Interference with distinct steps of sphingolipid synthesis and signaling attenuates proliferation of U87MG glioma cells

Biochemical Pharmacology

Volumn 96, Issue 2, 2015, Pages 119-130

  Bernhart, Eva ^a   Damm, Sabine ^a   Wintersperger, Andrea ^a   Nusshold, Christoph ^a,b   Brunner, Anna Martina ^a   Plastira, Ioanna ^a   Rechberger, Gerald ^c   Reicher, Helga ^a   Wadsack, Christian ^a   Zimmer, Andreas ^b,c   Malle, Ernst ^a   Sattler, Wolfgang ^a,b  

^a MEDICAL UNIVERSITY OF GRAZ   (Austria)

^b BIOTECHMED GRAZ   (Austria)

^c UNIVERSITY OF GRAZ   (Austria)

Author keywords

ABC transporter; Myriocin; p53; Proliferation; RNA interference; Sphingolipids

Indexed keywords

ABC TRANSPORTER A1; CERAMIDE; GLIBENCLAMIDE; PROTEIN P21; PROTEIN P53; SERINE PALMITOYLTRANSFERASE; SPHINGOLIPID; SPHINGOMYELIN; SPHINGOSINE 1 PHOSPHATE; THERMOZYMOCIDIN; SPHINGOSINE 1 PHOSPHATE RECEPTOR;

APOPTOSIS; ARTICLE; ASTROCYTE; CELL GROWTH; CELL PROLIFERATION; CONTROLLED STUDY; GENE SILENCING; GLIOBLASTOMA; GLIOMA CELL; HUMAN; HUMAN CELL; IN VITRO STUDY; INTRACELLULAR SIGNALING; LIPOGENESIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; RNA INTERFERENCE; ANTAGONISTS AND INHIBITORS; BIOSYNTHESIS; BRAIN TUMOR; GENETICS; GLIOMA; METABOLISM; PATHOLOGY; SIGNAL TRANSDUCTION; TUMOR CELL LINE;

APOPTOSIS; ATP BINDING CASSETTE TRANSPORTER 1; BRAIN NEOPLASMS; CELL LINE, TUMOR; CELL PROLIFERATION; GENE SILENCING; GLIOMA; HUMANS; RECEPTORS, LYSOSPHINGOLIPID; SERINE C-PALMITOYLTRANSFERASE; SIGNAL TRANSDUCTION; SPHINGOLIPIDS;

EID: 84930571241     PISSN: 00062952     EISSN: 18732968     Source Type: Journal    
DOI: 10.1016/j.bcp.2015.05.007     Document Type: Article

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