A sterol-regulatory element binding protein is required for cell polarity, hypoxia adaptation, azole drug resistance, and virulence in Aspergillus fumigatus

PLoS Pathogens

Volumn 4, Issue 11, 2008, Pages

  Willger, Sven D ^a   Puttikamonkul, Srisombat ^a   Kim, Kwang Hyung ^b   Burritt, James B ^a   Grahl, Nora ^a   Metzler, Laurel J ^c   Barbuch, Robert ^c   Bard, Martin ^c   Lawrence, Christopher B ^b   Cramer Jr , Robert A ^a  

^a MONTANA STATE UNIVERSITY   (United States)

^b VIRGINIA BIOINFORMATICS INSTITUTE   (United States)

^c INDIANA UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIFUNGAL AGENT; BINDING PROTEIN; ERGOSTEROL; FLUCONAZOLE; PYRROLE DERIVATIVE; STEROL; STEROL REGULATORY ELEMENT BINDING PROTEIN; VORICONAZOLE; FUNGAL PROTEIN;

ADAPTATION; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASPERGILLUS FUMIGATUS; CELL HYPOXIA; CELL POLARITY; CONTROLLED STUDY; DRUG SENSITIVITY; FUNGAL MORPHOLOGY; FUNGAL STRAIN; FUNGAL VIRULENCE; FUNGUS GROWTH; FUNGUS HYPHAE; GENE EXPRESSION PROFILING; GENETIC TRANSCRIPTION; LUNG ASPERGILLOSIS; MOULD; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PATHOGENICITY; PROTEIN DEPLETION; PROTEIN FUNCTION; STEROL SYNTHESIS; ANIMAL; ANOXIA; DRUG RESISTANCE; GENE EXPRESSION REGULATION; MOUSE STRAIN; PHYSIOLOGY; VIRULENCE;

ASPERGILLUS FUMIGATUS; FUNGI; MURINAE;

ADAPTATION, PHYSIOLOGICAL; ANIMALS; ANOXIA; ASPERGILLUS FUMIGATUS; AZOLES; CELL POLARITY; DRUG RESISTANCE; FUNGAL PROTEINS; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION, FUNGAL; MICE; MICE, INBRED STRAINS; STEROL REGULATORY ELEMENT BINDING PROTEINS; TRANSCRIPTION, GENETIC; VIRULENCE;

EID: 57149083070     PISSN: 15537366     EISSN: 15537374     Source Type: Journal    
DOI: 10.1371/journal.ppat.1000200     Document Type: Article

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