BOX DOMAIN PROTEINS; TH1 CELLS; UP-REGULATION;

EID: 84959458637     PISSN: 15384101     EISSN: 15514005     Source Type: Journal    
DOI: 10.1080/15384101.2015.1093703     Document Type: Article

References (36)

1. Zhu J, Yamane H, Paul WE. Differentiation of effector CD4 T cell populations (*). Annu Rev Immunol 2010; 28:445-89 ; PMID:20192806 ; http://dx.doi.org/10.1146/annurev-immunol-030409-101212
2. Zhu J, Paul WE. Peripheral CD4+ T-cell differentiation regulated by networks of cytokines and transcription factors. Immunol Rev 2010; 238:247-62 ; PMID:20969597 ; http://dx.doi.org/10.1111/j.1600-065X.2010.00951.x
3. Mosmann TR, Cherwinski H, Bond MW, Giedlin MA, Coffman RL. Two types of murine helper T cell clone. I. Definition according to profiles of lymphokine activities and secreted proteins. J Immunol 1986; 136:2348-57 ; PMID:2419430
4. Han Q, Bagheri N, Bradshaw EM, Hafler DA, Lauffenburger DA, Love JC. Polyfunctional responses by human T cells result from sequential release of cytokines. Proc Natl Acad SciU S A 2012; 109:1607-12 ; PMID:22160692 ; http://dx. doi.org/10.1073/pnas.1117194109
5. Korn T, Bettelli E, Oukka M, Kuchroo VK. IL-17 and Th17 Cells. Annu Rev Immunol 2009; 27:485-517 ; PMID:19132915 ; http://dx.doi.org/10.1146/annurev. immunol.021908.132710
6. Crotty S. Follicular helper CD4 T cells (TFH). Annu Rev Immunol 2011; 29:621-63 ; PMID:21314428 ; http://dx.doi.org/10.1146/annurev-immunol-031210-101400
7. Li L, Qiao D, Fu X, Lao S, Zhang X, Wu C. Identification of M. tuberculosis-specific Th1 cells expressing CD69 generated in vivo in pleural fluid cells from patients with tuberculous pleurisy. Plos One 2011; 6: e23700 ; PMID:21887301 ; http://dx.doi.org/10.1371/journal.pone.0023700
8. Li L, Qiao D, Li Q, Zhang X, Lao S, Wu C. Distinct polyfunctional CD4+ T cell responses to BCG, ESAT-6 and CFP-10 in tuberculous pleurisy. Tuberculosis (Edinb) 2012; 92:63-71 ; PMID:22154006 ; http://dx. doi.org/10.1016/j.tube.2011.11.004
9. Micci L, Cervasi B, Ende ZS, Iriele RI, Reyes-Aviles E, Vinton C, Else J, Silvestri G, Ansari AA, Villinger F, et al. Paucity of IL-21-producing CD4(+) T cells is associated with Th17 cell depletion in SIV infection of rhesus macaques. Blood 2012; 120:3925-35 ; PMID:22990011 ; http://dx.doi.org/10.1182/blood-2012-04-420240
10. Xiao L, Wei Y, Zhang YN, Luo X, Yang BY, Yu SF, Wu XM, Wu CY, Li HB. Increased IL-21 expression in chronic rhinosinusitis with nasalpolyps. Clin Exp Allergy 2015; 45:404-13 ; PMID:25495679 ; http://dx. doi.org/10.1111/cea.12475
11. Yamane H, Paul WE. Early signaling events that underlie fate decisions of naive CD4(+) T cells toward distinct Thelper cell subsets. Immunol Rev 2013; 252:12-23 ; PMID:23405892 ; http://dx.doi.org/10.1111/imr.12032
12. Linterman MA, Liston A, Vinuesa CG. T-follicular helper cell differentiation and the co-option of this pathway by non-helper cells. Immunol Rev 2012; 247:143-59 ; PMID:22500838 ; http://dx.doi.org/10.1111/j.1600-065X.2012.01121.x
13. Bird JJ, Brown DR, Mullen AC, Moskowitz NH, Mahowald MA, Sider JR, Gajewski TF, Wang CR, Reiner SL. Helper T cell differentiation is controlled by the cell cycle. Immunity 1998; 9:229-37 ; PMID:9729043 ; http://dx.doi.org/10.1016/S1074-7613(00)80605-6
14. Grogan JL, Mohrs M, Harmon B, Lacy DA, Sedat JW, Locksley RM. Early transcription and silencing of cytokine genes underlie polarization of T helper cell subsets. Immunity 2001; 14:205-15 ; PMID:11290331 ; http://dx.doi.org/10.1016/S1074-7613(01)00103-0
15. Baxter AG, Jordan MA. Plasticity is the differentiated state of CD4 T cells. Cell Mol Immunol 2013; 10:375-8 ; PMID:23921435 ; http://dx.doi.org/10.1038/cmi.2013.29
16. Koenen HJ, Smeets RL, Vink PM, van Rijssen E, Boots AM, Joosten I. Human CD25highFoxp3pos regulatory T cells differentiate into IL-17-producing cells. Blood 2008; 112:2340-52 ; PMID:18617638 ; http://dx.doi. org/10.1182/blood-2008-01-133967
17. Bettelli E, Carrier Y, Gao W, Korn T, Strom TB, Oukka M, Weiner HL, Kuchroo VK. Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells. Nature 2006; 441:235-8 ; PMID:16648838 ; http://dx.doi.org/10.1038/nature04753
18. Tsuji M, Komatsu N, Kawamoto S, Suzuki K, Kanagawa O, Honjo T, Hori S, Fagarasan S. Preferential generation of follicular B helper T cells from Foxp3C T cells in gut Peyer’s patches. Science 2009; 323:1488-92 ; PMID:19286559 ; http://dx.doi.org/10.1126/science.1169152
19. Hirota K, Turner JE, Villa M, Duarte JH, Demengeot J, Steinmetz OM, Stockinger B. Plasticity of Th17 cells in Peyer’s patches is responsible for the induction of T cell-dependent IgA responses. Nat Immunol 2013; 14:372-9 ; PMID:23475182 ; http://dx.doi.org/10.1038/ni.2552
20. Nakayamada S, Kanno Y, Takahashi H, Jankovic D, Lu KT, Johnson TA, Sun HW, Vahedi G, Hakim O, Handon R, et al. Early Th1 cell differentiation is marked by a Tfh cell-like transition. Immunity 2011; 35:919-31 ; PMID:22195747 ; http://dx.doi.org/10.1016/j.immuni.2011.11.012
21. Schmitt N, Morita R, Bourdery L, Bentebibel SE, Zurawski SM, Banchereau J, Ueno H. Human dendritic cells induce the differentiation of interleukin-21-producing T follicular helper-like cells through interleukin-12. Immunity 2009; 31:158-69 ; PMID:19592276 ; http://dx.doi.org/10.1016/j.immuni.2009.04.016
22. Lighvani AA, Frucht DM, Jankovic D, Yamane H, Aliberti J, Hissong BD, Nguyen BV, Gadina M, Sher A, Paul WE, et al. T-bet is rapidly induced by interferongamma in lymphoid and myeloid cells. Proc Natl Acad Sci U S A 2001; 98:15137-42 ; PMID:11752460 ; http://dx.doi.org/10.1073/pnas.261570598
23. Kim CH, Rott LS, Clark-Lewis I, Campbell DJ, Wu L, Butcher EC. Subspecialization of CXCR5C T cells: B helper activity is focused in a germinal center-localized subset of CXCR5C T cells. J Exp Med 2001; 193:1373-81 ; PMID:11413192 ; http://dx.doi.org/10.1084/jem.193.12.1373
24. Brandes M, Legler DF, Spoerri B, Schaerli P, Moser B. Activation-dependent modulation of B lymphocyte migration to chemokines. Int Immunol 2000; 12:1285-92 ; PMID:10967023 ; http://dx.doi.org/10.1093/intimm/12.9.1285
25. Schaerli P, Willimann K, Lang AB, Lipp M, Loetscher P, Moser B. CXC chemokine receptor 5 expression defines follicular homing T cells with B cell helper function. J Exp Med 2000; 192:1553-62 ; PMID:11104798 ; http://dx.doi.org/10.1084/jem.192.11.1553
26. Shekhar S, Yang X. The darker side of follicular helper T cells: from autoimmunity to immunodeficiency. Cell Mol Immunol 2012; 9:380-5 ; PMID:22885524 ; http://dx.doi.org/10.1038/cmi.2012.26
27. Basso K, Dalla-Favera R. BCL6: master regulator of the germinal center reaction and key oncogene in B cell lymphomagenesis. Adv Immunol 2010; 105:193-210 ; PMID:20510734 ; http://dx.doi.org/10.1016/S0065-2776(10)05007-8
28. Good KL, Bryant VL, Tangye SG. Kinetics of human B cell behavior and amplification of proliferative responses following stimulation with IL-21. J Immunol 2006; 177:5236-47 ; PMID:17015709 ; http://dx.doi. org/10.4049/jimmunol.177.8.5236
29. Leonard WJ, Spolski R. Interleukin-21: a modulator of lymphoid proliferation, apoptosis and differentiation. Nat Rev Immunol 2005; 5:688-98 ; PMID:16138102 ; http://dx.doi.org/10.1038/nri1688
30. Nurieva RI, Chung Y, Hwang D, Yang XO, Kang HS, Ma L, Wang YH, Watowich SS, Jetten AM, Tian Q, et al. Generation of T follicular helper cells ismediated by interleukin-21 but independent of T helper 1, 2, or 17 cell lineages. Immunity 2008; 29:138-49 ; PMID:18599325 ; http://dx. doi.org/10.1016/j.immuni.2008.05.009
31. Spolski R, Leonard WJ. IL-21 and T follicular helper cells. Int Immunol 2010; 22:7-12 ; PMID:19933709; http://dx.doi.org/10.1093/intimm/dxp112
32. Linterman MA, Beaton L, Yu D, Ramiscal RR, Srivastava M, Hogan JJ, Verma NK, Smyth MJ, Rigby RJ, Vinuesa CG. IL-21 acts directly on B cells to regulate Bcl ¡ 6 expression and germinal center responses. J Exp Med 2010; 207:353-63 ; PMID:20142429 ; http://dx.doi.org/10.1084/jem. 20091738
33. -6 in TH1 cells to regulate flexibility with a TFH-like gene profile. Nat Immunol 2012; 13:405-11 ; PMID:22406686 ; http://dx.doi.org/10.1038/ni.2242
34. Oestreich KJ, Weinmann AS. T-bet employs diverse regulatory mechanisms to repress transcription. Trends Immunol 2012; 33:78-83 ; PMID:22133865 ; http://dx.doi.org/10.1016/j. it.2011.10.005
35. Oestreich KJ, Weinmann AS. Master regulators or lineage-specifying? Changing views on CD4+ T cell transcription factors. NAT Rev Immunol 2012; 12:799-804 ; PMID:23059426 ; http://dx.doi.org/10.1038/nri3321
36. Afkarian M, Sedy JR, Yang J, Jacobson NG, Cereb N, Yang SY, Murphy TL, Murphy KM. T-bet is a STAT1-induced regulator of IL-12R expression in naive CD4+ T cells. Nat Immunol 2002; 3:549-57 ; PMID:12006974 ; http://dx.doi.org/10.1038/ni794