Disruption of Glut1 in Hematopoietic Stem Cells Prevents Myelopoiesis and Enhanced Glucose Flux in Atheromatous Plaques of ApoE -/- Mice

Circulation Research

Volumn 118, Issue 7, 2016, Pages 1062-1077

  Sarrazy, Vincent ^a   Viaud, Manon ^a   Westerterp, Marit ^b   Ivanov, Stoyan ^a   Giorgetti Peraldi, Sophie ^a   Guinamard, Rodolphe ^a   Gautier, Emmanuel L ^c,d,e   Thorp, Edward B ^f   De Vivo, Darryl C ^b   Yvan Charvet, Laurent ^a  

^a INSERM   (France)

^b Och Spine at New York Presbyterian Hospitals   (United States)

^c PITIÉ SALPÊTRIÈRE HOSPITAL   (France)

^d SORBONNE UNIVERSITÉ   (France)

^e Institute of Cardiometabolism and Nutrition (ICAN)   (France)

^f NORTHWESTERN UNIVERSITY   (United States)

Author keywords

atherosclerosis; bone marrow; cholesterol; glucose transporter type 1; glycolysis; myeloid cells

Indexed keywords

APOLIPOPROTEIN E; GLUCOSE; GLUCOSE TRANSPORTER 1; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; HYPOXIA INDUCIBLE FACTOR 1ALPHA; INTERLEUKIN 3; ALPHA-CYANO-(3,4-DIHYDROXY)-N-BENZYLCINNAMIDE; CD131 ANTIGEN; HIF1A PROTEIN, MOUSE; INTERLEUKIN 3 RECEPTOR; MESSENGER RNA; METFORMIN; SLC2A1 PROTEIN, MOUSE; TYRPHOSTIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; ATHEROSCLEROTIC PLAQUE; BETA CHAIN; BONE MARROW TRANSPLANTATION; CELL FATE; CELL METABOLISM; CELL PROLIFERATION; FLOW CYTOMETRY; GLUCOSE TRANSPORT; HEMATOPOIETIC STEM CELL; HYPERCHOLESTEROLEMIA; IN VITRO STUDY; LEUKOCYTE; MOUSE; MULTIPOTENTIAL PROGENITOR CELL; MYELOPOIESIS; NONHUMAN; PRIORITY JOURNAL; REGULATORY MECHANISM; STEM CELL; STEM CELL EXPANSION; ANIMAL; ANTAGONISTS AND INHIBITORS; BIOSYNTHESIS; C57BL MOUSE; CELL DIVISION; DEFICIENCY; DISEASE COURSE; ENERGY METABOLISM; GENE EXPRESSION REGULATION; GENETICS; GLYCOLYSIS; KNOCKOUT MOUSE; METABOLISM; MULTIPOTENT STEM CELL; PHYSIOLOGY; SPLEEN; THORACIC AORTA;

ANIMALS; AORTA, THORACIC; APOLIPOPROTEINS E; BONE MARROW TRANSPLANTATION; CELL DIVISION; CYTOKINE RECEPTOR COMMON BETA SUBUNIT; DISEASE PROGRESSION; ENERGY METABOLISM; GENE EXPRESSION REGULATION; GLUCOSE; GLUCOSE TRANSPORTER TYPE 1; GLYCOLYSIS; HEMATOPOIETIC STEM CELLS; HYPERCHOLESTEROLEMIA; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; METFORMIN; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MULTIPOTENT STEM CELLS; MYELOPOIESIS; PLAQUE, ATHEROSCLEROTIC; RECEPTORS, INTERLEUKIN-3; RNA, MESSENGER; SPLEEN; TYRPHOSTINS;

EID: 84959305758     PISSN: 00097330     EISSN: 15244571     Source Type: Journal    
DOI: 10.1161/CIRCRESAHA.115.307599     Document Type: Article

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