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Volumn 54, Issue 3, 2016, Pages 243-253

The contribution of Aspergillus fumigatus stress responses to virulence and antifungal resistance

Author keywords

aspergillosis; cell wall stress; fungicide resistance; heat shock; hypoxia; osmotic stress; oxidative stress

Indexed keywords

ANTIFUNGAL AGENT;

EID: 84959205374     PISSN: 12258873     EISSN: 19763794     Source Type: Journal    
DOI: 10.1007/s12275-016-5510-4     Document Type: Review
Times cited : (57)

References (81)
  • 1
    • 62949220164 scopus 로고    scopus 로고
    • Breakthrough Aspergillus fumigatus and Candida albicans double infection during caspofungin treatment: laboratory characteristics and implication for susceptibility testing
    • PID: 19104024
    • Arendrup, M.C., Garcia-Effron, G., Buzina, W., Mortensen, K.L., Reiter, N., Lundin, C., Jensen, H.E., Lass-Flörl, C., Perlin, D.S., and Bruun, B. 2009. Breakthrough Aspergillus fumigatus and Candida albicans double infection during caspofungin treatment: laboratory characteristics and implication for susceptibility testing. Antimicrob. Agents Chemother.53, 1185–1193.
    • (2009) Antimicrob. Agents Chemother. , vol.53 , pp. 1185-1193
    • Arendrup, M.C.1    Garcia-Effron, G.2    Buzina, W.3    Mortensen, K.L.4    Reiter, N.5    Lundin, C.6    Jensen, H.E.7    Lass-Flörl, C.8    Perlin, D.S.9    Bruun, B.10
  • 2
    • 33644889632 scopus 로고    scopus 로고
    • Common features and interesting differences in transcriptional responses to secretion stress in the fungi Trichoderma reesei and Saccharomyces cerevisiae
    • PID: 16504068
    • Arvas, M., Pakula, T., Lanthaler, K., Saloheimo, M., Valkonen, M., Suortti, T., Robson, G., and Penttilä, M. 2006. Common features and interesting differences in transcriptional responses to secretion stress in the fungi Trichoderma reesei and Saccharomyces cerevisiae. BMC Genomics7, 32.
    • (2006) BMC Genomics , vol.7 , pp. 32
    • Arvas, M.1    Pakula, T.2    Lanthaler, K.3    Saloheimo, M.4    Valkonen, M.5    Suortti, T.6    Robson, G.7    Penttilä, M.8
  • 4
    • 84908333934 scopus 로고    scopus 로고
    • The pH-responsive PacC transcription factor of Aspergillus fumigatus governs epithelial entry and tissue invasion during pulmonary aspergillosis
    • PID: 25329394
    • Bertuzzi, M., Schrettl, M., Alcazar-Fuoli, L., Cairns, T.C., Muñoz, A., Walker, L.A., Herbst, S., Safari, M., Cheverton, A.M., Chen, D., et al. 2014. The pH-responsive PacC transcription factor of Aspergillus fumigatus governs epithelial entry and tissue invasion during pulmonary aspergillosis. PLoS Pathog.10, e1004413.
    • (2014) PLoS Pathog. , vol.10 , pp. e1004413
    • Bertuzzi, M.1    Schrettl, M.2    Alcazar-Fuoli, L.3    Cairns, T.C.4    Muñoz, A.5    Walker, L.A.6    Herbst, S.7    Safari, M.8    Cheverton, A.M.9    Chen, D.10
  • 5
    • 84855278233 scopus 로고    scopus 로고
    • SREBP coordinates iron and ergosterol homeostasis to mediate triazole drug and hypoxia responses in the human fungal pathogen Aspergillus fumigatus
    • PID: 22144905
    • Blatzer, M., Barker, B.M., Willger, S.D., Beckmann, N., Blosser, S.J., Cornish, E.J., Mazurie, A., Grahl, N., Haas, H., and Cramer, R.A. 2011a. SREBP coordinates iron and ergosterol homeostasis to mediate triazole drug and hypoxia responses in the human fungal pathogen Aspergillus fumigatus. PLoS Genet.7, e1002374.
    • (2011) PLoS Genet. , vol.7 , pp. e1002374
    • Blatzer, M.1    Barker, B.M.2    Willger, S.D.3    Beckmann, N.4    Blosser, S.J.5    Cornish, E.J.6    Mazurie, A.7    Grahl, N.8    Haas, H.9    Cramer, R.A.10
  • 6
    • 80053239586 scopus 로고    scopus 로고
    • The metalloreductase FreB is involved in adaptation of Aspergillus fumigatus to iron starvation
    • PID: 21840411
    • Blatzer, M., Binder, U., and Haas, H. 2011b. The metalloreductase FreB is involved in adaptation of Aspergillus fumigatus to iron starvation. Fungal Genet. Biol.48, 1027–1033.
    • (2011) Fungal Genet. Biol. , vol.48 , pp. 1027
    • Blatzer, M.1    Binder, U.2    Haas, H.3
  • 9
    • 68049143143 scopus 로고    scopus 로고
    • Nitrosative and oxidative stress responses in fungal pathogenicity
    • PID: 19616469
    • Brown, A.J., Haynes, K., and Quinn, J. 2009. Nitrosative and oxidative stress responses in fungal pathogenicity. Curr. Opin. Microbiol.12, 384–391.
    • (2009) Curr. Opin. Microbiol. , vol.12 , pp. 384-391
    • Brown, A.J.1    Haynes, K.2    Quinn, J.3
  • 11
    • 33646850399 scopus 로고    scopus 로고
    • Signalling and oxidant adaptation in Candida albicans and Aspergillus fumigatus
    • PID: 16710324
    • Chauhan, N., Latge, J.P., and Calderone, R. 2006. Signalling and oxidant adaptation in Candida albicans and Aspergillus fumigatus. Nat. Rev. Microbiol.4, 435–444.
    • (2006) Nat. Rev. Microbiol. , vol.4 , pp. 435-444
    • Chauhan, N.1    Latge, J.P.2    Calderone, R.3
  • 12
    • 84912121231 scopus 로고    scopus 로고
    • ChIP-seq and in vivo transcriptome analyses of the Aspergillus fumigatus SREBP SrbA reveals a new regulator of the fungal hypoxia response and virulence
    • PID: 25375670
    • Chung, D., Barker, B.M., Carey, C.C., Merriman, B., Werner, E.R., Lechner, B.E., Dhingra, S., Cheng, C., Xu, W., Blosser, S.J., et al. 2014. ChIP-seq and in vivo transcriptome analyses of the Aspergillus fumigatus SREBP SrbA reveals a new regulator of the fungal hypoxia response and virulence. PLoS Pathog.10, e1004487.
    • (2014) PLoS Pathog. , vol.10 , pp. e1004487
    • Chung, D.1    Barker, B.M.2    Carey, C.C.3    Merriman, B.4    Werner, E.R.5    Lechner, B.E.6    Dhingra, S.7    Cheng, C.8    Xu, W.9    Blosser, S.J.10
  • 13
    • 39149087719 scopus 로고    scopus 로고
    • The evolution of fungal drug resistance: modulating the trajectory from genotype to phenotype
    • PID: 18246082
    • Cowen, L.E. 2008. The evolution of fungal drug resistance: modulating the trajectory from genotype to phenotype. Nat. Rev. Microbiol.6, 187–198.
    • (2008) Nat. Rev. Microbiol. , vol.6 , pp. 187-198
    • Cowen, L.E.1
  • 14
    • 25844530060 scopus 로고    scopus 로고
    • Hsp90 potentiates the rapid evolution of new traits: drug resistance in diverse fungi
    • PID: 16195452
    • Cowen, L.E. and Lindquist, S. 2005. Hsp90 potentiates the rapid evolution of new traits: drug resistance in diverse fungi. Science309, 2185–2189.
    • (2005) Science , vol.309 , pp. 2185-2189
    • Cowen, L.E.1    Lindquist, S.2
  • 18
    • 67650998748 scopus 로고    scopus 로고
    • Pathogenesis of Aspergillus fumigatus in invasive aspergillosis
    • PID: 19597008
    • Dagenais, T.R. and Keller, N.P. 2009. Pathogenesis of Aspergillus fumigatus in invasive aspergillosis. Clin. Microbiol. Rev.22, 447–465.
    • (2009) Clin. Microbiol. Rev. , vol.22 , pp. 447-465
    • Dagenais, T.R.1    Keller, N.P.2
  • 23
    • 77952799611 scopus 로고    scopus 로고
    • AfMkk2 is required for cell wall integrity signaling, adhesion, and full virulence of the human pathogen Aspergillus fumigatus
    • PID: 20452278
    • Dirr, F., Echtenacher, B., Heesemann, J., Hoffmann, P., Ebel, F., and Wagener, J. 2010. AfMkk2 is required for cell wall integrity signaling, adhesion, and full virulence of the human pathogen Aspergillus fumigatus. Int. J. Med. Microbiol.300, 496–502.
    • (2010) Int. J. Med. Microbiol. , vol.300 , pp. 496-502
    • Dirr, F.1    Echtenacher, B.2    Heesemann, J.3    Hoffmann, P.4    Ebel, F.5    Wagener, J.6
  • 24
    • 80055100404 scopus 로고    scopus 로고
    • HacA-independent functions of the ER stress sensor IreA synergize with the canonical UPR to influence virulence traits in Aspergillus fumigatus
    • PID: 22028661
    • Feng, X., Krishnan, K., Richie, D.L., Aimanianda, V., Hartl, L., Grahl, N., Powers-Fletcher, M.V., Zhang, M., Fuller, K.K., Nierman, W.C., et al. 2011. HacA-independent functions of the ER stress sensor IreA synergize with the canonical UPR to influence virulence traits in Aspergillus fumigatus. PLoS Pathog.7, e1002330.
    • (2011) PLoS Pathog. , vol.7 , pp. e1002330
    • Feng, X.1    Krishnan, K.2    Richie, D.L.3    Aimanianda, V.4    Hartl, L.5    Grahl, N.6    Powers-Fletcher, M.V.7    Zhang, M.8    Fuller, K.K.9    Nierman, W.C.10
  • 25
    • 77950167265 scopus 로고    scopus 로고
    • Transcriptional regulation of chitin synthases by calcineurin controls paradoxical growth of Aspergillus fumigatus in response to caspofungin
    • PID: 20124000
    • Fortwendel, J.R., Juvvadi, P.R., Perfect, B.Z., Rogg, L.E., Perfect, J.R., and Steinbach, W.J. 2010. Transcriptional regulation of chitin synthases by calcineurin controls paradoxical growth of Aspergillus fumigatus in response to caspofungin. Antimicrob. Agents Chemother.54, 1555–1563.
    • (2010) Antimicrob. Agents Chemother. , vol.54 , pp. 1555-1563
    • Fortwendel, J.R.1    Juvvadi, P.R.2    Perfect, B.Z.3    Rogg, L.E.4    Perfect, J.R.5    Steinbach, W.J.6
  • 26
    • 84878635961 scopus 로고    scopus 로고
    • Transcriptomic insights into the oxidative response of stress-exposed Aspergillus fumigatus
    • PID: 23278536
    • Fréalle, E., Aliouat-Denis, C.M., Delhaes, L., Hot, D., and Dei-Cas, E. 2013. Transcriptomic insights into the oxidative response of stress-exposed Aspergillus fumigatus. Curr. Pharm. Des.19, 3713–3737.
    • (2013) Curr. Pharm. Des. , vol.19 , pp. 3713-3737
    • Fréalle, E.1    Aliouat-Denis, C.M.2    Delhaes, L.3    Hot, D.4    Dei-Cas, E.5
  • 27
    • 36949012982 scopus 로고    scopus 로고
    • Comparative genomics of the environmental stress response in ascomycete fungi
    • PID: 17605132
    • Gasch, A.P. 2007. Comparative genomics of the environmental stress response in ascomycete fungi. Yeast24, 961–976.
    • (2007) Yeast , vol.24 , pp. 961-976
    • Gasch, A.P.1
  • 28
    • 79960941562 scopus 로고    scopus 로고
    • In vivo hypoxia and a fungal alcohol dehydrogenase influence the pathogenesis of invasive pulmonary aspergillosis
    • PID: 21811407
    • Grahl, N., Puttikamonkul, S., Macdonald, J.M., Gamcsik, M.P., Ngo, L.Y., Hohl, T.M., and Cramer, R.A. 2011. In vivo hypoxia and a fungal alcohol dehydrogenase influence the pathogenesis of invasive pulmonary aspergillosis. PLoS Pathog.7, e1002145.
    • (2011) PLoS Pathog. , vol.7 , pp. e1002145
    • Grahl, N.1    Puttikamonkul, S.2    Macdonald, J.M.3    Gamcsik, M.P.4    Ngo, L.Y.5    Hohl, T.M.6    Cramer, R.A.7
  • 29
    • 84891383248 scopus 로고    scopus 로고
    • NikA/TcsC histidine kinase is involved in conidiation, hyphal morphology, and responses to osmotic stress and antifungal chemicals in Aspergillus fumigatus
    • PID: 24312504
    • Hagiwara, D., Takahashi-Nakaguchi, A., Toyotome, T., Yoshimi, A., Abe, K., Kamei, K., Gonoi, T., and Kawamoto, S. 2013. NikA/TcsC histidine kinase is involved in conidiation, hyphal morphology, and responses to osmotic stress and antifungal chemicals in Aspergillus fumigatus. PLoS One8, e80881.
    • (2013) PLoS One , vol.8 , pp. e80881
    • Hagiwara, D.1    Takahashi-Nakaguchi, A.2    Toyotome, T.3    Yoshimi, A.4    Abe, K.5    Kamei, K.6    Gonoi, T.7    Kawamoto, S.8
  • 31
    • 84875855054 scopus 로고    scopus 로고
    • Aspergillus fumigatus melanins: interference with the host endocytosis pathway and impact on virulence
    • PID: 23346079
    • Heinekamp, T., Thywiβen, A., Macheleidt, J., Keller, S., Valiante, V., and Brakhage, A.A. 2013. Aspergillus fumigatus melanins: interference with the host endocytosis pathway and impact on virulence. Front Microbiol.3, 440.
    • (2013) Front Microbiol. , vol.3 , pp. 440
    • Heinekamp, T.1    Thywiβen, A.2    Macheleidt, J.3    Keller, S.4    Valiante, V.5    Brakhage, A.A.6
  • 32
    • 0031818693 scopus 로고    scopus 로고
    • The role of the Aspergillus fumigatus areA gene in invasive pulmonary aspergillosis
    • PID: 9669338
    • Hensel, M., Arst, H.N. Jr., Aufauvre-Brown, A., and Holden, D.W. 1998. The role of the Aspergillus fumigatus areA gene in invasive pulmonary aspergillosis. Mol. Gen. Genet.258, 553–557.
    • (1998) Mol. Gen. Genet. , vol.258 , pp. 553-557
    • Hensel, M.1    Arst, H.N.J.2    Aufauvre-Brown, A.3    Holden, D.W.4
  • 34
    • 36949031736 scopus 로고    scopus 로고
    • Methylcitrate synthase from Aspergillus fumigatus is essential for manifestation of invasive aspergillosis
    • PID: 17973657
    • Ibrahim-Granet, O., Dubourdeau, M., Latge, J.P., Ave, P., Huerre, M., Brakhage, A.A., and Brock, M. 2008. Methylcitrate synthase from Aspergillus fumigatus is essential for manifestation of invasive aspergillosis. Cell. Microbiol.10, 134–148.
    • (2008) Cell. Microbiol. , vol.10 , pp. 134-148
    • Ibrahim-Granet, O.1    Dubourdeau, M.2    Latge, J.P.3    Ave, P.4    Huerre, M.5    Brakhage, A.A.6    Brock, M.7
  • 35
    • 0030729225 scopus 로고    scopus 로고
    • Isolation and characterization of a pigmentless-conidium mutant of Aspergillus fumigatus with altered conidial surface and reduced virulence
    • PID: 9393803
    • Jahn, B., Koch, A., Schmidt, A., Wanner, G., Gehringer, H., Bhakdi, S., and Brakhage, A.A. 1997. Isolation and characterization of a pigmentless-conidium mutant of Aspergillus fumigatus with altered conidial surface and reduced virulence. Infect. Immun.65, 5110–5117.
    • (1997) Infect. Immun. , vol.65 , pp. 5110
    • Jahn, B.1    Koch, A.2    Schmidt, A.3    Wanner, G.4    Gehringer, H.5    Bhakdi, S.6    Brakhage, A.A.7
  • 36
    • 80053274411 scopus 로고    scopus 로고
    • The MAP kinase MpkA controls cell wall integrity, oxidative stress response, gliotoxin production and iron adaptation in Aspergillus fumigatus
    • PID: 21883519
    • Jain, R., Valiante, V., Remme, N., Docimo, T., Heinekamp, T., Hertweck, C., Gershenzon, J., Haas, H., and Brakhage, A.A. 2011. The MAP kinase MpkA controls cell wall integrity, oxidative stress response, gliotoxin production and iron adaptation in Aspergillus fumigatus. Mol. Microbiol.82, 39–53.
    • (2011) Mol. Microbiol. , vol.82 , pp. 39-53
    • Jain, R.1    Valiante, V.2    Remme, N.3    Docimo, T.4    Heinekamp, T.5    Hertweck, C.6    Gershenzon, J.7    Haas, H.8    Brakhage, A.A.9
  • 37
    • 84912134599 scopus 로고    scopus 로고
    • Calcineurinmediated regulation of hyphal growth, septation, and virulence in Aspergillus fumigatus
    • PID: 25118871
    • Juvvadi, P.R., Lamoth, F., and Steinbach, W.J. 2014. Calcineurinmediated regulation of hyphal growth, septation, and virulence in Aspergillus fumigatus. Mycopathologia178, 341–348.
    • (2014) Mycopathologia , vol.178 , pp. 341-348
    • Juvvadi, P.R.1    Lamoth, F.2    Steinbach, W.J.3
  • 38
    • 77957688051 scopus 로고    scopus 로고
    • Augmenting the activity of antifungal agents against aspergilli using structural analogues of benzoic acid as chemosensitizing agents
    • PID: 20943191
    • Kim, J.H., Campbell, B.C., Mahoney, N., Chan, K.L., Molyneux, R.J., and Balajee, A. 2010. Augmenting the activity of antifungal agents against aspergilli using structural analogues of benzoic acid as chemosensitizing agents. Fungal Biol.114, 817–824.
    • (2010) Fungal Biol. , vol.114 , pp. 817-824
    • Kim, J.H.1    Campbell, B.C.2    Mahoney, N.3    Chan, K.L.4    Molyneux, R.J.5    Balajee, A.6
  • 39
    • 34447625862 scopus 로고    scopus 로고
    • Enhanced activity of strobilurin and fludioxonil by using berberine and phenolic compounds to target fungal antioxidative stress response
    • PID: 17651208
    • Kim, J.H., Campbell, B.C., Mahoney, N., Chan, K.L., Molyneux, R.J., and May, G.S. 2007. Enhanced activity of strobilurin and fludioxonil by using berberine and phenolic compounds to target fungal antioxidative stress response. Lett. Appl. Microbiol.45, 134–141.
    • (2007) Lett. Appl. Microbiol. , vol.45 , pp. 134-141
    • Kim, J.H.1    Campbell, B.C.2    Mahoney, N.3    Chan, K.L.4    Molyneux, R.J.5    May, G.S.6
  • 40
    • 2442506787 scopus 로고    scopus 로고
    • The Aspergillus fumigatus transcriptional activator CpcA contributes significantly to the virulence of this fungal pathogen
    • PID: 15101984
    • Krappmann, S., Bignell, E.M., Reichard, U., Rogers, T., Haynes, K., and Braus, G.H. 2004. The Aspergillus fumigatus transcriptional activator CpcA contributes significantly to the virulence of this fungal pathogen. Mol. Microbiol.52, 785–799.
    • (2004) Mol. Microbiol. , vol.52 , pp. 785-799
    • Krappmann, S.1    Bignell, E.M.2    Reichard, U.3    Rogers, T.4    Haynes, K.5    Braus, G.H.6
  • 41
    • 84897849324 scopus 로고    scopus 로고
    • The fungal UPR: a regulatory hub for virulence traits in the mold pathogen Aspergillus fumigatus
    • PID: 24189125
    • Krishnan, K. and Askew, D.S. 2014. The fungal UPR: a regulatory hub for virulence traits in the mold pathogen Aspergillus fumigatus. Virulence5, 334–340.
    • (2014) Virulence , vol.5 , pp. 334-340
    • Krishnan, K.1    Askew, D.S.2
  • 42
    • 76449087788 scopus 로고    scopus 로고
    • Functional analysis of the superoxide dismutase family in Aspergillus fumigatus
    • PID: 20487287
    • Lambou, K., Lamarre, C., Beau, R., Dufour, N., and Latgé, J.P. 2010. Functional analysis of the superoxide dismutase family in Aspergillus fumigatus. Mol. Microbiol.75, 910–923.
    • (2010) Mol. Microbiol. , vol.75 , pp. 910-923
    • Lambou, K.1    Lamarre, C.2    Beau, R.3    Dufour, N.4    Latgé, J.P.5
  • 43
    • 84868130707 scopus 로고    scopus 로고
    • Heat shock protein 90 is required for conidiation and cell wall integrity in Aspergillus fumigatus
    • PID: 22822234
    • Lamoth, F., Juvvadi, P.R., Fortwendel, J.R., and Steinbach, W.J. 2012. Heat shock protein 90 is required for conidiation and cell wall integrity in Aspergillus fumigatus. Eukaryot. Cell11, 1324–1332.
    • (2012) Eukaryot. Cell , vol.11 , pp. 1324-1332
    • Lamoth, F.1    Juvvadi, P.R.2    Fortwendel, J.R.3    Steinbach, W.J.4
  • 44
    • 84863558332 scopus 로고    scopus 로고
    • Fungal antioxidant pathways promote survival against neutrophils during infection
    • PID: 22706306
    • Leal, S.M. Jr., Vareechon, C., Cowden, S., Cobb, B.A., Latgé, J.P., Momany, M., and Pearlman, E. 2012. Fungal antioxidant pathways promote survival against neutrophils during infection. J. Clin. Invest.122, 2482–2498.
    • (2012) J. Clin. Invest. , vol.122 , pp. 2482-2498
    • Leal, S.M.J.1    Vareechon, C.2    Cowden, S.3    Cobb, B.A.L.J.P.4    Momany, M.5    Pearlman, E.6
  • 46
    • 37549013791 scopus 로고    scopus 로고
    • The Aspergillus fumigatus transcriptional regulator AfYap1 represents the major regulator for defense against reactive oxygen intermediates but is dispensable for pathogenicity in an intranasal mouse infection model
    • PID: 17921349
    • Lessing, F., Kniemeyer, O., Wozniok, I., Loeffler, J., Kurzai, O., Haertl, A., and Brakhage, A.A. 2007. The Aspergillus fumigatus transcriptional regulator AfYap1 represents the major regulator for defense against reactive oxygen intermediates but is dispensable for pathogenicity in an intranasal mouse infection model. Eukaryot. Cell6, 2290–2302.
    • (2007) Eukaryot. Cell , vol.6 , pp. 2290-2302
    • Lessing, F.1    Kniemeyer, O.2    Wozniok, I.3    Loeffler, J.4    Kurzai, O.5    Haertl, A.6    Brakhage, A.A.7
  • 48
    • 42149129009 scopus 로고    scopus 로고
    • The sho1 sensor regulates growth, morphology, and oxidant adaptation in Aspergillus fumigatus but is not essential for development of invasive pulmonary aspergillosis
    • PID: 18227163
    • Ma, Y., Qiao, J., Liu, W., Wan, Z., Wang, X., Calderone, R., and Li, R. 2008. The sho1 sensor regulates growth, morphology, and oxidant adaptation in Aspergillus fumigatus but is not essential for development of invasive pulmonary aspergillosis. Infect. Immun.76, 1695–1701.
    • (2008) Infect. Immun. , vol.76 , pp. 1695-1701
    • Ma, Y.1    Qiao, J.2    Liu, W.3    Wan, Z.4    Wang, X.5    Calderone, R.6    Li, R.7
  • 49
    • 84918499268 scopus 로고    scopus 로고
    • The importance of connections between the cell wall integrity pathway and the unfolded protein response in filamentous fungi
    • PID: 25060881
    • Malavazi, I., Goldman, G.H., and Brown, N.A. 2014. The importance of connections between the cell wall integrity pathway and the unfolded protein response in filamentous fungi. Brief. Funct. Genomics13, 456–470.
    • (2014) Brief. Funct. Genomics , vol.13 , pp. 456-470
    • Malavazi, I.1    Goldman, G.H.2    Brown, N.A.3
  • 50
    • 84861848617 scopus 로고    scopus 로고
    • The two-component sensor kinase TcsC and its role in stress resistance of the human-pathogenic mold Aspergillus fumigatus
    • PID: 22675534
    • McCormick, A., Jacobsen, I.D., Broniszewska, M., Beck, J., Heesemann, J., and Ebel, F. 2012. The two-component sensor kinase TcsC and its role in stress resistance of the human-pathogenic mold Aspergillus fumigatus. PLoS One7, e38262.
    • (2012) PLoS One , vol.7 , pp. e38262
    • McCormick, A.1    Jacobsen, I.D.2    Broniszewska, M.3    Beck, J.4    Heesemann, J.5    Ebel, F.6
  • 52
    • 84866786889 scopus 로고    scopus 로고
    • Comparison of transcriptome technologies in the pathogenic fungus Aspergillus fumigatus reveals novel insights into the genome and MpkA dependent gene expression
    • PID: 23031507
    • Müller, S., Baldin, C., Groth, M., Guthke, R., Kniemeyer, O., Brakhage, A.A., and Valiante, V. 2012. Comparison of transcriptome technologies in the pathogenic fungus Aspergillus fumigatus reveals novel insights into the genome and MpkA dependent gene expression. BMC Genomics13, 519.
    • (2012) BMC Genomics , vol.13 , pp. 519
    • Müller, S.1    Baldin, C.2    Groth, M.3    Guthke, R.4    Kniemeyer, O.5    Brakhage, A.A.6    Valiante, V.7
  • 53
    • 0037406694 scopus 로고    scopus 로고
    • Deletion of the Aspergillus fumigatus gene encoding the Ras-related protein RhbA reduces virulence in a model of invasive pulmonary aspergillosis
    • PID: 12704156
    • Panepinto, J.C., Oliver, B.G., Fortwendel, J.R., Smith, D.L., Askew, D.S., and Rhodes, J.C. 2003. Deletion of the Aspergillus fumigatus gene encoding the Ras-related protein RhbA reduces virulence in a model of invasive pulmonary aspergillosis. Infect. Immun.71, 2819–2826.
    • (2003) Infect. Immun. , vol.71 , pp. 2819-2826
    • Panepinto, J.C.1    Oliver, B.G.2    Fortwendel, J.R.3    Smith, D.L.4    Askew, D.S.5    Rhodes, J.C.6
  • 55
    • 44949242315 scopus 로고    scopus 로고
    • Ambient pH gene regulation in fungi: making connections
    • PID: 18457952
    • Peñalva, M.A., Tilburn, J., Bignell, E., and Arst, H.N. Jr. 2008. Ambient pH gene regulation in fungi: making connections. Trends Microbiol.16, 291–300.
    • (2008) Trends Microbiol. , vol.16 , pp. 291-300
    • Peñalva, M.A.1    Tilburn, J.2    Bignell, E.3    Arst, H.N.J.4
  • 59
    • 70449723683 scopus 로고    scopus 로고
    • Vertebrate endothermy restricts most fungi as potential pathogens
    • PID: 19827944
    • Robert, V.A. and Casadevall, A. 2009. Vertebrate endothermy restricts most fungi as potential pathogens. J. Infect. Dis.200, 1623–1626.
    • (2009) J. Infect. Dis. , vol.200 , pp. 1623-1626
    • Robert, V.A.1    Casadevall, A.2
  • 60
    • 35848964834 scopus 로고    scopus 로고
    • A Ser678Pro substitution in Fks1p confers resistance to echinocandin drugs in Aspergillus fumigatus
    • PID: 17724146
    • Rocha, E.M., Garcia-Effron, G., Park, S., and Perlin, D.S. 2007. A Ser678Pro substitution in Fks1p confers resistance to echinocandin drugs in Aspergillus fumigatus. Antimicrob. Agents Chemother.51, 4174–4176.
    • (2007) Antimicrob. Agents Chemother. , vol.51 , pp. 4174-4176
    • Rocha, E.M.1    Garcia-Effron, G.2    Park, S.3    Perlin, D.S.4
  • 61
    • 84942938439 scopus 로고    scopus 로고
    • The Aspergillus fumigatus pkcAG579R mutant is defective in the activation of the cell wall integrity pathway but is dispensable for virulence in a neutropenic mouse infection model
    • PID: 26295576
    • Rocha, M.C., Godoy, K.F., de Castro, P.A., Hori, J.I., Bom, V.L., Brown, N.A., Cunha, A.F., Goldman, G.H., and Malavazi, I. 2015. The Aspergillus fumigatus pkcAG579R mutant is defective in the activation of the cell wall integrity pathway but is dispensable for virulence in a neutropenic mouse infection model. PLoS One10, e0135195.
    • (2015) PLoS One , vol.10 , pp. e0135195
    • Rocha, M.C.1    Godoy, K.F.2    de Castro, P.A.3    Hori, J.I.4    Bom, V.L.5    Brown, N.A.6    Cunha, A.F.7    Goldman, G.H.8    Malavazi, I.9
  • 62
    • 41649118938 scopus 로고    scopus 로고
    • Basal expression of the Aspergillus fumigatus transcriptional activator CpcA is sufficient to support pulmonary aspergillosis
    • PID: 18249572
    • Sasse, C., Bignell, E.M., Hasenberg, M., Haynes, K., Gunzer, M., Braus, G.H., and Krappmann, S. 2008. Basal expression of the Aspergillus fumigatus transcriptional activator CpcA is sufficient to support pulmonary aspergillosis. Fungal Genet. Biol.45, 693–704.
    • (2008) Fungal Genet. Biol. , vol.45 , pp. 693-704
    • Sasse, C.1    Bignell, E.M.2    Hasenberg, M.3    Haynes, K.4    Gunzer, M.5    Braus, G.H.6    Krappmann, S.7
  • 63
    • 33847709957 scopus 로고    scopus 로고
    • Aspergillus fumigatus does not require fatty acid metabolism via isocitrate lyase for development of invasive aspergillosis
    • PID: 17178786
    • Schöbel, F., Ibrahim-Granet, O., Avé, P., Latgé, J.P., Brakhage, A.A., and Brock, M. 2007. Aspergillus fumigatus does not require fatty acid metabolism via isocitrate lyase for development of invasive aspergillosis. Infect. Immun.75, 1237–1244.
    • (2007) Infect. Immun. , vol.75 , pp. 1237-1244
    • Schöbel, F.1    Ibrahim-Granet, O.2    Avé, P.3    Latgé, J.P.4    Brakhage, A.A.5    Brock, M.6
  • 65
    • 8644220677 scopus 로고    scopus 로고
    • Siderophore biosynthesis but not reductive iron assimilation is essential for Aspergillus fumigatus virulence
    • PID: 15504822
    • Schrettl, M., Bignell, E., Kragl, C., Joechl, C., Rogers, T., Arst, H.N. Jr., Haynes, K., and Haas, H. 2004. Siderophore biosynthesis but not reductive iron assimilation is essential for Aspergillus fumigatus virulence. J. Exp. Med.200, 1213–1219.
    • (2004) J. Exp. Med. , vol.200 , pp. 1213-1219
    • Schrettl, M.1    Bignell, E.2    Kragl, C.3    Joechl, C.4    Rogers, T.5    Arst, H.N.J.6    Haynes, K.7    Haas, H.8
  • 67
    • 80051799474 scopus 로고    scopus 로고
    • Iron homeostasis–Achilles’ heel of Aspergillus fumigatus
    • PID: 21724450
    • Schrettl, M. and Haas, H. 2011. Iron homeostasis–Achilles’ heel of Aspergillus fumigatus? Curr. Opin. Microbiol.14, 400–405.
    • (2011) Curr. Opin. Microbiol. , vol.14 , pp. 400-405
    • Schrettl, M.1    Haas, H.2
  • 72
    • 34249069582 scopus 로고    scopus 로고
    • Harnessing calcineurin as a novel anti-infective agent against invasive fungal infections
    • PID: 17505522
    • Steinbach, W.J., Reedy, J.L., Cramer, R.A. Jr., Perfect, J.R., and Heitman, J. 2007b. Harnessing calcineurin as a novel anti-infective agent against invasive fungal infections. Nat. Rev. Microbiol.5, 418–430.
    • (2007) Nat. Rev. Microbiol. , vol.5 , pp. 418-430
    • Steinbach, W.J.1    Reedy, J.L.2    Cramer, R.A.J.3    Perfect, J.R.4    Heitman, J.5
  • 73
    • 0141738468 scopus 로고    scopus 로고
    • Combination and sequential antifungal therapy for invasive Aspergillosis: Review of published in vitro and in vivo interactions and 6281 clinical cases from 1966 to 2001
    • PID: 12975752
    • Steinbach, J.W., Stevens, D.A., and Denning, D.W. 2003. Combination and sequential antifungal therapy for invasive Aspergillosis: Review of published in vitro and in vivo interactions and 6281 clinical cases from 1966 to 2001. Clin. Infect. Dis.37(Suppl 3), S188–224.
    • (2003) Clin. Infect. Dis. , vol.37 , Issue.3 , pp. S188-S224
    • Steinbach, J.W.1    Stevens, D.A.2    Denning, D.W.3
  • 74
    • 41649089725 scopus 로고    scopus 로고
    • The mitogen-activated protein kinase MpkA of Aspergillus fumigatus regulates cell wall signaling and oxidative stress response
    • PID: 17981060
    • Valiante, V., Heinekamp, T., Jain, R., Härtl, A., and Brakhage, A.A. 2008. The mitogen-activated protein kinase MpkA of Aspergillus fumigatus regulates cell wall signaling and oxidative stress response. Fungal Genet. Biol.45, 618–627.
    • (2008) Fungal Genet. Biol. , vol.45 , pp. 618-627
    • Valiante, V.1    Heinekamp, T.2    Jain, R.3    Härtl, A.4    Brakhage, A.A.5
  • 75
    • 70350411869 scopus 로고    scopus 로고
    • The MpkA MAP kinase module regulates cell wall integrity signaling and pyomelanin formation in Aspergillus fumigatus
    • PID: 19715768
    • Valiante, V., Jain, R., Heinekamp, T., and Brakhage, A.A. 2009. The MpkA MAP kinase module regulates cell wall integrity signaling and pyomelanin formation in Aspergillus fumigatus. Fungal Genet. Biol.46, 909–918.
    • (2009) Fungal Genet. Biol. , vol.46 , pp. 909-918
    • Valiante, V.1    Jain, R.2    Heinekamp, T.3    Brakhage, A.A.4
  • 76
    • 84927168440 scopus 로고    scopus 로고
    • The Aspergillus fumigatus cell wall integrity signaling pathway: drug target, compensatory pathways, and virulence
    • PID: 25932027
    • Valiante, V., Macheleidt, J., Föge, M., and Brakhage, A.A. 2015. The Aspergillus fumigatus cell wall integrity signaling pathway: drug target, compensatory pathways, and virulence. Front. Microbiol.6, 325.
    • (2015) Front. Microbiol. , vol.6 , pp. 325
    • Valiante, V.1    Macheleidt, J.2    Föge, M.3    Brakhage, A.A.4
  • 77
    • 79952657390 scopus 로고    scopus 로고
    • Implications of hypoxic microenvironments during invasive aspergillosis
    • Wezensky, S.J. and Cramer, R.A. Jr. 2014. Implications of hypoxic microenvironments during invasive aspergillosis. Med. Mycol.49(Suppl 1), S120–S124.
    • (2014) Med. Mycol. , vol.49 , pp. S120-S124
    • Wezensky, S.J.1    Cramer, R.A.J.2
  • 78
    • 57149083070 scopus 로고    scopus 로고
    • A sterol-regulatory element binding protein is required for cell polarity, hypoxia adaptation, azole drug resistance, and virulence in Aspergillus fumigatus
    • PID: 18989462
    • Willger, S.D., Puttikamonkul, S., Kim, K.H., Burritt, J.B., Grahl, N., Metzler, L.J., Barbuch, R., Bard, M., Lawrence, C.B., and Cramer, R.A. Jr. 2008. A sterol-regulatory element binding protein is required for cell polarity, hypoxia adaptation, azole drug resistance, and virulence in Aspergillus fumigatus. PLoS Pathog.4, e1000200.
    • (2008) PLoS Pathog. , vol.4 , pp. e1000200
    • Willger, S.D.1    Puttikamonkul, S.2    Kim, K.H.3    Burritt, J.B.4    Grahl, N.5    Metzler, L.J.6    Barbuch, R.7    Bard, M.8    Lawrence, C.B.9    Cramer, R.A.J.10
  • 81
    • 16544392041 scopus 로고    scopus 로고
    • A mitogenactivated protein kinase that senses nitrogen regulates conidial germination and growth in Aspergillus fumigatus
    • PID: 15075285
    • Xue, T., Nguyen, C.K., Romans, A., and May, G.S. 2004. A mitogenactivated protein kinase that senses nitrogen regulates conidial germination and growth in Aspergillus fumigatus. Eukaryot. Cell3, 557–560.
    • (2004) Eukaryot. Cell , vol.3 , pp. 557-560
    • Xue, T.1    Nguyen, C.K.2    Romans, A.3    May, G.S.4


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