Splenic metabolic activity predicts risk of future cardiovascular events: Demonstration of a cardiosplenic axis in humans

JACC: Cardiovascular Imaging

Volumn 8, Issue 2, 2015, Pages 121-130

  Emami, Hamed ^a   Singh, Parmanand ^a   Macnabb, Megan ^a   Vucic, Esad ^a   Lavender, Zachary ^a   Rudd, James H F ^b   Fayad, Zahi A ^c   Lehrer Graiwer, Joshua ^d   Korsgren, Magnus ^e   Figueroa, Amparo L ^a   Fredrickson, Jill ^d   Rubin, Barry ^f   Hoffmann, Udo ^a   Truong, Quynh A ^a   Min, James K ^g   Baruch, Amos ^d   Nasir, Khurram ^h   Nahrendorf, Matthias ^a   Tawakol, Ahmed ^a  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

^b UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^c MOUNT SINAI SCHOOL OF MEDICINE   (United States)

^d GENENTECH INC   (United States)

^e BioInvent International AB   (Sweden)

^f UNIVERSITY OF TORONTO   (Canada)

^g NEW YORK PRESBYTERIAN HOSPITAL   (United States)

^h MIAMI CANCER INSTITUTE   (United States)

Author keywords

acute coronary syndrome; atherosclerosis; events; FDG; inflammation; spleen

Indexed keywords

C REACTIVE PROTEIN; CALGRANULIN B; FLUORODEOXYGLUCOSE F 18; INTERLEUKIN 1BETA; MACROPHAGE SCAVENGER RECEPTOR 1; SCAVENGER RECEPTOR; TOLL LIKE RECEPTOR 2; TUMOR NECROSIS FACTOR; UNCLASSIFIED DRUG; RADIOPHARMACEUTICAL AGENT;

ACUTE CORONARY SYNDROME; ADULT; AGED; AORTA; ARTERY WALL; ARTICLE; BONE MARROW; CARDIOVASCULAR RISK; COMPUTER ASSISTED EMISSION TOMOGRAPHY; CONTROLLED STUDY; FEMALE; FOLLOW UP; GENE EXPRESSION REGULATION; HUMAN; IMAGE ANALYSIS; LEUKOCYTE; LEUKOCYTE ACTIVATION; MAJOR CLINICAL STUDY; MALE; METABOLISM; MIDDLE AGED; PREDICTIVE VALUE; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; REAL TIME POLYMERASE CHAIN REACTION; RISK ASSESSMENT; SPLEEN FUNCTION; UPREGULATION; VASCULITIS; ARTERITIS; BLOOD VESSEL CALCIFICATION; DISEASE COURSE; MULTIMODAL IMAGING; POSITRON EMISSION TOMOGRAPHY; PROCEDURES; PROGNOSIS; PROSPECTIVE STUDY; RISK FACTOR; SCINTISCANNING; SPLEEN; TIME;

ADULT; AGED; ARTERITIS; C-REACTIVE PROTEIN; DISEASE PROGRESSION; FEMALE; FLUORODEOXYGLUCOSE F18; FOLLOW-UP STUDIES; HUMANS; MALE; MIDDLE AGED; MULTIMODAL IMAGING; POSITRON-EMISSION TOMOGRAPHY; PREDICTIVE VALUE OF TESTS; PROGNOSIS; PROSPECTIVE STUDIES; RADIOPHARMACEUTICALS; RISK ASSESSMENT; RISK FACTORS; SPLEEN; TIME FACTORS; VASCULAR CALCIFICATION;

EID: 84923108209     PISSN: 1936878X     EISSN: 18767591     Source Type: Journal    
DOI: 10.1016/j.jcmg.2014.10.009     Document Type: Article

References (28)

1. W.D. Rosamond, L.E. Chambless, and A.R. Folsom Trends in the incidence of myocardial infarction and in mortality due to coronary heart disease, 1987 to 1994 N Engl J Med 339 1998 861 867
2. J.J. Thune, J.E. Signorovitch, and L. Kober Predictors and prognostic impact of recurrent myocardial infarction in patients with left ventricular dysfunction, heart failure, or both following a first myocardial infarction Eur J Heart Fail 13 2011 148 153
3. P. Dutta, G. Courties, and Y. Wei Myocardial infarction accelerates atherosclerosis Nature 487 2012 325 329
4. F.K. Swirski, M. Nahrendorf, and M. Etzrodt Identification of splenic reservoir monocytes and their deployment to inflammatory sites Science 325 2009 612 616
5. M.A. Ismahil, T. Hamid, S.S. Bansal, B. Patel, J.R. Kingery, and S.D. Prabhu Remodeling of the mononuclear phagocyte network underlies chronic inflammation and disease progression in heart failure: critical importance of the cardiosplenic axis Circ Res 114 2014 266 282
6. C.S. Robbins, I. Hilgendorf, and G.F. Weber Local proliferation dominates lesional macrophage accumulation in atherosclerosis Nat Med 19 2013 1166 1172
7. J.H. Rudd, J. Narula, and H.W. Strauss Imaging atherosclerotic plaque inflammation by fluorodeoxyglucose with positron emission tomography: ready for prime time? J Am Coll Cardiol 55 2010 2527 2535
8. D. Lardinois, W. Weder, and T.F. Hany Staging of non-small-cell lung cancer with integrated positron-emission tomography and computed tomography N Engl J Med 348 2003 2500 2507
9. F. Jamar, J. Buscombe, and A. Chiti EANM/SNMMI guideline for 18F-FDG use in inflammation and infection J Nucl Med 54 2013 647 658
10. A. Garedew, S.O. Henderson, and S. Moncada Activated macrophages utilize glycolytic ATP to maintain mitochondrial membrane potential and prevent apoptotic cell death Cell Death Differ 17 2010 1540 1550
11. J.-C. Rodriguez-Prados, P.G. Través, and J. Cuenca Substrate fate in activated macrophages: a comparison between innate, classic, and alternative activation J Immunol 185 2010 605 614
12. T. Satomi, M. Ogawa, and I. Mori Comparison of contrast agents for atherosclerosis imaging using cultured macrophages: FDG versus ultrasmall superparamagnetic iron oxide J Nucl Med 54 2013 999 1004
13. R. Kubota, K. Kubota, S. Yamada, M. Tada, T. Ido, and N. Tamahashi Microautoradiographic study for the differentiation of intratumoral macrophages, granulation tissues and cancer cells by the dynamics of fluorine-18-fluorodeoxyglucose uptake J Nucl Med 35 1994 104 112
14. K. Higashi, Y. Ueda, and M. Yagishita FDG PET measurement of the proliferative potential of non-small cell lung cancer J Nucl Med 41 2000 85 92
15. A. Tawakol, Z.A. Fayad, and R. Mogg Intensification of statin therapy results in a rapid reduction in atherosclerotic inflammation: results of a multicenter fluorodeoxyglucose-positron emission tomography/computed tomography feasibility study J Am Coll Cardiol 62 2013 909 917
16. S. Subramanian, A. Tawakol, and T.H. Burdo Arterial inflammation in patients with HIV JAMA 308 2012 379 386
17. P. Libby Inflammation in atherosclerosis Nature 420 2002 868 874
18. S. Kempe, H. Kestler, A. Lasar, and T. Wirth NF-kappaB control subjects the global pro-inflammatory response in endothelial cells: evidence for the regulation of a pro-atherogenic program Nucleic Acids Res 33 2005 5308 5319
19. R. Virmani, A.P. Burke, A. Farb, and F.D. Kolodgie Pathology of the unstable plaque Prog Cardiovasc Dis 44 2002 349 356
20. S.A. Murphy, C.P. Cannon, S.D. Wiviott, C.H. McCabe, and E. Braunwald Reduction in recurrent cardiovascular events with intensive lipid-lowering statin therapy compared with moderate lipid-lowering statin therapy after acute coronary syndromes from the PROVE IT-TIMI 22 (Pravastatin or Atorvastatin Evaluation and Infection Therapy-Thrombolysis In Myocardial Infarction 22) trial J Am Coll Cardiol 54 2009 2358 2362
21. P. Libby, P.M. Ridker, and G.K. Hansson Progress and challenges in translating the biology of atherosclerosis Nature 473 2011 317 325
22. E.J. Kim, S. Kim, H.S. Seo, and D.O. Kang The metabolic activity of the spleen and bone marrow in patients with acute myocardial infarction evaluated by 18F-FDG PET imaging Circ Cardiovasc Imaging 7 2014 454 460
23. K. Croce, H. Gao, and Y. Wang Myeloid-related protein-8/14 is critical for the biological response to vascular injury Circulation 120 2009 427 436
24. M. Piechota, A. Banaszewska, J. Dudziak, M. Slomczynski, and R. Plewa Highly upregulated expression of CD36 and MSR1 in circulating monocytes of patients with acute coronary syndromes Protein J 31 2012 511 518
25. M.M. Averill, S. Barnhart, and L. Becker S100A9 differentially modifies phenotypic states of neutrophils, macrophages, and dendritic cells: implications for atherosclerosis and adipose tissue inflammation Circulation 123 2011 1216 1226
26. M. Blich, A. Golan, and G. Arvatz Macrophage activation by heparanase is mediated by TLR-2 and TLR-4 and associates with plaque progression Arterioscler Thromb Vasc Biol 33 2013 e56 e65
27. M.J. Pittet, M. Nahrendorf, and F.K. Swirski The journey from stem cell to macrophage Ann N Y Acad Sci 1319 2014 1 18 Review
28. A.M. van der Laan, E.N. Ter Horst, and R. Delewi Monocyte subset accumulation in the human heart following acute myocardial infarction and the role of the spleen as monocyte reservoir Eur Heart J 35 2013 376 385