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Volumn 9, Issue 12, 2012, Pages 1405-1412

Cleavage factor Im is a key regulator of 3' UTR length

Author keywords

3' end processing; Alternative polyadenylation; CPSF5; CPSF6; CPSF7; mRNA processing

Indexed keywords

CLEAVAGE AND POLYADENYLATION SPECIFICITY FACTOR; CLEAVAGE FACTOR I; CLEAVAGE STIMULATION FACTOR; MESSENGER RNA PRECURSOR; TETRAMER; TRANSCRIPTOME; UNCLASSIFIED DRUG; CLEAVAGE FACTOR IM, HUMAN; CSTF2T PROTEIN, HUMAN; MESSENGER RNA; RNA BINDING PROTEIN;

EID: 84875175052     PISSN: 15476286     EISSN: 15558584     Source Type: Journal    
DOI: 10.4161/rna.22570     Document Type: Article
Times cited : (123)

References (42)
  • 1
    • 0033788228 scopus 로고    scopus 로고
    • The ends of the affair: Capping and polyadenylation
    • PMID:11017188
    • Shatkin AJ, Manley JL. The ends of the affair: capping and polyadenylation. Nat Struct Biol 2000; 7:838-42; PMID:11017188; http://dx.doi. org/10.1038/79583.
    • (2000) Nat Struct Biol , vol.7 , pp. 838-842
    • Shatkin, A.J.1    Manley, J.L.2
  • 3
    • 42449084129 scopus 로고    scopus 로고
    • Protein factors in pre-mRNA 3'-end processing
    • PMID:18158581
    • Mandel CR, Bai Y, Tong L. Protein factors in pre-mRNA 3'-end processing. Cell Mol Life Sci 2008; 65:1099-122; PMID:18158581; http://dx.doi. org/10.1007/s00018-007-7474-3.
    • (2008) Cell Mol Life Sci , vol.65 , pp. 1099-1122
    • Mandel, C.R.1    Bai, Y.2    Tong, L.3
  • 4
    • 77953284100 scopus 로고    scopus 로고
    • Molecular mechanisms of eukaryotic pre-mRNA 3' end processing regulation
    • PMID:20044349
    • Millevoi S, Vagner S. Molecular mechanisms of eukaryotic pre-mRNA 3' end processing regulation. Nucleic Acids Res 2010; 38:2757-74; PMID:20044349; http://dx.doi.org/10.1093/nar/g k p1176.
    • (2010) Nucleic Acids Res , vol.38 , pp. 2757-2774
    • Millevoi, S.1    Vagner, S.2
  • 6
    • 0025817865 scopus 로고
    • A novel poly(A)-binding protein acts as a specificity factor in the second phase of messenger RNA polyadenylation
    • Wahle E. A novel poly(A)-binding protein acts as a specificity factor in the second phase of messenger RNA polyadenylation. Cell 1991; 66:759-68; PMID:1878970; http://dx.doi.org/10.1016/0092-8 674 (91) 9 0119-J. (Pubitemid 121001709)
    • (1991) Cell , vol.66 , Issue.4 , pp. 759-768
    • Wahle, E.1
  • 7
    • 0029991323 scopus 로고    scopus 로고
    • m involved in the 3' end processing of messenger RNA precursors
    • PMID:8626397
    • m involved in the 3' end processing of messenger RNA precursors. J Biol Chem 1996; 271:6107-13; PMID:8626397; http://dx.doi.org/10.1074/jbc.271.11.6107.
    • (1996) J Biol Chem , vol.271 , pp. 6107-6113
    • Rüegsegger, U.1    Beyer, K.2    Keller, W.3
  • 8
    • 77953454014 scopus 로고    scopus 로고
    • Structural basis of UGUA recognition by the Nudix protein CFI(m)25 and implications for a regulatory role in mRNA 3' processing
    • PMID:20479262
    • Yang Q, Gilmartin GM, Doublié S. Structural basis of UGUA recognition by the Nudix protein CFI(m)25 and implications for a regulatory role in mRNA 3' processing. Proc Natl Acad Sci USA 2010; 107:10062-7; PMID:20479262; http://dx.doi. org/10.1073/pnas.1000848107.
    • (2010) Proc Natl Acad Sci USA , vol.107 , pp. 10062-10067
    • Yang, Q.1    Gilmartin, G.M.2    Doublié, S.3
  • 9
    • 0347416974 scopus 로고    scopus 로고
    • m
    • DOI 10.1016/S1097-2765(03)00453-2
    • m. Mol Cell 2003; 12:1467-76; PMID:14690600; http://dx.doi.org/10.1016/S1097-2765(03)00453-2. (Pubitemid 38037015)
    • (2003) Molecular Cell , vol.12 , Issue.6 , pp. 1467-1476
    • Brown, K.M.1    Gilmartin, G.M.2
  • 10
    • 79952459288 scopus 로고    scopus 로고
    • Crystal structure of a human cleavage factor CFI(m)25/CFI(m)68/RNA complex provides an insight into poly(A) site recognition and RNA looping
    • PMID:21295486
    • Yang Q, Coseno M, Gilmartin GM, Doublié S. Crystal structure of a human cleavage factor CFI(m)25/CFI(m)68/RNA complex provides an insight into poly(A) site recognition and RNA looping. Structure 2011; 19:368-77; PMID:21295486; http://dx.doi.org/10.1016/j.str.2010.12.021.
    • (2011) Structure , vol.19 , pp. 368-377
    • Yang, Q.1    Coseno, M.2    Gilmartin, G.M.3    Doublié, S.4
  • 12
    • 84859266588 scopus 로고    scopus 로고
    • The structure of human cleavage factor I(m) hints at functions beyond UGUA-specific RNA binding: A role in alternative polyadenylation and a potential link to 5' capping and splicing
    • PMID:21881408
    • Yang Q, Gilmartin GM, Doublié S. The structure of human cleavage factor I(m) hints at functions beyond UGUA-specific RNA binding: a role in alternative polyadenylation and a potential link to 5' capping and splicing. RNA Biol 2011; 8:748-53; PMID:21881408; http://dx.doi.org/10.4161/rna.8.5.16040.
    • (2011) RNA Biol , vol.8 , pp. 748-753
    • Yang, Q.1    Gilmartin, G.M.2    Doublié, S.3
  • 14
    • 33750200773 scopus 로고    scopus 로고
    • m links the splicing and 3′ end processing machineries
    • DOI 10.1038/sj.emboj.7601331, PII 7601331
    • Millevoi S, Loulergue C, Dettwiler S, Karaa SZ, Keller W, Antoniou M, et al. An interaction between U2AF 65 and CF I(m) links the splicing and 3' end processing machineries. EMBO J 2006; 25:4854-64; PMID:17024186; http://dx.doi.org/10.1038/sj.emboj.7601331. (Pubitemid 44607030)
    • (2006) EMBO Journal , vol.25 , Issue.20 , pp. 4854-4864
    • Millevoi, S.1    Loulergue, C.2    Dettwiler, S.3    Karaa, S.Z.4    Keller, W.5    Antoniou, M.6    Vagner, S.7
  • 15
    • 77955104829 scopus 로고    scopus 로고
    • Arginine methylation in subunits of mammalian pre-mRNA cleavage factor i
    • PMID:20562214
    • Martin G, Ostareck-Lederer A, Chari A, Neuenkirchen N, Dettwiler S, Blank D, et al. Arginine methylation in subunits of mammalian pre-mRNA cleavage factor I. RNA 2010; 16:1646-59; PMID:20562214; http://dx.doi.org/10.1261/rna. 2164210.
    • (2010) RNA , vol.16 , pp. 1646-1659
    • Martin, G.1    Ostareck-Lederer, A.2    Chari, A.3    Neuenkirchen, N.4    Dettwiler, S.5    Blank, D.6
  • 17
    • 84863093884 scopus 로고    scopus 로고
    • Genome-wide analysis of pre-mRNA 3' end processing reveals a decisive role of human cleavage factor i in the regulation of 3' UTR length
    • PMID:22813749
    • Martin G, Gruber AR, Keller W, Zavolan M. Genome-wide analysis of pre-mRNA 3' end processing reveals a decisive role of human cleavage factor I in the regulation of 3' UTR length. Cell Rep 2012; 1:753-63; PMID:22813749; http://dx.doi. org/10.1016/j.celrep.2012.05.003.
    • (2012) Cell Rep , vol.1 , pp. 753-763
    • Martin, G.1    Gruber, A.R.2    Keller, W.3    Zavolan, M.4
  • 18
    • 84857761249 scopus 로고    scopus 로고
    • Pre-mRNA 3'-end processing complex assembly and function
    • PMID:21957020
    • Chan S, Choi EA, Shi Y. Pre-mRNA 3'-end processing complex assembly and function. Wiley Interdiscip Rev RNA 2011; 2:321-35; PMID:21957020; http://dx.doi.org/10.1002/wrna.54.
    • (2011) Wiley Interdiscip Rev RNA , vol.2 , pp. 321-335
    • Chan, S.1    Choi, E.A.2    Shi, Y.3
  • 19
    • 84862526272 scopus 로고    scopus 로고
    • Signals for pre-mRNA cleavage and polyadenylation
    • PMID:22012871
    • Tian B, Graber JH. Signals for pre-mRNA cleavage and polyadenylation. Wiley Interdiscip Rev RNA 2012; 3:385-96; PMID:22012871; http://dx.doi. org/10.1002/wrna.116.
    • (2012) Wiley Interdiscip Rev RNA , vol.3 , pp. 385-396
    • Tian, B.1    Graber, J.H.2
  • 20
    • 46249092601 scopus 로고    scopus 로고
    • Proliferating cells express mRNAs with shortened 3′ untranslated regions and fewer microRNA target sites
    • DOI 10.1126/science.1155390
    • Sandberg R, Neilson JR, Sarma A, Sharp PA, Burge CB. Proliferating cells express mRNAs with shortened 3' untranslated regions and fewer microRNA target sites. Science 2008; 320:1643-7; PMID:18566288; ht t p://d x.doi.org/10.1126/ science.1155390. (Pubitemid 351931255)
    • (2008) Science , vol.320 , Issue.5883 , pp. 1643-1647
    • Sandberg, R.1    Neilson, J.R.2    Sarma, A.3    Sharp, P.A.4    Burge, C.B.5
  • 21
    • 77649314169 scopus 로고    scopus 로고
    • 3'-end sequencing for expression quantification (3SEQ) from archival tumor samples
    • PMID:20098735
    • Beck AH, Weng Z, Witten DM, Zhu S, Foley JW, Lacroute P, et al. 3'-end sequencing for expression quantification (3SEQ) from archival tumor samples. PLoS One 2010; 5:e8768; PMID:20098735; http://dx.doi.org/10.1371/journal.pone. 0008768.
    • (2010) PLoS One , vol.5
    • Beck, A.H.1    Weng, Z.2    Witten, D.M.3    Zhu, S.4    Foley, J.W.5    Lacroute, P.6
  • 22
    • 78649910014 scopus 로고    scopus 로고
    • Comprehensive polyadenylation site maps in yeast and human reveal pervasive alternative polyadenylation
    • PMID:21145465
    • Ozsolak F, Kapranov P, Foissac S, Kim SW, Fishilevich E, Monaghan AP, et al. Comprehensive polyadenylation site maps in yeast and human reveal pervasive alternative polyadenylation. Cell 2010; 143:1018-29; PMID:21145465; http://dx.doi. org/10.1016/j.cell.2010.11.020.
    • (2010) Cell , vol.143 , pp. 1018-1029
    • Ozsolak, F.1    Kapranov, P.2    Foissac, S.3    Kim, S.W.4    Fishilevich, E.5    Monaghan, A.P.6
  • 23
    • 78650972252 scopus 로고    scopus 로고
    • Formation, regulation and evolution of Caenorhabditis elegans 3'UTRs
    • PMID:21085120
    • Jan CH, Friedman RC, Ruby JG, Bartel DP. Formation, regulation and evolution of Caenorhabditis elegans 3'UTRs. Nature 2011; 469:97-101; PMID:21085120; http://dx.doi. org/10.1038/nature09616.
    • (2011) Nature , vol.469 , pp. 97-101
    • Jan, C.H.1    Friedman, R.C.2    Ruby, J.G.3    Bartel, D.P.4
  • 24
    • 80053337976 scopus 로고    scopus 로고
    • A multiplex RNA-seq strategy to profile poly(A+) RNA: Application to analysis of transcription response and 3' end formation
    • PMID:21515359
    • Fox-Walsh K, Davis-Turak J, Zhou Y, Li H, Fu XD. A multiplex RNA-seq strategy to profile poly(A+) RNA: application to analysis of transcription response and 3' end formation. Genomics 2011; 98:266-71; PMID:21515359; http://dx.doi. org/10.1016/j.ygeno.2011.04.003.
    • (2011) Genomics , vol.98 , pp. 266-271
    • Fox-Walsh, K.1    Davis-Turak, J.2    Zhou, Y.3    Li, H.4    Fu, X.D.5
  • 25
    • 79953014914 scopus 로고    scopus 로고
    • Complex and dynamic landscape of RNA polyadenylation revealed by PAS-Seq
    • PMID:21343387
    • Shepard PJ, Choi EA, Lu J, Flanagan LA, Hertel KJ, Shi Y. Complex and dynamic landscape of RNA polyadenylation revealed by PAS-Seq. RNA 2011; 17:761-72; PMID:21343387; http://dx.doi. org/10.1261/rna.2581711.
    • (2011) RNA , vol.17 , pp. 761-772
    • Shepard, P.J.1    Choi, E.A.2    Lu, J.3    Flanagan, L.A.4    Hertel, K.J.5    Shi, Y.6
  • 26
    • 79955554179 scopus 로고    scopus 로고
    • Differential genome-wide profiling of tandem 3' UTRs among human breast cancer and normal cells by high-throughput sequencing
    • PMID:21474764
    • Fu Y, Sun Y, Li Y, Li J, Rao X, Chen C, et al. Differential genome-wide profiling of tandem 3' UTRs among human breast cancer and normal cells by high-throughput sequencing. Genome Res 2011; 21:741-7; PMID:21474764; http://dx.doi. or g/10.1101/g r.1152 9 5.110.
    • (2011) Genome Res , vol.21 , pp. 741-747
    • Fu, Y.1    Sun, Y.2    Li, Y.3    Li, J.4    Rao, X.5    Chen, C.6
  • 27
    • 84861903786 scopus 로고    scopus 로고
    • A quantitative atlas of polyadenylation in five mammals
    • PMID:22454233
    • Derti A, Garrett-Engele P, Macisaac KD, Stevens RC, Sriram S, Chen R, et al. A quantitative atlas of polyadenylation in five mammals. Genome Res 2012; 22:1173-83; PMID:22454233; http://dx.doi. or g/10.1101/g r.132 5 63.111.
    • (2012) Genome Res , vol.22 , pp. 1173-1183
    • Derti, A.1    Garrett-Engele, P.2    MacIsaac, K.D.3    Stevens, R.C.4    Sriram, S.5    Chen, R.6
  • 28
    • 33646950851 scopus 로고    scopus 로고
    • Biased alternative polyadenylation in human tissues
    • PMID:16356263
    • Zhang H, Lee JY, Tian B. Biased alternative polyadenylation in human tissues. Genome Biol 2005; 6:R100; PMID:16356263; http://dx.doi. org/10.1186/gb-2005-6-12-r100.
    • (2005) Genome Biol , vol.6
    • Zhang, H.1    Lee, J.Y.2    Tian, B.3
  • 29
    • 66049104920 scopus 로고    scopus 로고
    • Progressive lengthening of 3' untranslated regions of mRNAs by alternative polyadenylation during mouse embryonic development
    • PMID:19372383
    • Ji Z, Lee JY, Pan Z, Jiang B, Tian B. Progressive lengthening of 3' untranslated regions of mRNAs by alternative polyadenylation during mouse embryonic development. Proc Natl Acad Sci USA 2009; 106:7028-33; PMID:19372383; http://dx.doi. org/10.1073/pnas.0900028106.
    • (2009) Proc Natl Acad Sci USA , vol.106 , pp. 7028-7033
    • Ji, Z.1    Lee, J.Y.2    Pan, Z.3    Jiang, B.4    Tian, B.5
  • 30
    • 77950920903 scopus 로고    scopus 로고
    • Transcriptome-wide identification of RNA-binding protein and microR-NA target sites by PAR-CLIP
    • PMID:20371350
    • Hafner M, Landthaler M, Burger L, Khorshid M, Hausser J, Berninger P, et al. Transcriptome-wide identification of RNA-binding protein and microR-NA target sites by PAR-CLIP. Cell 2010; 141:129-41; PMID:20371350; http://dx.doi.org/10.1016/j. cell.2010.03.009.
    • (2010) Cell , vol.141 , pp. 129-141
    • Hafner, M.1    Landthaler, M.2    Burger, L.3    Khorshid, M.4    Hausser, J.5    Berninger, P.6
  • 31
    • 79959813870 scopus 로고    scopus 로고
    • A quantitative analysis of CLIP methods for identifying binding sites of RNA-binding proteins
    • PMID:21572407
    • Kishore S, Jaskiewicz L, Burger L, Hausser J, Khorshid M, Zavolan M. A quantitative analysis of CLIP methods for identifying binding sites of RNA-binding proteins. Nat Methods 2011; 8:559-64; PMID:21572407; http://dx.doi.org/10.1038/nmeth.1608.
    • (2011) Nat Methods , vol.8 , pp. 559-564
    • Kishore, S.1    Jaskiewicz, L.2    Burger, L.3    Hausser, J.4    Khorshid, M.5    Zavolan, M.6
  • 32
    • 79960230895 scopus 로고    scopus 로고
    • Mapping in vivo protein-RNA interactions at single-nucleotide resolution from HITS-CLIP data
    • PMID:21633356
    • Zhang C, Darnell RB. Mapping in vivo protein-RNA interactions at single-nucleotide resolution from HITS-CLIP data. Nat Biotechnol 2011; 29:607-14; PMID:21633356; http://dx.doi.org/10.1038/nbt.1873.
    • (2011) Nat Biotechnol , vol.29 , pp. 607-614
    • Zhang, C.1    Darnell, R.B.2
  • 33
    • 77954387023 scopus 로고    scopus 로고
    • ICLIP reveals the function of hnRNP particles in splicing at individual nucleo-tide resolution
    • PMID:20601959
    • König J, Zarnack K, Rot G, Curk T, Kayikci M, Zupan B, et al. iCLIP reveals the function of hnRNP particles in splicing at individual nucleo-tide resolution. Nat Struct Mol Biol 2010; 17:909-15; PMID:20601959; http://dx.doi.org/10.1038/nsmb.1838.
    • (2010) Nat Struct Mol Biol , vol.17 , pp. 909-915
    • König, J.1    Zarnack, K.2    Rot, G.3    Curk, T.4    Kayikci, M.5    Zupan, B.6
  • 34
    • 77955948497 scopus 로고    scopus 로고
    • m is a heterotetrameric protein complex controlling alternative polyadenylation
    • PMID: 20695905
    • m is a heterotetrameric protein complex controlling alternative polyadenylation. Genes Cells 2010; 15:1003-13; PMID: 20695905; ht tp://d x.doi.org/10.1111/j.1365-2443.2010.01436.x.
    • (2010) Genes Cells , vol.15 , pp. 1003-1013
    • Kim, S.1    Yamamoto, J.2    Chen, Y.3    Aida, M.4    Wada, T.5    Handa, H.6
  • 35
    • 84863610792 scopus 로고    scopus 로고
    • U1 snRNP determines mRNA length and regulates isoform expression
    • PMID:22770214
    • Berg MG, Singh LN, Younis I, Liu Q, Pinto AM, Kaida D, et al. U1 snRNP determines mRNA length and regulates isoform expression. Cell 2012; 150:53-64; PMID:22770214; http://dx.doi.org/10.1016/j. cell.2012.05.029.
    • (2012) Cell , vol.150 , pp. 53-64
    • Berg, M.G.1    Singh, L.N.2    Younis, I.3    Liu, Q.4    Pinto, A.M.5    Kaida, D.6
  • 36
    • 78649847070 scopus 로고    scopus 로고
    • U1 snRNP protects pre-mRNAs from premature cleavage and polyadenylation
    • PMID:20881964
    • Kaida D, Berg MG, Younis I, Kasim M, Singh LN, Wan L, et al. U1 snRNP protects pre-mRNAs from premature cleavage and polyadenylation. Nature 2010; 468:664-8; PMID:20881964; http://dx.doi. org/10.1038/nature09479.
    • (2010) Nature , vol.468 , pp. 664-668
    • Kaida, D.1    Berg, M.G.2    Younis, I.3    Kasim, M.4    Singh, L.N.5    Wan, L.6
  • 37
    • 84860317107 scopus 로고    scopus 로고
    • The poly(A)-binding protein nuclear 1 suppresses alternative cleavage and polyadenylation sites
    • PMID:22502866
    • Jenal M, Elkon R, Loayza-Puch F, van Haaften G, Kühn U, Menzies FM, et al. The poly(A)-binding protein nuclear 1 suppresses alternative cleavage and polyadenylation sites. Cell 2012; 149:538-53; PMID:22502866; http://dx.doi.org/10.1016/j. cell.2012.03.022.
    • (2012) Cell , vol.149 , pp. 538-553
    • Jenal, M.1    Elkon, R.2    Loayza-Puch, F.3    Van Haaften, G.4    Kühn, U.5    Menzies, F.M.6
  • 38
    • 34447543029 scopus 로고    scopus 로고
    • Pre-mRNA 3′ cleavage is reversibly inhibited in vitro by cleavage factor dephosphorylation
    • Ryan K. Pre-mRNA 3' cleavage is reversibly inhibited in vitro by cleavage factor dephosphorylation. RNA Biol 2007; 4:26-33; PMID:17585202; http://dx.doi. org/10.4161/rna.4.1.4365. (Pubitemid 47328290)
    • (2007) RNA Biology , vol.4 , Issue.1 , pp. 26-33
    • Ryan, K.1
  • 39
    • 33947514003 scopus 로고    scopus 로고
    • Multiple histone deacetylases and the CREB-binding protein regulate pre-mRNA 3′-end processing
    • DOI 10.1074/jbc.M609745200
    • Shimazu T, Horinouchi S, Yoshida M. Multiple histone deacetylases and the CREB-binding protein regulate pre-mRNA 3'-end processing. J Biol Chem 2007; 282:4470-8; PMID:17172643; http://dx.doi.0 r g/10.1074/jbc.M609745200. (Pubitemid 47100930)
    • (2007) Journal of Biological Chemistry , vol.282 , Issue.7 , pp. 4470-4478
    • Shimazu, T.1    Horinouchi, S.2    Yoshida, M.3
  • 40
    • 0028173689 scopus 로고
    • The human U1A snRNP protein regulates polyadenylation via a direct interaction with poly(A) polymerase
    • DOI 10.1016/0092-8674(94)90116-3
    • Gunderson SI, Beyer K, Martin G, Keller W, Boelens WC, Mattaj LW. The human U1A snRNP protein regulates polyadenylation via a direct interaction with poly(A) polymerase. Cell 1994; 76:531-41; PMID:8313473; http://dx.doi.org/10. 1016/0092-8674 (94) 90116-3. (Pubitemid 24064173)
    • (1994) Cell , vol.76 , Issue.3 , pp. 531-541
    • Gunderson, S.I.1    Beyer, K.2    Martin, G.3    Keller, W.4    Boelens, W.C.5    Mattaj, I.W.6
  • 41
    • 0031610367 scopus 로고    scopus 로고
    • U1 snRNP inhibits pre-mRNA polyadenylation through a direct interaction between U1 70K and poly(A) polymerase
    • Gunderson SI, Polycarpou-Schwarz M, Mattaj IW. U1 snRNP inhibits pre-mRNA polyadenylation through a direct interaction between U1 70K and poly(A) polymerase. Mol Cell 1998; 1:255-64; PMID:9659922; http://dx.doi.org/10.1016/ S1097-2765(00)80026-X. (Pubitemid 128378666)
    • (1998) Molecular Cell , vol.1 , Issue.2 , pp. 255-264
    • Gunderson, S.I.1    Polycarpou-Schwarz, M.2    Mattaj, I.W.3
  • 42
    • 0031610366 scopus 로고    scopus 로고
    • s related to spliceosomal SR proteins and can be reconstituted in vitro from recombinant subunits
    • m is related to spliceosomal SR proteins and can be reconstituted in vitro from recombinant subunits. Mol Cell 1998; 1:243-53; PMID:9659921; http://dx.doi.org/10.1016/S1097-2765(00)80025-8. (Pubitemid 128378665)
    • (1998) Molecular Cell , vol.1 , Issue.2 , pp. 243-253
    • Ruegsegger, U.1    Blank, D.2    Keller, W.3


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