Testing the Role of Myeloid Cell Glucose Flux in Inflammation and Atherosclerosis

Cell Reports

Volumn 7, Issue 2, 2014, Pages 356-365

  Nishizawa, Tomohiro ^a,f   Kanter, Jenny E ^a   Kramer, Farah ^a   Barnhart, Shelley ^a   Shen, Xia ^a   Vivekanandan Giri, Anuradha ^c   Wall, Valerie Z ^a   Kowitz, Jason ^a   Devaraj, Sridevi ^d,e   O'Brien, Kevin D ^a   Pennathur, Subramaniam ^c   Tang, Jingjing ^a   Miyaoka, Robert S ^b   Raines, Elaine W ^a   Bornfeldt, Karin E ^a  

^a UNIVERSITY OF WASHINGTON   (United States)

^b UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

^c UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

^d BAYLOR COLLEGE OF MEDICINE   (United States)

^e TEXAS CHILDREN S HOSPITAL   (United States)

^f DAIICHI SANKYO CO   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

GLUCOSE TRANSPORTER 1; INTERLEUKIN 6; LONG CHAIN FATTY ACID COENZYME A LIGASE; MESSENGER RNA; TUMOR NECROSIS FACTOR ALPHA; CYTOKINE; GLUCOSE; LOW DENSITY LIPOPROTEIN RECEPTOR; SLC2A1 PROTEIN, MOUSE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; ATHEROSCLEROSIS; BONE MARROW CELL; CELL ACTIVATION; CELL PROLIFERATION; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOKINE RELEASE; ENDOPLASMIC RETICULUM STRESS; FATTY ACID OXIDATION; GLUCOSE TRANSPORT; GLYCOLYSIS; IMMUNOREACTIVITY; INFLAMMATION; MACROPHAGE; MONOCYTE; MOUSE; NEUTROPHIL; NONHUMAN; PERITONEUM MACROPHAGE; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; UPREGULATION; ACTIVE TRANSPORT; ANIMAL; GENETICS; METABOLISM; PENTOSE PHOSPHATE CYCLE;

ANIMALS; ATHEROSCLEROSIS; BIOLOGICAL TRANSPORT, ACTIVE; CYTOKINES; GLUCOSE; GLUCOSE TRANSPORTER TYPE 1; GLYCOLYSIS; INFLAMMATION; MICE; MYELOID CELLS; PENTOSE PHOSPHATE PATHWAY; RECEPTORS, LDL;

EID: 84899649118     PISSN: None     EISSN: 22111247     Source Type: Journal    
DOI: 10.1016/j.celrep.2014.03.028     Document Type: Article

References (20)

1. Adhikari N., Basi D.L., Carlson M., Mariash A., Hong Z., Lehman U., Mullegama S., Weir E.K., Hall J.L. Increase in GLUT1 in smooth muscle alters vascular contractility and increases inflammation in response to vascular injury. Arterioscler. Thromb. Vasc. Biol. 2011, 31:86-94.
2. Bornfeldt K.E., Tabas I. Insulin resistance, hyperglycemia, and atherosclerosis. Cell Metab. 2011, 14:575-585.
3. Brown A., Reynolds L.R., Bruemmer D. Intensive glycemic control and cardiovascular disease: an update. Nat. Rev. Cardiol. 2010, 7:369-375.
4. Cline G.W., Jucker B.M., Trajanoski Z., Rennings A.J., Shulman G.I. A novel 13C NMR method to assess intracellular glucose concentration in muscle, invivo. Am. J. Physiol. 1998, 274:E381-E389.
5. Everts B., Amiel E., van der Windt G.J., Freitas T.C., Chott R., Yarasheski K.E., Pearce E.L., Pearce E.J. Commitment to glycolysis sustains survival of NO-producing inflammatory dendritic cells. Blood 2012, 120:1422-1431.
6. Freemerman A.J., Johnson A.R., Sacks G.N., Milner J.J., Kirk E.L., Troester M.A., Macintyre A.N., Goraksha-Hicks P., Rathmell J.C., Makowski L. Metabolic reprogramming of macrophages: glucose transporter (GLUT1)-mediated glucose metabolism drives a pro- inflammatory phenotype. J.Biol. Chem. 2014, 289:7884-7896.
7. Gautier E.L., Westerterp M., Bhagwat N., Cremers S., Shih A., Abdel-Wahab O., Lütjohann D., Randolph G.J., Levine R.L., Tall A.R., Yvan-Charvet L. HDL and Glut1 inhibition reverse a hypermetabolic state in mouse models of myeloproliferative disorders. J.Exp. Med. 2013, 210:339-353.
8. Gough P.J., Raines E.W. Gene therapy of apolipoprotein E-deficient mice using a novel macrophage-specific retroviral vector. Blood 2003, 101:485-491.
9. Haschemi A., Kosma P., Gille L., Evans C.R., Burant C.F., Starkl P., Knapp B., Haas R., Schmid J.A., Jandl C., et al. The sedoheptulose kinase CARKL directs macrophage polarization through control of glucose metabolism. Cell Metab. 2012, 15:813-826.
10. Kanter J.E., Kramer F., Barnhart S., Averill M.M., Vivekanandan-Giri A., Vickery T., Li L.O., Becker L., Yuan W., Chait A., et al. Diabetes promotes an inflammatory macrophage phenotype and atherosclerosis through acyl-CoA synthetase 1. Proc. Natl. Acad. Sci. USA 2012, 109:E715-E724.
11. Krawczyk C.M., Holowka T., Sun J., Blagih J., Amiel E., DeBerardinis R.J., Cross J.R., Jung E., Thompson C.B., Jones R.G., Pearce E.J. Toll-like receptor-induced changes in glycolytic metabolism regulate dendritic cell activation. Blood 2010, 115:4742-4749.
12. Manolescu A.R., Witkowska K., Kinnaird A., Cessford T., Cheeseman C. Facilitated hexose transporters: new perspectives on form and function. Physiology (Bethesda) 2007, 22:234-240.
13. Nagareddy P.R., Murphy A.J., Stirzaker R.A., Hu Y., Yu S., Miller R.G., Ramkhelawon B., Distel E., Westerterp M., Huang L.S., et al. Hyperglycemia promotes myelopoiesis and impairs the resolution of atherosclerosis. Cell Metab. 2013, 17:695-708.
14. Nishizawa T., Bornfeldt K.E. Diabetic vascular disease and the potential role of macrophage glucose metabolism. Ann. Med. 2012, 44:555-563.
15. O'Neill L.A., Hardie D.G. Metabolism of inflammation limited by AMPK and pseudo-starvation. Nature 2013, 493:346-355.
16. Renard C.B., Kramer F., Johansson F., Lamharzi N., Tannock L.R., von Herrath M.G., Chait A., Bornfeldt K.E. Diabetes and diabetes-associated lipid abnormalities have distinct effects on initiation and progression of atherosclerotic lesions. J.Clin. Invest. 2004, 114:659-668.
17. Ruiz-García A., Monsalve E., Novellasdemunt L., Navarro-Sabaté A., Manzano A., Rivero S., Castrillo A., Casado M., Laborda J., Bartrons R., Díaz-Guerra M.J. Cooperation of adenosine with macrophage Toll-4 receptor agonists leads to increased glycolytic flux through the enhanced expression of PFKFB3 gene. J.Biol. Chem. 2011, 286:19247-19258.
18. Tannahill G.M., Curtis A.M., Adamik J., Palsson-McDermott E.M., McGettrick A.F., Goel G., Frezza C., Bernard N.J., Kelly B., Foley N.H., et al. Succinate is an inflammatory signal that induces IL-1β through HIF-1α. Nature 2013, 496:238-242.
19. Tsuruda T., Hatakeyama K., Nagamachi S., Sekita Y., Sakamoto S., Endo G.J., Nishimura M., Matsuyama M., Yoshimura K., Sato Y., et al. Inhibition of development of abdominal aortic aneurysm by glycolysis restriction. Arterioscler. Thromb. Vasc. Biol. 2012, 32:1410-1417.
20. Vats D., Mukundan L., Odegaard J.I., Zhang L., Smith K.L., Morel C.R., Wagner R.A., Greaves D.R., Murray P.J., Chawla A. Oxidative metabolism and PGC-1beta attenuate macrophage-mediated inflammation. Cell Metab. 2006, 4:13-24.