Astrocyte-derived retinoic acid: a novel regulator of blood–brain barrier function in multiple sclerosis

Acta Neuropathologica

Volumn 128, Issue 5, 2014, Pages 691-703

  Mizee, Mark R ^a   Nijland, Philip G ^a   van der Pol, Susanne M A ^a   Drexhage, Joost A R ^a   van het Hof, Bert ^a   Mebius, Reina ^a   van der Valk, Paul ^a   van Horssen, Jack ^a   Reijerkerk, Arie ^b   de Vries, Helga E ^a  

^a VU UNIVERSITY MEDICAL CENTER   (Netherlands)

^b To BBB Technologies BV   (Netherlands)

Author keywords

Blood brain barrier; Multiple sclerosis; Reactive astrocytes; Retinoic acid

Indexed keywords

ALDEHYDE DEHYDROGENASE ISOENZYME 1; GAMMA INTERFERON; GLIAL FIBRILLARY ACIDIC PROTEIN; HEME OXYGENASE 1; INTERLEUKIN 6; MONOCYTE CHEMOTACTIC PROTEIN 1; MYELIN; PROTEIN; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE DEHYDROGENASE; RETINAL DEHYDROGENASE; RETINAL DEHYDROGENASE 1; RETINAL DEHYDROGENASE 2; RETINOIC ACID; STIMULATED BY RETINOIC ACID 6 PROTEIN; TRANSCRIPTION FACTOR NRF2; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; VASCULAR CELL ADHESION MOLECULE 1; ALDEHYDE DEHYDROGENASE; ALDH1A2 PROTEIN, HUMAN; CYTOKINE; NFE2L2 PROTEIN, HUMAN;

ANTIINFLAMMATORY ACTIVITY; ANTIOXIDANT RESPONSIVE ELEMENT; ARTICLE; ASTROCYTE; BLOOD BRAIN BARRIER; CAPILLARY ENDOTHELIAL CELL; CELL ADHESION; CELL INFILTRATION; CELLULAR DISTRIBUTION; CONTROLLED STUDY; DNA STRUCTURE; EXTRACELLULAR SPACE; FLUORESCENCE ACTIVATED CELL SORTING; GENE EXPRESSION; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; IMMUNOREACTIVITY; LEUKOCYTE ADHERENCE; MONOCYTE; MULTIPLE SCLEROSIS; NERVOUS SYSTEM INFLAMMATION; NEUROPROTECTION; OXIDATIVE STRESS; PROMOTER REGION; PROTEIN EXPRESSION; RETINOIC ACID RESPONSIVE ELEMENT; WHITE MATTER; WHITE MATTER LESION; ADULT; AGED; AUTOPSY; BRAIN; CELL CULTURE; DRUG EFFECTS; ENDOTHELIUM CELL; FEMALE; GENETICS; HEK293 CELL LINE; MALE; METABOLISM; MIDDLE AGED; PATHOLOGY; PATHOPHYSIOLOGY; PHYSIOLOGY; TIME; VERY ELDERLY;

ADULT; AGED; AGED, 80 AND OVER; ALDEHYDE DEHYDROGENASE; ASTROCYTES; AUTOPSY; BLOOD-BRAIN BARRIER; BRAIN; CELLS, CULTURED; CYTOKINES; ENDOTHELIAL CELLS; FEMALE; GLIAL FIBRILLARY ACIDIC PROTEIN; HEK293 CELLS; HUMANS; MALE; MIDDLE AGED; MULTIPLE SCLEROSIS; NF-E2-RELATED FACTOR 2; REACTIVE OXYGEN SPECIES; RETINAL DEHYDROGENASE; TIME FACTORS; TRETINOIN;

EID: 84919902901     PISSN: 00016322     EISSN: 14320533     Source Type: Journal    
DOI: 10.1007/s00401-014-1335-6     Document Type: Article

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