Antiulcer and antioxidant activities of a new steroid from Morus alba

Life Sciences

Volumn 92, Issue 3, 2013, Pages 202-210

  Ahmad, Aftab ^a   Gupta, Gaurav ^b   Afzal, Muhammad ^b   Kazmi, Imran ^b   Anwar, Firoz ^b  

^a KING ABDULAZIZ UNIVERSITY   (Saudi Arabia)

^b Siddhartha Institute of Pharmacy   (India)

Author keywords

Anti ulcer; Ethanol; Histology; Lansoprazole; Morus alba; Pylorus ligation

Indexed keywords

ALCOHOL; ANTIOXIDANT; ANTIULCER AGENT; CATALASE; GLUTATHIONE; GLUTATHIONE PEROXIDASE; GLUTATHIONE REDUCTASE; LANSOPRAZOLE; MULBERRY EXTRACT; SUPEROXIDE DISMUTASE;

ANIMAL TISSUE; ANTIOXIDANT ACTIVITY; ANTIULCER ACTIVITY; ARTICLE; CARBON NUCLEAR MAGNETIC RESONANCE; COLUMN CHROMATOGRAPHY; CONTROLLED STUDY; DEPRESSION; DRUG STRUCTURE; FEMALE; INFRARED SPECTROSCOPY; MALE; MASS SPECTROMETRY; MORUS ALBA; MOUSE; NONHUMAN; PHYTOCHEMISTRY; PROTON NUCLEAR MAGNETIC RESONANCE; PYLORUS LIGATION; RAT; STOMACH; STOMACH MUCOSA; ULTRAVIOLET RADIATION;

ANIMALS; ANTI-ULCER AGENTS; ANTIOXIDANTS; CENTRAL NERVOUS SYSTEM DEPRESSANTS; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; ETHANOL; MICE; MOLECULAR STRUCTURE; MORUS; OXIDOREDUCTASES; PEPTIC ULCER; RATS; RATS, WISTAR; STEROIDS; STOMACH;

MORUS ALBA; RATTUS;

EID: 84873406874     PISSN: 00243205     EISSN: 18790631     Source Type: Journal    
DOI: 10.1016/j.lfs.2012.11.020     Document Type: Article

References (56)

1. A.M. Ameen, M.A. Hapipah, A.K. Abdul, N.S. Mohd, and I. Salmah Evaluation of the antiulcer activities of Morus alba extracts in experimentally induced gastric ulcer in rats Biomed Res 20 1 2009 35 39
2. Anonymous The wealth of India, a dictionary of raw materials and industrial products Raw materials 2001 CSIR, PID New Delhi 429 437
3. S. Arabshahi-Delouee, and A. Urooj Antioxidant properties of various solvent extracts of mulberry (Morus indica L.) leaves Food Chem 102 4 2007 1233 1240
4. N. Asano, T. Yamashita, K. Yasuda, K. Ikeda, H. Kizu, and Y. Kameda Polyhydroxylated alkaloids isolated from mulberry trees (Morus alba L.) and silkworms (Bombyx mori L.) J Agric Food Chem 49 9 2001 4208 4213
5. R.F. Beers, and I.W. Sizer A spectrophotometric method for measuring the breakdown of hydrogen peroxide by catalase J Biol Chem 195 1 1952 133 140
6. M. Burstein, H.R. Scholnic, and R. Morton Rapid method for the isolation of lipoproteins from human serum by precipitation with polyanions J Lipid Res 11 6 1970 583 587
7. I. Carlberg, and B. Mannervik Glutathione reductase Methods Enzymol 113 1985 484 490
8. E.M. Choi, and J.K. Hwang Effects of Morus alba leaf extract on the production of nitric oxide prostaglandin E2 and cytokines in RAW2647 macrophages Fitoterapia 76 7-8 2005 608 613
9. S.J. Corne, S.M. Morrissey, and R.J. Woods A method for the quantitative estimation of gastric barrier mucus J Physiol 242 1974 116 117
10. D. Das, and R.F. Banerjee Effect of stress on the antioxidant enzymes and gastric ulceration Mol Cell Biochem 125 2 1993 115 125
11. P.K. Debnath, K.O. Gode, D.D. Govinda, and A.K. Sanyal Effect of propranolol on gastric secretion in rats Br J Pharmacol 51 1974 213 216
12. J. Du, Z.D. He, R.W. Jiang, W.C. Ye, H.X. Xu, and P.P.H. But Antiviral flavonoids from the root bark of Morus alba L. Phytochemistry 62 8 2003 1235 1238
13. P. Dugo, P. Donato, F. Cacciola, M.P. Germano, A. Rapisarda, and L. Mondello Characterization of the polyphenolic fraction of Morus alba leaves extracts by HPLC coupled to a hybrid IT-TOF MS system J Sep Sci 32 21 2009 3627 3634
14. B. Enkhmaa, K. Shiwaku, T. Katsube, K. Kitajima, E. Anuurad, and M. Yamasaki Mulberry (Morus alba L.) leaves and their major flavonol quercetin 3-(6-malonylglucoside) attenuate atherosclerotic lesion development in LDL receptor-deficient mice J Nutr 135 2005 729 734
15. W.C. Evans, and G.E. Trease Pharmacognosy BraillIar Tiridel Can 11th ed. 1989 Macmillian Publishers
16. R.K. Goel, K. Sairam, Ch.V. Rao, and A. Raman Role of gastric antioxidant and anti-Helicobacter pylori activities in the antiulcerogenic activity of plantain banana (Musa sapientum var. paradisiaca) Indian J Exp Biol 39 7 2001 719 722
17. J.B. Harborne Phytochemical methods 1973 Chapman and Hall Ltd. London 48 189
18. P.B. Hawk, B.L. Oser, and H.W. Summerson Practical physiological chemistry 12th ed. 1947 Churchill London 347
19. F.J. Hidalgo, M.M. León, and R. Zamora Effect of b-sitosterol in the antioxidative activity of oxidized lipid-amine reaction products Food Res Int 42 8 2009 1215 1222
20. D. Hollander, A. Taranawski, W.J. Krause, and H. Gergely Protective effect of sucralfate against alcohol-induced gastric mucosal injury in the rat Gastroenterology 88 1985 366 374
21. M. Imran, H. Khan, M. Shah, R. Khan, and F. Khan Chemical composition and antioxidant activity of certain Morus species J Zhejiang Univ Sci B 11 12 2010 973 980
22. P. Kakkar, B. Das, and P.N. Viswanathan A modified spectrophotometric assay of superoxide dismutase Indian J Biochem Biophys 21 2 1984 130 132
23. A. Kamboj, and A.K. Saluja Isolation of stigmasterol and β sitosterol from petroleum ether extract of aerial parts of ageratum conyzoides (asteraceae) Int J Pharm Pharm Sci 3 1 2011 94 99
24. T. Katsube, N. Imawaka, Y. Kawano, Y. Yamazaki, K. Shiwaku, and Y. Yamane Antioxidant flavonol glycosides in mulberry (Morus alba L.) leaves isolated based on LDL antioxidant activity Food Chem 97 1 2006 25 31
25. S. Khan, R. Mehmood, M.H. Kazmi, and A. Malik Alliumonoate: a new cyclopentane derivative from Allium victorialis J Asian Nat Prod Res 13 12 2011 1165 1169
26. T. Kikuchi, M. Nihei, H. Nagai, H. Fukushi, K. Tabata, and T. Suzuki Albanol A from the root bark of Morus alba L. induces apoptotic cell death in HL60 human leukemia cell line Chem Pharm Bull 58 4 2010 568 571
27. S.H. Kim, N.J. Kim, J.S. Choi, and J.C. Park Determination of flavonoid by HPLC and biological activities from the leaves of Cudrania tricuspidata bureau J Korean Soc Food Sci Nutr 22 1993 68 72
28. H.G. Kim, M.S. Ju, J.S. Shim, M.C. Kim, S.H. Lee, and Y. Huh Mulberry fruit protects dopaminergic neurons in toxin-induced Parkinson's disease models Br J Nutr 104 2010 8 16
29. G.N. Kim, Y.I. Kwon, and H.D. Jang Mulberry leaf extract reduces postprandial hyperglycemia with few side effects by inhibiting α-glucosidase in normal rats J Med Food 14 7-8 2011 712 717
30. S.K. Kulkarni Hand book of experimental pharmacology 3rd ed. 1999 Vallabh Prakashan New Delhi 148 150
31. D.D. Kulkarni, D.D. Ghugale, and R. Narasimhan Chemical investigations of plant tissues grown in vitro: isolation of beta-sitosterol from Morus alba (Mulberry) callus tissue Indian J Exp Biol 8 4 1970 347
32. R.A. Lawrence, and R.F. Burk Glutathione peroxidase activity in selenium deficient rat liver Biochem Biophys Res Commun 71 4 1976 952 958
33. Y.J. Lee, D.H. Choi, E.J. Kim, H.Y. Kim, T.O. Kwon, and D.G. Kang Hypotensive, hypolipidemic, and vascular protective effects of Morus alba L. in rats fed an atherogenic diet Am J Chin Med 39 1 2011 39 52
34. C.H. Lowry, N.I. Roseborough, A.L. Farr, and R.J. Randall Protein measurement with folin phenol reagent J Biol Chem 193 1951 265 275
35. K. Mizuochi, T. Tanaka, I. Kouno, T. Fujioka, Y. Yoshimura, and K. Ishimaru New iridoid diesters of glucopyranose from Linaria canadensis (L.) Dum J Nat Med 65 1 2011 172 175
36. Y. Morimoto, K. Shimohara, S. Oshima, and T. Sukamoto Effect of the new anti-ulcer agent KB-5492 on experimental gastric mucosal lesions and defensive factors compared to those of terpenone and cimetidine Jpn J Pharmacol 57 1991 495 505
37. S.Y. Nam, H.K. Yi, J.C. Lee, J.C. Kim, C.H. Song, and J.W. Park Cortex mori extract induces cancer cell apoptosis through inhibition of microtubule assembly Arch Pharm Res 25 2 2002 191 196
38. T. Niidome, K. Takahashi, Y. Goto, S.M. Goh, N. Tanaka, and K. Kamei Mulberry leaf extract prevents amyloid beta-peptide fibril formation and neurotoxicity Neuroreport 18 8 2007 813 816
39. N. Nuengchamnong, K. Ingkaninan, W. Kaewruang, S. Wongareonwanakij, and B. Hongthongdaeng Quantitative determination of 1-deoxynojirimycin in mulberry leaves using liquid chromatography-tandem mass spectrometry J Pharm Biomed Anal 44 4 2007 853 858
40. H. Ohkawa, N. Ohishi, and K. Yagi Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction Anal Biochem 95 2 1979 351 358
41. M.J. Parnaham, and K. Brune Therapeutic control of inflammatory diseases Agents Actions 21 1987 232 234
42. S.J. Piao, L.X. Chen, N. Kang, and F. Qiu Simultaneous determination of five characteristic stilbene glycosides in root bark of Morus albus L. (Cortex Mori) using high-performance liquid chromatography Phytochem Anal 22 3 2011 230 235
43. M.F. Ramadan, M.M.A. Amer, and A.E. Awad Coriander (Coriandrum sativum L.) seed oil improves plasma lipid profile in rats fed a diet containing cholesterol Eur Food Res Technol 227 2008 1173 1182
44. C.V. Rao, S.K. Ojha, K. Radhakrishnan, R. Govindarajan, S. Rastogi, and S. Mehrotra Antiulcer activity of Utleria salicifolia rhizome extract J Ethnopharmacol 91 2-3 2004 243 249
45. J. Salinas-Chavira, O. Castillo-Martínez, J.E. Ramirez-Bribiesca, and M. Mellado Effect of increasing levels of white mulberry leaves (Morus alba) on ruminal dry matter degradability in lambs Trop Anim Health Prod 43 5 2011 995 999
46. J. Sedlak, and R.H. Lindsay Estimation of the total, protein bound, and nonprotein sulfhydryl groups in tissue with Ellmans reagent Anal Biochem 25 1 1968 192 205
47. H. Shay, S.A. Komarov, S.S. Fele, D. Meranze, H. Gruenstein, and H. Siplet A simple method for uniform production of gastric ulceration in rat Gastroenterology 1945 1945 43 61
48. A.N. Singab, H.A. El-Beshbishy, M. Yonekawa, T. Nomura, and T. Fukai Hypoglycemic effect of Egyptian Morus alba root bark extract: effect on diabetes and lipid peroxidation of streptozotocin-induced diabetic rats J Ethnopharmacol 100 3 2005 333 338
49. S. Singh, A. Khajuriaa, S.C. Tanejab, R.K. Khajuriab, J. Singh, and R.K. Johria The gastric ulcer protective effect of boswellic acids, a leukotriene inhibitor from Boswellia serrata, in rats Phytomedicine 15 2008 408 415
50. G.S. Smith, D.W. Mercer, J.M. Cross, J.C. Barreto, and T.A. Miller Gastric injury induced by ethanol and ischemia-reperfusion in the rat Dig Dis Sci 41 6 1996 1157 1164
51. A. Sofowara Medicinal plants and traditional medicine in Africa 1993 Spectrum Books Ltd. Ibadan 289 300
52. S. Tsuji, W. Sun, M. Tsujii, N. Kawai, A. Kimura, and Y. Kakiuchi Lansoprazole induces mucosal protection through gastrin receptor-dependent up-regulation of cyclooxygenase-2 in rats J Pharmacol Exp Ther 303 3 2002 1301 1308
53. M. Vatele, H.D. Doan, J.M. Chardigny, J.L. Sebedio, and A. Grandgirard Synthesis of methyl (5Z,8Z,11Z,14Z,17E)-eicosapentaenoate and methyl (4Z,7Z,10Z,13Z, 16Z,19E)-docosahexaenoate Chem Phys Lipids 74 2 1994 185 193
54. C.P. Wang, Y. Wang, X. Wang, X. Zhang, J.F. Ye, and L.S. Hu Mulberroside a possesses potent uricosuric and nephroprotective effects in hyperuricemic mice Planta Med 77 8 2011 786 794
55. S.K. Wattanapitayakul, L. Chularojmontri, A. Herunsalee, S. Charuchong-kolwongse, S. Niumsakul, and J.A. Bauer Screening of antioxidants from medicinal plants for cardioprotective effect against doxorubicin toxicity Basic Clin Pharmacol Toxicol 96 1 2005 80 87
56. X. Yang, L. Yang, and H. Zheng Hypolipidemic and antioxidant effects of mulberry (Morus alba L.) fruit in hyperlipidaemia rats Food Chem Toxicol 48 8-9 2010 2374 2379