Improving the safety of oral immunotherapy for food allergy

Pediatric Allergy and Immunology

Volumn 27, Issue 2, 2016, Pages 117-125

  Vazquez Ortiz, Marta ^a   Turner, Paul J ^a,b  

^a IMPERIAL COLLEGE LONDON   (United Kingdom)

^b UNIVERSITY OF SYDNEY   (Australia)

Author keywords

Children; Food allergy; Oral immunotherapy; Quality of life; Safety

Indexed keywords

ANTIHISTAMINIC AGENT; BIOLOGICAL MARKER; FOOD ALLERGEN; IMMUNOGLOBULIN E ANTIBODY; LEUKOTRIENE RECEPTOR BLOCKING AGENT; ALLERGEN;

ANTIGEN PRESENTING CELL; CLONAL ANERGY; COST EFFECTIVENESS ANALYSIS; DESENSITIZATION; DIETARY INTAKE; EGG ALLERGY; EPICUTANEOUS IMMUNOTHERAPY; FOOD ALLERGY; HEALTH ECONOMICS; HUMAN; IMMUNOLOGICAL TOLERANCE; IMMUNOMODULATION; IMMUNOTHERAPY; MILK ALLERGY; NONHUMAN; NUTRITION; ORAL IMMUNOTHERAPY; PEANUT ALLERGY; PRICK TEST; PRIORITY JOURNAL; QUALITY OF LIFE; REGULATORY T LYMPHOCYTE; REVIEW; SKIN TEST; SUBCUTANEOUS IMMUNOTHERAPY; SUBLINGUAL IMMUNOTHERAPY; ANAPHYLAXIS; ANIMAL; CHILD; COMPLICATION; FOOD HYPERSENSITIVITY; IMMUNOLOGY; ORAL DRUG ADMINISTRATION; TOTAL QUALITY MANAGEMENT;

ADMINISTRATION, ORAL; ALLERGENS; ANAPHYLAXIS; ANIMALS; CHILD; DESENSITIZATION, IMMUNOLOGIC; FOOD HYPERSENSITIVITY; HUMANS; QUALITY IMPROVEMENT;

EID: 84959229172     PISSN: 09056157     EISSN: 13993038     Source Type: Journal    
DOI: 10.1111/pai.12510     Document Type: Review

References (94)

1. Muraro A, Werfel T, Hoffmann-Sommergruber K, et al. EAACI food allergy and anaphylaxis guidelines: diagnosis and management of food allergy. Allergy 2014: 69: 1008-25.
2. Nwaru BI, Hickstein L, Panesar SS, et al. Prevalence of common food allergies in Europe: a systematic review and meta-analysis. Allergy 2014: 69: 992-1007.
3. Branum AM, Lukacs SL. Food allergy among children in the United States. Pediatrics 2009: 124: 1549-55.
4. Turner PJ, Gowland MH, Sharma V, et al. Increase in anaphylaxis-related hospitalizations but no increase in fatalities: an analysis of United Kingdom national anaphylaxis data, 1992-2012. J Allergy Clin Immunol 2015: 135: 956-63.
5. Prescott SL, Pawankar R, Allen KJ, et al. A global survey of changing patterns of food allergy burden in children. World Allergy Organ J 2013: 6: 21.
6. Skolnick HS, Conover-Walker MK, Koerner CB, Sampson HA, Burks W, Wood RA. The natural history of peanut allergy. J Allergy Clin Immunol 2001: 107: 367-74.
7. Begin P, Paradis L, Paradis J, et al. Natural resolution of peanut allergy: a 12-year longitudinal follow-up study. J Allergy Clin Immunol Pract 2013: 1: 528-30.
8. Wood RA, Sicherer SH, Vickery BP, et al. The natural history of milk allergy in an observational cohort. J Allergy Clin Immunol 2013: 131: 805-12.
9. Sicherer SH, Wood RA, Vickery BP, et al. The natural history of egg allergy in an observational cohort. J Allergy Clin Immunol 2014: 133: 492-9.
10. Skripak JM, Matsui EC, Mudd K, Wood RA. The natural history of IgE-mediated cow's milk allergy. J Allergy Clin Immunol 2007: 120: 1172-7.
11. Savage JH, Matsui EC, Skripak JM, Wood RA. The natural history of egg allergy. J Allergy Clin Immunol 2007: 120: 1413-7.
12. Umasunthar T, Leonardi-Bee J, Hodes M, et al. Incidence of fatal food anaphylaxis in people with food allergy: a systematic review and meta-analysis. Clin Exp Allergy 2013: 43: 1333-41.
13. Lau GY, Patel N, Umasunthar T, et al. Anxiety and stress in mothers of food-allergic children. Pediatr Allergy Immunol 2014: 25: 236-42.
14. Cummings AJ, Knibb RC, King RM, Lucas JS. The psychosocial impact of food allergy and food hypersensitivity in children, adolescents and their families: a review. Allergy 2010: 65: 933-45.
15. Christie L, Hine RJ, Parker JG, Burks W. Food allergies in children affect nutrient intake and growth. J Am Diet Assoc 2002: 102: 1648-51.
16. Taylor SL, Hefle SL. Food allergen labeling in the USA and Europe. Curr Opin Allergy Clin Immunol 2006: 6: 186-90.
17. Fox M, Mugford M, Voordouw J, et al. Health sector costs of self-reported food allergy in Europe: a patient-based cost of illness study. Eur J Public Health 2013: 23: 757-62.
18. Boyano-Martínez T, García-Ara C, Pedrosa M, Díaz-Pena JM, Quirce S. Accidental allergic reactions in children allergic to cow's milk proteins. J Allergy Clin Immunol 2009: 123: 883-8.
19. Turner PJ, Kemp AS, Campbell DE. Advisory food labels: consumers with allergies need more than "traces" of information. BMJ 2011: 343: d6180.
20. Food Standards Agency (FSA). "May contain" labelling-the consumer's perspective. 2002. Available at: www.food.gov.uk/multimedia/pdfs/maycontainreport.pdf
21. Noimark L, Gardner J, Warner JO. Parents' attitudes when purchasing products for children with nut allergy: a UK perspective. Pediatr Allergy Immunol 2009: 20: 500-4.
22. Sampson MA, Muñoz-Furlong A, Sicherer SH. Risk-taking and coping strategies of adolescents and young adults with food allergy. J Allergy Clin Immunol 2006: 117: 1440-5.
23. Simons FE, Clark S, Camargo CA Jr. Anaphylaxis in the community: learning from the survivors. J Allergy Clin Immunol 2009: 124: 301-6.
24. Marrs T, Lack G. Why do few food-allergic adolescents treat anaphylaxis with adrenaline?-Reviewing a pressing issue. Pediatr Allergy Immunol 2013: 24: 222-9.
25. Ford LS, Turner PJ, Campbell DE. Recommendations for the management of food allergies in a preschool/childcare setting and prevention of anaphylaxis. Expert Rev Clin Immunol 2014: 10: 867-74.
26. Bock SA, Munoz-Furlong A, Sampson HA. Fatalities due to anaphylactic reactions to foods. J Allergy Clin Immunol 2001: 107: 191-3.
27. Pumphrey RS, Gowland MH. Further fatal allergic reactions to food in the United Kingdom, 1999-2006. J Allergy Clin Immunol 2007: 119: 1018-9.
28. Nurmatov U, Devereux G, Worth A, Healy L, Sheikh A. Effectiveness and safety of orally administered immunotherapy for food allergies: a systematic review and meta-analysis. Br J Nutr 2014: 111: 12-22.
29. Savilahti EM, Kuitunen M, Valori M, et al. Use of IgE and IgG4 epitope binding to predict the outcome of oral immunotherapy in cow's milk allergy. Pediatr Allergy Immunol 2014: 25: 227-35.
30. Jones SM, Pons L, Roberts JL, et al. Clinical efficacy and immune regulation with peanut oral immunotherapy. J Allergy Clin Immunol 2009: 124: 292-300.
31. Vickery BP, Scurlock AM, Jones SM, Burks AW. Mechanisms of immune tolerance relevant to food allergy. J Allergy Clin Immunol 2011: 127: 576-84.
32. Staden U, Rolinck-Werninghaus C, Brewe F, Wahn U, Niggemann B, Beyer K. Specific oral tolerance induction in food allergy in children: efficacy and clinical patterns of reaction. Allergy 2007: 62: 1261-9.
33. Burks AW, Jones SM, Wood RA, et al. Oral immunotherapy for treatment of egg allergy in children. N Engl J Med 2012: 367: 233-43.
34. Vickery BP, Scurlock AM, Kulis M, et al. Sustained unresponsiveness to peanut in subjects who have completed peanut oral immunotherapy. J Allergy Clin Immunol 2014: 133: 468-75.
35. Wood RA, Sampson HA. Oral immunotherapy for the treatment of peanut allergy: is it ready for prime time? J Allergy Clin Immunol Pract 2014: 2: 97-8.
36. Brozek JL, Terracciano L, Hsu J, et al. Oral immunotherapy for IgE-mediated cow's milk allergy: a systematic review and meta-analysis. Clin Exp Allergy 2012: 42: 363-74.
37. Meglio P, Bartone E, Plantamura M, Arabito E, Giampietro PG. A protocol for oral desensitization in children with IgE-mediated cow's milk allergy. Allergy 2004: 59: 980-7.
38. Garcia Rodriguez R, Urra JM, Feo-Brito F, et al. Oral rush desensitization to egg: efficacy and safety. Clin Exp Allergy 2011: 41: 1289-96.
39. Martorell A, De La Hoz B, Ibañez MD, et al. Oral desensitization as a useful treatment in 2-year-old children with cow's milk allergy. Clin Exp Allergy 2011: 41: 1297-304.
40. Longo G, Barbi E, Berti I, et al. Specific oral tolerance induction in children with very severe cow's milk-induced reactions. J Allergy Clin Immunol 2008: 121: 343-7.
41. Vazquez-Ortiz M, Alvaro-Lozano M, Alsina L, et al. Safety and predictors of adverse events during oral immunotherapy for milk allergy: severity of reaction at oral challenge, specific IgE and prick test. Clin Exp Allergy 2013: 43: 92-102.
42. Anagnostou K, Islam S, King Y, et al. Assessing the efficacy of oral immunotherapy for the desensitisation of peanut allergy in children (STOP II): a phase 2 randomised controlled trial. Lancet 2014: 383: 1297-304.
43. Vazquez-Ortiz M, Alvaro M, Piquer M, et al. Life-threatening anaphylaxis to egg and milk oral immunotherapy in asthmatic teenagers. Ann Allergy Asthma Immunol 2014: 113: 482-4.
44. Nieto A, Fernandez-Silveira L, Mazon A, Caballero L. Life-threatening asthma reaction caused by desensitization to milk. Allergy 2010: 65: 1342-3.
45. Keet CA, Seopaul S, Knorr S, Narisety S, Skripak J, Wood RA. Long-term follow-up of oral immunotherapy for cow's milk allergy. J Allergy Clin Immunol 2013: 132: 737-9.
46. Burks AW, Wood RA, Jones SM, et al. Sublingual immunotherapy for peanut allergy: long-term follow-up of a randomized multicenter trial. J Allergy Clin Immunol 2015: 135: 1240-8.
47. Factor JM, Mendelson L, Lee J, Nouman G, Lester MR. Effect of oral immunotherapy to peanut on food-specific quality of life. Ann Allergy Asthma Immunol 2012: 109: 348-52.
48. Carraro S, Frigo AC, Perin M, et al. Impact of oral immunotherapy on quality of life in children with cow milk allergy: a pilot study. Int J Immunopathol Pharmacol 2012: 25: 793-8.
49. Otani IM, Bégin P, Kearney C, et al. Multiple-allergen oral immunotherapy improves quality of life in caregivers of food-allergic pediatric subjects. Allergy Asthma Clin Immunol 2014: 10: 25.
50. Vazquez-Ortiz M, Alvaro M, Piquer M, et al. Impact of oral immunotherapy on quality of life in egg allergic children. Pediatr Allergy Immunol 2015: 26: 291-4.
51. Vazquez-Ortiz M, Alvaro M, Piquer M, et al. Baseline specific IgE levels are useful to predict safety of oral immunotherapy in egg allergic children. Clin Exp Allergy 2014: 44: 130-41.
52. Canonica GW, Cox L, Pawankar R, et al. Sublingual immunotherapy: World Allergy Organization position paper 2013 update. World Allergy Organ J 2014: 7: 6.
53. Allam JP, Stojanovski G, Friedrichs N, et al. Distribution of Langerhans cells and mast cells within the human oral mucosa: new application sites of allergens in sublingual immunotherapy? Allergy 2008: 63: 720-7.
54. Narisety SD, Frischmeyer-Guerrerio PA, Keet CA, et al. A randomized, double-blind, placebo-controlled pilot study of sublingual versus oral immunotherapy for the treatment of peanut allergy. J Allergy Clin Immunol 2015: 135: 1275-82.
55. Fernández-Rivas M, Garrido-Fernández S, Nadal JA, et al. Randomized double-blind, placebo-controlled trial of sublingual immunotherapy with a Pru p 3 quantified peach extract. Allergy 2009: 64: 876-83.
56. Enrique E, Pineda F, Malek T, et al. Sublingual immunotherapy for hazelnut food allergy: a randomized, double-blind, placebo-controlled study with a standardized hazelnut extract. J Allergy Clin Immunol 2005: 116: 1073-9.
57. Keet CA, Frischmeyer-Guerrerio PA, Thyagarajan A, et al. The safety and efficacy of sublingual and oral immunotherapy for milk allergy. J Allergy Clin Immunol 2012: 129: 448-55.
58. Fleischer DM, Burks AW, Vickery BP, et al. Sublingual immunotherapy for peanut allergy: a randomized, double-blind, placebo-controlled multicenter trial. J Allergy Clin Immunol 2013: 131: 119-27.
59. Senti G, von Moos S, Kündig TM. Epicutaneous immunotherapy for aeroallergen and food allergy. Curr Treat Options Allergy 2013: 1: 68-78.
60. Mondoulet L, Dioszeghy V, Larcher T, et al. Epicutaneous immunotherapy (EPIT) blocks the allergic esophago-gastro-enteropathy induced by sustained oral exposure to peanuts in sensitized mice. PLoS One 2012: 7: e31967.
61. Dioszeghy V, Mondoulet L, Dhelft V, et al. The regulatory T cells induction by epicutaneous immunotherapy is sustained and mediates long-term protection from eosinophilic disorders in peanut-sensitized mice. Clin Exp Allergy 2014: 44: 867-81.
62. Dupont C, Kalach N, Soulaines P, Legoué-Morillon S, Piloquet H, Benhamou PH. Cow's milk epicutaneous immunotherapy in children: a pilot trial of safety, acceptability, and impact on allergic reactivity. J Allergy Clin Immunol 2010: 125: 1165-7.
63. Nelson HS, Lahr J, Rule R, Bock A, Leung D. Treatment of analphylactic sensitivity to peanuts by immunotherapy with injections of aqueous peanut extract. J Allergy Clin Immunol 1997: 99: 744-51.
64. Nowak-Wegrzyn A, Bloom KA, Sicherer SH, et al. Tolerance to extensively heated milk in children with cow's milk allergy. J Allergy Clin Immunol 2008: 122: 342-7.
65. Lemon-Mulé H, Sampson HA, Sicherer SH, Shreffler WG, Noone S, Nowak-Wegrzyn A. Immunologic changes in children with egg allergy ingesting extensively heated egg. J Allergy Clin Immunol 2008: 122: 977-83.
66. Turner PJ, Mehr S, Joshi P, et al. Safety of food challenges to extensively heated egg in egg-allergic children: a prospective cohort study. Pediatr Allergy Immunol 2013: 24: 450-5.
67. Martos G, Lopez-Exposito I, Bencharitiwong R, Berin MC, Nowak-Wegrzyn A. Mechanisms underlying differential food allergy response to heated egg. J Allergy Clin Immunol 2011: 127: 990-7.
68. Shin M, Lee J, Ahn K, Lee SI, Han Y. The influence of the presence of wheat flour on the antigenic activities of egg white proteins. Allergy Asthma Immunol Res 2013: 5: 42-7.
69. Kato Y, Oozawa E, Matsuda T. Decrease in antigenic and allergenic potentials of ovomucoid by heating in the presence of wheat flour: dependence on wheat variety and intermolecular disulfide bridges. J Agric Food Chem 2001: 49: 3661-5.
70. Kim JS, Nowak-Wegrzyn A, Sicherer SH, Noone S, Moshier EL, Sampson HA. Dietary baked milk accelerates the resolution of cow's milk allergy in children. J Allergy Clin Immunol 2011: 128: 125-31.
71. Leonard SA, Sampson HA, Sicherer SH, et al. Dietary baked egg accelerates resolution of egg allergy in children. J Allergy Clin Immunol 2012: 130: 473-80.
72. Chatchatee P, Järvinen KM, Bardina L, Beyer K, Sampson HA. Identification of IgE- and IgG-binding epitopes on alpha(s1)-casein: differences in patients with persistent and transient cow's milk allergy. J Allergy Clin Immunol 2001: 107: 379-83.
73. Järvinen KM, Beyer K, Vila L, Bardina L, Mishoe M, Sampson HA. Specificity of IgE antibodies to sequential epitopes of hen's egg ovomucoid as a marker for persistence of egg allergy. Allergy 2007: 62: 758-65.
74. Blanc F, Vissers YM, Adel-Patient K, et al. Boiling peanut Ara h 1 results in the formation of aggregates with reduced allergenicity. Mol Nutr Food Res 2011: 55: 1887-94.
75. Turner PJ, Mehr S, Sayers R, et al. Loss of allergenic proteins during boiling explains tolerance to boiled peanut in peanut allergy. J Allergy Clin Immunol 2014: 134: 751-3.
76. Nowak-Wegrzyn A. New perspectives for use of native and engineered recombinant food proteins in treatment of food allergy. Immunol Allergy Clin North Am 2007: 27: 105-27.
77. Wood RA, Sicherer SH, Burks AW, et al. A phase 1 study of heat/phenol-killed, E. coli-encapsulated, recombinant modified peanut proteins Ara h 1, Ara h 2, and Ara h 3 (EMP-123) for the treatment of peanut allergy. Allergy 2013: 68: 803-8.
78. Zuidmeer-Jongejan L, Fernandez-Rivas M, Poulsen LK, et al. FAST: towards safe and effective subcutaneous immunotherapy of persistent life-threatening food allergies. ClinTransl Allergy 2012: 2: 5.
79. Couroux P, Patel D, Armstrong K, Larché M, Hafner RP. Fel d 1-derived synthetic peptide immuno-regulatory epitopes show a long-term treatment effect in cat allergic subjects. ClinExp Allergy 2015: 45: 974-81.
80. Li S, Li XM, Burks AW, Sampson HA. Modulation of peanut allergy by peptide-based immunotherapy. J Allergy Clin Immunol 2001: 107: S233 (Abstract).
81. Prickett SR, Voskamp AL, Dacumos-Hill A, et al. Ara h 2 peptides containing dominant CD4+ T-cell epitopes: candidates for a peanut allergy therapeutic. J Allergy Clin Immunol 2011: 127: 608.
82. MacGlashan DW Jr, Bochner BS, Adelman DC, et al. Down-regulation of Fc(epsilon)RI expression on human basophils during in vivo treatment of atopic patients with anti-IgE antibody. J Immunol 1997: 158: 1438-45.
83. Manohar M, Nadeau KC. The Potential of Anti-IgE in Food Allergy Therapy. Curr Treat Options Allergy 2014: 1: 145-56.
84. Leung DYM, Sampson HA, Yunginger JW, et al. Effect of anti-IgE therapy in patients with peanut allergy. N Engl J Med 2003: 348: 986-93.
85. Nadeau KC, Schneider LC, Hoyte L, Borras I, Umetsu DT. Rapid oral desensitization in combination with Omalizumab therapy in patients with cow's milk allergy. J Allergy Clin Immunol 2011: 127: 1622-4.
86. Schneider LC, Rachid R, LeBovidge J, Blood E, Mittal M, Umetsu DT. A pilot study of omalizumab to facilitate rapid oral desensitization in high-risk peanut-allergic patients. J Allergy Clin Immunol 2013: 132: 1368-74.
87. Bégin P, Dominguez T, Wilson SP, et al. Phase 1 results of safety and tolerability in a rush oral immunotherapy protocol to multiple foods using Omalizumab. Allergy Asthma Clin Immunol 2014: 10: 7.
88. Lafuente I, Mazon A, Nieto M, Uixera S, Pina R, Nieto A. Possible recurrence of symptoms after discontinuation of omalizumab in anti-IgE-assisted desensitization to egg. Pediatr Allergy Immunol 2014: 25: 717-9.
89. Fiocchi A, Burks W, Bahna SL, et al. Clinical use of probiotics in pediatric allergy (CUPPA): a World Allergy Organization position paper. World Allergy Organ J 2012: 5: 148-67.
90. Tang ML, Ponsonby AL, Orsini F, et al. Administration of a probiotic with peanut oral immunotherapy: a randomized trial. J Allergy Clin Immunol 2015: 135: 737-44.
91. Frick OL, Teuber SS, Buchanan BB, et al. Allergen immunotherapy with heat-killed Listeria monocytogenes alleviates peanut and food-induced anaphylaxis in dogs. Allergy 2005: 60: 243-50.
92. Skripak JM, Nash SD, Rowley H, et al. A randomized, double/blind, placebo-controlled study of milk oral immunotherapy for cow's milk allergy. J Allergy Clin Immunol 2008: 122: 1154-60.
93. Takahashi M, Taniuchi S, Soejima K, Sudo K, Hatano Y, Kaneko K. New efficacy of LTRAs (montelukast sodium): it possibly prevents food-induced abdominal symptoms during oral immunotherapy. Allergy Asthma Clin Immunol 2014: 10: 3.
94. Lucendo AJ, Arias A, Tenias JM. Relation between eosinophilic esophagitis and oral immunotherapy for food allergy: a systematic review with meta-analysis. Ann Allergy Asthma Immunol 2014: 113: 624-9.