Angiopoietin-2-induced blood–brain barrier compromise and increased stroke size are rescued by VE-PTP-dependent restoration of Tie2 signaling

Acta Neuropathologica

Volumn 131, Issue 5, 2016, Pages 753-773

  Gurnik, Stefanie ^a   Devraj, Kavi ^a   Macas, Jadranka ^a   Yamaji, Maiko ^a   Starke, Julia ^a   Scholz, Alexander ^a   Sommer, Kathleen ^a   Di Tacchio, Mariangela ^a   Vutukuri, Rajkumar ^a   Beck, Heike ^b   Mittelbronn, Michel ^a   Foerch, Christian ^a   Pfeilschifter, Waltraud ^a   Liebner, Stefan ^a   Peters, Kevin G ^d   Plate, Karl H ^a,c   Reiss, Yvonne ^a  

^a GOETHE UNIVERSITY MEDICAL SCHOOL   (Germany)

^b LUDWIG MAXIMILIANS UNIVERSITY   (Germany)

^c DZHK GERMAN CENTRE FOR CARDIOVASCULAR RESEARCH   (Germany)

^d Aerpio Therapeutics Inc   (United States)

Author keywords

Angiopoietin 2; Blood brain barrier (BBB); Endothelium; Permeability; Stroke; Tie2 signaling; Vascular endothelial protein tyrosine phosphatase (VE PTP)

Indexed keywords

ANGIOPOIETIN; ANGIOPOIETIN 2; PROTEIN TYROSINE PHOSPHATASE; UNCLASSIFIED DRUG; VASCULAR ENDOTHELIAL PROTEIN TYROSINE PHOSPHATASE; ANGIOPOIETIN RECEPTOR; NERVE PROTEIN; RECEPTOR LIKE PROTEIN TYROSINE PHOSPHATASE; TEK PROTEIN, MOUSE;

ADULT; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD BRAIN BARRIER; BLOOD VESSEL PERMEABILITY; BRAIN PERICYTE; CEREBROVASCULAR ACCIDENT; CONTROLLED STUDY; DOWN REGULATION; ELECTRON MICROSCOPY; ENDOTHELIUM CELL; GAIN OF FUNCTION MUTATION; GLYCOCALYX; HUMAN; IMMUNOHISTOCHEMISTRY; IN VITRO STUDY; IN VIVO STUDY; MOUSE; NONHUMAN; PRIORITY JOURNAL; WILD TYPE; ANIMAL; ASTROCYTE; BRAIN EDEMA; CAPILLARY PERMEABILITY; CELL CULTURE; COMPLICATION; CYTOLOGY; DISEASE MODEL; DRUG EFFECTS; ENDOTHELIUM; FEMALE; GENETICS; IMPEDANCE; MALE; METABOLISM; MICROVASCULATURE; PATHOLOGY; PERICYTE; PHYSIOLOGY; SIGNAL TRANSDUCTION; STROKE; TRANSGENIC MOUSE; ULTRASTRUCTURE;

ANGIOPOIETIN-2; ANIMALS; ASTROCYTES; BLOOD-BRAIN BARRIER; BRAIN EDEMA; CAPILLARY PERMEABILITY; CELLS, CULTURED; DISEASE MODELS, ANIMAL; ELECTRIC IMPEDANCE; ENDOTHELIUM; FEMALE; HUMANS; IN VITRO TECHNIQUES; MALE; MICE; MICE, TRANSGENIC; MICROVESSELS; NERVE TISSUE PROTEINS; PERICYTES; RECEPTOR, TIE-2; RECEPTOR-LIKE PROTEIN TYROSINE PHOSPHATASES, CLASS 3; SIGNAL TRANSDUCTION; STROKE;

EID: 84959349563     PISSN: 00016322     EISSN: 14320533     Source Type: Journal    
DOI: 10.1007/s00401-016-1551-3     Document Type: Article

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