Mutational and expressional analyses of NRF2 and KEAP1 in sarcomas

Tumori

Volumn 98, Issue 4, 2012, Pages 510-515

  Je, Eun Mi ^a   An, Chang Hyeok ^a   Yoo, Nam Jin ^a   Lee, Sug Hyung ^a  

^a The Catholic University of Korea   (South Korea)

Author keywords

Cytoprotection; Expression; KEAP1; Mutation; NRF2; Sarcoma

Indexed keywords

KELCH LIKE ECH ASSOCIATED PROTEIN 1; TRANSCRIPTION FACTOR NRF2;

ARTICLE; CONTROLLED STUDY; GENE; GENE ACTIVATION; GENE EXPRESSION; GENE MUTATION; GLUTAMINE CYSTEINE LIGASE CATALYTIC GENE; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; KELCH LIKE ECH ASSOCIATED PROTEIN 1 GENE; MAJOR CLINICAL STUDY; MUTATIONAL ANALYSIS; MUTATOR GENE; NONHUMAN; SARCOMA; SIGNAL TRANSDUCTION; SINGLE STRAND CONFORMATION POLYMORPHISM; SOMATIC MUTATION; TRANSCRIPTION FACTOR NRF2 GENE;

EID: 84867202926     PISSN: 03008916     EISSN: 20382529     Source Type: Journal    
DOI: 10.1177/030089161209800417     Document Type: Article

References (25)

1. Kasai H, Kawai K: Oxidative DNA damages: mechanisms and significance in health and disease. Antioxid Redox Signal, 8: 981-983, 2006. (Pubitemid 44036514)
2. Banning A, Deubel S, Kluth D, Zhou Z, Brigelius-Flohe R: The GI-GPx gene is a target for Nrf2. Mol Cell Biol, 25: 4914-4923, 2005. (Pubitemid 40781093)
3. Ishii T, Itoh K, Takahashi S, Sato H, Yanagawa T, Katoh Y, Bannai S, Yamamoto M: Transcription factor Nrf2 coordinately regulates a group of oxidative stress-inducible genes in macrophages. J Biol Chem, 275: 16023-16029, 2000. (Pubitemid 30366908)
4. Katoh Y, Itoh K, Yoshida E, Miyagishi M, Fukamizu A, Yamamoto M: Two domains of Nrf2 cooperatively bind CBP, a CREB binding protein, and synergistically activate transcription. Genes Cells, 6: 857-868, 2001. (Pubitemid 33019739)
5. Kim YC, Masutani H, Yamaguchi Y, Itoh K, Yamamoto M, Yodoi J: Hemin-induced activation of the thioredoxin gene by Nrf2. A differential regulation of the antioxidant responsive element by a switch of its binding factors. J Biol Chem, 276: 18399-18406, 2001.
6. Hayes JD, McMahon M: NRF2 and KEAP1 mutations: permanent activation of an adaptive response in cancer. Trends Biochem Sci, 34: 176-188, 2009.
7. Zhang DD: Mechanistic studies of the Nrf2-Keap1 signaling pathway. Drug Metab Rev, 38: 769-789, 2006.
8. Kobayashi A, Kang MI, Okawa H, Ohtsuji M, Zenke Y, Chiba T, Igarashi K, Yamamoto M: Oxidative stress sensor Keap1 functions as an adaptor for Cul3-based E3 ligase to regulate proteasomal degradation of Nrf2. Mol Cell Biol, 24: 7130-7139, 2004. (Pubitemid 39014439)
9. Kobayashi A, Kang MI, Watai Y, Tong KI, Shibata T, Uchida K, Yamamoto M: Oxidative and electrophilic stresses activate Nrf2 through inhibition of ubiquitination activity of Keap1. Mol Cell Biol, 26: 221-229, 2006.
10. Zhang DD, Lo SC, Cross JV, Templeton DJ, Hannink M: Keap1 is a redox-regulated substrate adaptor protein for a Cul3-dependent ubiquitin ligase complex. Mol Cell Biol, 24: 10941-10953, 2004. (Pubitemid 39603148)
11. Lau A, Villeneuve NF, Sun Z, Wong PK, Zhang DD: Dual roles of Nrf2 in cancer. Pharmacol Res, 58: 262-270, 2008.
12. Iida K, Itoh K, Kumagai Y, Oyasu R, Hattori K, Kawai K, Shimazui T, Akaza H, Yamamoto M: Nrf2 is essential for the chemopreventive efficacy of oltipraz against urinary bladder carcinogenesis. Cancer Res, 64: 6424-6431, 2004. (Pubitemid 39297896)
13. Padmanabhan B, Tong KI, Ohta T, Nakamura Y, Scharlock M, Ohtsuji M, Kang MI, Kobayashi A, Yokoyama S, Yamamoto M: Structural basis for defects of Keap1 activity provoked by its point mutations in lung cancer. Mol Cell, 21: 689-700, 2006. (Pubitemid 43290735)
14. Shibata T, Ohta T, Tong KI, Kokubu A, Odogawa R, Tsuta K, Asamura H, Yamamoto M, Hirohashi S: Cancer related mutations in NRF2 impair its recognition by Keap1-Cul3 E3 ligase and promote malignancy. Proc Natl Acad Sci USA, 105: 13568-13573, 2008.
15. Kim YR, Oh JE, Kim MS, Kang MR, Park SW, Han JY, Eom HS, Yoo NJ, Lee SH: Oncogenic NRF2 mutations in squamous cell carcinomas of oesophagus and skin. J Pathol, 220: 446-451, 2010.
16. Singh A, Misra V, Thimmulappa RK, Lee H, Ames S, Hoque MO, Herman JG, Baylin SB, Sidransky D, Gabrielson E, Brock MV, Biswal S: Dysfunctional KEAP1-NRF2 interaction in non-small-cell lung cancer. PLoS Med, 3: e420, 2006.
17. Shibata T, Kokubu A, Gotoh M, Ojima H, Ohta T, Yamamoto M, Hirohashi S: Genetic alteration of Keap1 confers constitutive Nrf2 activation and resistance to chemotherapy in gallbladder cancer. Gastroenterology, 135: 1358-1368, 2008.
18. Takahashi T, Sonobe M, Menju T, Nakayama E, Mino N, Iwakiri S, Nagai S, Sato K, Miyahara R, Okubo K, Hirata T, Date H, Wada H: Mutations in Keap1 are a potential prognostic factor in resected non-small cell lung cancer. J Surg Oncol, 101: 500-506, 2010.
19. Muscarella LA, Parrella P, D'Alessandro V, la Torre A, Barbano R, Fontana A, Tancredi A, Guarnieri V, Balsamo T, Coco M, Copetti M, Pellegrini F, De Bonis P, Bisceglia M, Scaramuzzi G, Maiello E, Valori VM, Merla G, Vendemiale G, Fazio VM: Frequent epigenetics inactivation of KEAP1 gene in non-small cell lung cancer. Epigenetics, 6: 710-719, 2011.
20. Muscarella LA, Barbano R, D'Angelo V, Copetti M, Coco M, Balsamo T, la Torre A, Notarangelo A, Troiano M, Parisi S, Icolaro N, Catapano D, Valori VM, Pellegrini F, Merla G, Carella M, Fazio VM, Parrella P: Regulation of KEAP1 expression by promoter methylation in malignant gliomas and association with patient's outcome. Epigenetics, 6: 317-325, 2011.
21. Zhang P, Singh A, Yegnasubramanian S, Esopi D, Kombairaju P, Bodas M, Wu H, Bova SG, Biswal S: Loss of Kelchlike ECH-associated protein 1 function in prostate cancer cells causes chemoresistance and radioresistance and promotes tumor growth. Mol Cancer Ther, 9: 336-346, 2010.
22. Fletcher CDM, Unni KK, Mertens F: Pathology and genetics of tumors of soft tissue and bone. World Health Organization classification of tumors. IARC Press, Lyon, 2002.
23. Lee JW, Soung YH, Kim SY, Lee. HW, Park WS, Nam SW, Kim SH, Lee JY, Yoo NJ, Lee SH: PIK3CA gene is frequently mutated in breast carcinomas and hepatocellular carcinomas. Oncogene, 24: 1477-1480, 2005. (Pubitemid 40343128)
24. Niture SK, Jain AK, Shelton PM, Jaiswal AK: Src Subfamily kinases regulate nuclear export and degradation of transcription factor Nrf2 to switch off Nrf2-mediated antioxidant activation of cytoprotective gene expression. J Biol Chem, 286: 28821-28832, 2011.
25. Inami Y, Waguri S, Sakamoto A, Kouno T, Nakada K, Hino O, Watanabe S, Ando J, Iwadate M, Yamamoto M, Lee MS, Tanaka K, Komatsu M: Persistent activation of Nrf2 through p62 in hepatocellular carcinoma cells. J Cell Biol, 193: 275-284, 2011.