Implications of hypoxic microenvironments during invasive aspergillosis

Medical Mycology

Volumn 49, Issue SUPPL. 1, 2011, Pages

  Wezensky, Sara J ^a   Cramer Jr , Robert A ^a  

^a MONTANA STATE UNIVERSITY   (United States)

Author keywords

antifungal drugs; Aspergillus fumigatus; fungal virulence; hypoxia; invasive aspergillosis

Indexed keywords

AMPHOTERICIN B; ANIDULAFUNGIN; CORTISONE ACETATE; CYCLOPHOSPHAMIDE; HYPOXIA INDUCIBLE FACTOR 1ALPHA; HYPOXIA INDUCIBLE FACTOR 1BETA; HYPOXIA INDUCIBLE FACTOR 2ALPHA; VORICONAZOLE;

ANTIFUNGAL SUSCEPTIBILITY; ASPERGILLUS FUMIGATUS; CONFERENCE PAPER; DRUG EFFICACY; FUNGAL VIRULENCE; FUNGUS TRANSMISSION; HOST RESISTANCE; HYPOXIA; IN VIVO STUDY; INNATE IMMUNITY; INVASIVE ASPERGILLOSIS; MICROENVIRONMENT; NONHUMAN; PSEUDOMONAS AERUGINOSA; SALMONELLA TYPHIMURIUM; TISSUE INJURY; TREATMENT RESPONSE;

ANOXIA; ANTIFUNGAL AGENTS; ASPERGILLOSIS; ASPERGILLUS FUMIGATUS; HOST-PATHOGEN INTERACTIONS; STRESS, PHYSIOLOGICAL; VIRULENCE;

ASPERGILLUS; ASPERGILLUS FUMIGATUS;

EID: 79952657390     PISSN: 13693786     EISSN: 14602709     Source Type: Journal    
DOI: 10.3109/13693786.2010.495139     Document Type: Conference Paper

References (41)

1. Askew DS. Aspergillus fumigatus : virulence genes in a street-smart mold. Curr Opin Microbiol 2008; 11: 331-337.
2. Dagenais TR, Keller NP. Pathogenesis of Aspergillus fumigatus in invasive aspergillosis. Clin Microbiol Rev 2009; 22: 447-465.
3. Latge JP. Aspergillus fumigatus and aspergillosis. Clin Microbiol Rev 1999; 12: 310-350.
4. Latge JP. The pathobiology of Aspergillus fumigatus. Trends Micro-biol 2001; 9: 382-389.
5. Latge JP, Calderone R. Host-microbe interactions: fungi invasive human fungal opportunistic infections. Curr Opin Microbiol 2002; 5: 355-358.
6. Rhodes JC. Aspergillus fumigatus : growth and virulence. Med Mycol 2006; 44(Suppl. 1): S77-S81.
7. Matherne GP, Headrick JP, Coleman SD, Berne RM. Interstitial tran-sudate purines in normoxic and hypoxic immature and mature rabbit hearts. Pediatr Res 1990; 28: 348-353. (Pubitemid 20319744)
8. Van Belle H, Goossens F, Wynants J. Formation and release of purine catabolites during hypoperfusion, anoxia, and ischemia. Am J Physiol 1987; 252: H886-893.
9. Dewhirst MW. Concepts of oxygen transport at the microcirculatory level. Semin Radiat Oncol 1998; 8: 143-150. (Pubitemid 28323473)
10. Arnold F, West D, Kumar S. Wound healing: the effect of macrophage and tumour derived angiogenesis factors on skin graft vascularization. Br J Exp Pathol 1987; 68: 569-574.
11. Simmen HP, Battaglia H, Giovanoli P, Blaser J. Analysis of pH, pO2 and pCO2 in drainage f uid allows for rapid detection of infectious complications during the follow-up period after abdominal surgery. Infection 1994; 22: 386-389.
12. Denning DW, Ward PN, Fenelon LE, Benbow EW. Lack of vessel wall elastolysis in human invasive pulmonary aspergillosis. Infect Immun 1992; 60: 5153-5156.
13. Hall LA, Denning DW. Oxygen requirements of Aspergillus species. J Med Microbiol 1994; 41: 311-315. (Pubitemid 24353610)
14. Taubitz A, Bauer B, Heesemann J, Ebel F. Role of respiration in the germination process of the pathogenic mold Aspergillus fumigatus. Curr Microbiol 2007; 54: 354-360. (Pubitemid 46733869)
15. Tarrand JJ, Han XY, Kontoyiannis DP, May GS. Aspergillus hyphae in infected tissue: evidence of physiologic adaptation and effect on culture recovery. J Clin Microbiol 2005; 43: 382-386. (Pubitemid 40096327)
16. Brock M, Jouvion G, Droin-Bergere S, et al . Bioluminescent Asper-gillus fumigatus, a new tool for drug eff ciency testing and in vivo monitoring of invasive aspergillosis. Appl Environ Microbiol 2008; 74: 7023-7035.
17. Willger SD, Grahl N, Cramer RA, Jr. Aspergillus fumigatus metabolism: clues to mechanisms of in vivo fungal growth and virulence. Med Mycol 2009; 47(Suppl. 1): S72-S79.
18. Grahl N, Cramer RA, Jr. Regulation of hypoxia adaptation: an overlooked virulence attribute of pathogenic fungi? Med Mycol 2009; 47: 1-16.
19. Willger SD, Puttikamonkul S, Kim KH, et al . A sterol-regulatory element binding protein is required for cell polarity, hypoxia adaptation, azole drug resistance, and virulence in Aspergillus fumigatus. PLoS Pathog 2008; 4: e1000200.
20. Bien CM, Espenshade PJ. Sterol regulatory element binding proteins in fungi: hypoxic transcription factors linked to pathogenesis. Eukaryot Cell 2010; 9: 352-359.
21. Nizet V, Johnson RS. Interdependence of hypoxic and innate immune responses. Nat Rev Immunol 2009; 9: 609-617.
22. Fang HY, Hughes R, Murdoch C, et al . Hypoxia-inducible factors 1 and 2 are important transcriptional effectors in primary macrophages experiencing hypoxia. Blood 2009; 114: 844-859.
23. Rius J, Guma M, Schachtrup C, et al . NF-kappaB links innate immunity to the hypoxic response through transcriptional regulation of HIF-1alpha. Nature 2008; 453: 807-811. (Pubitemid 351793778)
24. Degrossoli A, Giorgio S. Functional alterations in macrophages after hypoxia selection. Exp Biol Med (Maywood) 2007; 232: 88-95. (Pubitemid 46089944)
25. Anand RJ, Gribar SC, Li J, et al . Hypoxia causes an increase in phagocytosis by macrophages in a HIF-1{alpha}-dependent manner. J Leu-koc Biol 2007.
26. Walmsley SR, Print C, Farahi N, et al . Hypoxia-induced neutrophil survival is mediated by HIF-1alpha-dependent NF-kappaB activity. J Exp Med 2005; 201: 105-115. (Pubitemid 40130088)
27. Neumann AK, Yang J, Biju MP, et al . Hypoxia inducible factor 1 alpha regulates T cell receptor signal transduction. Proc Natl Acad Sci USA 2005; 102: 17071-17076. (Pubitemid 41692685)
28. Cramer T, Johnson RS. A novel role for the hypoxia inducible transcription factor HIF-1alpha: critical regulation of inf ammatory cell function. Cell Cycle 2003; 2: 192-193.
29. Schofield CJ, Ratcliffe PJ. Signalling hypoxia by HIF hydroxylases. Biochem Biophys Res Commun 2005; 338: 617-626. (Pubitemid 41541972)
30. Gordan JD, Simon MC. Hypoxia-inducible factors: central regulators of the tumor phenotype. Curr Opin Genet Dev 2007; 17: 71-77. (Pubitemid 46109295)
31. Peyssonnaux C, Datta V, Cramer T, et al . HIF-1alpha expression regulates the bactericidal capacity of phagocytes. J Clin Invest 2005; 115: 1806-1815. (Pubitemid 40979719)
32. Cramer T, Yamanishi Y, Clausen BE, et al . HIF-1alpha is essential for myeloid cell-mediated inf ammation. Cell 2003; 112: 645-657. (Pubitemid 36331777)
33. Spear W, Chan D, Coppens I, et al . The host cell transcription factor hypoxia-inducible factor 1 is required for Toxoplasma gondii growth and survival at physiological oxygen levels. Cell Microbiol 2006; 8: 339-352. (Pubitemid 43356055)
34. Ben-Ami R, Lewis RE, Leventakos K, Kontoyiannis DP. Aspergillus fumigatus inhibits angiogenesis through the production of gliotoxin and other secondary metabolites. Blood 2009; 114: 5393-5399.
35. Sokol-Anderson ML, Brajtburg J, Medoff G. Amphotericin B-induced oxidative damage and killing of Candida albicans. J Infect Dis 1986; 154: 76-83. (Pubitemid 16088305)
36. Warn PA, Sharp A, Guinea J, Denning DW. Effect of hypoxic conditions on in vitro susceptibility testing of amphotericin B, itraconazole and micafungin against Aspergillus and Candida. J Antimicrob Chemother 2004; 53: 743-749. (Pubitemid 38660273)
37. Perkhofer S, Jost D, Dierich MP, Lass-Florl C. Susceptibility testing of anidulafungin and voriconazole alone and in combination against conidia and hyphae of Aspergillus spp. under hypoxic conditions. Antimicrob Agents Chemother 2008; 52: 1873-1875. (Pubitemid 351614693)
38. Stephens-Romero SD, Mednick AJ, Feldmesser M. The pathogenesis of fatal outcome in murine pulmonary aspergillosis depends on the neutrophil depletion strategy. Infect Immun 2005; 73: 114-125. (Pubitemid 40041101)
39. Balloy V, Huerre M, Latge JP, Chignard M. Differences in patterns of infection and inflammation for corticosteroid treatment and chemotherapy in experimental invasive pulmonary aspergillosis. Infect Immun 2005; 73: 494-503. (Pubitemid 40041144)
40. Klinkenberg LG, Sutherland LA, Bishai WR, Karakousis PC. Metron-idazole lacks activity against Mycobacterium tuberculosis in an in vivo hypoxic granuloma model of latency. J Infect Dis 2008; 198 : 275-283. (Pubitemid 352019294)
41. Todd BL, Stewart EV, Burg JS, Hughes AL, Espenshade PJ. Sterol regulatory element binding protein is a principal regulator of anaerobic gene expression in f ssion yeast. Mol Cell Biol 2006; 26: 2817-2831.