The Aspergillus fumigatus pkcAG579R mutant is defective in the activation of the cell wall integrity pathway but is dispensable for virulence in a neutropenic mouse infection model

PLoS ONE

Volumn 10, Issue 8, 2015, Pages

  Rocha, Marina Campos ^a   De Godoy, Krissia Franco ^a   De Castro, Patrícia Alves ^b   Hori, Juliana Issa ^b   Pedro Bom, Vinícius Leite ^b   Brown, Neil Andrew ^c   Da Cunha, Anderson Ferreira ^a   Goldman, Gustavo Henrique ^b,d   Malavazi, Iran ^a   Yu, Jae Hyuk ^e  

^a FEDERAL UNIVERSITY OF SÃO CARLOS   (Brazil)

^b UNIVERSITY OF SÃO PAULO   (Brazil)

^c ROTHAMSTED RESEARCH   (United Kingdom)

^d BRAZILIAN CENTER FOR RESEARCH IN ENERGY AND MATERIALS CNPEM   (Brazil)

^e UNIVERSITY OF WISCONSIN MADISON   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

MITOGEN ACTIVATED PROTEIN KINASE; PROTEIN KINASE C; TUMOR NECROSIS FACTOR ALPHA; FUNGAL PROTEIN; PROTEIN KINASE C ALPHA; TUMOR NECROSIS FACTOR;

AMINO ACID SUBSTITUTION; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIGEN RECOGNITION; ARTICLE; ASPERGILLUS FUMIGATUS; CELL STRESS; CELL WALL; CONTROLLED STUDY; CYTOKINE PRODUCTION; ENDOPLASMIC RETICULUM STRESS; FEMALE; FUNGAL VIRULENCE; FUNGUS GROWTH; FUNGUS MUTANT; GENE ACTIVATION; GENE EXPRESSION; INVASIVE ASPERGILLOSIS; LOSS OF FUNCTION MUTATION; LUNG ASPERGILLOSIS; MACROPHAGE; MOUSE; MOUSE MODEL; NEUTROPENIA; NONHUMAN; OXIDATIVE STRESS; PHAGOCYTOSIS; PKCA GENE; SIGNAL TRANSDUCTION; UNFOLDED PROTEIN RESPONSE; ANIMAL; BAGG ALBINO MOUSE; BIOSYNTHESIS; CHEMISTRY; DISEASE MODEL; FUNGUS SPORE; GENE EXPRESSION REGULATION; GENETIC ENGINEERING; GENETICS; HUMAN; METABOLISM; MICROBIOLOGY; MORTALITY; MUTATION; PATHOGENICITY; PATHOLOGY; PROTEIN TERTIARY STRUCTURE; SURVIVAL ANALYSIS; VIRULENCE;

ANIMALS; ASPERGILLUS FUMIGATUS; CELL WALL; DISEASE MODELS, ANIMAL; ENDOPLASMIC RETICULUM STRESS; FEMALE; FUNGAL PROTEINS; GENE EXPRESSION REGULATION, FUNGAL; GENETIC ENGINEERING; HUMANS; INVASIVE PULMONARY ASPERGILLOSIS; MICE; MICE, INBRED BALB C; MITOGEN-ACTIVATED PROTEIN KINASES; MUTATION; NEUTROPENIA; PHAGOCYTOSIS; PROTEIN KINASE C-ALPHA; PROTEIN STRUCTURE, TERTIARY; SIGNAL TRANSDUCTION; SPORES, FUNGAL; SURVIVAL ANALYSIS; TUMOR NECROSIS FACTOR-ALPHA; UNFOLDED PROTEIN RESPONSE; VIRULENCE;

EID: 84942938439     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0135195     Document Type: Article

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