Increased IL-21 expression in chronic rhinosinusitis with nasalpolyps

Clinical and Experimental Allergy

Volumn 45, Issue 2, 2015, Pages 404-413

  Xiao, L ^a   Wei, Y ^b   Zhang, Y N ^a   Luo, X ^c   Yang, B Y ^a   Yu, S F ^a   Wu, X M ^b   Wu, C Y ^a   Li, H B ^b,d  

^a SUN YAT SEN UNIVERSITY   (China)

^b THE FIRST AFFILIATED HOSPITAL OF SUN YAT SEN UNIVERSITY   (China)

^c Guangzhou Women and Children's Medical Center   (China)

^d SHANGHAI JIAO TONG UNIVERSITY SCHOOL OF MEDICINE   (China)

Author keywords

Asthma; B cell; Chronic rhinosinusitis; IL 21; Immunoglobulin; Nasal polyp; Plasma cells

Indexed keywords

CD40 LIGAND; IMMUNOGLOBULIN A; IMMUNOGLOBULIN G; INTERLEUKIN 21; MESSENGER RNA; RECOMBINANT INTERLEUKIN 21; INTERLEUKIN DERIVATIVE; RECOMBINANT PROTEIN;

ADULT; ARTICLE; ASTHMA; B LYMPHOCYTE; B LYMPHOCYTE ACTIVATION; B LYMPHOCYTE DIFFERENTIATION; CD4+ T LYMPHOCYTE; CHRONIC RHINOSINUSITIS; CONTROLLED STUDY; DISEASE ACTIVITY; DISEASE SEVERITY; EOSINOPHILIA; FEMALE; HUMAN; HUMAN TISSUE; IMMUNOGLOBULIN PRODUCTION; IN VITRO STUDY; MAJOR CLINICAL STUDY; MALE; NATURAL KILLER T CELL; NOSE MUCOSA; NOSE POLYP; PATHOGENESIS; PERIPHERAL BLOOD MONONUCLEAR CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; TH1 CELL; TH17 CELL; TUMOR VOLUME; CASE CONTROL STUDY; CHRONIC DISEASE; COMPLICATION; CYTOLOGY; DRUG EFFECTS; GENE EXPRESSION; GENETICS; IMMUNOLOGY; IMMUNOPHENOTYPING; METABOLISM; MIDDLE AGED; MONONUCLEAR CELL; NASAL POLYPS; PATHOLOGY; RHINITIS; SEVERITY OF ILLNESS INDEX; SINUSITIS; T LYMPHOCYTE SUBPOPULATION; YOUNG ADULT;

ADULT; B-LYMPHOCYTES; CASE-CONTROL STUDIES; CHRONIC DISEASE; FEMALE; GENE EXPRESSION; HUMANS; IMMUNOPHENOTYPING; INTERLEUKINS; LEUKOCYTES, MONONUCLEAR; MALE; MIDDLE AGED; NASAL MUCOSA; NASAL POLYPS; RECOMBINANT PROTEINS; RHINITIS; RNA, MESSENGER; SEVERITY OF ILLNESS INDEX; SINUSITIS; T-LYMPHOCYTE SUBSETS; YOUNG ADULT;

EID: 84923104023     PISSN: 09547894     EISSN: 13652222     Source Type: Journal    
DOI: 10.1111/cea.12475     Document Type: Article

References (32)

1. Leonard WJ, Spolski R. Interleukin-21: a modulator of lymphoid proliferation, apoptosis and differentiation. Nat Rev Immunol 2005; 5:688-98.
2. Sarra M, Franzè E, Pallone F et al. Targeting interleukin-21 in inflammatory diseases. Expert Opin Ther Targets 2011; 15:695-702.
3. Zotos D, Coquet JM, Zhang Y et al. IL-21 regulates germinal center B cell differentiation and proliferation through a B cell-intrinsic mechanism. J Exp Med 2010; 207:365-78.
4. Linterman MA, Beaton L, Yu D et al. IL-21 acts directly on B cells to regulate Bcl-6 expression and germinal center responses. J Exp Med 2010; 207:353-63.
5. Vogelzang A, McGuire HM, Yu D et al. A fundamental role for interleukin-21 in the generation of T follicular helper cells. Immunity 2008; 29:127-37.
6. Li J, Pan HF, Cen H et al. Interleukin-21 as a potential therapeutic target for systemic lupus erythematosus. Mol Biol Rep 2011; 38:4077-81.
7. Yuan FL, Hu W, Lu WG et al. Targeting interleukin-21 in rheumatoid arthritis. Mol Biol Rep 2011; 38:1717-21.
8. Fokkens WJ, Lund VJ, Mullol J et al. EPOS 2012: European position paper on rhinosinusitis and nasal polyps 2012. A summary for otorhinolaryngologists. Rhinology 2012; 50:1-12.
9. Van Crombruggen K, Zhang N, Gevaert P et al. Pathogenesis of chronic rhinosinusitis: inflammation. J Allergy Clin Immunol 2011; 128:728-32.
10. Hsu J, Peters AT. Pathophysiology of chronic rhinosinusitis with nasal polyp. Am J Rhinol Allergy 2011; 25:285-90.
11. Hulse KE, Norton JE, Suh L et al. Chronic rhinosinusitis with nasal polyps is characterized by B-cell inflammation and EBV-induced protein 2 expression. J Allergy Clin Immunol 2013; 131:1075-83.
12. Van Zele T, Gevaert P, Holtappels G et al. Local immunoglobulin production in nasal polyposis is modulated by superantigens. Clin Exp Allergy 2007; 37:1840-7.
13. Tan BK, Li QZ, Suh L et al. Evidence for intranasal antinuclear autoantibodies in patients with chronic rhinosinusitis with nasal polyps. J Allergy Clin Immunol 2011; 128:1198-206.
14. Kato A, Hulse KE, Tan BK et al. B-lymphocyte lineage cells and the respiratory system. J Allergy Clin Immunol 2013; 131:933-57.
15. Wen W, Liu W, Zhang L et al. Increased neutrophilia in nasal polyps reduces the response to oral corticosteroid therapy. J Allergy Clin Immunol 2012; 129:1522-8.
16. Gevaert P, Nouri-Aria KT, Wu H et al. Local receptor revision and class switching to IgE in chronic rhinosinusitis with nasal polyps. Allergy 2013; 68:55-63.
17. Dolff S, Abdulahad WH, Westra J et al. Increase in IL-21 producing T-cells in patients with systemic lupus erythematosus. Arthritis Res Ther 2011; 13:R157.
18. Liu R, Wu Q, Su D et al. A regulatory effect of IL-21 on T follicular helper-like cell and B cell in rheumatoid arthritis. Arthritis Res Ther 2012; 14:R255.
19. Tzartos JS, Craner MJ, Friese MA et al. IL-21 and IL-21 receptor expression in lymphocytes and neurons in multiple sclerosis brain. Am J Pathol 2011; 178:794-802.
20. Wei Y, Xia W, Ye X et al. The antimicrobial protein short palate, lung, and nasal epithelium clone 1 (SPLUNC1) is differentially modulated in eosinophilic and noneosinophilic chronic rhinosinusitis with nasal polyps. J Allergy Clin Immunol 2014; 133:420-8.
21. Bachert C, Zhang N, Holtappels G et al. Presence of IL-5 protein and IgE antibodies to staphylococcal enterotoxins in nasal polyps is associated with comorbid asthma. J Allergy Clin Immunol 2010; 126:962-8.
22. Kato A, Peters A, Suh L et al. Evidence of a role for B cell-activating factor of the TNF family in the pathogenesis of chronic rhinosinusitis with nasal polyps. J Allergy Clin Immunol 2008; 121:1385-92.
23. Bluestone JA, Mackay CR, O'Shea JJ et al. The functional plasticity of T cell subsets. Nat Rev Immunol 2009; 9:811-6.
24. O'Shea JJ, Paul WE. Mechanisms underlying lineage commitment and plasticity of helper CD4 + T cells. Science 2010; 327:1098-102.
25. Takhar P, Smurthwaite L, Coker HA et al. Allergen drives class switching to IgE in the nasal mucosa in allergic rhinitis. J Immunol 2005; 174:5024-32.
26. Takhar P, Corrigan CJ, Smurthwaite L et al. Class switch recombination to IgE in the bronchial mucosa of atopic and nonatopic patients with asthma. J Allergy Clin Immunol 2007; 119:213-8.
27. Tangye SG, Ma CS, Brink R et al. The good, the bad and the ugly - TFH cells in human health and disease. Nat Rev Immunol 2013; 13:412-26.
28. Holtzman MJ. Asthma as a chronic disease of the innate and adaptive immune systems responding to viruses and allergens. J Clin Invest 2012; 122:2741-8.
29. Talay O, Yan D, Brightbill HD et al. IgE+ memory B cells and plasma cells generated through a germinal-center pathway. Nat Immunol 2012; 13:396-404.
30. Cao PP, Li HB, Wang BF et al. Distinct immunopathologic characteristics of various types of chronic rhinosinusitis in adult Chinese. J Allergy Clin Immunol 2009; 124:478-84.
31. Jiang XD, Li GY, Li L et al. The characterization of IL-17A expression in patients with chronic rhinosinusitis with nasal polyps. Am J Rhinol Allergy 2011; 25:e171-5.
32. Sanz I, Wei C, Lee FE et al. Phenotypic and functional heterogeneity of human memory B cells. Semin Immunol 2008; 20:67-82.