A critical role for alternative polyadenylation factor CPSF6 in targeting HIV-1 integration to transcriptionally active chromatin

Proceedings of the National Academy of Sciences of the United States of America

Volumn 113, Issue 8, 2016, Pages E1054-E1063

  Sowd, Gregory A ^a   Serrao, Erik ^a   Wang, Hao ^a   Wang, Weifeng ^a   Fadel, Hind J ^b   Poeschla, Eric M ^c   Engelman, Alan N ^a  

^a DANA FARBER CANCER INSTITUTE   (United States)

^b MAYO CLINIC   (United States)

^c UNIVERSITY OF COLORADO SCHOOL OF MEDICINE   (United States)

Author keywords

CFIm68; CPSF6; HIV 1; Integration; LEDGF

Indexed keywords

CLEAVAGE AND POLYADENYLATION SPECIFICITY FACTOR; CLEAVAGE AND POLYADENYLATION SPECIFICITY FACTOR 6; HISTONE; INTEGRASE; LENS EPITHELIUM DERIVED GROWTH FACTOR; PROTEIN P75; UNCLASSIFIED DRUG; VIRUS DNA; CHROMATIN; CLEAVAGE FACTOR IM, HUMAN; PSIP1 PROTEIN, HUMAN; SIGNAL TRANSDUCING ADAPTOR PROTEIN; TRANSCRIPTION FACTOR;

3' UNTRANSLATED REGION; ARTICLE; CELL FUNCTION; COMPARATIVE STUDY; CONTROLLED STUDY; CRISPR CAS SYSTEM; EUCHROMATIN; GENE; GENE SILENCING; GENETIC TRANSCRIPTION; HISTONE MODIFICATION; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; MOLONEY MURINE LEUKEMIA VIRUS; NONHUMAN; NUCLEAR IMPORT; POLYADENYLATION; PRIORITY JOURNAL; PROTEIN DEPLETION; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; VIRUS CAPSID; VIRUS DNA CELL DNA INTERACTION; VIRUS GENE; VIRUS INFECTIVITY; CHROMATIN; GENETICS; HEK293 CELL LINE; METABOLISM; MUTATION; PHYSIOLOGY; VIROLOGY;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; CAPSID; CHROMATIN; GENE KNOCKDOWN TECHNIQUES; HEK293 CELLS; HIV-1; HUMANS; MRNA CLEAVAGE AND POLYADENYLATION FACTORS; MUTATION; TRANSCRIPTION FACTORS; TRANSCRIPTION, GENETIC; VIRUS INTEGRATION;

EID: 84959239787     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1524213113     Document Type: Article

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