메뉴 건너뛰기




Volumn 13, Issue 1, 2016, Pages

High-fructose and high-fat diet-induced disorders in rats: Impact on diabetes risk, hepatic and vascular complications

Author keywords

Endothelial dysfunction; Hepatic complications; High fat high fructose diet; Metabolic syndrome; Oxidative stress; Type 2 diabetes; Vascular complications

Indexed keywords

C PEPTIDE; CHOLESTEROL; LEPTIN; REACTIVE OXYGEN METABOLITE;

EID: 84959249502     PISSN: None     EISSN: 17437075     Source Type: Journal    
DOI: 10.1186/s12986-016-0074-1     Document Type: Article
Times cited : (257)

References (62)
  • 1
    • 79960202841 scopus 로고    scopus 로고
    • Type 2 diabetes across generations: from pathophysiology to prevention and management
    • Nolan CJ, Damm P, Prentki M. Type 2 diabetes across generations: from pathophysiology to prevention and management. Lancet. 2011;378(9786):169-81.
    • (2011) Lancet , vol.378 , Issue.9786 , pp. 169-181
    • Nolan, C.J.1    Damm, P.2    Prentki, M.3
  • 2
    • 84889099226 scopus 로고    scopus 로고
    • Genetic and epigenetic control of metabolic health
    • Schwenk RW, Vogel H, Schurmann A. Genetic and epigenetic control of metabolic health. Mol Metab. 2013;2(4):337-47.
    • (2013) Mol Metab , vol.2 , Issue.4 , pp. 337-347
    • Schwenk, R.W.1    Vogel, H.2    Schurmann, A.3
  • 3
    • 0034794325 scopus 로고    scopus 로고
    • Intrauterine diabetic environment confers risks for type 2 diabetes mellitus and obesity in the offspring, in addition to genetic susceptibility
    • Dabelea D, Pettitt DJ. Intrauterine diabetic environment confers risks for type 2 diabetes mellitus and obesity in the offspring, in addition to genetic susceptibility. J Pediatr Endocrinol Metab. 2001;14(8):1085-91.
    • (2001) J Pediatr Endocrinol Metab , vol.14 , Issue.8 , pp. 1085-1091
    • Dabelea, D.1    Pettitt, D.J.2
  • 4
    • 0033960379 scopus 로고    scopus 로고
    • Dietary glycemic index and obesity
    • Ludwig DS. Dietary glycemic index and obesity. J Nutr. 2000;130(2S Suppl):280S-3S.
    • (2000) J Nutr , vol.130 , pp. 280S-283S
    • Ludwig, D.S.1
  • 5
    • 75149166672 scopus 로고    scopus 로고
    • Metabolic effects of fructose and the worldwide increase in obesity
    • Tappy L, Le KA. Metabolic effects of fructose and the worldwide increase in obesity. Physiol Rev. 2010;90(1):23-46.
    • (2010) Physiol Rev , vol.90 , Issue.1 , pp. 23-46
    • Tappy, L.1    Le, K.A.2
  • 7
    • 77649216849 scopus 로고    scopus 로고
    • Is sugar consumption detrimental to health? A review of the evidence 1995-2006
    • Ruxton CH, Gardner EJ, McNulty HM. Is sugar consumption detrimental to health? A review of the evidence 1995-2006. Crit Rev Food Sci Nutr. 2010;50(1):1-19.
    • (2010) Crit Rev Food Sci Nutr , vol.50 , Issue.1 , pp. 1-19
    • Ruxton, C.H.1    Gardner, E.J.2    McNulty, H.M.3
  • 9
    • 78349283092 scopus 로고    scopus 로고
    • Fructose: A highly lipogenic nutrient implicated in insulin resistance, hepatic steatosis, and the metabolic syndrome
    • Dekker MJ, Su Q, Baker C, Rutledge AC, Adeli K. Fructose: A highly lipogenic nutrient implicated in insulin resistance, hepatic steatosis, and the metabolic syndrome. Am J Physiol Endocrinol Metab. 2010;299(5):E685-94.
    • (2010) Am J Physiol Endocrinol Metab , vol.299 , Issue.5 , pp. E685-E694
    • Dekker, M.J.1    Su, Q.2    Baker, C.3    Rutledge, A.C.4    Adeli, K.5
  • 10
    • 0346220398 scopus 로고    scopus 로고
    • Prevention of fructose-induced hypertension by dietary vitamins
    • Vasdev S, Longerich L, Gill V. Prevention of fructose-induced hypertension by dietary vitamins. Clin Biochem. 2004;37(1):1-9.
    • (2004) Clin Biochem , vol.37 , Issue.1 , pp. 1-9
    • Vasdev, S.1    Longerich, L.2    Gill, V.3
  • 11
    • 84874524849 scopus 로고    scopus 로고
    • The relationship of sugar to population-level diabetes prevalence: An econometric analysis of repeated cross-sectional data
    • Basu S, Yoffe P, Hills N, Lustig RH. The relationship of sugar to population-level diabetes prevalence: An econometric analysis of repeated cross-sectional data. PLoS One. 2013;8(2):e57873.
    • (2013) PLoS One , vol.8 , Issue.2 , pp. e57873
    • Basu, S.1    Yoffe, P.2    Hills, N.3    Lustig, R.H.4
  • 12
    • 0036514133 scopus 로고    scopus 로고
    • Dietary fat and meat intake in relation to risk of type 2 diabetes in men
    • van Dam RM, Willett WC, Rimm EB, Stampfer MJ, Hu FB. Dietary fat and meat intake in relation to risk of type 2 diabetes in men. Diabetes Care. 2002;25(3):417-24.
    • (2002) Diabetes Care , vol.25 , Issue.3 , pp. 417-424
    • Van Dam, R.M.1    Willett, W.C.2    Rimm, E.B.3    Stampfer, M.J.4    Hu, F.B.5
  • 15
    • 65449156905 scopus 로고    scopus 로고
    • NAFLD as a risk factor for the development of diabetes and the metabolic syndrome: An eleven-year follow-up study
    • Adams LA, Waters OR, Knuiman MW, Elliott RR, Olynyk JK. NAFLD as a risk factor for the development of diabetes and the metabolic syndrome: An eleven-year follow-up study. Am J Gastroenterol. 2009;104(4):861-7.
    • (2009) Am J Gastroenterol , vol.104 , Issue.4 , pp. 861-867
    • Adams, L.A.1    Waters, O.R.2    Knuiman, M.W.3    Elliott, R.R.4    Olynyk, J.K.5
  • 16
    • 53549112749 scopus 로고    scopus 로고
    • Increased risk of cardiovascular disease in non-alcoholic fatty liver disease: Causal effect or epiphenomenon?
    • Targher G, Marra F, Marchesini G. Increased risk of cardiovascular disease in non-alcoholic fatty liver disease: causal effect or epiphenomenon? Diabetologia. 2008;51(11):1947-53.
    • (2008) Diabetologia , vol.51 , Issue.11 , pp. 1947-1953
    • Targher, G.1    Marra, F.2    Marchesini, G.3
  • 17
    • 4043077961 scopus 로고    scopus 로고
    • Molecular mediators of hepatic steatosis and liver injury
    • Browning JD, Horton JD. Molecular mediators of hepatic steatosis and liver injury. J Clin Invest. 2004;114(2):147-52.
    • (2004) J Clin Invest , vol.114 , Issue.2 , pp. 147-152
    • Browning, J.D.1    Horton, J.D.2
  • 18
    • 84885911965 scopus 로고    scopus 로고
    • Multiple hits, including oxidative stress, as pathogenesis and treatment target in non-alcoholic steatohepatitis (NASH)
    • Takaki A, Kawai D, Yamamoto K. Multiple hits, including oxidative stress, as pathogenesis and treatment target in non-alcoholic steatohepatitis (NASH). Int J Mol Sci. 2013;14(10):20704-28.
    • (2013) Int J Mol Sci , vol.14 , Issue.10 , pp. 20704-20728
    • Takaki, A.1    Kawai, D.2    Yamamoto, K.3
  • 19
    • 0036086130 scopus 로고    scopus 로고
    • Free radicals in the physiological control of cell function
    • Droge W. Free radicals in the physiological control of cell function. Physiol Rev. 2002;82(1):47-95.
    • (2002) Physiol Rev , vol.82 , Issue.1 , pp. 47-95
    • Droge, W.1
  • 21
    • 78651377497 scopus 로고    scopus 로고
    • Chronic intake of red wine polyphenols by young rats prevents aging-induced endothelial dysfunction and decline in physical performance: Role of NADPH oxidase
    • Dal-Ros S, Zoll J, Lang AL, Auger C, Keller N, Bronner C, et al. Chronic intake of red wine polyphenols by young rats prevents aging-induced endothelial dysfunction and decline in physical performance: role of NADPH oxidase. Biochem Biophys Res Commun. 2011;404(2):743-9.
    • (2011) Biochem Biophys Res Commun , vol.404 , Issue.2 , pp. 743-749
    • Dal-Ros, S.1    Zoll, J.2    Lang, A.L.3    Auger, C.4    Keller, N.5    Bronner, C.6
  • 22
    • 28844461131 scopus 로고    scopus 로고
    • Proposed mechanisms for the induction of insulin resistance by oxidative stress
    • Bloch-Damti A, Bashan N. Proposed mechanisms for the induction of insulin resistance by oxidative stress. Antioxid Redox Signal. 2005;7(11-12):1553-67.
    • (2005) Antioxid Redox Signal , vol.7 , Issue.11-12 , pp. 1553-1567
    • Bloch-Damti, A.1    Bashan, N.2
  • 23
    • 58549094758 scopus 로고    scopus 로고
    • The pathologic continuum of diabetic vascular disease
    • Orasanu G, Plutzky J. The pathologic continuum of diabetic vascular disease. J Am Coll Cardiol. 2009;53(5 Suppl):S35-42.
    • (2009) J Am Coll Cardiol , vol.53 , pp. S35-42
    • Orasanu, G.1    Plutzky, J.2
  • 24
    • 84884324699 scopus 로고    scopus 로고
    • Endothelial dysfunction - A major mediator of diabetic vascular disease
    • Sena CM, Pereira AM, Seica R. Endothelial dysfunction - a major mediator of diabetic vascular disease. Biochim Biophys Acta. 2013;1832(12):2216-31.
    • (2013) Biochim Biophys Acta , vol.1832 , Issue.12 , pp. 2216-2231
    • Sena, C.M.1    Pereira, A.M.2    Seica, R.3
  • 25
    • 85047682948 scopus 로고    scopus 로고
    • Experimental rodent models of type 2 diabetes: A review
    • Islam MS, du Loots T. Experimental rodent models of type 2 diabetes: A review. Methods Find Exp Clin Pharmacol. 2009;31(4):249-61.
    • (2009) Methods Find Exp Clin Pharmacol , vol.31 , Issue.4 , pp. 249-261
    • Islam, M.S.1    Du Loots, T.2
  • 26
    • 0012877095 scopus 로고    scopus 로고
    • Genetic models for non insulin dependent diabetes mellitus in rodents
    • Kim JH, Nishina PM, Naggert JK. Genetic models for non insulin dependent diabetes mellitus in rodents. J Basic Clin Physiol Pharmacol. 1998;9(2-4):325-45.
    • (1998) J Basic Clin Physiol Pharmacol , vol.9 , Issue.2-4 , pp. 325-345
    • Kim, J.H.1    Nishina, P.M.2    Naggert, J.K.3
  • 27
    • 0036128120 scopus 로고    scopus 로고
    • Early events involved in the development of insulin resistance in Zucker fatty rat
    • Liu RH, Mizuta M, Kurose T, Matsukura S. Early events involved in the development of insulin resistance in Zucker fatty rat. Int J Obes Relat Metab Disord. 2002;26(3):318-26.
    • (2002) Int J Obes Relat Metab Disord , vol.26 , Issue.3 , pp. 318-326
    • Liu, R.H.1    Mizuta, M.2    Kurose, T.3    Matsukura, S.4
  • 29
    • 37549029242 scopus 로고    scopus 로고
    • The mechanisms of alloxan- and streptozotocin-induced diabetes
    • Lenzen S. The mechanisms of alloxan- and streptozotocin-induced diabetes. Diabetologia. 2008;51(2):216-26.
    • (2008) Diabetologia , vol.51 , Issue.2 , pp. 216-226
    • Lenzen, S.1
  • 33
    • 20044374023 scopus 로고    scopus 로고
    • Design and validation of a histological scoring system for nonalcoholic fatty liver disease
    • Kleiner DE, Brunt EM, Van Natta M, Behling C, Contos MJ, Cummings OW, et al. Design and validation of a histological scoring system for nonalcoholic fatty liver disease. Hepatology. 2005;41(6):1313-21.
    • (2005) Hepatology , vol.41 , Issue.6 , pp. 1313-1321
    • Kleiner, D.E.1    Brunt, E.M.2    Van Natta, M.3    Behling, C.4    Contos, M.J.5    Cummings, O.W.6
  • 35
    • 85031972600 scopus 로고    scopus 로고
    • Oxidative stress status and liver tissue defenses in diabetic rats during intensive subcutaneous insulin therapy
    • Dal S, Jeandidier N, Seyfritz E, Bietiger W, Peronet C, Moreau F, et al. Oxidative stress status and liver tissue defenses in diabetic rats during intensive subcutaneous insulin therapy. Exp Biol Med. 2015.
    • (2015) Exp Biol Med.
    • Dal, S.1    Jeandidier, N.2    Seyfritz, E.3    Bietiger, W.4    Peronet, C.5    Moreau, F.6
  • 36
    • 0017184389 scopus 로고
    • A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding
    • Bradford MM. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem. 1976;72:248-54.
    • (1976) Anal Biochem , vol.72 , pp. 248-254
    • Bradford, M.M.1
  • 37
    • 84867007389 scopus 로고    scopus 로고
    • Regulation of adipose differentiation by fructose and GluT5
    • Du L, Heaney AP. Regulation of adipose differentiation by fructose and GluT5. Mol Endocrinol. 2012;26(10):1773-82.
    • (2012) Mol Endocrinol , vol.26 , Issue.10 , pp. 1773-1782
    • Du, L.1    Heaney, A.P.2
  • 38
    • 21344443664 scopus 로고    scopus 로고
    • Effect of fructose overfeeding and fish oil administration on hepatic de novo lipogenesis and insulin sensitivity in healthy men
    • Faeh D, Minehira K, Schwarz JM, Periasamy R, Park S, Tappy L. Effect of fructose overfeeding and fish oil administration on hepatic de novo lipogenesis and insulin sensitivity in healthy men. Diabetes. 2005;54(7):1907-13.
    • (2005) Diabetes , vol.54 , Issue.7 , pp. 1907-1913
    • Faeh, D.1    Minehira, K.2    Schwarz, J.M.3    Periasamy, R.4    Park, S.5    Tappy, L.6
  • 39
    • 33845482041 scopus 로고    scopus 로고
    • A 4-wk high-fructose diet alters lipid metabolism without affecting insulin sensitivity or ectopic lipids in healthy humans
    • Le KA, Faeh D, Stettler R, Ith M, Kreis R, Vermathen P, et al. A 4-wk high-fructose diet alters lipid metabolism without affecting insulin sensitivity or ectopic lipids in healthy humans. Am J Clin Nutr. 2006;84(6):1374-9.
    • (2006) Am J Clin Nutr , vol.84 , Issue.6 , pp. 1374-1379
    • Le, K.A.1    Faeh, D.2    Stettler, R.3    Ith, M.4    Kreis, R.5    Vermathen, P.6
  • 40
    • 78649670076 scopus 로고    scopus 로고
    • Chronic consumption of a high-fat/high-fructose diet renders the liver incapable of net hepatic glucose uptake
    • Coate KC, Scott M, Farmer B, Moore MC, Smith M, Roop J, et al. Chronic consumption of a high-fat/high-fructose diet renders the liver incapable of net hepatic glucose uptake. Am J Physiol Endocrinol Metab. 2010;299(6):E887-98.
    • (2010) Am J Physiol Endocrinol Metab , vol.299 , Issue.6 , pp. E887-E898
    • Coate, K.C.1    Scott, M.2    Farmer, B.3    Moore, M.C.4    Smith, M.5    Roop, J.6
  • 41
    • 84879474902 scopus 로고    scopus 로고
    • Fructose in perspective
    • Feinman RD, Fine EJ. Fructose in perspective. Nutr Metab. 2013;10(1):45.
    • (2013) Nutr Metab , vol.10 , Issue.1 , pp. 45
    • Feinman, R.D.1    Fine, E.J.2
  • 42
    • 42749092583 scopus 로고    scopus 로고
    • Dietary fructose induces a wide range of genes with distinct shift in carbohydrate and lipid metabolism in fed and fasted rat liver
    • Koo HY, Wallig MA, Chung BH, Nara TY, Cho BH, Nakamura MT. Dietary fructose induces a wide range of genes with distinct shift in carbohydrate and lipid metabolism in fed and fasted rat liver. Biochim Biophys Acta. 2008;1782(5):341-8.
    • (2008) Biochim Biophys Acta , vol.1782 , Issue.5 , pp. 341-348
    • Koo, H.Y.1    Wallig, M.A.2    Chung, B.H.3    Nara, T.Y.4    Cho, B.H.5    Nakamura, M.T.6
  • 43
    • 84928211440 scopus 로고    scopus 로고
    • Liver glycogen reduces food intake and attenuates obesity in a high-fat diet-fed mouse model
    • Lopez-Soldado I, Zafra D, Duran J, Adrover A, Calbo J, Guinovart JJ. Liver glycogen reduces food intake and attenuates obesity in a high-fat diet-fed mouse model. Diabetes. 2015;64(3):796-807.
    • (2015) Diabetes , vol.64 , Issue.3 , pp. 796-807
    • Lopez-Soldado, I.1    Zafra, D.2    Duran, J.3    Adrover, A.4    Calbo, J.5    Guinovart, J.J.6
  • 44
    • 80054121137 scopus 로고    scopus 로고
    • Restoration of hepatic glycogen deposition reduces hyperglycaemia, hyperphagia and gluconeogenic enzymes in a streptozotocin-induced model of diabetes in rats
    • Ros S, Garcia-Rocha M, Calbo J, Guinovart JJ. Restoration of hepatic glycogen deposition reduces hyperglycaemia, hyperphagia and gluconeogenic enzymes in a streptozotocin-induced model of diabetes in rats. Diabetologia. 2011;54(10):2639-48.
    • (2011) Diabetologia , vol.54 , Issue.10 , pp. 2639-2648
    • Ros, S.1    Garcia-Rocha, M.2    Calbo, J.3    Guinovart, J.J.4
  • 45
    • 84867360556 scopus 로고    scopus 로고
    • Apocynin administration prevents the changes induced by a fructose-rich diet on rat liver metabolism and the antioxidant system
    • Castro MC, Francini F, Schinella G, Caldiz CI, Zubiria MG, Gagliardino JJ, et al. Apocynin administration prevents the changes induced by a fructose-rich diet on rat liver metabolism and the antioxidant system. Clin Sci. 2012;123(12):681-92.
    • (2012) Clin Sci , vol.123 , Issue.12 , pp. 681-692
    • Castro, M.C.1    Francini, F.2    Schinella, G.3    Caldiz, C.I.4    Zubiria, M.G.5    Gagliardino, J.J.6
  • 46
    • 27144450970 scopus 로고    scopus 로고
    • Insulin-sensitive protein kinases (atypical protein kinase C and protein kinase B/Akt): Actions and defects in obesity and type II diabetes
    • Farese RV, Sajan MP, Standaert ML. Insulin-sensitive protein kinases (atypical protein kinase C and protein kinase B/Akt): Actions and defects in obesity and type II diabetes. Exp Biol Med. 2005;230(9):593-605.
    • (2005) Exp Biol Med , vol.230 , Issue.9 , pp. 593-605
    • Farese, R.V.1    Sajan, M.P.2    Standaert, M.L.3
  • 47
    • 84896722464 scopus 로고    scopus 로고
    • Adaptive immune responses triggered by oxidative stress contribute to hepatic inflammation in NASH
    • Sutti S, Jindal A, Locatelli I, Vacchiano M, Gigliotti L, Bozzola C, et al. Adaptive immune responses triggered by oxidative stress contribute to hepatic inflammation in NASH. Hepatology. 2014;59(3):886-97.
    • (2014) Hepatology , vol.59 , Issue.3 , pp. 886-897
    • Sutti, S.1    Jindal, A.2    Locatelli, I.3    Vacchiano, M.4    Gigliotti, L.5    Bozzola, C.6
  • 48
  • 50
    • 0031947715 scopus 로고    scopus 로고
    • Steatohepatitis: A tale of two "hits"?
    • Day CP, James OF. Steatohepatitis: A tale of two "hits"? Gastroenterology. 1998;114(4):842-5.
    • (1998) Gastroenterology , vol.114 , Issue.4 , pp. 842-845
    • Day, C.P.1    James, O.F.2
  • 51
    • 0000284744 scopus 로고
    • Protective mechanism against reactive oxygen species
    • I.M. Arias J.L. Boyer Fausto W.B. Jakoby D.A. Schachter D.A. Shafritz (eds) Raven Press, Ltd New York
    • Masayasu I. Protective mechanism against reactive oxygen species. In: Arias IM, Boyer JL, Fausto, Jakoby WB, Schachter DA, Shafritz DA, editors. The liver: Biology and Pathobiology. New York: Raven Press, Ltd; 1994. p. 443-59.
    • (1994) The Liver: Biology and Pathobiology , pp. 443-459
    • Masayasu, I.1
  • 52
    • 33645745733 scopus 로고    scopus 로고
    • Activation of oxidative stress by acute glucose fluctuations compared with sustained chronic hyperglycemia in patients with type 2 diabetes
    • Monnier L, Mas E, Ginet C, Michel F, Villon L, Cristol JP, et al. Activation of oxidative stress by acute glucose fluctuations compared with sustained chronic hyperglycemia in patients with type 2 diabetes. JAMA. 2006;295(14):1681-7.
    • (2006) JAMA , vol.295 , Issue.14 , pp. 1681-1687
    • Monnier, L.1    Mas, E.2    Ginet, C.3    Michel, F.4    Villon, L.5    Cristol, J.P.6
  • 53
    • 0034733746 scopus 로고    scopus 로고
    • Ethanol and arachidonic acid increase alpha 2(I) collagen expression in rat hepatic stellate cells overexpressing cytochrome P450 2E1. Role of H2O2 and cyclooxygenase-2
    • Nieto N, Greenwel P, Friedman SL, Zhang F, Dannenberg AJ, Cederbaum AI. Ethanol and arachidonic acid increase alpha 2(I) collagen expression in rat hepatic stellate cells overexpressing cytochrome P450 2E1. Role of H2O2 and cyclooxygenase-2. J Biol Chem. 2000;275(26):20136-45.
    • (2000) J Biol Chem , vol.275 , Issue.26 , pp. 20136-20145
    • Nieto, N.1    Greenwel, P.2    Friedman, S.L.3    Zhang, F.4    Dannenberg, A.J.5    Cederbaum, A.I.6
  • 54
    • 77951632831 scopus 로고    scopus 로고
    • Mitochondrial dysfunction precedes insulin resistance and hepatic steatosis and contributes to the natural history of non-alcoholic fatty liver disease in an obese rodent model
    • Rector RS, Thyfault JP, Uptergrove GM, Morris EM, Naples SP, Borengasser SJ, et al. Mitochondrial dysfunction precedes insulin resistance and hepatic steatosis and contributes to the natural history of non-alcoholic fatty liver disease in an obese rodent model. J Hepatol. 2010;52(5):727-36.
    • (2010) J Hepatol , vol.52 , Issue.5 , pp. 727-736
    • Rector, R.S.1    Thyfault, J.P.2    Uptergrove, G.M.3    Morris, E.M.4    Naples, S.P.5    Borengasser, S.J.6
  • 55
    • 67649170396 scopus 로고    scopus 로고
    • Nonalcoholic fatty liver disease as a contributor to hypercoagulation and thrombophilia in the metabolic syndrome
    • Targher G, Chonchol M, Miele L, Zoppini G, Pichiri I, Muggeo M. Nonalcoholic fatty liver disease as a contributor to hypercoagulation and thrombophilia in the metabolic syndrome. Semin Thromb Hemost. 2009;35(3):277-87.
    • (2009) Semin Thromb Hemost , vol.35 , Issue.3 , pp. 277-287
    • Targher, G.1    Chonchol, M.2    Miele, L.3    Zoppini, G.4    Pichiri, I.5    Muggeo, M.6
  • 56
    • 77956386834 scopus 로고    scopus 로고
    • Reactive oxygen-derived free radicals are key to the endothelial dysfunction of diabetes
    • Shi Y, Vanhoutte PM. Reactive oxygen-derived free radicals are key to the endothelial dysfunction of diabetes. J Diabetes. 2009;1(3):151-62.
    • (2009) J Diabetes , vol.1 , Issue.3 , pp. 151-162
    • Shi, Y.1    Vanhoutte, P.M.2
  • 57
    • 0032867409 scopus 로고    scopus 로고
    • Body fat distribution predicts the degree of endothelial dysfunction in uncomplicated obesity
    • Arcaro G, Zamboni M, Rossi L, Turcato E, Covi G, Armellini F, et al. Body fat distribution predicts the degree of endothelial dysfunction in uncomplicated obesity. Int J Obes Relat Metab Disord. 1999;23(9):936-42.
    • (1999) Int J Obes Relat Metab Disord , vol.23 , Issue.9 , pp. 936-942
    • Arcaro, G.1    Zamboni, M.2    Rossi, L.3    Turcato, E.4    Covi, G.5    Armellini, F.6
  • 59
    • 0029977757 scopus 로고    scopus 로고
    • Obesity/insulin resistance is associated with endothelial dysfunction. Implications for the syndrome of insulin resistance
    • Steinberg HO, Chaker H, Leaming R, Johnson A, Brechtel G, Baron AD. Obesity/insulin resistance is associated with endothelial dysfunction. Implications for the syndrome of insulin resistance. J Clin Invest. 1996;97(11):2601-10.
    • (1996) J Clin Invest , vol.97 , Issue.11 , pp. 2601-2610
    • Steinberg, H.O.1    Chaker, H.2    Leaming, R.3    Johnson, A.4    Brechtel, G.5    Baron, A.D.6
  • 60
    • 0242349764 scopus 로고    scopus 로고
    • Oxidative stress and cardiovascular injury: Part II: Animal and human studies
    • Griendling KK, FitzGerald GA. Oxidative stress and cardiovascular injury: Part II: Animal and human studies. Circulation. 2003;108(17):2034-40.
    • (2003) Circulation , vol.108 , Issue.17 , pp. 2034-2040
    • Griendling, K.K.1    FitzGerald, G.A.2
  • 61
    • 0034016962 scopus 로고    scopus 로고
    • Endothelial dysfunction as a possible link between C-reactive protein levels and cardiovascular disease
    • Cleland SJ, Sattar N, Petrie JR, Forouhi NG, Elliott HL, Connell JM. Endothelial dysfunction as a possible link between C-reactive protein levels and cardiovascular disease. Clin Sci. 2000;98(5):531-5.
    • (2000) Clin Sci , vol.98 , Issue.5 , pp. 531-535
    • Cleland, S.J.1    Sattar, N.2    Petrie, J.R.3    Forouhi, N.G.4    Elliott, H.L.5    Connell, J.M.6
  • 62
    • 83655172387 scopus 로고    scopus 로고
    • The link between metabolic abnormalities and endothelial dysfunction in type 2 diabetes: An update
    • Zhang H, Dellsperger KC, Zhang C. The link between metabolic abnormalities and endothelial dysfunction in type 2 diabetes: An update. Basic Res Cardiol. 2012;107(1):237.
    • (2012) Basic Res Cardiol , vol.107 , Issue.1 , pp. 237
    • Zhang, H.1    Dellsperger, K.C.2    Zhang, C.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.