Methanol extract of bauhinia purpurea leaf possesses anti-ulcer activity

Medical Principles and Practice

Volumn 21, Issue 5, 2012, Pages 476-482

  Zakaria, Z A ^a   Abdul Hisam, E E ^b   Norhafizah, M ^a   Rofiee, M S ^b   Othman, F ^a   Hasiah, A H ^a   Vasudevan, M ^b  

^a UNIVERSITY PUTRA MALAYSIA   (Malaysia)

^b UNIVERSITI TEKNOLOGI MARA   (Malaysia)

Author keywords

Anti ulcer activity; Bauhinia purpurea; Flavonoids; Methanol extract; Polyphenols; Saponins

Indexed keywords

ALCOHOL; BAUHINIA PURPUREA EXTRACT; INDOMETACIN; METHANOL; OMEPRAZOLE; SODIUM CHLORIDE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIULCER ACTIVITY; ARTICLE; CONTROLLED STUDY; HISTOPATHOLOGY; MALE; NONHUMAN; PLANT LEAF; RAT; SOLVENT EXTRACTION; STOMACH MUCUS; STOMACH PH; STOMACH ULCER; STOMACH WALL;

ANIMALS; BAUHINIA; DOSE-RESPONSE RELATIONSHIP, DRUG; GASTROINTESTINAL AGENTS; INDOMETHACIN; MALE; METHANOL; OMEPRAZOLE; PLANT EXTRACTS; PLANT LEAVES; RATS; RATS, SPRAGUE-DAWLEY; STOMACH ULCER; ULCER;

EID: 84865010508     PISSN: 10117571     EISSN: 14230151     Source Type: Journal    
DOI: 10.1159/000336593     Document Type: Article

References (29)

1. Janardhanan K, Vadivel V, Pugalenthi M: Biodiversity in Indian underexploited/tribal pulses; in Jaiwal KP, Singh RP (eds): Improvement Strategies for Leguminosae Biotechnology. Dordrecht, Kluwer Academic Press, 2003, pp 353-405.
2. Zakaria ZA, Wen LY, Abdul Rahman NI, Abdul Ayub AH, Sulaiman MR, Gopalan HK: Antinociceptive, anti-inflammatory and antipyretic properties of the aqueous extract of Bauhinia purpurea leaves in experimental animals. Med Princ Pract 2007; 16: 443-449.
3. Mukherjee KPK, Gopal TK, Subburaju T, Dhanbal SB, Duraiswamy B, Elango K, Suresh B: Studies on the anti-diarrheal profiles of Bauhinia purpurea L. leaves (Caesal-piniaceae) extract. Nat Prod Sci 1998; 4: 234-237.
4. Zakaria ZA, Abdul Rahman NI, Wen LY, Abdul Ayub AH, Sulaiman MR, Mat Jais AM, Gopalan HK, Fatimah CA: Antinoci-ceptive and anti-inflammatory activities of the chloroform extract of Bauhinia purpurea (Leguminosae) leaves. Int J Trop Med 2009; 4:140-145.
5. Boonphong S, Puangsombat P, Baramee A, Mahidol C, Ruchirawat S, Kittakoop P: Bio-active compounds from Bauhinia purpurea possessing antimalarial, antimycobacterial, antifungal, anti-inflammatory, and cytotox-ic activities. J Nat Prod 2007; 70:795-801.
6. Zakaria ZA: Free radical scavenging activity of some plants available in Malaysia. Iranian J Pharmacol Ther 2007; 6:87-91.
7. Zakaria ZA, Rofiee MS, Teh LK, Salleh MZ, Sulaiman MR, Somchit MN: Bauhinia pur-purea leaves ex t racts ex hibited in vitro anti-proliferative and antioxidant activities. Afr J Biotechnol 2011; 10:65-74.
8. Panda S, Kar A: Withania somnifera and Bauhinia purpurea in the regulation of circulating thyroid hormone concentrations in female mice. J Ethnopharmacol 1999; 67: 233-239.
9. Jatwa R, Kar A: Amelioration of metformin-induced hypothyroidism by Withania som-nifera and Bauhinia purpurea extracts in type 2 diabetic mice. Phy tother Res 2009; 23: 1140-1145.
10. Mohamed EA, Lim CP, Ebrika OS, Asmawi MZ, Sadikun A, Yam MF: Toxicity evaluation of a standardised 50% ethanol extract of Orthosiphon stamineus. J Ethnopharmacol 2011; 133: 358-363.
11. Noor SM, Mahmood AA, Salmah I, Philip K: Prevention of acute gastric mucosal lesions by Rafflesia hasseltii in rats. J Anim Vet Adv 2006; 5:161-164.
12. Abdulla MA, Al-Bayaty FH, Younis LT, Abu Hassan MI: Anti-ulcer activity of Centella asiatica leaf extract against ethanol-induced gastric mucosal injury in rats. J Med Plant Res 2010; 4:1253-1259.
13. Nwafor PA, Okwuasaba FK, Binda LG: An-tidiarrhoeal and antiulcerogenic effects of methanolic extract of Asparagus pubescens root in rats. J Ethnopharmacol 2000; 72:421-427.
14. Shay H, Komarov SA, Fels SS, Meranze D, Gruenstein M, Siplet H: A simple method for the uniform production of gastric ulceration in the rat. Gastroenterology 1945; 5:43-61.
15. Corne SJ, Morrisey SM, Woods RJ: A method for the quantitative estimation of gastric barrier mucus. J Physiol 1974; 242: 116-117.
16. Ikhiri K, Boureima D, Dan-Kouloudo D: Chemical screening of medicinal plants used in the traditional pharmacopoeia of Niger. Int J Pharmacog 1992; 30:251-262.
17. Bighetti AE, Antonio MA, Kohn LK, Rehder VLG, Foglio MA, Possenti A, Vilela L, Car-valho JE: Antiulcerogenic activity of a crude hydroalcoholic extract and coumarin isolated from Mikania laevigata Schultz Bip. Phytomedicine 2006; 12:72-77.
18. Rachchh MA, Jain SM: Gastroprotective effect of Benincasa hispida fruit extract. Indian J Pharmacol 2008; 40: 271-275.
19. Nordmann R: Alcohol and antioxidant systems. Alcohol Alcohol 1994; 29:513-522.
20. Swarnakar S, Ganguly K, Kundu P, Banerjee A, Maity P, Sharma AV: Curcumin regulates expression and activity of matrix metallo-proteinases 9 and 2 during prevention and healing of indomethacin-induced gastric ulcer. J Biol Chem 2005; 280:9409-9415.
21. Wallace JL: Prostaglandins, NSAIDs, and gastric mucosal protection: why doesn't the stomach digest it self? Phy siol Rev 2008; 88: 1547-1565.
22. Aly AM, Al-Alousi L, Salem HA: Licorice: a possible anti-inflammatory and anti-ulcer drug. AAPS PharmSciTech 2005; 6:E74-E82.
23. 4-induced liver damage. J Nat Rem 2004; 4:120-126.
24. Singh S, Khajuria A, Taneja SC, Khajuria RK, Singh J, Johri RK, Qazi GN: The gastric ulcer protective effect of boswellic acids, a leuko-triene inhibitor from Boswellia serrata in rats. Phytomedicine 2008; 15:408-415.
25. Khare S, Asad M, Dhamanigi SS, Prasad VS: Antiulcer activity of cod liver oil in rats. Indian J Pharmacol 2008; 40:209-214.
26. Yadav S, Bhadoria BK: Two dimeric flavo-noids from Bauhinia purpurea. Indian J Chem 2005; 44 B: 2604-2607.
27. Ragasa CY, Hofilena JG, Rideout J: Secondary metabolite from Bauhinia purpurea. Philippine J Sci 2004; 133: 1-6.
28. Tsimogiannis D, Samiotaki M, Panayotou G, Oreopoulou V: Characterization of flavo-noid subgroups and hydroxy substitution by HPLC-MS/MS. Molecules 2007; 12: 593-606.
29. Raj Narayana K, Sripal Reddy M, Chaluvadi MR, Krishna DR: Bioflavonoids classification, pharmacological, biochemical effects and therapeutic potential. Indian J Pharmacol 2001; 33:2-16.