The Sho1 sensor regulates growth, morphology, and oxidant adaptation in Aspergillus fumigatus but is not essential for development of invasive pulmonary aspergillosis

Infection and Immunity

Volumn 76, Issue 4, 2008, Pages 1695-1701

  Ma, Yan ^a   Qiao, Jianjun ^a   Liu, Wei ^a   Wan, Zhe ^a   Wang, Xiaohong ^a   Calderone, Richard ^b   Li, Ruoyu ^a  

^a PEKING UNIVERSITY FIRST HOSPITAL   (China)

^b GEORGETOWN UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADAPTOR PROTEIN; DIAMIDE; GLYCEROL; HYDROGEN PEROXIDE; MENADIONE; MITOGEN ACTIVATED PROTEIN KINASE; PROTEIN SHO1; UNCLASSIFIED DRUG; FUNGAL PROTEIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASPERGILLUS FUMIGATUS; BIOSENSOR; CONIDIUM; CONTROLLED STUDY; DISEASE COURSE; DRUG SENSITIVITY; EVOLUTIONARY ADAPTATION; FUNGAL MORPHOLOGY; FUNGAL SPORE GERMINATION; FUNGAL STRAIN; FUNGAL VIRULENCE; FUNGUS GROWTH; GENE DELETION; HISTOPATHOLOGY; LUNG ASPERGILLOSIS; MALE; MOUSE; NONHUMAN; OXIDATIVE STRESS; PATHOGENESIS; PRIORITY JOURNAL; SACCHAROMYCES CEREVISIAE; SIGNAL TRANSDUCTION; ANIMAL; BAGG ALBINO MOUSE; FUNGUS SPORE; GENETICS; METABOLISM; MICROBIOLOGY;

ANIMALS; ASPERGILLOSIS, ALLERGIC BRONCHOPULMONARY; ASPERGILLUS FUMIGATUS; FUNGAL PROTEINS; GENE DELETION; MALE; MICE; MICE, INBRED BALB C; OXIDATIVE STRESS; SPORES, FUNGAL;

EID: 42149129009     PISSN: 00199567     EISSN: None     Source Type: Journal    
DOI: 10.1128/IAI.01507-07     Document Type: Article

References (33)

1. Alonso-Monge, R., F. Navarro-Garcia, E. Roman, A. I. Negredo, B. Eisman, C. Nombela, and J. Pla. 2003. The Hog1 mitogen-activated protein kinase is essential in the oxidative stress response and chlamydospore formation in Candida albicans. Eukaryot. Cell 2:351-361.
2. Bhabhra, R., M. D. Miley, E. Mylonakis, D. Boettner, J. Fortwendel, J. C. Panepinto, M. Postow, J. C. Rhodes, and D. S. Askew. 2004. Disruption of the Aspergillus fumigatus gene encoding nucleolar protein CgrA impairs thermotolerant growth and reduces virulence. Infect. Immun. 72:4731-4740.
3. Brewster, J. L., T. de Valoir, N. D. Dwyer, E. Winter, and M. C. Gustin. 1993. An osmosensing signal transduction pathway in yeast. Science 259:1760-1763.
4. Bundock, P., A. den Dulk-Ras, A. Beijersbergen, and P. J. Hooykaas. 1995. Trans-kingdom T-DNA transfer from Agrobacterium tumefaciens to Saccharomyces cerevisiae. EMBO J. 14:3206-3214.
5. Chauhan, N., J. P. Latge, and R. Calderone. 2006. Signalling and oxidant adaptation in Candida albicans and Aspergillus fumigatus. Nat. Rev. Microbiol. 4:435-444.
6. Denning, D. W. 1998. Invasive aspergillosis. Clin. Infect. Dis. 26:781-803. (Quiz, 26:804-805.)
7. Du, C., J. Sarfati, J. P. Latge, and R. Calderone. 2006. The role of the sakA (Hog1) and tcsB (sln1) genes in the oxidant adaptation of Aspergillus fumigatus. Med. Mycol. 44:211-218.
8. Fortwendel, J. R., W. Zhao, R. Bhabhra, S. Park, D. S. Perlin, D. S. Askew, and J. C. Rhodes. 2005. A fungus-specific ras homolog contributes to the hyphal growth and virulence of Aspergillus fumigatus. Eukaryot. Cell 4:1982-1989.
9. Fradin, C., M. Kretschmar, T. Nichterlein, C. Gaillardin, C. d'Enfert, and B. Hube. 2003. Stage-specific gene expression of Candida albicans in human blood. Mol. Microbiol. 47:1523-1543.
10. Hospenthal, D. R., K. J. Kwon-Chung, and J. E. Bennett. 1998. Concentrations of airborne Aspergillus compared to the incidence of invasive aspergillosis: lack of correlation. Med. Mycol. 36:165-168.
11. Kontoyiannis, D. P., and G. P. Bodey. 2002. Invasive aspergillosis in 2002: an update. Eur. J. Clin. Microbiol. Infect. Dis. 21:161-172.
12. Kupfahl, C., T. Heinekamp, G. Geginat, T. Ruppert, A. Hartl, H. Hof, and A. A. Brakhage. 2006. Deletion of the gliP gene of Aspergillus fumigatus results in loss of gliotoxin production but has no effect on virulence of the fungus in a low-dose mouse infection model. Mol. Microbiol. 62:292-302.
13. Lamarre, C., O. Ibrahim-Granet, C. Du, R. Calderone, and J. P. Latge. 2007. Characterization of the SKN7 ortholog of Aspergillus fumigatus. Fungal Genet. Biol. 44:682-690.
14. Latge, J. P. 1999. Aspergillus fumigatus and aspergillosis. Clin. Microbiol. Rev. 12:310-350.
15. Lessing, F., O. Kniemeyer, I. Wozniok, J. Loeffler, O. Kurzai, A. Haertl, and A. A. Brakhage. 2007. The Aspergillus fumigatus transcriptional regulator AfYap1 represents the major regulator for defense against reactive oxygen intermediates but is dispensable for pathogenicity in an intranasal mouse infection model. Eukaryot. Cell 6:2290-2302.
16. Liu, W., G. S. May, M. S. Lionakis, R. E. Lewis, and D. P. Kontoyiannis. 2004. Extra copies of the Aspergillus fumigatus squalene epoxidase gene confer resistance to terbinafine: genetic approach to studying gene dose-dependent resistance to antifungals in A. fumigatus. Antimicrob. Agents Chemother. 48:2490-2496.
17. Osherov, N., D. P. Kontoyiannis, A. Romans, and G. S. May. 2001. Resistance to itraconazole in Aspergillus nidulans and Aspergillus fumigatus is conferred by extra copies of the A. nidulans P-450 14α-demethylase gene, pdmA. J. Antimicrob. Chemother. 48:75-81.
18. Paisley, D., G. D. Robson, and D. W. Denning. 2005. Correlation between in vitro growth rate and in vivo virulence in Aspergillus fumigatus. Med. Mycol. 43:397-401.
19. Philippe, B., O. Ibrahim-Granet, M. C. Prevost, M. A. Gougerot-Pocidalo, M. Sanchez Perez, A. Van der Meeren, and J. P. Latge. 2003. Killing of Aspergillus fumigatus by alveolar macrophages is mediated by reactive oxidant intermediates. Infect. Immun. 71:3034-3042.
20. Posas, F., S. M. Wurgler-Murphy, T. Maeda, E. A. Witten, T. C. Thai, and H. Saito. 1996. Yeast HOG1 MAP kinase cascade is regulated by a multistep phosphorelay mechanism in the SLN1-YPD1-SSK1 "two-component" osmosensor. Cell 86:865-875.
21. Raitt, D. C., F. Posas, and H. Saito. 2000. Yeast Cdc42 GTPase and Ste20 PAK-like kinase regulate Sho1-dependent activation of the Hog1 MAPK pathway. EMBO J. 19:4623-4631.
22. Ramesh, S. A., B. N. Kaiser, T. Franks, G. Collins, and M. Sedgley. 2006. Improved methods in Agrobacterium-mediated transformation of almond using positive (mannose/pmi) or negative (kanamycin resistance) selection-based protocols. Plant Cell Rep. 25:821-828.
23. Roman, E., C. Nombela, and J. Pla. 2005. The Sho1 adaptor protein links oxidative stress to morphogenesis and cell wall biosynthesis in the fungal pathogen Candida albicans. Mol. Cell. Biol. 25:10611-10627.
24. Sheppard, D. C., G. Rieg, L. Y. Chiang, S. G. Filler, J. E. Edwards, Jr., and A. S. Ibrahim. 2004. Novel inhalational murine model of invasive pulmonary aspergillosis. Antimicrob. Agents Chemother. 48:1908-1911.
25. Singh, K. K. 2000. The Saccharomyces cerevisiae Sln1p-Ssk1p two-component system mediates response to oxidative stress and in an oxidant-specitic fashion. Free Radic. Biol. Med. 29:1043-1050.
26. Steinbach, W. J., D. K. Benjamin, Jr., S. A. Trasi, J. L. Miller, W. A. Schell, A. K. Zaas, W. M. Foster, and J. R. Perfect. 2004. Value of an inhalational model of invasive aspergillosis. Med. Mycol. 42:417-425.
27. Sugui, J. A., Y. C. Chang, and K. J. Kwon-Chung. 2005. Agrobacterium tumefaciens-mediated transformation of Aspergillus fumigatus: an efficient tool for insertional mutagenesis and targeted gene disruption. Appl. Environ. Microbiol. 71:1798-1802.
28. Sugui, J. A., J. Pardo, Y. C. Chang, A. Mullbacher, K. A. Zarember, E. M. Galvez, L. Brinster, P. Zerfas, J. I. Gallin, M. M. Simon, and K. J. Kwon-Chung. 2007. Role of laeA in the regulation of alb1, gliP, conidial morphology, and virulence in Aspergillus fumigatus. Eukaryot. Cell 6:1552-1561.
29. Sugui, J. A., J. Pardo, Y. C. Chang, K. A. Zarember, G. Nardone, E. M. Galvez, A. Mullbacher, J. I. Gallin, M. M. Simon, and K. J. Kwon-Chung. 2007. Gliotoxin is a virulence factor of Aspergillus fumigatus: gliP deletion attenuates virulence in mice immunosuppressed with hydrocortisone. Eukaryot. Cell 6:1562-1569.
30. Temple, M. D., G. G. Perrone, and I. W. Dawes. 2005. Complex cellular responses to reactive oxygen species. Trends Cell Biol. 15:319-326.
31. Xue, T., C. K. Nguyen, A. Romans, D. P. Kontoyiannis, and G. S. May. 2004. Isogenic auxotrophic mutant strains in the Aspergillus fumigatus genome reference strain AF293. Arch. Microbiol. 182:346-353.
32. Zhao, W., J. C. Panepinto, J. R. Fortwendel, L. Fox, B. G. Oliver, D. S. Askew, and J. C. Rhodes. 2006. Deletion of the regulatory subunit of protein kinase A in Aspergillus fumigatus alters morphology, sensitivity to oxidative damage, and virulence. Infect. Immun. 74:4865-4874.
33. Zuber, S., M. J. Hynes, and A. Andrianopoulos. 2002. G-protein signaling mediates asexual development at 25 degrees C but has no effect on yeast-like growth at 37 degrees C in the dimorphic fungus Penicillium mameffei. Eukaryot. Cell 1:440-447.