Activation of the MAPK/Akt/Nrf2-Egr1/HO-1-GCLc axis protects MG-63 osteosarcoma cells against 15d-PGJ2-mediated cell death

Biochemical Pharmacology

Volumn 104, Issue , 2016, Pages 29-41

  Koyani, Chintan N ^a   Kitz, Kerstin ^a,b   Rossmann, Christine ^a   Bernhart, Eva ^a   Huber, Evelyn ^a   Trummer, Christopher ^a   Windischhofer, Werner ^a   Sattler, Wolfgang ^a   Malle, Ernst ^a  

^a MEDICAL UNIVERSITY OF GRAZ   (Austria)

^b Fresenius Kabi Austria GmbH   (Austria)

Author keywords

15d PGJ2; Chemotherapy; Peroxisome proliferator activated receptor ; PI3K Akt axis; Pro survival signalling; ROS; Tumour protein p53

Indexed keywords

15 DEOXY OMEGA 12,,14 PROGESTERONE J2; 15 HYDROXYPROSTAGLANDIN DEHYDROGENASE; CARBON; CASPASE 3; EARLY GROWTH RESPONSE FACTOR 1; GLUTAMATE CYSTEINE LIGASE; GLUTATHIONE; HEME OXYGENASE 1; LAMIN; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE P38; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; PROCASPASE 3; PROSTAGLANDIN; PROTEIN KINASE B; REACTIVE OXYGEN METABOLITE; TRANSCRIPTION FACTOR NRF2; UNCLASSIFIED DRUG; 15-DEOXYPROSTAGLANDIN J2; EGR1 PROTEIN, HUMAN; HMOX1 PROTEIN, HUMAN; NFE2L2 PROTEIN, HUMAN; PROSTAGLANDIN D2;

ARTICLE; CATALYSIS; CELL DEATH; CELL NUCLEUS; CELL SURVIVAL; CONTROLLED STUDY; CYTOSOL; ENZYME ACTIVATION; ENZYME PHOSPHORYLATION; HUMAN; HUMAN CELL; OSTEOSARCOMA; PRIORITY JOURNAL; PROTEIN EXPRESSION; REAL TIME POLYMERASE CHAIN REACTION; RNA ISOLATION; WESTERN BLOTTING; ANALOGS AND DERIVATIVES; APOPTOSIS; DRUG EFFECTS; ENZYME ACTIVE SITE; GENE SILENCING; GENETICS; METABOLISM; OSTEOBLAST; OXIDATION REDUCTION REACTION; PATHOLOGY; PHOSPHORYLATION; SIGNAL TRANSDUCTION; TUMOR CELL LINE;

APOPTOSIS; CATALYTIC DOMAIN; CELL LINE, TUMOR; CELL SURVIVAL; EARLY GROWTH RESPONSE PROTEIN 1; GENE SILENCING; GLUTAMATE-CYSTEINE LIGASE; HEME OXYGENASE-1; HUMANS; MITOGEN-ACTIVATED PROTEIN KINASES; NF-E2-RELATED FACTOR 2; OSTEOBLASTS; OSTEOSARCOMA; OXIDATION-REDUCTION; PHOSPHORYLATION; PROSTAGLANDIN D2; PROTO-ONCOGENE PROTEINS C-AKT; REACTIVE OXYGEN SPECIES; SIGNAL TRANSDUCTION;

EID: 84959206163     PISSN: 00062952     EISSN: 18732968     Source Type: Journal    
DOI: 10.1016/j.bcp.2016.01.011     Document Type: Article

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