Critical roles of cellular glutathione homeostasis and jnk activation in andrographolide-mediated apoptotic cell death in human hepatoma cells

Molecular Carcinogenesis

Volumn 50, Issue 8, 2011, Pages 580-591

  Ji, Lili ^a,b   Shen, Kaikai ^a   Jiang, Ping ^a   Morahan, Grant ^c   Wang, Zhengtao ^a,b  

^a SHANGHAI UNIVERSITY OF TRADITIONAL CHINESE MEDICINE   (China)

^b Shanghai R and D Centre for Standardization of Chinese Medicines   (China)

^c UNIVERSITY OF WESTERN AUSTRALIA   (Australia)

Author keywords

Andrographolide; Apoptosis; Cellular GSH homeostasis; Hepatocellular carcinoma

Indexed keywords

ANDROGRAPHOLIDE; APOPTOSIS SIGNAL REGULATING KINASE 1; BUTHIONINE SULFOXIMINE; GLUTAMATE CYSTEINE LIGASE; GLUTATHIONE; GLUTATHIONE ETHYL ESTER; MITOGEN ACTIVATED PROTEIN KINASE KINASE 4; STRESS ACTIVATED PROTEIN KINASE; STRESS ACTIVATED PROTEIN KINASE INHIBITOR;

ANIMAL MODEL; APOPTOSIS; ARTICLE; BIOSYNTHESIS; COLONY FORMATION; CONTROLLED STUDY; CYTOTOXICITY; ENZYME ACTIVATION; HEPATOMA CELL; HOMEOSTASIS; HUMAN; HUMAN CELL; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL;

ANDROGRAPHIS; ANIMALS; ANTI-INFLAMMATORY AGENTS; ANTIMETABOLITES, ANTINEOPLASTIC; ANTINEOPLASTIC AGENTS, PHYTOGENIC; APOPTOSIS; BUTHIONINE SULFOXIMINE; CARCINOMA, HEPATOCELLULAR; DITERPENES; GLUTATHIONE; HEP G2 CELLS; HUMANS; JNK MITOGEN-ACTIVATED PROTEIN KINASES; LIVER NEOPLASMS; MALE; MICE; MICE, NUDE;

ANDROGRAPHIS PANICULATA; MUS MUSCULUS;

EID: 79959994119     PISSN: 08991987     EISSN: 10982744     Source Type: Journal    
DOI: 10.1002/mc.20741     Document Type: Article

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